PIMASERTIB and SEROUS RETINAL DETACHMENTS

© by Ophthalmic Communications Society, Inc.Purpose: To report a case of multifocal serous retinal detachments associated with pimasertib. Methods: The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it. Conclusion: The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood. Copyringhtpublished_or_final_versio

Identification and antibiotic susceptibility patterns of vaginal microbiome isolated from pregnant and non-pregnant women

Background and objective. An abnormal vaginal discharge and an increase in intestinal aerobic bacteria indicate a vaginal infection. The aim of this study was to assess the antimicrobial susceptibility profiles of bacterial species present in the vaginal microbiota of both non-pregnant and pregnant women. Material and method. A total of 211 vaginal swabs were collected from 120 pregnant and 91 non-pregnant women. The VITEK 2 Compact Automated System validates bacterial isolate diagnosis and antibiotic susceptibility. Results. Out of 120 vaginal samples of pregnant women, 105 samples were identified as Gram-positive (GP) (79) and Gram-negative (GN) (26) while 15 samples were unidentified by VITEK®. The 91 nonpregnant samples comprised identified GP (53), GN (23) and unidentified samples (15). The GP bacteria were highly resistant to Oxacillin (OX1) in both groups, while the GN bacteria were resistant to Ceftazidime (CAZ) and ticarcillin (TIC) in nonpregnant group and TIC in the pregnant groups. The GP bacteria in both groups were sensitive to Tigecycline (TGC). Pregnant and non-pregnant GN bacteria were sensitive to Meropenem (MEM) (61.5%) and Piperacillin/Tazobactam (TZP) (91.3%), respectively. Conclusion. The current study showed that TZP and MEM were both groups' most effective antibiotics against GN isolates. GP bacteria were significantly TGC-sensitive

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Utveckling av kraftsensors-rigg för vindtunnel : En ny design för kraftsensors-rigg för Mittuniversitets vindtunnel

En vindtunnel används för att simulera luftflödet som verkar på till exempel en nerskalad modell av en verklig flygplansvinge eller ett fordon. Detta hjälper att förstå och ta fram de komponenter som påverkar interaktionen samt krafter och moment.  Mittuniversitetets laboratorium är i behov av en ny kraftsensors-rigg, detta är en rigg som mäter krafter som påverkar på en vinge profil inuti en vindtunnel. En vidareutveckling av den befintliga kraftsensors-riggen skulle innebära en alltför lång arbetsprocess, därför bestämdes det att utvecklas en ny design av sensor-riggen som löser några felkällor som den tidigare sensor- riggen har; vilka är inexakta mätvärde samt att den befintliga riggen mäter enbart lyftkraften. Genom framtagning av en ny kraftsensors-rigg som går att tillverka i Mittuniversitetets lokaler minskar tiden för att utföra vindtunnel tester samt ökar mätvärdenas noggrannhet. Syftet med detta arbete har varit att ta fram konstruktion av en ny kraftsensors-rigg som kan mäta krafter i x- och y-axeln det vill säga lyft och dragkraft. Kraftsensors-riggen kommer att installeras i vindtunneln som finns i Mittuniversitets laboratorium.  I detta projekt följs det designprocessens arbetsgång som är uppdelat i fyra faser. Den första fasen, förstudiefasen, definierades produktens kravspecifikation och funktionsanalys. Den andra fasen, kreativa fasen, inleddes med brainstorming för att generera konceptlösnings idéer. Sedan används Pugh-matrisen i konceptutvärdering- och framtagningsfasen för att utvärdera och välja konceptet utifrån en kvantitativ-metod. Sedan modellerades en tredimensionell modell för det färdiga konceptet med hjälp av CAD. Slutligen i konstruktion-utvecklingsfasen framställdes konstruktionen med hjälp av CAD:s modeller. därefter skrevs de komplexa delarna ut med en 3D-utskrivare samtidigt som de mindre komplexa delar framställdes av trä med en laser skärare för att spara på material samt kostnader, till slut byggdes och testades riggen i Mittuniversitets verkstad.  Projektet resulterade i en kraftsensors-rigg som kan mäta både luftmotstånd-och lyftkraften i en låg hastighet vindtunnel med noggrannare mätvärde än den tidigare riggen.   A wind tunnel is used to simulate the air flow that acts on, for example, a scaled-down model of a real aircraft wing or a vehicle. Which allows a better understanding of the components that affect the interactions between the air and the object of study, that is to say the forces and torque affecting the object. In order to fully utilize the wind tunnel in the laboratory at Mid Sweden, it has proved necessary to design a new wind tunnel force balance, which is a structure that measures forces affecting objects inside the wind tunnel. The reason being is that the current force balance sensor has some issues concerning accuracy of measurement and the lack of measuring other forces than lifting forces. A further development of the existing force balance would involve too long a work process, so it was decided to develop a new design of a wind tunnel force balance that solves some sources of error that the previous design of the force balance has and introduce an air resistance measurement component. By developing a new force balance that can be manufactured in Mid Sweden University's premises, the time for performing wind tunnel testing is reduced and the accuracy of the measured values is increased. The purpose of this project has been to develop a construction of a new force balance that can measure forces in the x- and y-axis, meaning lifting and air resistance. The force balance will be installed in the wind tunnel located in Mid Sweden University's laboratory.  In this project, the workflow of the design process is followed, which is divided into four phases. The first phase, the research phase, defined the product's requirements specification and functional analysis. The second phase, concept development and control art, began with brainstorming to generate concept solution ideas. The Pugh matrix was then used in the prototyping and validation phase to evaluate and select the concept based on a quantitative method. Then a three-dimensional model for the finalized concept was modelled using CAD. Finally, in the testing and refining phase, the design was produced using the CAD models. Then the complex components were printed with a 3D-printer while the less complex component were made of wood using a laser cutter to save on materials and costs, finally the rig was built and tested in Mid Sweden University's workshop.  The project resulted in a force balance that can measure both air resistance and lifting force in a low-speed wind tunnel with a more accurate measurements than the previous force balance.

Utveckling av kraftsensors-rigg för vindtunnel : En ny design för kraftsensors-rigg för Mittuniversitets vindtunnel

En vindtunnel används för att simulera luftflödet som verkar på till exempel en nerskalad modell av en verklig flygplansvinge eller ett fordon. Detta hjälper att förstå och ta fram de komponenter som påverkar interaktionen samt krafter och moment.  Mittuniversitetets laboratorium är i behov av en ny kraftsensors-rigg, detta är en rigg som mäter krafter som påverkar på en vinge profil inuti en vindtunnel. En vidareutveckling av den befintliga kraftsensors-riggen skulle innebära en alltför lång arbetsprocess, därför bestämdes det att utvecklas en ny design av sensor-riggen som löser några felkällor som den tidigare sensor- riggen har; vilka är inexakta mätvärde samt att den befintliga riggen mäter enbart lyftkraften. Genom framtagning av en ny kraftsensors-rigg som går att tillverka i Mittuniversitetets lokaler minskar tiden för att utföra vindtunnel tester samt ökar mätvärdenas noggrannhet. Syftet med detta arbete har varit att ta fram konstruktion av en ny kraftsensors-rigg som kan mäta krafter i x- och y-axeln det vill säga lyft och dragkraft. Kraftsensors-riggen kommer att installeras i vindtunneln som finns i Mittuniversitets laboratorium.  I detta projekt följs det designprocessens arbetsgång som är uppdelat i fyra faser. Den första fasen, förstudiefasen, definierades produktens kravspecifikation och funktionsanalys. Den andra fasen, kreativa fasen, inleddes med brainstorming för att generera konceptlösnings idéer. Sedan används Pugh-matrisen i konceptutvärdering- och framtagningsfasen för att utvärdera och välja konceptet utifrån en kvantitativ-metod. Sedan modellerades en tredimensionell modell för det färdiga konceptet med hjälp av CAD. Slutligen i konstruktion-utvecklingsfasen framställdes konstruktionen med hjälp av CAD:s modeller. därefter skrevs de komplexa delarna ut med en 3D-utskrivare samtidigt som de mindre komplexa delar framställdes av trä med en laser skärare för att spara på material samt kostnader, till slut byggdes och testades riggen i Mittuniversitets verkstad.  Projektet resulterade i en kraftsensors-rigg som kan mäta både luftmotstånd-och lyftkraften i en låg hastighet vindtunnel med noggrannare mätvärde än den tidigare riggen.   A wind tunnel is used to simulate the air flow that acts on, for example, a scaled-down model of a real aircraft wing or a vehicle. Which allows a better understanding of the components that affect the interactions between the air and the object of study, that is to say the forces and torque affecting the object. In order to fully utilize the wind tunnel in the laboratory at Mid Sweden, it has proved necessary to design a new wind tunnel force balance, which is a structure that measures forces affecting objects inside the wind tunnel. The reason being is that the current force balance sensor has some issues concerning accuracy of measurement and the lack of measuring other forces than lifting forces. A further development of the existing force balance would involve too long a work process, so it was decided to develop a new design of a wind tunnel force balance that solves some sources of error that the previous design of the force balance has and introduce an air resistance measurement component. By developing a new force balance that can be manufactured in Mid Sweden University's premises, the time for performing wind tunnel testing is reduced and the accuracy of the measured values is increased. The purpose of this project has been to develop a construction of a new force balance that can measure forces in the x- and y-axis, meaning lifting and air resistance. The force balance will be installed in the wind tunnel located in Mid Sweden University's laboratory.  In this project, the workflow of the design process is followed, which is divided into four phases. The first phase, the research phase, defined the product's requirements specification and functional analysis. The second phase, concept development and control art, began with brainstorming to generate concept solution ideas. The Pugh matrix was then used in the prototyping and validation phase to evaluate and select the concept based on a quantitative method. Then a three-dimensional model for the finalized concept was modelled using CAD. Finally, in the testing and refining phase, the design was produced using the CAD models. Then the complex components were printed with a 3D-printer while the less complex component were made of wood using a laser cutter to save on materials and costs, finally the rig was built and tested in Mid Sweden University's workshop.  The project resulted in a force balance that can measure both air resistance and lifting force in a low-speed wind tunnel with a more accurate measurements than the previous force balance.

Vključevanje v vzgojno-izobraževalni sistem iz perspektive staršev in otrok beguncev

This article is based on a research project executed by the authors in 2021. It revolves around the experiences of refugee children and parents within the Slovenian educational system. Data was acquired from twelve families. Interviewees spoke about the positive and negative aspects of educational integration. Those mainly consisted of language difficulties, learning difficulties, and discrimination. The presented research aims to shift the perspective from the “easy integration” read about in laws and strategies to the more complex perspective held by the “subjects” of integration. They mostly perceive it as a long-lasting, nuanced, and troublesome process.Članek temelji na raziskavi, ki so jo avtorji opravili leta 2021. V središče postavlja izkušnje otrok in staršev beguncev z vključevanjem v slovenski vzgojno-izobraževalni sistem. Sogovorniki iz dvanajstih družin so spregovorili o pozitivnih in negativnih vidikih vključevanja v vzgojno-izobraževalni sistem. Med njimi so prevladovale težave z učenjem jezika, učne težave, diskriminacija. Proces vključevanja, ki v zakonih in strategijah deluje kot enoznačen »postopek« prilagajanja otrok na nove jezikovne, kulturne, izobraževalne in institucionalne razmere, v raziskavi predstavljamo iz perspektive »subjektov vključevanja«. Ti proces doživljajo kot dolgotrajen, niansiran in težaven

Diabetes Insipidus due to Metastases of Undiagnosed Lung Cancer: A Case Report from Syria

Pituitary metastases (PM) are extremely uncommon, accounting for less than 1% of all intracranial metastases. PM of an undiagnosed malignancy can commonly present with symptoms of hormonal deficiencies, central diabetes insipidus, and/or visual symptoms. Lung and breast malignancies are the most common cancers associated with PM. Despite advances in diagnostic and therapeutic options, the prognosis remains poor and is influenced by primary malignancy and treatment methods. We report a case of a patient with PM from lung cancer who had polyuria, polydipsia, and nonspecific symptoms. A full evaluation confirmed central diabetes insipidus, hypogonadism, and metastatic lung cancer. We also discuss the current literature on PM diagnosis and management, emphasizing the need for a comprehensive evaluation of all available data. This is the first case of PM reported from Syria, to our knowledge

Contribution à l'Etude des Compensateurs Actifs des Réseaux Electriques Basse Tension ((Automatisation des systèmes de puissance électriques))

Dans cette thèse, nous avons abordé les structures de filtres actifs parallèles, séries et combinées (UPQC) en vue d'étudier la compensation de tous les types de perturbations susceptibles d'apparaître dans le réseau électrique. De plus, dans l'objectif d'améliorer la qualité de l'énergie électrique, en la rendant conforme aux nouvelles contraintes normatives, nous avons également été amené à développer et à appliquer des méthodes d'automatique avancées. Dans ce cadre, cette thèse rapporte de plusieurs structures de régulation, notamment d'une version amélioré du RST, cette dernière repoussant les limites d'application du RST classique. De plus, dans l'objectif de réaliser un filtre actif parallèle, une étude approfondie de faisabilité expérimentale a été effectuée, prenant en compte les contraintes industrielles du produit aussi bien au niveau de sa conception que de son application.In an electrical network, unbalanced and harmonic currents generated by nonlinear and unbalanced loads can cause harmonics and unbalanced voltage. These voltage perturbations along with voltage sag can strongly degrade customer power quality. Nowadays, the active filtres such as shunt, series and combined shunt-series are studied as a flexible solution to compensate all current and voltage perturbations. Therefore, in order to improve power system quality, we have studied advanced control methods applied on the structures of the above mentioned active filtres. For such requirements, we have developed a new RST control method in order to extend the application spectrum of RST controller. Thus, an universal shunt active filter has been developed using a continuous and discret time experimentalSTRASBOURG-Sc. et Techniques (674822102) / SudocBELFORT-UTBM-SEVENANS (900942101) / SudocSudocFranceF

THE IMPACT OF SHIFTING TOWARDS ECO-FRIENDLY TRANSPORTATION AT THE UNIVERSITY OF BAGHDAD, AL-JADRIYA CAMPUS (UBAC)

In recent years, the UBAC has seen severe traffic congestion, resulting in various environmental and traffic problems at the university and its environs. This congestion was due to the significant expansions in buildings andan increase in the number of colleges in addition to the extensive use of private transport modes by students and university employees. This research was an attempt to find a solution for transportation problems in the UBAC, through studying the current transportation system inside the campus, and then suggesting alternatives to enhance the situation in the Campus and its environs as well. The study solutions focused on replacing the current diesel buses with battery-electric buses and restricting some of the private cars toward the Campus. This study supposes this transformation will reduce the CO2 emissions by (54%) in the morning peak hours and by (64%) in the afternoon peak hours, enhance the Passenger Car Unit (PCU) by (31%) in the morning peak hours and by (41%) in the afternoon peak hours, and will improve parking capacity by 114% inside the campus