Model order reduction of large scale ODE systems : MOR for ANSYS versus ROM workbench

In this paper we compare the numerical results obtained by different model order reduction software tools, in order to test their scalability for relevant problems of the microelectronic-industry. MOR for ANSYS [2J is implemented in C++ and ROM Workbench [3J is a MATLAB code. The chosen benchmarks are large scale linear ODE systems, which arise from the finite element discretisation of electro-thermal MEMS models

Особенности митохондриальной патологии у человека

Статья посвящена анализу современного уровня знаний о механизмах возникновения и особенностях митохондриальной патологии, обусловливающих сложности ее диагностики и терапии.Стаття присвячена аналізу сучасного рівня знань про механізми виникнення та особливості виникнення мітохондріальної патології, що обумовлюють складність її діагностики та терапії.This article is concerned with the analysis of the present findings about the mechanisms of emergency and features of mitochondrial abnormality which lead to the difficulties in its diagnostics and therapy

What future research should bring to help resolving the debate about the efficacy of EEG-neurofeedback in children with ADHD

In recent years a rising amount of randomized controlled trials, reviews, and meta-analyses relating to the efficacy of electroencephalographic-neurofeedback (EEG-NF) in children with attention-deficit/hyperactivity disorder (ADHD) have been published. Although clinical reports and open treatment studies suggest EEG-NF to be effective, double blind placebo-controlled studies as well as a rigorous meta-analysis failed to find support for the efficacy of EEG-NF. Since absence of evidence does not equate with evidence of absence, we will outline how future research might overcome the present methodological limitations. To provide conclusive evidence for the presence or absence of the efficacy of EEG-NF in the treatment of ADHD, there is a need to set up a well-designed study that ensures optimal implementation and embedding of the training, and possibly incorporates different forms of neurofeedback

Approximating the influence coefficients of non-planar elastic solids for conformal contact analysis

The exact contact theory is an efficient alternative to the more general yet computationally expensive Finite Element Method for the detailed study of elastostatic contact problems. For its application in conformal contact problems, the exact contact theory needs to be fed with influence coefficients (ICs) appropriate for non-planar solids. An analytical approximation of the ICs for non-planar solids was proposed in a previous work, avoiding the involved process generally necessary to obtain ICs accurately. This work presents further developments of this approximation, further comparison with numerically obtained ICs, and evaluates the errors incurred when using approximated ICs in conformal contact.This work has been partly financed within the European Horizon 2020 Joint Technology Initiative Shift2Rail, through contract no. 826255 (IN2TRACK2). The authors wish to thank as well the Spanish Research Ministry MICINN/Economy and Competitiveness Ministry MINECO and MCI/AEI for their funding through contracts TRA2014-59599-R and PID2019-109483RB-I00, including funding by the FEDER-ERDF European Regional Development Fund, and also the Basque Government for financial assistance through IT919-1

Recovery from multi‐millennial natural coastal hypoxia in the Stockholm Archipelago, Baltic Sea, terminated by modern human activity

Enhanced nutrient input and warming have led to the development of low oxygen (hypoxia) in coastal waters globally. For many coastal areas, insight into redox conditions prior to human impact is lacking. Here, we reconstructed bottom water redox conditions and sea surface temperatures (SSTs) for the coastal Stockholm Archipelago over the past 3000 yr. Elevated sedimentary concentrations of molybdenum indicate (seasonal) hypoxia between 1000b.c.e.and 1500c.e. Biomarker-based (TEX86) SST reconstructions indicate that the recovery from hypoxia after 1500c.e.coincided with a period of significant cooling (similar to 2 degrees C), while human activity in the study area, deduced from trends in sedimentary lead and existing paleobotanical and archeological records, had significantly increased. A strong increase in sedimentary lead and zinc, related to more intense human activity in the 18(th)and 19(th)century, and the onset of modern warming precede the return of hypoxia in the Stockholm Archipelago. We conclude that climatic cooling played an important role in the recovery from natural hypoxia after 1500c.e., but that eutrophication and warming, related to modern human activity, led to the return of hypoxia in the 20(th)century. Our findings imply that ongoing global warming may exacerbate hypoxia in the coastal zone of the Baltic Sea