341 research outputs found
Very-high energy gamma-ray astronomy: A 23-year success story in high-energy astroparticle physics
Very-high energy (VHE) gamma quanta contribute only a minuscule fraction -
below one per million - to the flux of cosmic rays. Nevertheless, being neutral
particles they are currently the best "messengers" of processes from the
relativistic/ultra-relativistic Universe because they can be extrapolated back
to their origin. The window of VHE gamma rays was opened only in 1989 by the
Whipple collaboration, reporting the observation of TeV gamma rays from the
Crab nebula. After a slow start, this new field of research is now rapidly
expanding with the discovery of more than 150 VHE gamma-ray emitting sources.
Progress is intimately related with the steady improvement of detectors and
rapidly increasing computing power. We give an overview of the early attempts
before and around 1989 and the progress after the pioneering work of the
Whipple collaboration. The main focus of this article is on the development of
experimental techniques for Earth-bound gamma-ray detectors; consequently, more
emphasis is given to those experiments that made an initial breakthrough rather
than to the successors which often had and have a similar (sometimes even
higher) scientific output as the pioneering experiments. The considered energy
threshold is about 30 GeV. At lower energies, observations can presently only
be performed with balloon or satellite-borne detectors. Irrespective of the
stormy experimental progress, the success story could not have been called a
success story without a broad scientific output. Therefore we conclude this
article with a summary of the scientific rationales and main results achieved
over the last two decades.Comment: 45 pages, 38 figures, review prepared for EPJ-H special issue "Cosmic
rays, gamma rays and neutrinos: A survey of 100 years of research
Galactic Structure Toward the Carina Tangent
This investigation presents a photometric study of the Galactic structure
toward the Carina arm tangent. The field is located between 280 deg and 286 deg
galactic longitude and -4 deg to 4 deg galactic latitude. All currently
available uvbybeta data is used to obtain homogeneous color excesses and
distances for more than 260 stars of spectral types O to G. We present revised
distances and average extinction for the open clusters and cluster candidates
NGC 3293, NGC 3114, Loden 46 and Loden 112. The cluster candidate Loden 112
appears to be a very compact group at a true distance modulus of 11.06 +\- 0.11
(s.e.) (1629 +84,-80 pc), significantly closer than previous estimates. We
found other OB stars at that same distance and, based on their proper motions,
suggest a new OB association at coordinates 282 deg < l < 285 deg, -2 deg < b <
2 deg. Utilizing BV photometry and spectral classification of the known O-type
stars in the very young open cluster Wd 2 we provide a new distance estimate of
14.13 +\-0.16 (s.e.) (6698 +512,-475 pc), in excellent agreement with recent
distance determinations to the giant molecular structures in this direction. We
also discuss a possible connection between the HII region RCW 45 and the
highly-reddened B+ star CPD -55 3036 and provide a revised distance for the
luminous blue variable HR Car.Comment: accepted to PAS
Engineering gamma delta T cells limits tonic signaling associated with chimeric antigen receptors
Despite the benefits of chimeric antigen receptor (CAR)–T cell therapies against lymphoid malignancies, responses in solid tumors have been more limited and off-target toxicities have been more marked. Among the possible design limitations of CAR-T cells for cancer are unwanted tonic (antigen-independent) signaling and off-target activation. Efforts to overcome these hurdles have been blunted by a lack of mechanistic understanding. Here, we showed that single-cell analysis with time course mass cytometry provided a rapid means of assessing CAR-T cell activation. We compared signal transduction in expanded T cells to that in T cells transduced to express second-generation CARs and found that cell expansion enhanced the response to stimulation. However, expansion also induced tonic signaling and reduced network plasticity, which were associated with expression of the T cell exhaustion markers PD-1 and TIM-3. Because this was most evident in pathways downstream of CD3ζ, we performed similar analyses on γδT cells that expressed chimeric costimulatory receptors (CCRs) lacking CD3ζ but containing DAP10 stimulatory domains. These CCR-γδT cells did not exhibit tonic signaling but were efficiently activated and mounted cytotoxic responses in the presence of CCR-specific stimuli or cognate leukemic cells. Single-cell signaling analysis enabled detailed characterization of CAR-T and CCR-T cell activation to better understand their functional activities. Furthermore, we demonstrated that CCR-γδT cells may offer the potential to avoid on-target, off-tumor toxicity and allo-reactivity in the context of myeloid malignancies
Sommerfeld Enhancement from Multiple Mediators
We study the Sommerfeld enhancement experienced by a scattering object that
couples to a tower of mediators. This can occur in, e.g., models of secluded
dark matter when the mediator scale is generated naturally by hidden-sector
confinement. Specializing to the case of a confining CFT, we show that
off-resonant values of the enhancement can be increased by ~ 20% for cases of
interest when (i) the (strongly-coupled) CFT admits a weakly-coupled dual
description and (ii) the conformal symmetry holds up to the Planck scale.
Larger enhancements are possible for lower UV scales due to an increase in the
coupling strength of the tower.Comment: 17p, 2 figures; v2 JHEP version (inconsequential typo fixed,
references added
Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths
We review observations of several classes of neutron-star-powered outflows:
pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe
interacting directly with interstellar medium (ISM), and magnetar-powered
outflows. We describe radio, X-ray, and gamma-ray observations of PWNe,
focusing first on integrated spectral-energy distributions (SEDs) and global
spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering
array of morphologies, with jets, trails, and other structures. Several of the
23 so far identified magnetars show evidence for continuous or sporadic
emission of material, sometimes associated with giant flares, and a few
possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published
in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray
Bursts and Blazars: Physics of Extreme Energy Release
Secluded Dark Matter Coupled to a Hidden CFT
Models of secluded dark matter offer a variant on the standard WIMP picture
and can modify our expectations for hidden sector phenomenology and detection.
In this work we extend a minimal model of secluded dark matter, comprised of a
U(1)'-charged dark matter candidate, to include a confining hidden-sector CFT.
This provides a technically natural explanation for the hierarchically small
mediator-scale, with hidden-sector confinement generating m_{gamma'}>0.
Furthermore, the thermal history of the universe can differ markedly from the
WIMP picture due to (i) new annihilation channels, (ii) a (potentially) large
number of hidden-sector degrees of freedom, and (iii) a hidden-sector phase
transition at temperatures T << M_{dm} after freeze out. The mediator allows
both the dark matter and the Standard Model to communicate with the CFT, thus
modifying the low-energy phenomenology and cosmic-ray signals from the secluded
sector.Comment: ~50p, 8 figs; v2 JHEP versio
Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression
: Sickle cell disease and β-thalassemia affect the production of the adult β-hemoglobin chain. The clinical severity is lessened by mutations that cause fetal γ-globin expression in adult life (i.e., the hereditary persistence of fetal hemoglobin). Mutations clustering ~200 nucleotides upstream of the HBG transcriptional start sites either reduce binding of the LRF repressor or recruit the KLF1 activator. Here, we use base editing to generate a variety of mutations in the -200 region of the HBG promoters, including potent combinations of four to eight γ-globin-inducing mutations. Editing of patient hematopoietic stem/progenitor cells is safe, leads to fetal hemoglobin reactivation and rescues the pathological phenotype. Creation of a KLF1 activator binding site is the most potent strategy - even in long-term repopulating hematopoietic stem/progenitor cells. Compared with a Cas9-nuclease approach, base editing avoids the generation of insertions, deletions and large genomic rearrangements and results in higher γ-globin levels. Our results demonstrate that base editing of HBG promoters is a safe, universal strategy for treating β-hemoglobinopathies
Detection of variable VHE gamma-ray emission from the extra-galactic gamma-ray binary LMC P3
Context. Recently, the high-energy (HE, 0.1-100 GeV) -ray emission
from the object LMC P3 in the Large Magellanic Cloud (LMC) has been discovered
to be modulated with a 10.3-day period, making it the first extra-galactic
-ray binary.
Aims. This work aims at the detection of very-high-energy (VHE, >100 GeV)
-ray emission and the search for modulation of the VHE signal with the
orbital period of the binary system.
Methods. LMC P3 has been observed with the High Energy Stereoscopic System
(H.E.S.S.); the acceptance-corrected exposure time is 100 h. The data set has
been folded with the known orbital period of the system in order to test for
variability of the emission. Energy spectra are obtained for the orbit-averaged
data set, and for the orbital phase bin around the VHE maximum.
Results. VHE -ray emission is detected with a statistical
significance of 6.4 . The data clearly show variability which is
phase-locked to the orbital period of the system. Periodicity cannot be deduced
from the H.E.S.S. data set alone. The orbit-averaged luminosity in the
TeV energy range is erg/s. A luminosity of erg/s is reached during 20% of the orbit. HE and VHE
-ray emissions are anti-correlated. LMC P3 is the most luminous
-ray binary known so far.Comment: 5 pages, 3 figures, 1 table, accepted for publication in A&
Characterizing the gamma-ray long-term variability of PKS 2155-304 with H.E.S.S. and Fermi-LAT
Studying the temporal variability of BL Lac objects at the highest energies
provides unique insights into the extreme physical processes occurring in
relativistic jets and in the vicinity of super-massive black holes. To this
end, the long-term variability of the BL Lac object PKS 2155-304 is analyzed in
the high (HE, 100 MeV 200 GeV)
gamma-ray domain. Over the course of ~9 yr of H.E.S.S observations the VHE
light curve in the quiescent state is consistent with a log-normal behavior.
The VHE variability in this state is well described by flicker noise
(power-spectral-density index {\ss}_VHE = 1.10 +0.10 -0.13) on time scales
larger than one day. An analysis of 5.5 yr of HE Fermi LAT data gives
consistent results ({\ss}_HE = 1.20 +0.21 -0.23, on time scales larger than 10
days) compatible with the VHE findings. The HE and VHE power spectral densities
show a scale invariance across the probed time ranges. A direct linear
correlation between the VHE and HE fluxes could neither be excluded nor firmly
established. These long-term-variability properties are discussed and compared
to the red noise behavior ({\ss} ~ 2) seen on shorter time scales during
VHE-flaring states. The difference in power spectral noise behavior at VHE
energies during quiescent and flaring states provides evidence that these
states are influenced by different physical processes, while the compatibility
of the HE and VHE long-term results is suggestive of a common physical link as
it might be introduced by an underlying jet-disk connection.Comment: 11 pages, 16 figure
Optical spectroscopy of Be/gamma-ray binaries
© ESO, 2016.We report optical spectroscopic observations of the Be/γ-ray binaries LSI+61303, MWC 148 and MWC 656. The peak separation and equivalent widths of prominent emission lines (Hα, Hβ, Hγ, HeI, and FeII) are measured. We estimated the circumstellar disc size, compared it with separation between the components, and discussed the disc truncation. We find that in LSI+61°303 the compact object comes into contact with the outer parts of the circumstellar disc at periastron, in MWC 148 the compact object goes deeply into the disc during the periastron passage, and in MWC 656 the black hole is accreting from the outer parts of the circumstellar disc along the entire orbit. The interstellar extinction was estimated using interstellar lines. The rotation of the mass donors appears to be similar to the rotation of the mass donors in Be/X-ray binaries. We suggest that X-ray/optical periodicity ~1 day deserves to be searched for
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