Gravity waves, scale asymptotics, and the pseudo-incompressible equations

Multiple-scale asymptotics is used to analyze the Euler equations for the dynamical situation of a gravity wave (GW) near breaking level. A simple saturation argument in combination with linear theory is used to obtain the relevant dynamical scales. As small expansion parameter the ratio of inverse of the vertical wave number and potentialtemperature and pressure scale heights is used, which we allow to be of the same order of magnitude here. It is shown that the resulting equation hierarchy is consistent with that obtained from the pseudo-incompressible equations, both for non-hydrostatic and hydrostatic gravity waves, while this is not the case for the anelastic equations unless the additional assumption of sufficiently weak stratication is adopted. To describe vertical propagation of wave packets over several atmospheric scale heights, WKB theory is used to show that the pseudo-incompressible flow divergence generates the same amplitude equation that also obtains from the full Euler equations. This gives a mathematical justication for the use of the pseudo-incompressible equations for studies of gravity-wave breaking in the atmosphere for arbitrary background stratication. The WKB theory interestingly also holds at wave amplitudes close to static instability. In the mean-flow equations we obtain in addition to the classic wave-induced momentum-flux divergences a wave-induced correction of hydrostatic balance in the vertical-momentum equation which cannot be obtained from Boussinesq or anelastic dynamics

Mortality risk and mental disorders: longitudinal results from the Upper Bavarian Study

The object of the study was the assessment of the mortality risk for persons with a mental disorder in an unselected representative community sample assessed longitudinally. Subjects from a rural area in Upper Bavaria (Germany) participated in semi-structured interviews conducted by research physicians in the 1970s (first assessment) and death-certificate diagnoses were obtained after an interval up to 13 years later. The sample consisted of 1668 community residents aged 15 years and over. Cox regression estimates resulted in an odds ratio of 1·35 (confidence interval 1·01 to 1·81) for persons with a mental disorder classified as marked to very severe. The odds ratio increased with increasing severity of mental illness from 1·04 for mild disorders, 1·30 for marked disorders, to 1·64 for severe or very severe disorders. The relative risk (odds ratio) for persons with a mental disorder only and no somatic disorder was 1·22, for persons with only a somatic disorder 2·00, and for those with both a mental and a somatic disorder 2·13. The presence of somatic illness was responsible for most of the excess mortality. Somatic disorders associated with excess mortality in mental disorders were diseases of the nervous system or sensory organs, diseases of the circulatory system, diseases of the gastrointestinal tract, and diseases of the skeleton, muscles and connective tissue (ICD-8). Thus, while mental illness alone had a limited effect on excess mortality, comorbidity with certain somatic disorders had a significant effec

The interaction between synoptic-scale balanced flow and a finite-amplitude mesoscale wave field throughout all atmospheric layers: weak and moderately strong stratification

The interaction between locally monochromatic finite-amplitude mesoscale waves, their nonlinearly induced higher harmonics, and a synoptic-scale flow is reconsidered, both in the tropospheric regime of weak stratification and in the stratospheric regime of moderately strong stratification. A review of the basic assumptions of quasi-geostrophic theory on an f-plane yields all synoptic scales in terms of a minimal number of natural variables, i.e. two out of the speed of sound, gravitational acceleration and Coriolis parameter. The wave scaling is defined so that all spatial and temporal scales are shorter by one order in the Rossby number, and by assuming their buoyancy field to be close to static instability. WKB theory is applied, with the Rossby number as scale separation parameter, combined with a systematic Rossby-number expansion of all fields. Classic results for synoptic-scale-flow balances and inertia-gravity-wave (IGW) dynamics are recovered. These are supplemented by explicit expressions for the interaction between mesoscale geostrophic modes (GMs), a possibly somewhat overlooked agent of horizontal coupling in the atmosphere, and the synoptic-scale flow. It is shown that IGW higher harmonics are slaved to the basic IGW, and that their amplitude is one order of magnitude smaller than the basic-wave amplitude. GM higher harmonics are not that weak and they are in intense nonlinear interaction between themselves and the basic GM. Compressible dynamics plays a significant role in the stratospheric stratification regime, where anelastic theory would yield insufficient results. Supplementing classic derivations, it is moreover shown that, in the absence of mesoscale waves, quasi-geostrophic theory holds also in the stratospheric stratification regime

Critical boron-doping levels for generation of dislocations in synthetic diamond

Defects induced by boron doping in diamond layers were studied by transmission electron microscopy. The existence of a critical boron doping level above which defects are generated is reported. This level is found to be dependent on the CH4 /H2 molar ratios and on growth directions. The critical boron concentration lied in the 6.5–17.0 X 10 20 at/cm3 range in the direction and at 3.2 X 1021 at/cm 3 for the one. Strain related effects induced by the doping are shown not to be responsible. From the location of dislocations and their Burger vectors, a model is proposed, together with their generation mechanism.6 page

Subkelvin tunneling spectroscopy showing Bardeen-Cooper-Schrieffer superconductivity in heavily boron-doped silicon epilayers

Scanning tunneling spectroscopies in the subKelvin temperature range were performed on superconducting Silicon epilayers doped with Boron in the atomic percent range. The resulting local differential conductance behaved as expected for a homogeneous superconductor, with an energy gap dispersion below +/- 10%. The spectral shape, the amplitude and temperature dependence of the superconductivity gap follow the BCS model, bringing further support to the hypothesis of a hole pairing mechanism mediated by phonons in the weak coupling limit.Comment: 4 pages, 3 figure

Porin from the halophilic species Ectothiorhodospira vacuolata: cloning, structure of the gene and comparison with other porins

The gene coding for the anion-specific porin of the halophilic eubacterium Ectothiorhodospira (Ect.) vacuolata was cloned and sequenced, the first such gene so analyzed from a purple sulfur bacterium. It encodes a precursor protein consisting of 374 amino acid (aa)-residues including a signal peptide of 22-aa residues. Comparison with aa sequences of porins from several other members of the Proteobacteria revealed little homology. Only two regions showed local homology with the previously sequenced porins of Neisseria species, Comamonas acidovorans, Bordetella pertussis, Alcaligenes eutrophus, and Burkholderia cepacia. Genomic Southern blot hybridization studies were carried out with a probe derived from the 5′ end of the gene coding for the porin of Ect. vacuolata. Two related species, Ect. haloalkaliphila and Ect. shaposhnikovii, exhibited a clear signal, while the extremely halophilic bacterium Halorhodospira (Hlr.) halophila (formerly Ect. halophila) did not show any cross-hybridization even at low stringency. This result is in good accordance with a recently proposed reassignment within the family Ectothiorhodospiraceae, which included the separation of the extremely halophilic species into the new genus Halorhodospira

Band structure parameters of metallic diamond from angle-resolved photoemission spectroscopy

International audienceThe electronic band structure of heavily boron doped diamond was investigated by angle-resolved photoemission spectroscopy on (100)-oriented epilayers. A unique set of Luttinger parameters was deduced from a comparison of the experimental band structure of metallic diamond along the Delta (GammaX) and Sigma(GammaK) high-symmetry directions of the reciprocal space, with theoretical band structure calculations performed both within the local density approximation and by an analytical k·p approach. In this way, we were able to describe the experimental band structure over a large three-dimensional region of the reciprocal space and to estimate hole effective masses in agreement with previous theoretical and experimental papers

Local boron doping quantification in homoepitaxial diamond structures

The capability of transmission electronmicroscopy (TEM) using the high angle annular dark fieldmode (HAADF,also labelled Z-contrast) to quantify boron concentration, in the high doping range between 1019cm−3 and 1021cm−3, is demonstrated. Thanks to the large relative variation of atomic number Z between carbon and boron, doping concentration maps and profiles are obtained with a nanometer-scale resolution. A novel numerical simulation procedure allows the boron concentration quantification and demonstrates the high sensitivity and spatial resolution of the technique.4 page

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report

<p>Abstract</p> <p>Background</p> <p>Gastric adenocarcinoma is rare in children and adolescents, with about 17 cases under age 21 in the world's literature. We report a case of invasive well-differentiated metastatic gastric cancer in a Brazilian 12-year-old boy without documented familial history of cancer.</p> <p>Case presentation</p> <p>The patient, diagnosed with metastatic disease, died seven months after surgery. DNA from intra-surgical specimens revealed a <it>TP53 </it>mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node). In all mutation-positive tissues, p.R337H occurred on the same background, a founder allele identified by a specific haplotype previously described in Brazilian Li-Fraumeni syndrome patients. The same mutant haplotype, corresponding to a founder mutation present in 0.3% of the general population in Southern Brazil, was found in the genome of the father. Presence of this inherited haplotype in the tumor as well as in the father's germline, suggests a rare case of microchimerism in this patient, who may have harbored a small number of mutant cells originating in another individual, perhaps a dizygotic twin that died early in gestation.</p> <p>Conclusion</p> <p>This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil.</p