Motivación y bienestar en personas adultas que practican Taygetos

El objetivo de este estudio de investigación fue determinar la correlación que existe entre la motivación deportiva y el bienestar subjetivo (BS) en un grupo de personas adultas que practican el modelo de entrenamiento funcional Taygetos en Arequipa. La muestra de este estudio descriptivo-correlacional fue un total de 53 personas entre hombres y mujeres que tienen entre 22 y 40 años que se agrupan diariamente para realizar un entrenamiento funcional de mediana intensidad al aire libre. Las personas fueron evaluadas con el Cuestionario de Motivación en el Deporte (CMD) para medir la motivación (externa, introyectada, identificada, intrínseca y desmotivación) en la práctica deportiva y La Escala de Felicidad de Lima para medir el bienestar subjetivo (sentido de la vida, satisfacción con la vida, realización personal y alegría de vivir). Los resultados muestran que existe una correlación significativa y positiva entre la motivación intrínseca y el bienestar subjetivo (p < 0.05). Con los presentes resultados se comprueba que la motivación intrínseca influye en el bienestar subjetivo, demostrando que, a mayor motivación intrínseca, mayor bienestar subjetivo. Asimismo, se evidencia que la desmotivación también influye en el bienestar subjetivo, lo cual señala que, a mayor desmotivación, mayor bienestar subjetivo. Palabras claves: bienestar subjetivo, desmotivación, entrenamiento funcional, motivación, motivación intrínseca, Taygetos.Tesi

BeCAPTCHA: Behavioral bot detection using touchscreen and mobile sensors benchmarked on HuMIdb

In this paper we study the suitability of a new generation of CAPTCHA methods based on smartphone interactions. The heterogeneous flow of data generated during the interaction with the smartphones can be used to model human behavior when interacting with the technology and improve bot detection algorithms. For this, we propose BeCAPTCHA, a CAPTCHA method based on the analysis of the touchscreen information obtained during a single drag and drop task in combination with the accelerometer data. The goal of BeCAPTCHA is to determine whether the drag and drop task was realized by a human or a bot. We evaluate the method by generating fake samples synthesized with Generative Adversarial Neural Networks and handcrafted methods. Our results suggest the potential of mobile sensors to characterize the human behavior and develop a new generation of CAPTCHAs. The experiments are evaluated with HuMIdb1 (Human Mobile Interaction database), a novel multimodal mobile database that comprises 14 mobile sensors acquired from 600 users. HuMIdb is freely available to the research communityThis work has been supported by projects: PRIMA, Spain (H2020-MSCA-ITN-2019-860315), TRESPASS-ETN, Spain (H2020-MSCA-ITN-2019-860813), BIBECA RTI2018-101248-B-I00 (MINECO/FEDER), and BioGuard, Spain (Ayudas Fundación BBVA a Equipos de Investigación Científica 2017). Spanish Patent Application P20203006

Acinetobacter baumannii from grass: novel but non-resistant clones

Acinetobacter baumannii is one the most worrisome nosocomial pathogens, which has long been considered almost mainly as a hospital-associated bacterium. There have been some studies about animal and environmental isolates over the last decade. However, little effort has been made to determine if this pathogen dwells in the grass. Here, we aim to determine the evolutionary relationships and antibiotic resistance of clones of A. baumannii sampled from grass to the major human international clones and animal clones. Two hundred and forty genomes were considered in total from four different sources for this study. Our core and accessory genomic epidemiology analyses showed that grass isolates cluster in seven groups well differentiated from one another and from the major human and animal isolates. Furthermore, we found new sequence types under both multilocus sequence typing schemes: two under the Pasteur scheme and seven for the Oxford scheme. The grass isolates contained fewer antibiotic-resistance genes and were not resistant to the antibiotics tested. Our results demonstrate that these novel clones appear to have limited antibiotic resistance potential. Given our findings, we propose that genomic epidemiology and surveillance of A. baumannii should go beyond the hospital settings and consider the environment in an explicit One Health approach

FIXTURA DE PRUEBA PARA LA CARACTERIZACIÓN DE CONTROLADORES PARA CONVERTIDORES BIDIRECCIONALES CA-CD

La corrección del factor de potencia y la elevación de voltaje en el bus de CD  son las principales prestaciones de los convertidores electrónicos bidireccionales CA-CD; Para obtenerlas, se deben de implementar técnicas de control que utilizan lazos de retroalimentación de corriente y de voltaje. Cuando en la práctica se sintonizan los controladores en convertidores que trabajan en el orden de los Kilo Watts y se determina el porcentaje de variación del voltaje de línea que soporta el convertidor, la corriente de línea pierde completamente su estabilidad y provoca que los módulos de IGBTs o MOSFETs de potencia se dañen permanentemente junto con sus impulsores. Esto se traduce en pérdidas económicas substanciales en cada prueba; En este documento se propone una fixtura de prueba que emula la línea eléctrica para caracterizar los controladores de convertidores bidireccionales, sin exponer sus componentes electrónicos.  Palabra(s) Clave(s): emulador de línea eléctrica, inestabilidad, perturbación, señal de control, sintonización de controladores

Kisspeptina en becerras prepúberes: I. Influencia de la edad en la respuesta de LH, FSH y GH a kisspeptina-10 y su asociación con IGF-I, leptina y estradiol

To evaluate effects of age on the response of LH, FSH and GH to kisspeptin-10 (KISS) in prepubertal heifers and its association with circulating levels of IGF-I, estradiol (E2) and leptin, 21 heifer calves that were 4, 7 or 11 mo old, received an iv injection of KISS (5 μg/kg). LH, FSH and GH were quantified in blood serum taken every 15 min (4 h pre- and 4 h post-KISS-10). In three pre- and six post-KISS samples, IGF-I, leptin and E2 were determined. All heifers responded to KISS with an LH increment but the response magnitude differed among groups since maximum value was higher (P<0.05) in 11 mo (11.6+1.3 ng/ml) than in 7 mo (7.2±1.3 ng/ml) and 4 mo (6.1±1.3 ng/ml) old calves. Duration of response differed (P<0.05) among ages (11 mo=132.9+20 mina; 7 mo=92±20 mina,b; 4 mo=64.3±20 minb). For FSH, all and 11 mo calves responded to KISS but only 71.4 % of 4 mo did. In GH, 71.4 % of 4 mo and 85.7 % of 7 mo calves responded to KISS whereas 100 % of 11 mo animals responded. FSH and GH did not differ among age groups. The 11 mo heifers had the highest IGF-I and E2 but the lowest leptin levels. In conclusion, KISS evokes LH increments in all calves 4 to 11 mo old, but the response increases with age in association with high circulating IGF-I and E2 and low leptin. The response of FSH and GH to KISS is not influenced by age or variations in circulating IGF-I, E2 or leptin. El objetivo fue evaluar la respuesta de LH, FSH y GH a kisspeptina-10 (KISS) en becerras prepúberes de distintas edades, y su asociación con IGF-I, E2 y leptina circulantes. A 21 becerras de 4, 7 y 11 meses de edad se les aplicó una inyección i.v. de 5 µg de KISS/kg de peso. En suero obtenido de la yugular (cada 15 min, 4 h pre hasta 4 h post-KISS) se cuantificó LH, FSH y GH. En nueve muestras (tres pre y seis post-KISS) se determinó IGF-I, leptina y estradiol (E2). En todas las becerras aumentó la LH post-KISS, con un valor máximo (6.1±1.3a, 7.2±1.3a, 11.6+1.3b ng/ml) y duración de respuesta (64.3±20a, 92±20b, 132.9+20c min) que aumentó (P<0.05) con la edad. Para FSH, 71.4, 100 y 100 % de las becerras de 4, 7 y 11 meses respondieron a KISS-10; situación que para GH fue 71.4, 85.7 y 100 %, respectivamente. La magnitud de la respuesta de FSH y GH a KISS fue similar entre edades. Las becerras de 11 meses tuvieron las máximas concentraciones de IGF-I y E2 y las menores de leptina. Se concluye que KISS-10 evoca un aumento de LH en becerras de 4 a 11 meses, cuya magnitud de respuesta se asocia con la edad, con el incremento en sangre periférica de IGF-I y E2 y con la disminución de leptina sérica; en contraste, la respuesta de GH y FSH a KISS-10 no es afectada por la edad ni por las variaciones en IGF-I, E2 y leptina

TERASENSE: THz device technology laboratory: final summary

The use of THz frequencies, particularly W and G band allows reaching higher resolution and deeper penetration in emerging applications like imaging, sensing, etc. The development of those new applications lays on reliable technologies, background of expertise and know-how. The CDS2008-00068 TERASENSE CONSOLIDER project has given the opportunity to extent upwards in frequency the previous background of the microwaves research group partners. This article summarizes the developments of the TERASENSE work package “THz Device Technology Laboratory”.This work was supported by the Spanish Ministerio de Ciencia e Innovación through the CONSOLIDER-INGENIO 2010 program reference CSD2008-00068 TERASENSE

TERASENSE: THz device technology laboratory

The use of THz frequencies, particularly W and G band allows reaching higher resolution and deeper penetration in emerging applications like imaging, sensing, etc. The development of those new applications lays on reliable technologies, background of expertise and know-how. The CDS2008-00068 TERASENSE CONSOLIDER project has given the opportunity to extent upwards in frequency the previous background of the microwaves research group partners. This article summarizes the developments of the TERASENSE work package “THz Device Technology Laboratory”

Varietal description of two genotypes of manzano chili pepper (Capsicum pubescens Ruiz & Pav.)

Objective: the objective of this research work was to obtain the varietal description of two varieties of chile manzano in Las Montañas in the center of Veracruz, México. Design/methodology/approach: the varietal characterization module was established under greenhouse conditions at the Centro de Bachillerato Tecnológico Agropecuario No. 99 in the municipality of Coscomatepec de Bravo. The recorded descriptors were in accordance with the International of Plant Genetic Resources Institute for Capsicum and the Graphic Handbook for Variety Description of manzano hot pepper. The plants were characterized from the seedling to the adult plant. The agronomic management of the crop was carried out in accordance with the manual for the production of manzano hot pepper in Las Montañas of the state of Veracruz. Results: all qualitative descriptors were constant for the two varieties MEXUVNE1-15-C2 and MEXUVCU1-16-C2 from seedling to fruiting; in contrast, there were dissimilarities in plant height, stem, leaf, flower, fruit and seed dimensions. Limitations of the study/implications: the pandemic caused by COVID-19 was the main limitation so that some descriptors were not recorded in a timely manner as indicated in the Graphic Handbook. Findings/conclusions: both varieties are very similar; however, the greatest distinction was in the quantitative type descriptors such as: plant height, fruit length, fruit diameter and number of seeds.Objective: The objective of this research study was to obtain the varietal description of two varieties of manzano chili pepper in Las Montañas region, in central Veracruz, Mexico. Design/methodology/approach: The varietal characterization module was established under greenhouse conditions. The markers recorded were in accordance with the International Plant Genetic Resources Institute for Capsicum and the Graphic Handbook for Variety Description of manzano chili pepper. The plants were characterized from seedling in greenhouse to adult plant. The agronomic management of the crop was carried out in accordance with the manual for the production of manzano chili pepper in Las Montañas, state of Veracruz. Results: All qualitative markers were constant for the two varieties, MEXUVNE1-15-C2 and MEXUVCU1-16-C2, from seedling to fruit setting. In contrast, there were dissimilarities in plant height, and stem, leaf, flower, fruit and seed dimensions. Study limitations/implications: The pandemic caused by COVID-19 was the main limitation, resulting in some markers not being recorded in a timely manner as indicated in the Graphic Handbook. Findings/conclusions: Both varieties are very similar; however, the greatest distinction was in the quantitative markers, such as: plant height, fruit length, fruit diameter and number of seeds

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals