11 research outputs found
Performance of the gas gain monitoring system of the CMS RPC muon detector
The RPC muon detector of the CMS experiment at the LHC (CERN, Geneva,
Switzerland) is equipped with a Gas Gain Monitoring (GGM) system. A report on
the stability of the system during the 2011-2012 data taking run is given, as
well as the observation of an effect which suggests a novel method for the
monitoring of gas mixture composition.Comment: Presented at RPC2014, Beijing, China. Accepted for publication on
JINS
Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy
Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus
Novel 2H-pyrazolo[4,3-c]hexahydropyridine derivatives: Synthesis, crystal structure, fluorescence properties and cytotoxicity evaluation against human breast cancer cells
Synthesis, cytotoxicity against cancer and normal cell lines of novel hydrazide–hydrazone derivatives bearing 5H-chromen-5-one
Synthesis, in vitro Antibacterial and in vivo Anti-Inflammatory Activity of Some New Pyridines
Synthesis and anti-Plasmodium falciparum evaluation of novel pyrazolopyrimidine derivatives
Erratum: Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy
Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/ MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus
Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy (Scientific Reports (2017) 7 (43953) DOI: 10.1038/srep43953)
Giant cell arteritis (GCA) and Takayasu\u2019s arteritis (TAK) are major forms of large-vessel vasculitis (LVV)
that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping
data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated.
The HLA region harboured the main disease-specific associations. GCA was mostly associated with
class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/
MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced
in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately.
Consequently, no significant genetic correlation between these two diseases was observed when
HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B
gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets
(rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk
factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide
evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common
susceptibility factors were suggested, especially within the IL12B locus