ON THE PROJECTIONS OF COMMUTATIVE C*-ALGEBRAS

Gelfand and Naimark proved that the Banach algebra of continuous complex-valued functions on a compact space Ω is the only example of commutative unital C*-algebras. We study the C*-algebra C(Ω) and its main elements, such as projections. Also, we discuss the mapping between projections, which preserves orthogonality (orthoisomorphism). A bijective θ between projections induces a bijective Θ between the Boolean algebra of clopen subsets of X. Then, we give main properties of such Θ. For a compact subset X of ℝ, we classify the projections of C(X) by introducing the similar relation on P(C(X)). We introduce an ordering on the classes of similar projections. We prove that if θ is an orthoisomorphism between the projections, then it preserves the support-number, and if θ is an orthoisomorphism between the projections, which preserves singleton-minimals projections, then θ preserves similarity of projections. Also, an orthoisomorphism θ preserving singleton-minimals projections, induces a bijection on the classes of similar projection, which preserves the ordering of classes. We explain the ordering of classes of similar projections by different example

Particle size and rate of biochar affected the phytoavailability of Cd and Pb by mustard plants grown in contaminated soils

Various amendments are used to reduce the phytoavailability of heavy metals in contaminated soils, but recently the use of biochar is receiving serious attention. In this study, two particle sizes of an oil palm empty fruit bunch biochar (EFBB); 2 mm (C-EFBB) were applied at either 0, 0.5, or 1% (w/w) to soils contaminated with either Cd or Pb and the phytoavailability of these metals by mustard plants grown on the soils was evaluated. Results revealed that the application of EFBB at 1% significantly increased plant growth parameters as compared with the control in Cd-soil. However, there was no significant effect of EFBB application rate on plant growth parameters in Pb-soil. There was a significant difference in the concentrations of Cd and Pb in the plant root and shoot between soils receiving different particle sizes of EFBB. The treatment of 1% F-EFBB gave the lowest concentration of the Cd concentration in the shoot (115.200 mgkg−1) and Pb concentration in the root and shoot (4196.000 and 78.467 mgkg−1, respectively) as compared with the other treatments. Therefore, F-EFBB application at high rates can be recommended for reducing the phytoavailability of Cd and Pb in contaminated soils

The level of IL-1?, IL-10 and IL-17A in Alzheimer's disease patients: Comparative study

The objective of this study is to evaluate the level of cytokines IL-1?, IL-10 and IL-17A in the serum of patients with Alzheimer's disease (AD), vascular dementia (VD) and down syndrome (DS). The results showed that Serum level of IL-1? was significantly increased in AD patients (3.79 ± 0.26 pg/ml) as compared with DS patients (2.78 ± 0.39 pg/ml) or controls (2.78 ± 0.22 pg/ml), while no significant difference was observed between AD and VD (3.25 ± 0.20 pg/ml) patients or between VD patients, DS patients and controls. The serum level of IL-10 was approximated in VD and DS patients and controls (3.39 ± 0.24, 2.77 ± 0.39 and 3.41 ± 0.35 pg/ml, respectively), but was significantly (P ? 0.05) increased in AD patients (5.73 ± 0.55 pg/ml) as compared to these groups. The serum level IL-17A was significantly increased in AD and VD patients (6.28 ± 0.35 and 5.32 ± 0.42 pg/ml, respectively) as compared with DS patients (3.75 ± 0.40 pg/ml) or controls (4.05 ± 0.28 pg/ml).IL-10 is important to diffrentiation between AD and VD

Incidence of hepatitis Gvirus in patients with hematological malignancies withrepeated blood transfusion

Background: Hepatitis G virus and GB virus C (GBV-C

Loading celecoxib into solid lipid nanoparticles significantly enhanced the anticancer activity

Introduction: Celecoxib (CXB), COX-2 enzyme inhibitor, has been approved recently for the treatment of colorectal polyps. Solid lipid nanoparticles (SLN) have turned out to be an attractive carrier alternative to liposomes and polymeric nanoparticles due to superior stability and biocompatibility. This work aimed to optimize CXB-loaded SLN for colon delivery with high potential toward enhancing the anticancer activity. Methods: An ultrasonic melt-emulsification method was employed in this work for the preparation of SLN. Briefly, an emulsion was formed after mixing melted lipid with heated aqueous surfactant solution heated to equal temperature by probe-sonication and dispersed in chilled distilled water for 10 minutes. The physical attributes were characterized for their particle sizes, charges, morphology, and entrapment efficiency (%EE), in addition to DSC and FTIR. The in vitro drug release profiles were evaluated and the anticancer activity was examined utilizing MTT assay in three cancer-cell-lines; HT29, Daoy, and HepG2. Results: All the prepared SLN formulations exhibited particle sizes in the nano scale ranging from 238nm to 757nm. There was dependence on the type and ratio of the surfactant used and the nature of lipid combination. The zeta-potential values (mv) were mostly in the -30s mv indicating higher stability potential of all SLN formulations. The minimum %EE was found equal to 86.76% (F9) which is advantageous of the method for large scale production. The disappearance of CXB characteristic melting peak from DSC thermograms of all formulations elucidates the amorphous nature of the SLN-entrapped CXB. The SEM images indicated the spherical nature of the SLN and CXB loading. The in vitro release profile showed a slow constant rate with no burst release which is uncommon with SLN. Both F9 and F14 showed a complete CXB release within 24-hour with only 25% within the first 5 hours. This makes them suitable for colonic targeting. F9 exhibited a significant % cell death in the three tested cancer cell lines after only 24 hours incubation and maintained the effect for 72 hours. In the case of F14, the significant % cell death was achieved with HT29 cell line after 24 hours and only after 72 hours for HepG cells, while non-significant effect was observed with Doay cells. Conclusion/Implications: The produced CXB-loaded SLN showed unique properties of slow release with no burst in addition to high %EE. The anticancer activity was extremely significant for one formulation in both HepG and HT29 cells which is highly promising

Superotemporal Predisposition to Traumatic Subretinal Fibrosis in Stargardt Disease: A Case Report

PURPOSE: Subretinal fibrosis has been reported as a presumed late sequela of orbital trauma in those with Stargardt disease (STGD). This case report highlights the sequential pathologic changes in response to trauma utilizing multimodal imaging. OBSERVATIONS: An asymptomatic 19-year-old female with no significant ocular history presented for possible drusen. Initial imaging noted yellow-white pisciform perifoveal flecks in both eyes with corresponding hyper-and hypo-fluorescent lesions on fundus autofluorescence and hyperreflective deposits on near-infrared and spectral-domain optical coherence tomography (SD-OCT). A few months later, the patient presented with a new onset black shadow in the right eye after a traumatic periorbital injury, with multi-modal imaging revealing sequelae of commotio retinae superotemporally. Follow-up imaging three months later revealed a large patch of hyperpigmented chorioretinal scar corresponding to the region of commotio. SD-OCT delineated findings consistent with subretinal fibrosis. Given the constellation of findings and subsequent genetic testing, the patient was diagnosed with STGD. CONCLUSIONS AND IMPORTANCE: Multimodal imaging allows for the detection of traumatic transformation of STGD and monitoring for early signs of massive lipofuscin release within the immediate post-traumatic period. Given the impact of minor orbital trauma on prognosis, caution should be taken to minimize and prevent orbital trauma in patients with STGD

Clinical Study Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer: A Single-Institutional Analysis in Saudi Arabia

Background. This study was undertaken to evaluate the impact of prognostic factors on the locoregional failure-free survival of early breast cancer patients. Methods. In this single-institutional study, 213 breast cancer patients were retrospectively analysed. Fiftyfive of 213 patients were ≤40 years of age at diagnosis. The impact of patient-or treatment-related factors on the locoregional failure-free survival was assessed using the Kaplan-Meier method. The simultaneous impact of factors on the locoregional failure-free survival was assessed using the Cox proportional hazards regression analysis. Results. The median follow-up time of the censored patients was 22 months (mean 28 months, range 3-92 months). On univariate analysis, statistically significant factors for the locoregional failure-free survival were the age (≤40 versus >40 years), T stage (Tis, T0-2 versus T3-4), molecular tumor type (luminal A versus luminal B, Her2neu overexpression, or triple negative), and lymphovascular status (LV0 versus LV1). On multivariate analysis, age and T stage remained statistically significant. Conclusions. Being 40 years or younger has a statistically significant independent adverse impact on the locoregional failure-free survival of patients with early breast cancer

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer: A Single-Institutional Analysis in Saudi Arabia

Background. This study was undertaken to evaluate the impact of prognostic factors on the locoregional failure-free survival of early breast cancer patients.Methods. In this single-institutional study, 213 breast cancer patients were retrospectively analysed. Fifty-five of 213 patients were ≤40 years of age at diagnosis. The impact of patient- or treatment-related factors on the locoregional failure-free survival was assessed using the Kaplan-Meier method. The simultaneous impact of factors on the locoregional failure-free survival was assessed using the Cox proportional hazards regression analysis.Results. The median follow-up time of the censored patients was 22 months (mean 28 months, range 3–92 months). On univariate analysis, statistically significant factors for the locoregional failure-free survival were the age (≤40 versus &gt;40 years), T stage (Tis, T0–2 versus T3-4), molecular tumor type (luminal A versus luminal B, Her2neu overexpression, or triple negative), and lymphovascular status (LV0 versus LV1). On multivariate analysis, age and T stage remained statistically significant.Conclusions. Being 40 years or younger has a statistically significant independent adverse impact on the locoregional failure-free survival of patients with early breast cancer.</jats:p