Researching the lives of disabled children and young people

Why a Special Issue of Children & Society dedicated to disabled children and young people? The simple answer to that question is ‘because disabled children are children first and foremost’. The vast majority of disabled children and young people in the western world live at home with their families, most attending mainstream schools, and disabled children and young people worldwide have rights to inclusion and equal treatment enshrined in national legislation and international conventions. Yet they often remain left out – from generic children’s research, from policy-making about children’s services and, in their everyday lives, from inclusion in friendship groups and social and sporting activities

Photoprocesses in protoplanetary disks

Circumstellar disks are exposed to intense ultraviolet radiation from the young star. In the inner disks, the UV radiation can be enhanced by more than seven orders of magnitude compared with the average interstellar field, resulting in a physical and chemical structure that resembles that of a dense photon-dominated region (PDR). This intense UV field affects the chemistry, the vertical structure of the disk, and the gas temperature, especially in the surface layers of the disk. The parameters which make disks different from traditional PDRs are discussed, including the shape of the UV radiation field, grain growth, the absence of PAHs, the gas/dust ratio and the presence of inner holes. New photorates for selected species, including simple ions, are presented. Also, a summary of available cross sections at Lyman alpha 1216 A is made. Rates are computed for radiation fields with color temperatures ranging from 4000 to 30,000 K, and can be applied to a wide variety of astrophysical regions including exo-planetary atmospheres. The importance of photoprocesses is illustrated for a number of representative disk models, including disk models with grain growth and settling.Comment: A website with the final published version and all photodissociation cross sections and rates can be found at http://www.strw.leidenuniv.nl/~ewine/phot

A lifetime’s adventure in extracellular K+ regulation: the Scottish connection

In a career that has spanned 45 years and shows no signs of slowing down, Dr Bruce Ransom has devoted considerable time and energy to studying regulation of interstitial K+. When Bruce commenced his studies in 1969 virtually nothing was known of the functions of glial cells, but Bruce’s research contributed to the physiological assignation of function to mammalian astrocytes, namely interstitial K+ buffering. The experiments that I describe in this review concern the response of the membrane potential (Em) of in vivo cat cortical astrocytes to changes in [K+]o, an experimental manoeuvre that was achieved in two different ways. The first involved recording the Em of an astrocyte while the initial aCSF was switched to one with different K+, whereas in the second series of experiments the cortex was stimulated and the response of the astrocyte Em to the K+ released from neighbouring neurons was recorded. The astrocytes responded in a qualitatively predictable manner, but quantitatively the changes were not as predicted by the Nernst equation. Elevations in interstitial K+ are not sustained and K+ returns to baseline rapidly due to the buffering capacity of astrocytes, a phenomenon studied by Bruce, and his son Chris, published 27 years after Bruce’s initial publications. Thus, a lifetime spent investigating K+ buffering has seen enormous advances in glial research, from the time cells were identified as ‘presumed’ glial cells or ‘silent cells’, to the present day, where glial cells are recognised as contributing to every important physiological brain function

Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions.

The PHENIX collaboration presents first measurements of low-momentum (0.41  GeV/c) direct-photon yield dN_{γ}^{dir}/dη is a smooth function of dN_{ch}/dη and can be well described as proportional to (dN_{ch}/dη)^{α} with α≈1.25. This scaling behavior holds for a wide range of beam energies at the Relativistic Heavy Ion Collider and the Large Hadron Collider, for centrality selected samples, as well as for different A+A collision systems. At a given beam energy, the scaling also holds for high p_{T} (>5  GeV/c), but when results from different collision energies are compared, an additional sqrt[s_{NN}]-dependent multiplicative factor is needed to describe the integrated-direct-photon yield

Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid

Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using “Phase solubility study” with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K and two pH values 2 and 7. The influence of different 2HP-β-CD concentration on solubility of drugs at different pH and temperatures has been investigated. The 2HP-β-CD-drug complex stability constants (Ks), and dissociations constants (Kd), as well as the thermodynamic parameters of reaction, i.e., the free energy change (ΔG), the enthalpy change (ΔH) and the entropy change (ΔS), were determined. The experimental data indicated formation of 1:1 inclusion complexes, which were found effective binders increasing the solubility of drugs

High-density disc reflection spectroscopy of low-mass active galactic nuclei

The standard alpha-disc model predicts an anti-correlation between the density of the inner accretion disc and the black hole mass times square of the accretion rate, as seen in higher mass ($M_{\rm BH}>10^{6} M_{\odot}$) active galactic nuclei (AGNs). In this work, we test the predictions of the alpha-disc model and study the properties of the inner accretion flow for the low-mass end ($M_{\rm BH}\approx 10^{5-6}M_{\odot}$) of AGNs. We utilize a new high-density disc reflection model where the density parameter varies from $n_{\rm e}=10^{15}$ to $10^{20}$ cm$^{-3}$ and apply it to the broadband X-ray (0.3-10 keV) spectra of the low-mass AGN sample. The sources span a wide range of Eddington fractions and are consistent with being sub-Eddington or near-Eddington. The X-ray spectra reveal a soft X-ray excess below $\sim 1.5$ keV which is well modeled by high-density reflection from an ionized accretion disc of density $n_{\rm e}\sim 10^{18}$ cm$^{-3}$ on average. The results suggest a radiation pressure-dominated disc with an average of 70% fraction of the disc power transferred to the corona, consistent with that observed in higher mass AGNs. We show that the disc density higher than $10^{15}$ cm$^{-3}$ can result from the radiation pressure compression when the disc surface does not hold a strong magnetic pressure gradient. We find tentative evidence for a drop in black hole spin at low-mass regimes.Comment: 20 pages, 10 figures, 6 tables. Accepted for publication in MNRA

Molecular cloning and expression analysis of a zebrafish novel zinc finger protein gene rnf141

ZNF230 is a novel zinc finger gene cloned by our laboratory. In order to understand the potential functions of this gene in vertebrate development, we cloned the zebrafish orthologue of human ZNF230, named rnf141. The cDNA fragment of rnf141 was obtained by rapid amplification of cDNA ends (RACE). The open reading frame (ORF) encodes a polypeptide of 222 amino acids which shares 75.65% identity with the human ZNF230. RT-PCR analysis in zebrafish embryo and adult tissues revealed that rnf141 transcripts are maternally derived and that rnf141 mRNA has a broad distribution. Zygotic rnf141 message is strongly localized in the central nervous system, as shown by whole-mount in situ hybridization. Knockdown and over expression of rnf141 can induce abnormal phenotypes, including abnormal development of brain, as well as yolk sac and axis extendsion. Marker gene analysis showed that rnf141 may play a role in normal dorsoventral patterning of zebrafish embryos, suggesting that rnf141 may have a broad function during early development of vertebrates