A World of Difference: Divergent Word Interpretations among People

Divergent word usages reflect differences among people. In this paper, we present a novel angle for studying word usage divergence -- word interpretations. We propose an approach that quantifies semantic differences in interpretations among different groups of people. The effectiveness of our approach is validated by quantitative evaluations. Experiment results indicate that divergences in word interpretations exist. We further apply the approach to two well studied types of differences between people -- gender and region. The detected words with divergent interpretations reveal the unique features of specific groups of people. For gender, we discover that certain different interests, social attitudes, and characters between males and females are reflected in their divergent interpretations of many words. For region, we find that specific interpretations of certain words reveal the geographical and cultural features of different regions.Comment: 4 pages, 1 figure, published at ICWSM'1

Association of the Low Pregnancy-Associated Plasma Protein A and Pregnancy Complications in the First Trimester: A Prospective Cohort Study

Background and Aims: This study aimed to assess the association between the low maternal serum of pregnancy-associated plasma protein-A (PAPP-A) during the first trimester and pregnancy outcomes. Materials and Methods: We conducted a prospective cohort study of 118 pregnant women undergoing first-trimester screening between 2016 and 2017 at Taleghani and Imam Hussein hospital in Tehran, Iran. We recorded demographic data and blood samples were to analyze the value of PAPP-A, based on which we divided the participants into two groups: PAPP-A>10 percentile as a control group and PAPP-A≤10th percentile as a study group. The pregnancies underwent follow-up observations for obstetric complications during pregnancy. Chi-square or Fisher exact test and Mann-Whitney U test were applied to analyze data by SPSS 26. Results: In this study,118 pregnant women were enrolled. Our results show a significant association between low PAPP-A (<10th percentile) and preterm labor, small for gestational age (SGA), hypertension, preeclampsia (P<0.05), but no statistically significant difference was found between low PAPP-A and stillbirth. Demographic data, including age, gravida, parity, BMI, had no relationship with low PAPP-A, significantly (P>0.05). Conclusion: Low PAPP-A is associated with adverse outcomes; thus, measuring the PAPP-A within the first trimester is suggested for timely management

Language shift and linguistic insecurity

Variation in language is constant and inevitable. In a vital speech community some variation disappears as speakers age, and some results in long-term change, but all change will be preceded by a period of variation. Speakers of endangered languages may perceive variation in an especially negative light when it is thought to be due to contact with the dominant language. This contributes to negative evaluations of young people’s speech by older speakers, and in turn contributes to the linguistic insecurity of young speakers, which may result in even further shift toward the dominant language. In this paper we discuss language variation in the context of shift with respect to the notion of linguistic insecurity and what we identify as three distinct types of linguistic insecurity, particularly in cases of indigenous language loss in the Americas. We conclude with some observations on the positive results of directly addressing linguistic insecurity in language maintenance/revitalization programs.National Foreign Language Resource Cente

Methods for Modeling Social Factors in Language Shift

In this paper we expand our understanding of language endangerment by shifting the focus from small language communities to minority language communities with speaker populations in the millions. We argue for a methodological shift toward examining language shift scenarios more broadly and quantitatively for two main reasons: 1) it is becoming increasingly clear that a large speaker population does not protect against language shift (Anderbeck 2013); 2) we need to make a distinction between the symptoms and the causes of language shift, where factors such as a dwindling number of child speakers should be seen as symptoms of language shift that are caused by other factors (Himmelmann 2010). In this paper we use Indonesia as a case study and analyze a sample of the 2010 census. We treat language choice as a sociolinguistic variable and analyze the correlation between six social factors and language choice (local languages vs. the national language, Indonesian). These results provide a starting point for creating more comprehensive models of the sociolinguistics of language shift

Styles, standards and meaning

Abstract Style, in the study of variation and change, is intimately linked with broader questions about linguistic innovation and change, standards, social norms, and individual speakers’ stances. This article examines style when applied to lesser-studied languages. Style is both (i) the product of speakers’ choices among variants, and (ii) something reflexively produced through the association of variants and the social position of the users of those variants. In the context of the languages considered here, we ask “What questions do we have about variation in this language and what notion(s) of style will answer them?” We highlight methodological, conceptual and analytical challenges for the notion of style as it is usually operationalised in variationist sociolinguistics. We demonstrate that style is a useful research heuristic which – when marshalled alongside locally-oriented accounts of, or proxies for “standard” and “prestige”, in apparent time – allows us to describe language and explore change. It is also a means for exploring social meaning, which speakers may have more or less conscious control over

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a diverse repertoire of tyrosine kinase–linked and G protein–coupled receptors. Src family kinases (SFKs) play a central role in initiating and propagating signaling from several platelet surface receptors; however, the underlying mechanism of how SFK activity is regulated in platelets remains unclear. CD148 is the only receptor-like protein tyrosine phosphatase identified in platelets to date. In the present study, we show that mutant mice lacking CD148 exhibited a bleeding tendency and defective arterial thrombosis. Basal SFK activity was found to be markedly reduced in CD148-deficient platelets, resulting in a global hyporesponsiveness to agonists that signal through SFKs, including collagen and fibrinogen. G protein–coupled receptor responses to thrombin and other agonists were also marginally reduced. These results highlight CD148 as a global regulator of platelet activation and a novel antithrombotic drug targe

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and perinatal lethality. Furthermore, we find that conditional deletion of Syk in the haematopoietic lineage, or conditional deletion of CLEC-2 or Syk in the megakaryocyte/platelet lineage, also causes defects in brain vascular and lymphatic development, although the mice are viable. In contrast, conditional deletion of Syk in other haematopoietic lineages had no effect on viability or brain vasculature and lymphatic development. We show that platelets, but not platelet releasate, modulate the migration and intercellular adhesion of lymphatic endothelial cells through a pathway that is dependent on CLEC-2 and Syk. These studies demonstrate that megakaryocyte/platelet expression of CLEC-2 and Syk is required for normal brain vasculature and lymphatic development and that platelet CLEC-2 and Syk directly modulate lymphatic endothelial cell behaviour in vitro

The Effect of Bariatric Surgery on Polycystic Ovary Syndrome (PCOS) Symptoms and Related Hormones Improvement in Women with Morbid Obesity

Background: Obesity is associated with developing polycystic ovary syndrome (PCOS). The present study investigated whether weight loss after bariatric surgery could improve symptoms and related hormones in women with morbid obesity.Methods: In a retrospective observational study, 50 women aged 18-40 years with body mass index (BMI)=42.3 kg/m2 who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were enrolled. Evaluation of anthropometric data, serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), fasting plasmaglucose (FPG), and lipid profile were measured preoperatively and at 1-year follow-upResults: Of 50 women, 32 (64%) women were diagnosed to have PCOS. The mean BMI at 1-year follow-up was 27.05 kg/m2. Hirsutism and irregular menstruation resolved entirely among 68.8% (11/16) and 100% (18/18) at 1-year follow-up. There was a significant decrease in total serum testosterone (2.1±0.2 to 0.9±0.1 ng/mL) and LH (8.5±3.36 to 5.02±2.4 mIU/mL) at 1-year follow-up, whether changes in levels of serum FSH, PRL were not significant.Conclusion: Bariatric surgery was effective in weight loss and improvement of PCOS symptoms and related hormones in women with morbid obesity. Thus, women with PCOS and morbid obesity should be eligible for bariatric surgery

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2

Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2. SLP-76 is constitutively associated with the adapter Gads in platelets, which also binds to tyrosine phosphorylated LAT, thereby providing a potential pathway of regulation of SLP-76. Objective: In the present study, we have compared the role of Gads alongside that of LAT following activation of the major platelet glycoprotein receptors using mice deficient in the two adapter proteins. Results: Gads was found to be required for the efficient onset of aggregation and secretion in response to submaximal stimulation of GPVI and CLEC-2, but to be dispensable for activation following stronger stimulation of the two receptors. Gads was also dispensable for spreading induced through integrin aIIbb3 or the GPIb–IX–V complex.Further, Gads plays a negligible role in aggregate formation on collagen at an arteriolar rate of shear. In stark contrast, platelets deficient in the adapter LAT exhibit a marked decrease in aggregation and secretion following activation of GPVI and CLEC-2, and are unable to form stable aggregates on collagen at arteriolar shear. Conclusions: The results demonstrate that Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. These results reveal the presence of a Gads-independent pathway of platelet activation downstream of LAT