386 research outputs found
One-Loop QCD Corrections to the Thermal Wilson Line Model
We calculate the time independent four-point function in high temperature (T)
QCD and obtain the leading momentum dependent terms. Furthermore, we relate
these derivative interactions to derivative terms in a recently proposed finite
T effective action based on the SU(3) Wilson Line and its trace, the Polyakov
Loop. By this procedure we thus obtain a perturbative matching at finite T
between QCD and the effective model. In particular, we calculate the leading
perturbative QCD-correction to the kinetic term for the Polyakov Loop.Comment: Minor changes, one reference adde
Matrix elements relevant for Delta I=1/2 rule and epsilon-prime from Lattice QCD with staggered fermions
We perform a study of matrix elements relevant for the Delta I=1/2 rule and
the direct CP-violation parameter epsilon-prime from first principles by
computer simulation in Lattice QCD. We use staggered (Kogut-Susskind) fermions,
and employ the chiral perturbation theory method for studying K to 2 Pi decays.
Having obtained a reasonable statistical accuracy, we observe an enhancement of
the Delta I=1/2 amplitude, consistent with experiment within our large
systematic errors. Finite volume and quenching effects have been studied and
were found small compared to noise. The estimates of epsilon-prime are hindered
by large uncertainties associated with operator matching. In this paper we
explain the simulation method, present the results and address the systematic
uncertainties.Comment: 40 pages, 17 figures, LATEX with epsf, to be submitted to Phys. Rev.
D. Minor errors are corrected, some wording and notation change
Connection between Chiral Symmetry Restoration and Deconfinement
We propose a simple explanation for the connection between chiral symmetry
restoration and deconfinement in QCD at high temperature. In the Higgs
description of the QCD vacuum both spontaneous chiral symmetry breaking and
effective gluon masses are generated by the condensate of a color octet
quark-antiquark pair. The transition to the high temperature state proceeds by
the melting of this condensate. Quarks and gluons become (approximately)
massless at the same critical temperature. For instanton-dominated effective
multiquark interactions and three light quarks with equal mass we find a first
order phase transition at a critical temperature around 170 MeV.Comment: New section on vortices,33 pages,LaTe
Cultural orientations and preference for HRM policies and practices:the case of Oman
This study empirically examines the influence of cultural orientations on employee preferences of human resource management (HRM) policies and practices in Oman. Data were collected from 712 employees working in six large Omani organizations. The findings indicate that there is a number of differences among Omani employees regarding value orientations due especially to age, education and work experience. The findings show a strong orientation towards mastery, harmony, thinking and doing, and a weak orientation towards hierarchy, collectivism, subjugation and human nature-as-evil. The results demonstrate a clear link between value orientations and preferences for particular HRM policies and practices. Group-oriented HRM practices are preferred by those who scored high on collectivism and being orientations, and those who scored low on thinking and doing orientations. Hierarchy-oriented HRM practices are preferred by those scoring high on hierarchy, subjugation and human nature-as-bad orientations, and those scoring low on thinking and mastery orientations. Finally, preference for loose and informal HRM practices was positively associated with being, and negatively associated with thinking, doing and harmony orientations. The theoretical and practical implications of these findings are discussed in detail
Lattice Calculation of Heavy-Light Decay Constants with Two Flavors of Dynamical Quarks
We present results for , , , and their ratios in
the presence of two flavors of light sea quarks (). We use Wilson light
valence quarks and Wilson and static heavy valence quarks; the sea quarks are
simulated with staggered fermions. Additional quenched simulations with
nonperturbatively improved clover fermions allow us to improve our control of
the continuum extrapolation. For our central values the masses of the sea
quarks are not extrapolated to the physical , masses; that is, the
central values are "partially quenched." A calculation using "fat-link clover"
valence fermions is also discussed but is not included in our final results. We
find, for example,
MeV, , MeV, and , where in each case the first error is
statistical and the remaining three are systematic: the error within the
partially quenched approximation, the error due to the missing strange
sea quark and to partial quenching, and an estimate of the effects of chiral
logarithms at small quark mass. The last error, though quite significant in
decay constant ratios, appears to be smaller than has been recently suggested
by Kronfeld and Ryan, and Yamada. We emphasize, however, that as in other
lattice computations to date, the lattice quark masses are not very light
and chiral log effects may not be fully under control.Comment: Revised version includes an attempt to estimate the effects of chiral
logarithms at small quark mass; central values are unchanged but one more
systematic error has been added. Sections III E and V D are completely new;
some changes for clarity have also been made elsewhere. 82 pages; 32 figure
A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2- Primary Breast Cancer
©2020 American Association for Cancer Research. PURPOSE: Fulvestrant, the first-in-class selective estrogen receptor (ER) degrader (SERD), is clinically effective in patients with ER+ breast cancer, but it has administration and pharmacokinetic limitations. Pharmacodynamic data suggest complete ER degradation is not achieved at fulvestrant's clinically feasible dose. This presurgical study (NCT03236974) compared the pharmacodynamic effects of fulvestrant with AZD9496, a novel, orally bioavailable, nonsteroidal, potent SERD, in treatment-naïve patients with ER+ HER2- primary breast cancer awaiting curative intent surgery. PATIENTS AND METHODS: Patients were randomized 1:1 to receive AZD9496 250 mg twice daily from day 1 for 5-14 days, or fulvestrant 500 mg on day 1. On-treatment imaging-guided core tumor biopsies were taken between day 5 and 14 and compared with pretreatment diagnostic biopsies. The primary objective was to compare the effects of AZD9496 and fulvestrant on ER expression. Secondary objectives included changes in progesterone receptor (PR) and Ki-67 pharmacokinetic/pharmacodynamic relationships and safety. RESULTS: Forty-six women received treatment (AZD9496 n = 22; fulvestrant n = 24); 35 paired biopsies were evaluable (AZD9496 n = 15; fulvestrant n = 20). The least square mean estimate for ER H-score reduction was 24% after AZD9496 versus 36% after fulvestrant treatment (P = 0.86). AZD9496 also reduced PR H-scores (-33.3%) and Ki-67 levels (-39.9%) from baseline, but was also not superior to fulvestrant (PR: -68.7%, P = 0.97; Ki-67: -75.4%, P = 0.98). No new safety findings were identified. CONCLUSIONS: This was the first presurgical study to demonstrate that an oral SERD affects its key biological targets. However, AZD9496 was not superior to fulvestrant at the dose tested
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