Evaluation of Pavement Markings on Low-Volume Rural Roadways in Iowa

Many rural roadways in Iowa have centerline and/or edgeline pavement markings. The current Manual on Uniform Traffic Control Devices (MUTCD), however, requires centerline and/or edgeline pavement markings only along streets and roadways with traffic volumes much greater than 400 vehicles per day (the volume-based definition of a low-volume roadway in the MUTCD). This project was initiated to gather and summarize information about the state of practice related to the installation and maintenance of pavement markings along low-volume rural roadways in Iowa. Additional information was also collected to provide more guidance in the pavement-marking decision-making process. The tasks completed include an examination and summary of past research, the collection of legal input related to the use of pavement markings in Iowa, and a survey of Iowa county engineers that focused on their current pavement-marking practices. A basic safety benefit-cost evaluation of pavementmarking applications was also performed. Overall, the literature on the effectiveness of pavement markings and their safety impacts is limited. A number of studies have been completed with varying levels of robustness and reliability in their results. The Highway Safety Manual includes crash modification factors for the installation of centerline markings that it indicates should be used with caution, and one for the installation of edgeline and centerline markings that equates to a 24 percent total serious and minor-injury crash reduction. A more recent study from Louisiana also found a 15 percent reduction in total crashes after the addition of edgelines. The legal input acquired as part of this project was generally common knowledge. It indicated that once a traffic control device has been installed, the jurisdiction must properly and adequately maintain it. The survey completed found that, of the great majority of the respondents (97 percent), painted centerline/no passing zones and edgelines on at least some of their paved low-volume rural roadways. A much smaller percentage took this approach, or just painted centerlines/no passing zones, along their seal-coated roadways. The basic cost-benefit evaluation found that the percentage of crash reduction needed from pavement markings to make them beneficial was very low (i.e., 5.1 percent, at most). Overall, it was concluded that pavement markings are widely used in Iowa along low-volume paved roadways and sometimes seal-coated roadways. In addition, there is a safety benefit to the installation of pavement markings. but the research into that impact is limited, particularly along low-volume roadways. It is recommended that further analysis be completed on potential pavement-marking safety impacts, that a pavement-marking database be developed, and that a committee be initiated to help develop policies related to pavement-marking removal

Upper extremity transplantation in non-human primates: an orthotopic model for translational research

Vascularized composite allotransplantation (VCA) offers unparalleled restoration of function and form following devastating musculoskeletal and soft tissue injury. However, the potential adverse effects of life-long immunosuppression remain a significant cause for concern. Therefore, while the surgical techniques necessary for VCA have developed rapidly, the immunological aspects of these procedures and the potential functional significance of immunological processes on vascularized composite allografts remain areas in which further research is required. The functional complexity of these procedures, combined with the preclinical nature of many of the research questions, necessitates the use of large animal models to most effectively address some of the outstanding hypotheses. Cynomolgus macaques are among the premier large animal models for immunological research. This manuscript describes development of an orthotopic model of upper extremity transplantation in cynomolgus macaques. Following study of the anatomy to determine feasibility, in vivo proof of concept was achieved by autologous amputation and replantation in two animals, following which a preliminary series of four allotransplants was performed. The anatomy encountered and techniques required for successful transplantation are closely comparable to those in clinical upper extremity transplantation. This is a technically challenging model, but offers a rigorous pre-clinical platform for translational research in transplant immunology, and is suitable for detailed study of the impact of immunologic processes on functional outcomes following VCA

Product Design: A Review and Research Agenda for Management Studies

This paper reviews research on product design in the broad domain of business studies. It highlights established and emerging perspectives and lines of inquiry, and organizes them around three core areas, corresponding to different stages of the design process (design activities, design choices, design results). Avenues for further research at the intersection of these bodies of research are identified and discussed, and the authors argue that management scholars possess conceptual and methodological tools suited to enriching research on design and effectively pursuing lines of investigation only partially addressed by other communities, such as the construction and deployment of design capabilities, or the organizational and institutional context of design activities

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Finite capacity production planning with random demand and limited information

Production planning has a fundamental role in any manufacturing operation. The problem is to decide what type of, and how much, product should be produced in future time periods. The decisions should be based on many factors, including period machine capacity, profit margins, holding costs, etc. Of primary importance is the estimate of demand for manufacturer's products in upcoming periods.Our focus is to address the production planning problem by including in our models the randomness that exists in our estimates for future demands. We solve the problem with two variants of Monte Carlo sampling based optimization techniques, to which we refer as "simulation based optimization" methods. The first variant assumes that we know the actual demand distribution (assumed to be continuous) with which we approximate the true optimal solution by averaging sample estimates of the corresponding expected value function. The second approach is useful when we have limited information about the demand distribution. We illustrate the robustness of the approach by comparing a three mass-point approximation of the continuous distribution to the results obtained using the continuous distribution. This second approach is particularly appealing as it results in a solution that is close to optimal while being much faster than the continuous distribution approach

Construction of vicinal 4°/3°-carbons via reductive Cope rearrangement

Herein reported is a strategy for constructing vicinal 4°/3° carbons via reductive Cope rearrangement. Substrates have been designed which exhibit Cope rearrangement kinetic barriers in the range of ~23 kcal/mol with isothermic favorability (G ~0). These fluxional/shape-shifting molecules can be driven forward by chemoselective reduction to useful polyfunctionalized building blocks

Autonomous journaling response using data model LUTS

Matching journal entries to appropriate context responses can be a daunting problem, especially when there are no salient keyword matches between the entry and the proposed library of appropriate responses. We examine a real-world application for matching interactive journaling requests for guidance to an a priori established archive of sufficient multimedia responses. We show the analysis required to enable a Data Model based algorithm to group journaling entries according to intrinsic context information and type. We demonstrate a new lookup table (LUT) classifier that exploits all available data in LUT for

Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization

Temporary coverage of severely burned patients with cadaver allograft skin represents an important component of burn care, but is limited by availability and cost. Porcine skin shares many physical properties with human skin, but is susceptible to hyperacute rejection due to preformed antibodies to α-1,3-galactose (Gal), a carbohydrate on all porcine cells. Our preliminary studies have suggested that skin grafts from α-1,3-galactosyltransferase knock out (GalT-KO) miniature swine might provide temporary wound coverage comparable to allografts, since GalT-KO swine lack this carbohydrate. To further evaluate this possibility, eight non-human primates received primary autologous, allogeneic, GalT-KO, and GalT + xenogeneic skin grafts. Additionally, secondary grafts were placed to assess whether sensitization would affect the rejection time course of identical-type grafts. We demonstrate that both GalT-KO xenografts and allografts provide temporary coverage of partial- and full-thickness wounds for up to 11 days. In contrast, GalT + xenografts displayed hyperacute rejection, with no signs of vascularization and rapid avulsion from wounds. Furthermore, secondary GalT-KO transplants failed to vascularize, demonstrating that primary graft rejection sensitizes the recipient. We conclude that GalT-KO xenografts may provide temporary coverage of wounds for a duration equivalent to allografts, and thus, could serve as a readily available alternative treatment of severe burns