Analysis of Mullerian developmental defects in a tertiary care hospital: a four year experience

Background: Mullerian duct anomalies are congenital anomalies of the female genital tract. Mullerian duct anomalies affect the reproductive health of the female to a varied extent. This may present as obstructive or as non-obstructive anomalies. When clinically suspected, proper investigations are required to confirm the diagnosis including ultrasonography, laparoscopy and hysteroscopy.Methods: In the present study, all the patients presenting with Mullerian duct anomalies to the gynaecology OPD at General Hospital, Sola, GMERS Medical College, Ahmedabad during the four year duration from 2011 to 2014 were included. These patients were analysed with respect to their incidence, presenting complain, age at presentation, classified according to AFS classification after proper diagnosis and managed individually.Results: The incidence of Mullerian duct anomalies was found to be 0.084%.52.9% belonged to the age group of 21 to 25 years. Most of these patients (73.5%) presented with chronic complains. Only a few presented with acute symptoms (14.7%) whereas a few were asymptomatic (11.8%). Septate uterus (20.6%) was the most common anomaly diagnosed at our setup followed by bicornuate uterus (17.7%) and tansverse vaginal septum (17.6%). History along with clinical and USG examination were adequate in diagnosis of patients with vaginal agenesis, didelphic, bicornuate uterus, TVS and imperforate hymen. Laparoscopy was needed to confirm cases of MRKH & unicornuate uterus and hysteroscopy for cases of septate uterus. Arcuate uterus was diagnosed during LSCS. Conclusions: It was thus concluded that with timely evaluation, diagnosis and optimal management, their menstrual disturbances are relieved early in adolescence period recuperating their psychiatric health & improving their reproductive carrier. Delay in management may cause serious complications and potential infertility

Design of Double Barrier Ceramic Radio Frequency Vacuum Window

Vacuum windows are an essential part of any radio frequency (RF) system which launches/couples RF power from an atmospheric to a vacuum environment. This paper describes the RF design of a double barrier ceramic coaxial vacuum window. Alumina 99.5% pure is considered as ceramic barrier material while inner and outer conductors are oxygen-free copper. As the initial design approach the thickness, slope, depth of ceramic in the conductor is varied and the performance of the window is studied. The design is optimised to achieve the best insertion loss, return loss response for operating frequency range up to 65MHz

2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology as a framework for the project. Accordingly, the direction and strength of the recommendations are based on the quality of evidence, the balance between desirable and undesirable effects, patients'and clinicians'values and preferences, and resource use. Eight overarching principles and nine specific recommendations were developed covering several aspects of PMR, including basic and follow-up investigations of patients under treatment, risk factor assessment, medical access for patients and specialist referral, treatment strategies such as initial glucocorticoid (GC) doses and subsequent tapering regimens, use of intramuscular GCs and disease modifying anti-rheumatic drugs (DMARDs), as well as the roles of non-steroidal anti-rheumatic drugs and non-pharmacological interventions. These recommendations will inform primary, secondary and tertiary care physicians about an international consensus on the management of PMR. These recommendations should serve to inform clinicians about best practices in the care of patients with PMR

A Rigidity-Enhanced Antimicrobial Activity: A Case for Linear Cationic α-Helical Peptide HP(2–20) and Its Four Analogues

Linear cationic α-helical antimicrobial peptides are referred to as one of the most likely substitutes for common antibiotics, due to their relatively simple structures (≤40 residues) and various antimicrobial activities against a wide range of pathogens. Of those, HP(2–20) was isolated from Helicobacter pylori ribosomal protein. To reveal a mechanical determinant that may mediate the antimicrobial activities, we examined the mechanical properties and structural stabilities of HP(2–20) and its four analogues of same chain length by steered molecular dynamics simulation. The results indicated the following: the resistance of H-bonds to the tensile extension mediated the early extensive stage; with the loss of H-bonds, the tensile force was dispensed to prompt the conformational phase transition; and Young's moduli (N/m2) of the peptides were about 4∼8×109. These mechanical features were sensitive to the variation of the residue compositions. Furthermore, we found that the antimicrobial activity is rigidity-enhanced, that is, a harder peptide has stronger antimicrobial activity. It suggests that the molecular spring constant may be used to seek a new structure-activity relationship for different α-helical peptide groups. This exciting result was reasonably explained by a possible mechanical mechanism that regulates both the membrane pore formation and the peptide insertion

The Potential of Antimicrobial Peptides as Biocides

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and development stagnates. This review will examine the potential of antimicrobial peptides, both natural and synthetic, as novel biocidal agents in the battle against multi-drug resistant pathogen infections

Clitoria ternatea L.Fabaceae

Clitoria albiflora Mattei; Clitoria bracteata Poir.; Clitoria mearnsii De Wild.; Clitoria philippensis Perr.; Clitoria spectabilis Salisb.; Clitoria tanganicensis Micheli; Clitoria ternatea f. fasciculata Fantz; Clitoria ternatea var. major Paxton; Clitoria ternatea var. pleniflora Fantz; Clitoria ternatensium Crantz; Clitoria zanzibarensis Vatke; Deguelia javanica (Miq.) Taub.; Derris javanica Miq.; Lathyrus spectabilis Forssk.; Nauchea bracteata Dupuis ex Descourt.; Nauchea ternatea (L.) Descourt.; Phaseolus clitorius Noronha; Pterocarpus javanicus (Miq.) Kuntze; Ternatea indica J.St.-Hil.; Ternatea ternatea (L.) Kuntze; Ternatea vulgaris Kunth (POWO 2019

WATER-SOLUBLE COMPOUND TARGETED TO MITOCHONDRIA, COMPOSITION COMPRISING THEM AND PREPARATION METHOD THEREOF

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