Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer

The importance of canonical and non-canonical Wnt signal transduction cascades in embryonic development and tissue homeostasis is well recognized. The aberrant activation of these pathways in the adult leads to abnormal cellular behaviors, and tumor progression is frequently a consequence. Here we discuss recent findings and analogies between Wnt signaling in developmental processes and tumor progression, with a particular focus on cell motility and matrix invasion and highlight the roles of the ARF (ADP-Ribosylation Factor) and Rho-family small GTP-binding proteins. Wnt-regulated signal transduction from cell surface receptors, signaling endosomes and/or extracellular vesicles has the potential to profoundly influence cell movement, matrix degradation and paracrine signaling in both development and disease

Role for a Cindr–Arf6 axis in patterning emerging epithelia

The fly pupal eye is used to explore dArf6 activity regulated by the Arf GTPase–activating proteins (ArfGAPs) dAsap and dArfGAP3 and Arf GTP exchange factors Schizo and dPsd, which promote cellular extensions that presage cell rearrangements. The adaptor protein Cindr bound to dArfGAP3 and dAsap to sequester ArfGAP function to Neph1/nephrin adhesion complexes, liberating active dArf6 elsewhere