1,395 research outputs found
Electron Dispersion and Parallel Electron Beam Observed Near the Separatrix
The separatrix region is the region between the separatrix and the reconnection jet. Due to the E×B drift and velocity filter effect in which high‐energy particles with high parallel speed can be seen prior to low‐energy particles along the field line, electrons are separated from ions. The electron dynamics in this region is of interest; however it has not been studied in detail, because of the insufficient resolution of plasma data. We present a slow separatrix crossing event observed by Magnetospheric Multiscale (MMS) satellite constellation on 1 January 2016, from the magnetosheath side with high‐resolution burst mode data. The electron edge and ion edge are clearly distinguished in the separatrix region. Two types of electron dispersion, one with a short duration (~0.3 s) and the other with a longer duration (~13 s) were detected between the electron and ion edges. The rapid dispersion (with small time scale) is mainly in the parallel direction, which might originate from a thin layer with non‐frozen‐in electrons close to the separatrix. The gradual (long time scale) dispersion is seen from parallel to perpendicular directions, which comes from the E×B drift of a curved D‐shape distribution of electrons. The width of the electron diffusion region on the magnetosheath side is estimated based on MMS observation. The observation also reveals an unexpected parallel electron beam outside of the electron edge. Wave‐particle interaction or parallel potential in the inflow region may be responsible for the generation of this electron population
Categorification of skew-symmetrizable cluster algebras
We propose a new framework for categorifying skew-symmetrizable cluster
algebras. Starting from an exact stably 2-Calabi-Yau category C endowed with
the action of a finite group G, we construct a G-equivariant mutation on the
set of maximal rigid G-invariant objects of C. Using an appropriate cluster
character, we can then attach to these data an explicit skew-symmetrizable
cluster algebra. As an application we prove the linear independence of the
cluster monomials in this setting. Finally, we illustrate our construction with
examples associated with partial flag varieties and unipotent subgroups of
Kac-Moody groups, generalizing to the non simply-laced case several results of
Gei\ss-Leclerc-Schr\"oer.Comment: 64 page
Improved genome editing in human cell lines using the CRISPR method
The Cas9/CRISPR system has become a popular choice for genome editing. In this system, binding of a single guide (sg) RNA to a cognate genomic sequence enables the Cas9 nuclease to induce a double-strand break at that locus. This break is next repaired by an error-prone mechanism, leading to mutation and gene disruption. In this study we describe a range of refinements of the method, including stable cell lines expressing Cas9, and a PCR based protocol for the generation of the sgRNA. We also describe a simple methodology that allows both elimination of Cas9 from cells after gene disruption and re-introduction of the disrupted gene. This advance enables easy assessment of the off target effects associated with gene disruption, as well as phenotype-based structure-function analysis. In our study, we used the Fan1 DNA repair gene as control in these experiments. Cas9/CRISPR-mediated Fan1 disruption occurred at frequencies of around 29%, and resulted in the anticipated spectrum of genotoxin hypersensitivity, which was rescued by re-introduction of Fan1
Massive migration from the steppe is a source for Indo-European languages in Europe
We generated genome-wide data from 69 Europeans who lived between 8,000-3,000
years ago by enriching ancient DNA libraries for a target set of almost four
hundred thousand polymorphisms. Enrichment of these positions decreases the
sequencing required for genome-wide ancient DNA analysis by a median of around
250-fold, allowing us to study an order of magnitude more individuals than
previous studies and to obtain new insights about the past. We show that the
populations of western and far eastern Europe followed opposite trajectories
between 8,000-5,000 years ago. At the beginning of the Neolithic period in
Europe, ~8,000-7,000 years ago, closely related groups of early farmers
appeared in Germany, Hungary, and Spain, different from indigenous
hunter-gatherers, whereas Russia was inhabited by a distinctive population of
hunter-gatherers with high affinity to a ~24,000 year old Siberian6 . By
~6,000-5,000 years ago, a resurgence of hunter-gatherer ancestry had occurred
throughout much of Europe, but in Russia, the Yamnaya steppe herders of this
time were descended not only from the preceding eastern European
hunter-gatherers, but from a population of Near Eastern ancestry. Western and
Eastern Europe came into contact ~4,500 years ago, as the Late Neolithic Corded
Ware people from Germany traced ~3/4 of their ancestry to the Yamnaya,
documenting a massive migration into the heartland of Europe from its eastern
periphery. This steppe ancestry persisted in all sampled central Europeans
until at least ~3,000 years ago, and is ubiquitous in present-day Europeans.
These results provide support for the theory of a steppe origin of at least
some of the Indo-European languages of Europe
A fresh look at the evolution and diversification of photochemical reaction centers
In this review, I reexamine the origin and diversification of photochemical reaction centers based on the known phylogenetic relations of the core subunits, and with the aid of sequence and structural alignments. I show, for example, that the protein folds at the C-terminus of the D1 and D2 subunits of Photosystem II, which are essential for the coordination of the water-oxidizing complex, were already in place in the most ancestral Type II reaction center subunit. I then evaluate the evolution of reaction centers in the context of the rise and expansion of the different groups of bacteria based on recent large-scale phylogenetic analyses. I find that the Heliobacteriaceae family of Firmicutes appears to be the earliest branching of the known groups of phototrophic bacteria; however, the origin of photochemical reaction centers and chlorophyll synthesis cannot be placed in this group. Moreover, it becomes evident that the Acidobacteria and the Proteobacteria shared a more recent common phototrophic ancestor, and this is also likely for the Chloroflexi and the Cyanobacteria. Finally, I argue that the discrepancies among the phylogenies of the reaction center proteins, chlorophyll synthesis enzymes, and the species tree of bacteria are best explained if both types of photochemical reaction centers evolved before the diversification of the known phyla of phototrophic bacteria. The primordial phototrophic ancestor must have had both Type I and Type II reaction centers
The rapid assembly of an elliptical galaxy of 400 billion solar masses at a redshift of 2.3
Stellar archeology shows that massive elliptical galaxies today formed
rapidly about ten billion years ago with star formation rates above several
hundreds solar masses per year (M_sun/yr). Their progenitors are likely the
sub-millimeter-bright galaxies (SMGs) at redshifts (z) greater than 2. While
SMGs' mean molecular gas mass of 5x10^10 M_sun can explain the formation of
typical elliptical galaxies, it is inadequate to form ellipticals that already
have stellar masses above 2x10^11 M_sun at z ~ 2. Here we report
multi-wavelength high-resolution observations of a rare merger of two massive
SMGs at z = 2.3. The system is currently forming stars at a tremendous rate of
2,000 M_sun/yr. With a star formation efficiency an order-of-magnitude greater
than that of normal galaxies, it will quench the star formation by exhausting
the gas reservoir in only ~200 million years. At a projected separation of 19
kiloparsecs, the two massive starbursts are about to merge and form a passive
elliptical galaxy with a stellar mass of ~4x10^11 M_sun. Our observations show
that gas-rich major galaxy mergers, concurrent with intense star formation, can
form the most massive elliptical galaxies by z ~ 1.5.Comment: Appearing in Nature online on May 22 and in print on May 30.
Submitted here is the accepted version (including the Supplementary
Information), see nature.com for the final versio
Listing Maximal Independent Sets with Minimal Space and Bounded Delay
International audienceAn independent set is a set of nodes in a graph such that no two of them are adjacent. It is maximal if there is no node outside the independent set that may join it. Listing maximal independent sets in graphs can be applied, for example, to sample nodes belonging to different communities or clusters in network analysis and document clustering. The problem has a rich history as it is related to maximal cliques, dominance sets, vertex covers and 3-colorings in graphs. We are interested in reducing the delay, which is the worst-case time between any two consecutively output solutions, and the memory footprint, which is the additional working space behind the read-only input graph
Accurate and fast methods to estimate the population mutation rate from error prone sequences
“When the going gets tough, the tough get going”: Motivation towards closure and effort investment in the performance of cognitive tasks
Cluster Lenses
Clusters of galaxies are the most recently assembled, massive, bound
structures in the Universe. As predicted by General Relativity, given their
masses, clusters strongly deform space-time in their vicinity. Clusters act as
some of the most powerful gravitational lenses in the Universe. Light rays
traversing through clusters from distant sources are hence deflected, and the
resulting images of these distant objects therefore appear distorted and
magnified. Lensing by clusters occurs in two regimes, each with unique
observational signatures. The strong lensing regime is characterized by effects
readily seen by eye, namely, the production of giant arcs, multiple-images, and
arclets. The weak lensing regime is characterized by small deformations in the
shapes of background galaxies only detectable statistically. Cluster lenses
have been exploited successfully to address several important current questions
in cosmology: (i) the study of the lens(es) - understanding cluster mass
distributions and issues pertaining to cluster formation and evolution, as well
as constraining the nature of dark matter; (ii) the study of the lensed objects
- probing the properties of the background lensed galaxy population - which is
statistically at higher redshifts and of lower intrinsic luminosity thus
enabling the probing of galaxy formation at the earliest times right up to the
Dark Ages; and (iii) the study of the geometry of the Universe - as the
strength of lensing depends on the ratios of angular diameter distances between
the lens, source and observer, lens deflections are sensitive to the value of
cosmological parameters and offer a powerful geometric tool to probe Dark
Energy. In this review, we present the basics of cluster lensing and provide a
current status report of the field.Comment: About 120 pages - Published in Open Access at:
http://www.springerlink.com/content/j183018170485723/ . arXiv admin note:
text overlap with arXiv:astro-ph/0504478 and arXiv:1003.3674 by other author
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