60 research outputs found
The efficacy of three mycotoxin adsorbents to alleviate aflatoxin B1-induced toxicity in Oreochromis niloticus
Scientific Opinion on the risk for public and animal health related to the presence of sterigmatocystin in food and feed
Zizyphus spina-Christi Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity
Aflatoxins (AF), a group of closely related, extremely toxic mycotoxins, produced by Aspergillus flavus and A. parasiticus can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic, and teratogenic to different animal species. Zizyphus spina-Christi L. extract was investigated for its antifungal and antimicrobial activities. The aim of the present work was to evaluate the antioxidant activity of the methanol extract of Z. spina-Christi L. leaves against the oxidative stress of aflatoxin in rats. Fourty male Sprague-Dawley male rats were divided into four groups including the control group, the group fed aflatoxin-contaminated diet (3 mg/kg diet) and the groups treated with Zizyphus extract (5 mg/kg b.w) alone or in combination with AF for 15 days. Biochemical analysis reveled that treatment with AF resulted in a significant increase in ALT, AST, cholesterol, triglycerides, uric acid, TNFa, LPO, NO and CEA, whereas it decrease significantly GPX and SOD. The histopatholgical examination of the liver, kidney and testis showed sever histological changes typical to those reported for aflatoxicosis. Animals treated with Zizyphus extract alone or plus AF showed a significant improvement in all biochemical parameters and histological picture of liver, kidney and testis. It could be concluded that Zizyphus extract have a power protective role against aflatoxicosis. Keywords: Aflatoxin, antioxidant, hepatotoxicity, Zizyphus spina-Christi, African Journal of Traditional and Complementary Medicine Vol. 4 (3) 2007: pp. 248-25
Effectiveness of activated carbon and Egyptian montmorillonite in the protection against deoxynivalenol-induced cytotoxicity and genotoxicity in rats
Panax ginseng extract modulates oxidative stress, DNA fragmentation and up-regulate gene expression in rats sub chronically treated with aflatoxin B1 and fumonisin B1
Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats
Ameliorative effects of thyme and calendula extracts alone or in combination against aflatoxins-induced oxidative stress and genotoxicity in rat liver
Ginseng aqueous extract ameliorates lambdaâcyhalothrinâacetamiprid insecticide mixture for hepatorenal toxicity in rats: Role of oxidative stressâmediated proinflammatory and proapoptotic protein expressions
Effects of dietary supplementation with palygorskite on nutrient utilization in weaned piglets
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