Pengaruh motivasi belajar matematika dan kecemasan matematis terhadap kemampuan berpikir tingkat tinggi siswa kelas XI SMAN 1 Limbangan tahun pelajaran 2022/2023

Kemampuan berpikir tingkat tinggi yang dimiliki siswa diantaranya dipengaruhi oleh motivasi belajar matematika dan kecemasan matematis sehingga perlu mengontrol kedua hal tersebut agar kemampuan berpikir tingkat tinggi siswa menjadi lebih baik. Penelitian ini bertujuan untuk mengetahui: (1) apakah terdapat pengaruh yang signifikan motivasi belajar matematika (X_1) terhadap kemampuan berpikir tingkat tinggi (Y) siswa kelas XI SMAN 1 Limbangan tahun pelajaran 2021/2022; (2) apakah terdapat pengaruh yang signifikan kecemasan matematis (X_2) terhadap kemampuan berpikir tingkat tinggi (Y) siswa kelas XI SMAN 1 Limbangan tahun pelajaran 2021/2022; (3) apakah terdapat pengaruh yang signifikan motivasi belajar matematika (X_1) dan kecemasan matematis (X_2) secara simultan terhadap kemampuan berpikir tingkat tinggi (Y) siswa kelas XI SMAN 1 Limbangan tahun pelajaran 2022/2023. Populasi dalam penelitian ini adalah seluruh siswa kelas XI di SMAN 1 Limbangan tahun pelajaran 2022/2023. Sampel penelitian adalah seluruh siswa kelas XI yang berjumlah 215 siswa yang diambil menggunakan teknik saturation sampling. Data penelitian dikumpulkan menggunakan metode angket dan tes. Hasil penelitian ini adalah: (1) terdapat pengaruh yang signifikan antara motivasi belajar matematika terhadap kemampuan berpikir tingkat tinggi; (2) terdapat pengaruh yang tidak signifikan antara kecemasan matematis terhadap kemampuan berpikir tingkat tinggi; (3) terdapat pengaruh yang signifikan antara motivasi belajar matematika dan kecemasan matematis secara simultan terhadap kemampuan berpikir tingkat tinggi

A glucose biosensor based on novel Lutetium bis-phthalocyanine incorporated silica-polyaniline conducting nanobeads

The facile preparation of highly sensitive electrochemical bioprobe based on lutetium 13 phthalocyanine incorporated silica nanoparticles (SiO2(LuPc2)) grafted with Poly(vinyl 14 alcohol-vinyl acetate) itaconic acid (PANI(PVIA)) doped polyaniline conducting nanobeads 15 (SiO2(LuPc2)PANI(PVIA)-CNB) is reported. The preparation of CNB involves two stages (i) 16 pristine synthesis of LuPc2 incorporated SiO2 and PANI(PVIA); (ii) covalent grafting of 17 PANI(PVIA) onto the surface of SiO2(LuPc2). The morphology and other physico-chemical 18 characteristics of CNB were investigated. The scanning electron microscopy images show 19 that the average particle size of SiO2(LuPc2)PANI(PVIA)-CNB was between 180-220 nm. 20 The amperometric measurements showed that the fabricated SiO2(LuPc2)PANI(PVIA)-21 CNB/GOx biosensor exhibited wide linear range (1-16 mM) detection of glucose with a low 22 detection limit of 0.1 mM. SiO2(LuPc2)PANI(PVIA)-CNB/GOx biosensor exhibited high 23 sensitivity (38.53 μA mM−1 cm−2) towards the detection of glucose under optimized 24 conditions. Besides, the real (juice and serum) sample analysis based on a standard addition 25 method and direct detection method showed high precision for measuring glucose at 26 SiO2(LuPc2)PANI(PVIA)-CNB/GOx biosensor. The SiO2(LuPc2)PANI(PVIA)-CNB/GOx 27 biosensor stored under refrigerated condition over a period of 45 days retains ~ 96.4 % 28 glucose response current

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity