Regiocontroled S N

International audienceAbstract An efficient and original synthesis of various 2,4,7‐trisubstituted pyrido[3,2‐ d ]pyrimidines is reported. The first access to and the chemical interest of 2,4,7‐trichloropyrido[3,2‐ d ]pyrimidine is described. Double arylations and S N Ar reactions occurred selectively at the C4 and C2 positions of 2,4,7‐trichloropyrido[3,2‐ d ]pyrimidine. The reactions at the C7 position were achieved under microwave irradiation in a few minutes. A one‐step synthesis of a 2,4,7‐tris(aminated) derivative was achieved as a highly efficient alternative