Monitoring the Impact of Health Care Reforms on Americans 50-64: Awareness and Coverage Expectations

This survey found widespread awareness among Americans ages 50 to 64 about the new health insurance Marketplace that had been created by the Affordable Care Act (ACA). Those with the most to gain from the ACA -- the uninsured and those with nongroup (individual) insurance -- expressed the greatest interest in using the Marketplace to learn about new coverage options. Most of those already insured expected to keep their same source of coverage in 2014, whereas the uninsured had mixed expectations. This paper is part of a series that looks at the experiences of 50- to 64-year-olds during the ACA's first open enrollment period

Monitoring the Impact of Health Reform on Americans 50-64: Use of Insurance Marketplaces

This survey found that 9 out of 10 Americans ages 50 to 64 were aware of the new health insurance Marketplace that had been created by the Affordable Care Act (ACA). The survey found that, despite widespread awareness of the Marketplace among this age group, relatively few who knew about the Marketplace were interested in using it to acquire new coverage. The survey also found that 50- to 64-year-olds' use of the Marketplace varied widely by health insurance status and income. This paper is part of a series that looks at the experiences of 50- to 64-year-olds during the ACA's first open enrollment period

Development of the natural working fluid‐based refrigeration system for domestic scale freeze‐dryer

In this work, the analysis of the refrigeration system designed for the FrostX 10 freeze‐dryer is presented. The main goal of this study was to experimentally investigate the reference R452a freeze‐dryer and prepare recommendations for a machine based on the R290 refrigeration unit. In order to guarantee the temperature requirements and efficient operation of that unit, the analysis of suitable natural refrigerants was performed. Consequently, propane (R290) was selected. In addition, a number of modifications were introduced for the prototype system. System analysis showed that the replacement of the refrigerant in the existing system improves the system energy efficiency by approximately 18%. During the experimental campaign of the basic refrigeration unit, an unstable operation of the evaporator was found. The concept of a new cooling system for a prototype device was presented. The configuration and type of heat exchanger to maximise the performance of the ice trap of the freeze‐dryer were proposed.Development of the natural working fluid‐based refrigeration system for domestic scale freeze‐dryeracceptedVersio

Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

BACKGROUND: ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID). Unlike conventional NSAIDs which are associated with gastric ulcerogenic effects, ML 3000 causes little or no damage to the gastric mucosa, even though it significantly depresses gastric prostaglandin synthesis. METHODS: As part of an effort to clarify mechanisms underlying the gastric sparing properties of ML 3000, we studied the effects of ML 3000 on H,K-ATPase activity in vitro, on acid accumulation in isolated gastric parietal cells, and on IL-8 secretion by gastric epithelial cells in culture. RESULTS: SCH28080-sensitive H,K-ATPase activity in highly-purified pig gastric microsomes was dose-dependently inhibited by ML 3000 (IC(50) = 16.4 μM). Inhibition was reversible, and insensitive to ML 3000 acidification in the pH range 2.0–8.0. In rabbit gastric parietal cells, ML 3000 dose-dependently inhibited histamine-stimulated acid accumulation (IC(50) = 40 μM) and forskolin-stimulated acid accumulation (IC(50) = 45 μM). Lastly, in human gastric adenocarcinoma (AGS) cells, ML 3000 dose-dependently inhibited both baseline and IL-1β-stimulated (20 ng/ml) IL-8 secretion with IC(50)s of 0.46 μM and 1.1 μM respectively. CONCLUSION: The data indicate that ML 3000 affects acid-secretory mechanisms downstream of cAMP mobilization induced by histamine H(2) receptor activation, that it directly inhibits H,K-ATPase specific activity, and that baseline gastric epithelial cell IL-8 secretory inhibition may be mediated by ML 3000 inhibition of 5-lipoxygenase activity. We conclude that these gastric function inhibitory data may underlie the gastric sparing properties of ML 3000

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Application range of the HEM approach for CO2 expansion inside two-phase ejectors for supermarket refrigeration systems

In this study, the accuracy of the homogeneous equilibrium (HEM) applied to 3-D CFD-based simulations of CO2 expansion inside two-phase ejectors is presented. The HEM approach previously reported in the literature were assessed by comparing the computed and measured mass flow rates that pass through an ejector motive nozzle. In addition, the HEM approach implemented using CFD was tested over a vast range of ejector operating regimes. To ensure that all of the computations were performed consistently, a validated CFD model combined within an in-house developed script was used. The comparison of the experimental and computational results showed that the HEM accuracy varied for the different sets of operating parameters. Accurate results were obtained for operating regimes near or above the CO2 critical point. The model accuracy decreased with the decreasing temperature and decreasing distance to the saturation line.acceptedVersio