Разгрузочно-сегрегационная установка песчаникового бута с энергонезависимым приводом комплектующего оборудования

For the road industry, it is quite important to reduce costs and energy consumption, as well as energy recovery in process plants. To solve this problem at one of the stages of the industrial process, which is production of road metal, an important material for road construction, it is proposed to develop autonomous power unit based on recuperation of the kinetic energy of dump trucks, namely a unloading and screening unit of crushing and screening plant with non-volatile drive of auxiliary equipment.A non-volatile unloading and screening unit separates the feedstock at the primary stage of production in a non-volatile operating mode, using recovery of the kinetic energy of trucks been unloaded. After loading rubble sandstone into the receiving hopper, the unit activates the process of material segregation into coarse and fine fractions. The respective fractions are fed to the appropriate feeders for subsequent technological processing. The advantage of the unit is the autonomy of the vibrator and feeders’ drives, which helps to raise the efficiency of the process of unloading and separation of the rubble sandstone and reduce energy costs for production of the finished product.The evaluation of the functional capabilities of the non-volatile hydraulic drive of the unloading and screening unit was carried out for hydraulic motors of the screening and conveying equipment. The apron feeder of KM PP-2–10–60B type providing a continuous and uniform supply of feedstock was assumed as the basic equipment, and the volume of working fluid in the hydraulic accumulator supplied by hydraulic jacks was calculated. The results showed that two hydraulic jacks with the specified parameters can provide the required flow and allowed determining the amount of energy stored in the accumulator during feedstock loading. The calculated power of the hydraulic motor allows its use in the feeder. The economic efficiency of the installation with an autonomous drive is estimated considering the mode of operation, the number of shifts and the tariff for electricity.Для автодорожной отрасли важны снижение себестоимости и энергопотребления, а также рекуперация энергии в технологических установках. Для решения этой проблемы в одном из производственных звеньев отрасли – производстве щебня, который является важным строительным материалом в автодорожной отрасли, – предлагается создание автономных энергетических установок, основанных на рекуперации кинетической энергии автосамосвалов, а именно разгрузочно-сегрегационной установки ДСК с энергонезависимым приводом комплектующего оборудования.Энергонезависимая разгрузочно-сегрегационная установка осуществляет разделение исходного сырья на начальной стадии производства при энергонезависимом режиме эксплуатации, используя рекуперацию кинетической энергии разгружаемых автомобилей. После загрузки песчаникового бута в приёмный бункер, установка активизирует процесс сегрегации материала на крупную и мелкую фракции. Полученные фракции подаются на соответствующие питатели для последующей технологической переработки. Преимуществом установки является автономность приводов вибратора и питателей, что способствует росту эффективности процесса разгрузки и сегрегации песчаникового бута, снижению энергозатрат на производство готового продукта.Оценка функциональных возможностей энергонезависимого гидропривода разгрузочно-сегрегационной установки выполнена для гидромоторов сегрегационного и транспортирующего оборудования. В качестве базового оборудования принят пластинчатый питатель КМ ПП-2–10–60Б, который способен обеспечить непрерывную и равномерную подачу исходного сырья. Рассчитан объём рабочей жидкости в гидроаккумуляторе, подача которой обеспечивается гидродомкратами. Результаты показали, что два гидродомкрата с заданными параметрами способны обеспечить необходимую подачу. Количество энергии, накапливаемой в гидроаккумуляторе при загрузке материала, определено. Рассчитанная мощность гидромотора позволяет его использование в питателе. Оценена экономическая эффективность установки с автономным приводом, учитывая режим работы, количество смен и тариф на электроэнергию

Spectral luminescence properties of indotricarbocyanine dye in biological tissues

We have established that the shape and position of the maximum in the fluorescence spectrum of an indotricarbocyanine dye in tumor and normal tissues in vivo change over time after intravenous injection of the dye. Based on analysis of the spectral properties of the dye in vivo and in blood plasma, the dependence of the properties on the time since injection has shown that in the living body, the environment of the dye molecule changes as the photosensitizer goes from the skin into the tissue. We have established that in tissues in vivo, the dye molecules are localized in a region with low dielectric constant of the medium. We have shown that the change in the ratio of the concentrations of the different forms of hemoglobin in the blood has an effect on the absorption and shape of the fluorescence spectrum of the dye in tissues in vivo

First results of the Kourovka Planet Search: discovery of transiting exoplanet candidates in the first three target fields

We present the first results of our search for transiting exoplanet candidates as part of the Kourovka Planet Search (KPS) project. The primary objective of the project is to search for new hot Jupiters which transit their host stars, mainly in the Galactic plane, in the $R_c$ magnitude range of 11 to 14 mag. Our observations were performed with the telescope of the MASTER robotic network, installed at the Kourovka astronomical observatory of the Ural Federal University (Russia), and the Rowe-Ackermann Schmidt Astrograph, installed at the private Acton Sky Portal Observatory (USA). As test observations, we observed three celestial fields of size $2\times2$ deg$^2$ during the period from 2012 to 2015. As a result, we discovered four transiting exoplanet candidates among the 39000 stars of the input catalogue. In this paper, we provide the description of the project and analyse additional photometric, spectral, and speckle interferometric observations of the discovered transiting exoplanet candidates. Three of the four transiting exoplanet candidates are most likely astrophysical false positives, while the nature of the fourth (most promising) candidate remains to be ascertained. Also, we propose an alternative observing strategy that could increase the project's exoplanet haul.Comment: 11 pages, 16 figures; Accepted for publication in Monthly Notices of the Royal Astronomical Society 201

Spin physics with antiprotons

New possibilities arising from the availability at GSI of antiproton beams, possibly polarised, are discussed. The investigation of the nucleon structure can be boosted by accessing in Drell-Yan processes experimental asymmetries related to cross-sections in which the parton distribution functions (PDF) only appear, without any contribution from fragmentation functions; such processes are not affected by the chiral suppression of the transversity function $h_1(x)$. Spin asymmetries in hyperon production and Single Spin Asymmetries are discussed as well, together with further items like electric and magnetic nucleonic form factors and open charm production. Counting rates estimations are provided for each physical case. The sketch of a possible experimental apparatus is proposed.Comment: Presented for the proceedings of ASI "Spin and Symmetry", Prague, July 5-10, 2004, to be published in Czech. J. Phys. 55 (2005

On the Number of Zeros of Abelian Integrals: A Constructive Solution of the Infinitesimal Hilbert Sixteenth Problem

We prove that the number of limit cycles generated by a small non-conservative perturbation of a Hamiltonian polynomial vector field on the plane, is bounded by a double exponential of the degree of the fields. This solves the long-standing tangential Hilbert 16th problem. The proof uses only the fact that Abelian integrals of a given degree are horizontal sections of a regular flat meromorphic connection (Gauss-Manin connection) with a quasiunipotent monodromy group.Comment: Final revisio

Interrelations between viral load and cellular immunity in patients with COVID-19 of varying severity

Assessment of viral load levels in various biological samples taken from the respiratory tract can be an indicator of an ongoing process of active viral replication and may be used to monitor severe respiratory viral infections. The study of the relationship between SARS-CoV-2 viral load and immunological laboratory parameters is an important step in the search for clinical markers of COVID-19.The aim of this research was to quantify viral load in patients with COVID-19 and to identify the relation-ship between viral load and changes in the parameters of the cellular component of the immune system.A laboratory examination was carried out on 74 patients diagnosed with COVID-19, they were divided into 3 groups based on the severity of the disease: mild, moderate, severe. Total viral load in clinical samples was determined by the number of SARS-CoV-2 RNA copies per 100 copies of the reference RNaseP gene.     A comprehensive assessment of the cellular component of the immune system was performed using flow cytometry and direct monoclonal antibodies, and the IL-6, and C-reactive protein concentrations were determined.We revealed a relationship between the development of serious clinical conditions in the patients with COVID-19, and the levels of viral load. High levels of viral RNA in biological samples correlate with main indicators of the T cell component of the immune system associated with disease severity. In a subgroup of patients with an extremely high viral load, strong positive correlations were found between the relative numbers of cytotoxic lymphocytes (CD3+CD8+), activated T lymphocytes (CD3+HLA-DR+), as well as absolute and relative numbers of activated B lymphocytes and NK cells (CD3-CD25+).Laboratory monitoring of the cellular component of the immune system, along with the assessment of viral loads, should improve  early assessment of clinical condition in the patients with COVID-19. Changes   in expression levels of activation markers on immune cells can be potentially viewed as indicators of recovery during COVID-19

Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution)

Aim: to review the modern approaches to the diagnosis and treatment of C. difficile-associated disease in adults and present the resolution of the Expert Council held on March 25, 2023 in Moscow.General provisions. C. difficile is the most important nosocomial pathogen which spores are also commonly found in the environment. Microbiota impairment, primarily due to the use of antibacterial drugs, is a key stage in the development of C. difficile-associated disease. A search for an infection should be carried out only in patients with diarrhea, and it is advisable to use at least 2 laboratory methods. The drug of choice for first-line treatment is vancomycin. If drug treatment is ineffective or the patient has recurrent clostridial infection, fecal microbiota transplantation should be considered. The probiotic strain Saccharomyces boulardii CNCM I-745 has a direct inhibitory effect on C. difficile toxin A, promotes normalization of the intestinal microbiota composition, and decreases the inflammatory reaction in colonic mucosa colonized with a toxigenic strain of C. difficile.Conclusions. Addition of the probiotic strain Saccharomyces boulardii CNCM I-745 to antibacterial therapy promotes both primary and secondary prevention of C. difficile-associated disease

Эпидемиологические и фармакоэкономические аспекты ВИЧ-инфекции у военнослужащих

The goals of the research are to determine the latent morbidity and financial losses of the Russian Ministry of Defense due to the dismissal of service members with HIV infection at symptomatic stages; to establish the supposed clinical and pharmacoeconomic effectiveness of the early detection and treatment of service members.The materials compile 379 case histories of patients of the only specialized department for HIV-positive military personnel in the Armed Forces for 2017–2019, as well as various reporting forms. The study uses the following methods for the analysis: Markov chains are employed to calculate QALYs (Quality Adjusted Life Years), “cost-effectiveness”, and “willingness to pay”. The research compares two competitive models: “Current Situation” - without the introduction of algorithms for early detection and treatment of HIV infection, and “Prognosis” - with the introduction of these algorithms.The following results are obtained: implementing a mandatory triennial screening for HIV-antibodies among military personnel allows to raise the detection of HIV-positive military personnel in the early stages of the disease by 55%. At the same time, early administered antiretroviral therapy prevents the progression of HIV infection, while the number of military personnel who have reached symptomatic stages of HIV infection and the number of deaths decreases by 35,6% and 80,2% (six-fold), respectively. The economic effectiveness of these measures includes a reduced cost of treatment and an increased length of military service. The sensitivity analysis of the method shows that the proposed measures remain pharmacoeconomically highly effective with a wide variability of the initial data.Conclusion. The results of the study demonstrate that a significant improvement of the epidemiological situation in the field of HIV infection in the Armed Forces is achievable at very low economic costs. With the full implementation of the proposed measures, the cohort of military personnel of the Armed Forces is able to achieve the World Health Organization’s “90-90-90”criteria of in 3–5 years.Цель: определение скрытой заболеваемости и финансовых потерь Минобороны России вследствие увольнения военнослужащих с ВИЧ-инфекцией в стадии вторичных заболеваний, а также установление предполагаемой клинической и фармакоэкономической эффективности мероприятий по раннему выявлению и лечению военнослужащих.Материалы составили 379 историй болезни пациентов единственного в Вооруженных силах специализированного отделения для ВИЧ-позитивных военнослужащих за 2017–2019 гг., а также различные формы отчетности. Для анализа использованы следующие методы: Марковское моделирование процесса позволило определить QALY (Quality Adjusted Life Years – годы жизни с поправкой на качество) и провести фармакоэкономический анализ «Затраты – эффективность» и «Порог готовности платить». Сравнивались две конкурентные модели, названные «Актуальная ситуация» – без введения алгоритмов раннего выявления и лечения ВИЧ-инфекции и «Прогноз» – при введении указанных алгоритмов.Результаты: введение обязательного периодического лабораторного обследования 1 раз в 3 года для военнослужащих по контракту позволит увеличить на 55% выявление ВИЧ-позитивных военнослужащих на ранних стадиях заболевания. При этом раннее назначение антиретровирусной терапии позволит предупредить прогрессирование ВИЧ-инфекции, число военнослужащих, достигших стадии 4 ВИЧ-инфекции, снизится на 35,6%, а число летальных исходов – на 80,2% (в 6 раз), что обеспечит существенную экономическую эффективность за счет снижения стоимости лечения и увеличения длительности военной службы. Анализ чувствительности метода показал, что предложенные мероприятия остаются фармакоэкономически высокоэффективными при широкой вариативности исходных данных.Заключение. По результатам проведенного исследования показано, что существенное улучшение эпидемиологической обстановки в области ВИЧ-инфекции в Вооруженных силах достижимо при очень малых экономических затратах. При полноценной реализации предложенных мероприятий когорта военнослужащих Вооруженных сил Российской Федерации способна достичь критериев Всемирной организации здравоохранения «90-90-90» уже через 3–5 лет

The COMPASS Experiment at CERN

The COMPASS experiment makes use of the CERN SPS high-intensitymuon and hadron beams for the investigation of the nucleon spin structure and the spectroscopy of hadrons. One or more outgoing particles are detected in coincidence with the incoming muon or hadron. A large polarized target inside a superconducting solenoid is used for the measurements with the muon beam. Outgoing particles are detected by a two-stage, large angle and large momentum range spectrometer. The setup is built using several types of tracking detectors, according to the expected incident rate, required space resolution and the solid angle to be covered. Particle identification is achieved using a RICH counter and both hadron and electromagnetic calorimeters. The setup has been successfully operated from 2002 onwards using a muon beam. Data with a hadron beam were also collected in 2004. This article describes the main features and performances of the spectrometer in 2004; a short summary of the 2006 upgrade is also given.Comment: 84 papes, 74 figure