Land cover classification and change during mine reclamation in Northeast Florida using multispectral imagery

Titanium is commonly used in the aerospace industry because it is lightweight and durable in extreme temperatures. The Green Cove Springs Mine, near Green Cove Springs, Florida, was used for mining and processing titanium and other minerals from 1972 until 2009. Since then, the mine area is being reclaimed, or rehabilitated and restored to its natural state, as required by Florida Department of Environmental Protection regulations. In this study, we use high-resolution multispectral satellite and aerial imagery obtained from 2016 to 2022 to examine land cover (LC) changes at the Green Cove Springs Mine during this reclamation period. We use the National Land Cover Database (NLCD; 30-m resolution) to identify regions of no LC change and train a support vector machine classification of LC across the entire mine area at a much finer scale

Monitoring and Pay: An Experiment on Employee Performance under Endogenous Supervision

We present an experimental test of a shirking model where monitoring intensity is endogenous and effort a continuous variable. Wage level, monitoring intensity and consequently the desired enforceable effort level are jointly determined by the maximization problem of the firm. As a result, monitoring and pay should be complements. In our experiment, between and within treatment variation is qualitatively in line with the normative predictions of the model under standard assumptions. Yet, we also find evidence for reciprocal behavior. Our data analysis shows, however, that it does not pay for the employer to solely rely on the reciprocity of employees

Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes

IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic. Host kinase regulators of dengue virus (DENV) infection have the potential to be disrupted by existing therapeutics to prevent infection and/or disease progression.MethodsTo evaluate kinase regulation of DENV infection, we performed kinase regression (KiR), a machine learning approach that predicts kinase regulators of infection using existing drug-target information and a small drug screen. We infected hepatocytes with DENV in vitro in the presence of a panel of 38 kinase inhibitors then quantified the effect of each inhibitor on infection rate. We employed elastic net regularization on these data to obtain predictions of which of 291 kinases are regulating DENV infection.ResultsThirty-six kinases were predicted to have a functional role. Intriguingly, seven of the predicted kinases – EPH receptor A4 (EPHA4), EPH receptor B3 (EPHB3), EPH receptor B4 (EPHB4), erb-b2 receptor tyrosine kinase 2 (ERBB2), fibroblast growth factor receptor 2 (FGFR2), Insulin like growth factor 1 receptor (IGF1R), and ret proto-oncogene (RET) – belong to the receptor tyrosine kinase (RTK) family, which are already therapeutic targets in the clinic. We demonstrate that predicted RTKs are expressed at higher levels in DENV infected cells. Knockdown of EPHB4, ERBB2, FGFR2, or IGF1R reduces DENV infection in hepatocytes. Finally, we observe differential temporal induction of ERBB2 and IGF1R following DENV infection, highlighting their unique roles in regulating DENV.DiscussionCollectively, our findings underscore the significance of multiple RTKs in DENV infection and advocate further exploration of RTK-oriented interventions against dengue

Timing and Predictors of Recanalization After Anticoagulation in Cerebral Venous Thrombosis.

BACKGROUND AND PURPOSE Vessel recanalization after cerebral venous thrombosis (CVT) is associated with favorable outcomes and lower mortality. Several studies examined the timing and predictors of recanalization after CVT with mixed results. We aimed to investigate predictors and timing of recanalization after CVT. METHODS We used data from the multicenter, international AntiCoagulaTION in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT) study of consecutive patients with CVT from January 2015 to December 2020. Our analysis included patients that had undergone repeat venous neuroimaging more than 30 days after initiation of anticoagulation treatment. Prespecified variables were included in univariate and multivariable analyses to identify independent predictors of failure to recanalize. RESULTS Among the 551 patients (mean age, 44.4±16.2 years, 66.2% women) that met inclusion criteria, 486 (88.2%) had complete or partial, and 65 (11.8%) had no recanalization. The median time to first follow-up imaging study was 110 days (interquartile range, 60-187). In multivariable analysis, older age (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.03-1.07), male sex (OR, 0.44; 95% CI, 0.24-0.80), and lack of parenchymal changes on baseline imaging (OR, 0.53; 95% CI, 0.29-0.96) were associated with no recanalization. The majority of improvement in recanalization (71.1%) occurred before 3 months from initial diagnosis. A high percentage of complete recanalization (59.0%) took place within the first 3 months after CVT diagnosis. CONCLUSION Older age, male sex, and lack of parenchymal changes were associated with no recanalization after CVT. The majority recanalization occurred early in the disease course suggesting limited further recanalization with anticoagulation beyond 3 months. Large prospective studies are needed to confirm our findings

The Grizzly, September 24, 1991

Ursinus Day Academic Convocation Changes Face • Alcohol Policy Enforcement Tightens • Freshman Class Elections Held • Dr. Hall Honored • U.S.G.A. Minutes • Student Response Team Regroups • Demas Presents... Barry Hixson • Sororities Begin Formal Rushing • Finally! Student Center Opens • Golf Gets New Head Coach • Paul Harryn Launches Berman Season • DeLuca Hypnotizes Audience • Movie Reviews: Pacific Heights; New Jack City; Hot Shots • Volleyball Nets a Win • Lady Bears Stick It to Opponents • Nick\u27s NFL Notes • Bears Harass Hoyas in Opener • Soccer Kicks Off Season with Win • U.C. Tavern? • Questions of Freedom • Defense of History • Life Science Building Upgraded to State-Of-The-Art Facility • Pre-med Committee Evaluation Meeting • Medicine in The Gulf Warhttps://digitalcommons.ursinus.edu/grizzlynews/1277/thumbnail.jp

The Grizzly, October 1, 1991

Whittaker Relates Gulf Experience • Sorority Pledging Underway • U.S.E.A.C. Conference a Success • Ursinus Students Feel the Excitement of Habitat • College Tutorial Project Thrives • U.C. Welcomes New Instructors • Leadershop 1991 • U.S.G.A. Finds a Home • A Plea for Help • GN\u27R: Illusion ... of Good Music • State Museum Exhibits Berman Sculptures • Jane Ira Bloom Jazzes It Up • Sky Sands Strikes Ursinus • Aerobics Attack • The Tempting Temple • Field Hockey Faces Tough Times • Bears Terrorized by Western Maryland • Lady Bears Finish 4th • Bears Tee Off • Runners Get Recognition • Soccer Splits Two • Cross Country Cruises to 3rd Place • Gift to Give • Alcohol Policy Enforcement Tightens • Intellect Over Image • Wismer Whine • Healing the Wounds of the Gulf War • The Search For the Chemical Promisehttps://digitalcommons.ursinus.edu/grizzlynews/1278/thumbnail.jp

Planet Formation Imager (PFI): Science vision and key requirements

The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to ∼100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the Hill Sphere of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs

Combining genomic and epidemiological data to compare the transmissibility of SARS-CoV-2 variants Alpha and Iota.

SARS-CoV-2 variants shaped the second year of the COVID-19 pandemic and the discourse around effective control measures. Evaluating the threat posed by a new variant is essential for adapting response efforts when community transmission is detected. In this study, we compare the dynamics of two variants, Alpha and Iota, by integrating genomic surveillance data to estimate the effective reproduction number (Rt) of the variants. We use Connecticut, United States, in which Alpha and Iota co-circulated in 2021. We find that the Rt of these variants were up to 50% larger than that of other variants. We then use phylogeography to show that while both variants were introduced into Connecticut at comparable frequencies, clades that resulted from introductions of Alpha were larger than those resulting from Iota introductions. By monitoring the dynamics of individual variants throughout our study period, we demonstrate the importance of routine surveillance in the response to COVID-19

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.Peer reviewe