A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C

'n Temporaliteitspedagogiese studie van die vennootskap kerk en skool met spesiale verwysing na die werk van die Morawiese Broederkerk te Genadendal, 1737-1989

Thesis (MEd) -- Stellenbosch University, 1989.ENGLISH ABSTRACT: Much has been written about the history of the Moravian Church in South Africa and especially about Genadendal. In this thesis however, an effort is made by means of a temporality-pedagogic study to show the relationship, in the field of education, between church and school. The aim of this study is to establish the contribution made by the Moravian Church, especially in Genadendal with regards to education and schooling.AFRIKAANSE OPSOMMING: Vele geskrifte oor die geskiedenis van die Morwiese Broederkerk In Suid-Afrika en oor Genadendal in besonder het al die lig gesien. In hierdie tesis egter, word 'n poging aangewend om deur middel van 'n temporaliteitspedagogiese studie die vennootskap tussen kerk en skool aan te dui. Die doel van die studie is om vas te stel watter bydrae die Morawiese Kerk veral in Genadendal ten opsigte van opvoeding en onderwys gemaak het