Microbial, inflammatory and clinical determinants of acute exacerbations of chronic obstructive pulmonary disease

Sem resumo disponível.publishe

Photochemical studies of cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6): Blue light-induced nucleobase binding.

The ruthenium(II) compounds cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 (I) and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6) (II) (4-bzpy=4-benzoylpyridine, bpy=2,2'-bipyridine) were synthesized and characterized by spectroscopic and electrochemical techniques. The crystal structure of II was determined by X-ray diffraction. The photochemical behavior of I in aqueous solution shows that irradiation with ultraviolet light (365nm) releases both CO and 4-bzpy leading to the formation of the cis-[Ru(bpy)2(H2O)2]2+ ion as identified by NMR and electronic spectroscopy. Carbon monoxide release was confirmed with the myoglobin method and by gas chromatographic analysis of the headspace. CO release was not observed when aqueous I was irradiated with blue light (453nm). Changes in the electronic and 1H NMR spectra indicate that I undergoes photoaquation of 4-bzpy to form cis-[Ru(bpy)2(CO)(H2O)]2+. Blue light irradiation of aqueous II released the coordinated 4-bzpy to give the cis-[Ru(bpy)2(H2O)(Cl)]2+ ion. When the latter reaction was carried out in the presence of the nucleobase guanine, Ru-guanine adducts were formed, indicating that the metal containing photoproduct may also participate in biologically relevant reactions. The photochemical behavior of I indicates that it can release either CO or 4-bzpy depending on the wavelength chosen, a feature that may have therapeutic application

Living in between a house and a home: Where’s the comfort zone anyway? Dislocated identities in Morrison’s The Bluest Eye and Cisneros’ The House on Mango Street

Este artículo propone una reflexión sobre representaciones literarias del hogar en contraste con las colocaciones existentes en los medios, en el ámbito psicológico y sociológico (hogar vs zona de confort). La elección de dos textos poscoloniales, uno de Toni Morrison, The Bluest Eye (1970), y otro de Sandra Cisneros, The House on Mango Street (1984), proporciona el punto de partida para el análisis de experiencias sociales y culturales cambiantes, centrando la atención en la búsqueda de identidad de los personajes en un marco multicultural y multilingüe como es Estados Unidos. El artículo ofrece una breve aproximación teórica (Anderson 1991) para después centrarse en un estudio de corpus que permite cartografiar estas transformaciones y desplazamientos (Baker 2006), recurriendo al mismo tiempo a un detallado análisis de los contextos en los que aparecen las palabras clave hogar y casa, junto con sus patrones de colocación, en los textos estudiados (del nivel oracional al textual, siguiendo a Biber et al. 1998; Sinclair 2004, entre otros). Este análisis pretende finalmente revelar el modo en el que las escritoras emplean las estructuras lingüísticas y, más importante aún, qué significa sentirse en casa cuando los personajes nunca se han sentido bienvenidos, o la lucha interna / externa de los personajes por desarrollar un sentido de pertenencia en entornos perturbados.This paper aims to provide a reflection on literary representations of home alternatively to current collocations in the media, in the psychological and sociological realm (home vs comfort zone). The selection of two postcolonial texts, one by Morrison, The Bluest Eye (1970), and another by Cisneros, The House on Mango Street (1984), provides ways-in to discuss changing social and cultural experiences with a focus on characters’ search for identity in a multicultural and multilingual setting, as is the one in the United States. The study will depart from a brief theoretical survey (Anderson 1991) to a corpus-based approach which maps such shifts and changes (Baker 2006) while resorting to a close analysis of contexts of occurrence of the keywords home and house, along with their patterns of collocation, in the texts under scope (from the sentence to the textual levels, following Biber et al. 1998; Sinclair 2004, among other). The analysis is meant to unveil ways in which writers make use of linguistic structures and most importantly what it means to be at home when characters never felt welcome there, or characters’ inner / outer struggle to develop a sense of belonging in disrupted settings.info:eu-repo/semantics/publishedVersio

Conflicting voices in literary discourse - A corpus analysis of you and one

UID/ELT/00657/2013This paper discusses the possibilities of a corpus analysis applied to literary study and interpretation. It is thus its goal to present some findings related to the disambiguation of some pronominal references, i.e. you and one, as they occur in speech and thought presentation in prose fiction, across periods in the 20th century. The texts selected are two of Virginia Woolf's novels (early and late modernist period) and one by Hugo Hamilton (in the postmodern era). The analysis benefits from a multi-layered interpretive framework drawing on discou rse analysis, corpus-based approaches and literary study, particularly in that it unpacks ways in which writers make use of linguistic structures. These involve readers in a dialogic interpretation of the text's "polyphony" and "heteroglossia", either conveying the generic pronoun reference or the protagonist's inner voice.publishersversionpublishe

Microbial shifts during an acute exacerbation of chronic obstructive pulmonary disease

No abstract available.publishe

Where’s the comfort zone anyway? Dislocated Identities in Morrison’s The Bluest Eye and Cisnero’s The House of Mango Street

UIDB/00657/2020 UIDP/00657/2020Este artículo propone una reflexión sobre representaciones literarias del hogar en contraste con las colocaciones existentes en los medios, en el ámbito psicológico y sociológico (hogar vs zona de confort). La elección de dos textos poscoloniales, uno de Toni Morrison, The Bluest Eye (1970), y otro de Sandra Cisneros, The House on Mango Street (1984), proporciona el punto de partida para el análisis de experiencias sociales y culturales cambiantes, centrando la atención en la búsqueda de identidad de los personajes en un marco multicultural y multilingüe como es Estados Unidos. El artículo ofrece una breve aproximación teórica (Anderson 1991) para después centrarse en un estudio de corpus que permite cartografiar estas transformaciones y desplazamientos (Baker 2006), recurriendo al mismo tiempo a un detallado análisis de los contextos en los que aparecen las palabras clave hogar y casa, junto con sus patrones de colocación, en los textos estudiados (del nivel oracional al textual, siguiendo a Biber et al. 1998; Sinclair 2004, entre otros). Este análisis pretende finalmente revelar el modo en el que las escritoras emplean las estructuras lingüísticas y, más importante aún, qué significa sentirse en casa cuando los personajes nunca se han sentido bienvenidos, o la lucha interna / externa de los personajes por desarrollar un sentido de pertenencia en entornos perturbados. This paper aims to provide a reflection on literary representations of home alternatively to current collocations in the media, in the psychological and sociological realm (home vs comfort zone). The selection of two postcolonial texts, one by Morrison, The Bluest Eye (1970), and another by Cisneros, The House on Mango Street (1984), provides ways-in to discuss changing social and cultural experiences with a focus on characters’ search for identity in a multicultural and multilingual setting, as is the one in the United States. The study will depart from a brief theoretical survey (Anderson 1991) to a corpus-based approach which maps such shifts and changes (Baker 2006) while resorting to a close analysis of contexts of occurrence of the keywords home and house, along with their patterns of collocation, in the texts under scope (from the sentence to the textual levels, following Biber et al. 1998; Sinclair 2004, among other). The analysis is meant to unveil ways in which writers make use of linguistic structures and most importantly what it means to be at home when characters never felt welcome there, or characters’ inner / outer struggle to develop a sense of belonging in disrupted settings.publishersversionpublishe

Physical pain in formal caregivers of dependent older people

Sem resumo disponível.publishe

A escola é um lugar para todo mundo!

The summary makes public reflections on inclusive education through the film Forget Me Not. It is a documentary that tells the story of Emilio, three years old, who was born with Down’s Syndrome and is preparing to enter public school in New York City. The educational system of this city follows a segregating model, leading Emílio's family to have experiences of struggle for an inclusive school. The documentary invites us to be strange and to change paradigms in the life history of people with intellectual disabilities regarding accessibility and permanence in educational institutions. Scientific research finds that environments that value difference benefit students with and without disabilities. Among children with Down’s syndrome, there is evidence that the amount of time spent with peers without disabilities is associated with better memory, language skills, and literacy.O resumo publiciza reflexões sobre a educação inclusiva por meio do filme Um lugar para todo mundo. Trata-se de um documentário que narra a história de Emilio, de três anos, que nasceu com síndrome de Down e está se preparando para ingressar na escola pública de Nova York. O sistema educacional, desta cidade, segue um modelo segregador, levando a família de Emílio a experenciar barreiras na luta por uma escola inclusiva. O documentário nos convida ao estranhamento e à mudança de paradigmas relativos a histórias de vida de pessoas com deficiência intelectual, no que toca à acessibilidade e à permanência em instituições educativas. Pesquisas científicas constatam que ambientes que valorizam a diferença são benéficos para alunos com e sem deficiência. Entre crianças com síndrome de Down, há evidências de que a quantidade de tempo vivenciado com colegas sem deficiência está associada a uma melhor memória, a habilidades de linguagem e à alfabetização

Desenvolvimento de estimação de estados em tempo-real para a rede de distribuição

Tese de mestrado integrado. Engenharia Electrotécnica e de Computadores. Faculdade de Engenharia. Universidade do Porto. 201

Salivary microbiota composition is associated with severe exacerbations

People with COPD present microbiota dysbiosis. Clinical implications of this finding are still unknown and need validation. Here, we tested the association between salivary microbiota and COPD and its ability to discriminate different types of patients. 67 patients with COPD (57male, 68±9y, FEV1pp 48±19, GOLD A-12, B-31, C-5, D-19) were characterised based on sociodemographic, anthropometric, clinical data and 16S rRNA profiling of their salivary microbiota. An unsupervised clustering analysis based on patients’ beta diversity was performed to query its relationship with the disease. Two major clusters (comprising 90% of individuals) differing drastically in severity were observed. Cluster1 aggregated all patients hospitalized in the previous year due to acute exacerbations, 71% of GOLD D patients and included a higher frequency of patients under oxygen therapy and heavier smoking history than Cluster 2 (Fig 1A). Furthermore, Cluster1 had a lower microbiota diversity (MW-U, p=0.008) (Fig 1B) and was enriched in Proteobacteria or Firmicutes, particularly Streptococcus. In contrast, Cluster2 was significantly enriched in Bacteroidetes, particularly Alloprevotella and Prevotella (Fig 1C). Saliva’s microbiota showed a strong association with COPD, especially in terms of severe exacerbations, supporting the use of salivary microbiota for further studies in this population.publishe