13 research outputs found
A comprehensive overview of radioguided surgery using gamma detection probe technology
- Author
- A Agrawal
- A Ayhan
- A Ayhan
- A Bembenek
- A Bembenek
- A Benevento
- A Blom
- A Chella
- A Cuschieri
- A Gil-Moreno
- A Gonfiotti
- A Gruaz-Guyon
- A Hubalewska
- A Hubalewska-Dydejczyk
- A HĂ€cker
- A Iagaru
- A Lal
- A Leibovitz
- A Luini
- A Meyer
- A Mussa
- A Muxi
- A Patel
- A Renda
- A Sardi
- A Sardi
- A Schattner
- A Seal
- A Sherif
- A Sherif
- A Thor
- A Thor
- A Thor
- A Woznick
- AA Dunne
- AC Barros
- AC Federico
- AC Morris Jr
- AC van Akkooi
- ACG Mitchell
- AD Hill
- AF KovĂĄcs
- AF KovĂĄcs
- AH Chakera
- AJ Bilchik
- AJ Bilchik
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- AJ Wilhelm
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- B Esmaeli
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- B Meller
- B Meller
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- B Zulfikaroglu
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- BJ Sickle-Santanello
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- BR Haugen
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- C De Cicco
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- C Levenback
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- C Michl
- C Mojzisik
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- C Ohyama
- C Ulmer
- C Ulmer
- C Wang
- CA Hoefnagel
- CA Nieroda
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- Cathy M Mojzisik
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- YS Lin
- ZR Shi
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology
Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC
- Author
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- Viren B
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- Wallbank M
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- Waters D
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- Wetstein M
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- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson C
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- Wisniewski W
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- Xiao Y
- Xie F
- Yandel E
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- Yankelevich A
- Yershov N
- Yonehara K
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- Zaki R
- Zalesak J
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- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zetina LMM
- Zeug K
- Zhang C
- Zhao M
- Zhivun E
- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'IOP Publishing'
- Publication date
- 04/08/2021
- Field of study
The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 Ă 6 Ă 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components
Searching for solar KDAR with DUNE
- Author
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- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
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- Adinolfi M
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- Battat JBR
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- Blaszczyk FDM
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- Brandt A
- Bremer J
- Brew C
- Brianne E
- Brice SJ
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- Bromberg C
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- Brooke J
- Bross A
- Brunetti G
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- Budd H
- Bueno LM
- Butorov I
- Cagnoli I
- Caicedo DAM
- Caiulo D
- Calabrese R
- Calafiura P
- Calcutt J
- Calin M
- Calvez S
- Calvo E
- Caminata A
- Campanelli M
- Cankocak K
- Caratelli D
- Carini G
- Carlus B
- Carneiro MF
- Carniti P
- Carranza H
- Carroll T
- Castillo A
- Castromonte C
- Catano-Mur E
- Cattadori C
- Cavalier F
- Cavanna F
- Centro S
- Cerati G
- Cervelli A
- Chalifour M
- Chappell A
- Chardonnet E
- Charitonidis N
- Chatterjee A
- Chattopadhyay S
- Chen H
- Chen M
- Chen Y
- Chen Z
- Cheon Y
- Cherdack D
- Chi C
- Childress S
- Chiriacescu A
- Chisnall G
- Cho K
- Choate S
- Chokheli D
- Chong PS
- Choubey S
- Christensen A
- Christian D
- Christodoulou G
- Chukanov A
- Chung M
- Church E
- Cicero V
- Clarke P
- Coan TE
- Cocco AG
- Coelho JAB
- Conley E
- Conley R
- Conrad JM
- Convery M
- Copello S
- Corwin L
- Cremaldi L
- Cremonesi L
- Crespo-AnadĂłn JI
- Crisler M
- Cristaldo E
- Cross R
- Cudd A
- Cuesta C
- Cui Y
- Cussans D
- da Motta H
- Dalager O
- David C
- David Q
- Davies GS
- Davini S
- Dawson J
- De Bonis I
- de GouvĂȘa A
- De Holanda PC
- De Jong P
- De Lurgio P
- de Oliveira MAL
- De Roeck A
- De Romeri V
- De Souza G
- de Souza HV
- De K
- Debbins P
- Decowski MP
- Deisting A
- Del Campo AO
- Delbart A
- Delepine D
- Delgado M
- Delgado MAR
- Dell'Acqua A
- DeMuth DM
- Dennis S
- Densham C
- Deptuch GW
- Devi R
- Dharmapalan R
- Di Domizio S
- Di Giulio L
- Di Noto L
- Dias M
- Diaz DG
- Diaz F
- Ding P
- Distefano C
- Diurba R
- Diwan M
- Djurcic Z
- Doering D
- Dolan S
- Dolek F
- Dolinski MJ
- Domine L
- Douglas D
- Douillet D
- Drake G
- Drielsma F
- Duarte L
- Duchesneau D
- Duffy K
- DUNE Collaboration
- Dunne P
- Durkin T
- Duyang H
- Dvornikov O
- Dwyer DA
- Dyshkant AS
- DĂaz JS
- Eads M
- Earle A
- Edmunds D
- Eisch J
- Emberger L
- Emery S
- Ereditato A
- Erjavec T
- Escobar CO
- Eurin G
- Evans JJ
- Ewart E
- Ezeribe AC
- F.
- Fahey K
- Fajardo LSG
- Falcone A
- Fani M
- Farnese C
- Farzan Y
- Fedoseev D
- Felix J
- Feng Y
- Fernandez-Martinez E
- Ferraro F
- Fields L
- Filip P
- Filthaut F
- Fiorentini A
- Fiorini M
- Fitzpatrick RS
- Flanagan W
- Fleming B
- Flight R
- Forero DV
- Forero JFC
- Fowler J
- Fox W
- Franc J
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- Franco D
- Freeman J
- Freestone J
- Fried J
- Friedland A
- Fuess S
- Furic IK
- Furmanski AP
- Gabrielli A
- Gago A
- Gallagher H
- Gallas A
- Gallego-Ros A
- Gallice N
- Galymov V
- Gamberini E
- Gamble T
- Ganacim F
- Gandhi R
- Gandrajula R
- Gao F
- Gao S
- Garcia-Gamez D
- GarcĂa-Peris MĂ
- Gardiner S
- Gastler D
- Gauvreau J
- Ge G
- Gelli B
- Gendotti A
- Gent S
- Ghorbani-Moghaddam Z
- Giammaria P
- Giammaria T
- Gibin D
- Gil-Botella I
- Gilligan S
- Girerd C
- Giri AK
- Gnani D
- Gogota O
- Gold M
- Gollapinni S
- Gollwitzer K
- Gomes RA
- Gonnella F
- Gonzalez-Cuevas JA
- Gonzalez-Lopez M
- Goodman MC
- Goodwin O
- Goswami S
- Gotti C
- Goudzovski E
- Grace C
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- Granados E
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- Guardincerri E
- Guarino V
- Guarise M
- Guenette R
- Guerard E
- Guerzoni M
- Guglielmi A
- Guo B
- Guthikonda KK
- Gutierrez R
- Guzowski P
- Guzzo MM
- Gwon S
- Ha C
- Habig A
- Hadavand H
- Haenni R
- Hahn A
- Haiston J
- Hamacher-Baumann P
- Hamernik T
- Hamilton P
- Han J
- Harris DA
- Hartnell J
- Harton J
- Hasegawa T
- Hasnip C
- Hatcher R
- Hatfield KW
- Hatzikoutelis A
- Hayes C
- Hayrapetyan K
- Hays J
- Hazen E
- He M
- Heavey A
- Heeger KM
- Heise J
- Hennessy K
- Henry S
- Herner K
- Hertel L
- Hewes J
- Higuera A
- Hill T
- Hillier SJ
- Himmel A
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- Trzaska WH
- Tsai Y
- Tsai Y-T
- Tsamalaidze Z
- Tsang KV
- Tsverava N
- Tufanli S
- Tull C
- Tyley E
- Tzanov M
- Uboldi L
- Uchida MA
- Urheim J
- Usher T
- Uzunyan S
- Vagins MR
- Vahle P
- Valdiviesso GA
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- Varanini F
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- Vasina S
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- Ventura S
- Verdugo A
- Vergani S
- Vermeulen MA
- Verzocchi M
- Vicenzi M
- Vignoli C
- Vilela C
- Villanueva AC
- Viren B
- Vrba T
- Wachala T
- Waldron AV
- Wallbank M
- Wallis C
- Wang H
- Wang J
- Wang L
- Wang MHLS
- Wang Y
- Wang Y
- Warburton K
- Warner D
- Wascko MO
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- Weber M
- Wei H
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- Wenman D
- Wetstein M
- White A
- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson C
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- Wilson RJ
- Wisniewski W
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- Wret C
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- Wu W
- Xiao Y
- Xie F
- Yandel E
- Yang G
- Yang K
- Yang S
- Yang T
- Yankelevich A
- Yershov N
- Yonehara K
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zetina LMM
- Zeug K
- Zhang C
- Zhao M
- Zhivun E
- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- Publication date
- Field of study
Therapeutic gene targeting
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Roles of the C-terminal domains of topoisomerase II alpha and topoisomerase II beta in regulation of the decatenation checkpoint
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 14/04/2017
- Field of study
Topoisomerase (topo) IIα and IIÎČ maintain genome stability and are targets for anti-tumor drugs. In this study, we demonstrate that the decatenation checkpoint is regulated, not only by topo IIα, as previously reported, but also by topo IIÎČ. The decatenation checkpoint is most efficient when both isoforms are present. Regulation of this checkpoint and sensitivity to topo II-targeted drugs is influenced by the C-terminal domain (CTD) of the topo II isoforms and by a conserved non-catalytic tyrosine, Y640 in topo IIα and Y656 in topo IIÎČ. Deletion of most of the CTD of topo IIα, while preserving the nuclear localization signal (NLS), enhances the decatenation checkpoint and sensitivity to topo II-targeted drugs. In contrast, deletion of most of the CTD of topo IIÎČ, while preserving the NLS, and mutation of Y640 in topo IIα and Y656 in topo IIÎČ inhibits these activities. Structural studies suggest that the differential impact of the CTD on topo IIα and topo IIÎČ function may be due to differences in CTD charge distribution and differential alignment of the CTD with reference to transport DNA. Together these results suggest that topo IIα and topo IIÎČ cooperate to maintain genome stability, which may be distinctly modulated by their CTDs
Interplay between the Westerlies and Asian monsoon recorded in Lake Qinghai sediments since 32 ka
- Author
- ACG Henderson
- ACG Henderson
- AM Berger
- CA Dykoski
- DC Barber
- DK Rea
- DT Shindell
- E Kalnay
- FH Chen
- G Bond
- G Marino
- GA Meehl
- GH Denton
- GH Denton
- GH Denton
- GS Lister
- H Xu
- H Xu
- HY Lu
- J Shen
- JB Murton
- LC Peterson
- P Damon
- PA Meyers
- PJ Reimer
- PJJ Slota
- PU Clark
- RG Fairbanks
- SC Porter
- SC Porter
- SM Colman
- SY Yu
- T Murakami
- T Watanabe
- WG Liu
- WJ Zhou
- WJ Zhou
- XM Fang
- XQ Liu
- XZ Li
- XZ Li
- Y Zhang
- YJ Wang
- Z Liu
- ZD Jin
- ZD Jin
- ZS An
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Abrupt deglaciation on the northeastern Tibetan Plateau: evidence from Lake Qinghai
- Author
- ACG Henderson
- ACG Henderson
- Andrew C. G. Henderson
- AP Burnett
- C Zhao
- CF Li
- D Rhode
- DB Madsen
- DK Rea
- DP Sun
- DX Yuan
- Erik T. Brown
- FH Chen
- FH Chen
- FSR Pausata
- GS Lister
- H Zhao
- HD Schulz
- J Shen
- JE Kutzbach
- JL Xiao
- JM Hayes
- Jonathan A. Holmes
- Josef P. Werne
- JP Werne
- JP Yan
- JQ Yu
- JZ Hou
- M Blaauw
- M Blaauw
- M DeNiro
- M Konert
- MH OâLeary
- MR Talbot
- P Huybers
- PA Meyers
- PA Meyers
- S Mischke
- S Mischke
- S Mischke
- S Mischke
- SC Porter
- SL Weber
- SM Colman
- SRH Zimmerman
- Steven M. Colman
- SY Yu
- U Herzschuh
- WR Boos
- X Liu
- X Liu
- X Liu
- X Liu
- Xiuju Liu
- Y Li
- Y Zhao
- Y Zhao
- YJ Wang
- ZD Jin
- ZS An
- ZS An
- ZS An
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Gene targeting is enhanced in human cells overexpressing hRAD51
- Author
- A Choulika
- A Edwards
- A Shinohara
- A Shinohara
- AC Porter
- ACG Porter
- AS Waldman
- B Thyagarajan
- BC Waldman
- BC Waldman
- BL Johnson
- C Deng
- DF Muris
- DG Taghian
- DL Pittman
- DS Lim
- DW Melton
- DW Russell
- E Sonoda
- EB Kmiec
- F Liang
- F Smih
- J Essers
- J Sambrook
- JB Scheerer
- JE Itzhaki
- K Kunzelmann
- L Amaravadi
- M Jasin
- M Jasin
- MC Rice
- MK Dosanjh
- MS Park
- N Liu
- NS Templeton
- O Bezzubova
- O Smithies
- P Baumann
- P Rouet
- P Sung
- PJ Southern
- R Kanaar
- RJ Bollag
- RJ Yåñez
- S Andersson
- S Doi
- S Rasheed
- S Sato
- S Vispé
- SJ Xia
- SL Mansour
- SL Pennington
- T Rijkers
- UK Laemmli
- Y Yamaguchi-Iwai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular and functional analysis of the virus- and interferon-inducible human MxA promoter
- Author
- ACG Porter
- AP Feinberg
- C-M Fan
- DS Kessler
- F Weitz
- G Opdenakker
- H Arnheiter
- H Hug
- H Jabobsen
- H Kirchner
- J Pavlovic
- J Sambrook
- JC Myers
- JF Goetschy
- JL Taylor
- JN MacDonald
- JT Kadonaga
- KC Chang
- LE Reid
- M Aebi
- M Asano
- M Revel
- MA Horisberger
- MA Horisberger
- MA Horisberger
- MA Horisberger
- MG Wathelet
- MN Rutherford
- N Reich
- P Bucher
- P Chomczynski
- P Dreiding
- P Staeheli
- P Staeheli
- P Staeheli
- P Staeheli
- R Pine
- RL Friedman
- RM Fourney
- S Goddbourn
- S Pestka
- ST Smale
- ST Smale
- T Enoch
- T Fujita
- W Nikovits Jr.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Novel cationic lipids for gene delivery and gene therapy
- Author
- BEHR JP
- BEHR JP
- BISHOP JM
- BLESSING T
- BOUKHNIKACHVILI T
- BOULIKAS T
- BYK G
- BYK G
- CAPLEN NJ ALTON
- EL OUAHABI A
- ESCRIOU V
- FELGNER JH
- FELGNER PL
- FRENCH ANDERSON W
- GAO X
- HARBOTTLE RP
- HAWLEY-NELSON P
- HAWLEY-NELSON P
- HIRSCH-LERNER D
- KOLTOVER I
- LASIC DD
- LASIC DD
- LEE ER
- LEE ER
- LEE SG
- OUDRHIRI N
- PITARD B
- RADLER JO
- RUYSSCHAERT JM
- SMITH A
- SMITH KT
- STERNBERG B
- STRAYER DS
- VIGNERON JP
- WALKER S
- WHEELER CJ
- YANEZ RJ PORTER ACG
- YANG Y
- ZUIDAM NJ
- ZUIDAM NJ
- Publication venue
- 'Informa Healthcare'
- Publication date
- Field of study