396 research outputs found
Aprendizaje y educación afectivo-sexual: una revisión de los planteamientos iniciales del aprendizaje de las cuestiones sexuales
[Resumen] La importancia de analizar cómo se produce
el aprendizaje sexual así como las fuentes
más utilizadas para el mismo, resulta de
gran interés para progresar en el desarrollo de
la educación afectivo - sexual y para que las
instituciones educativas participen y se responsabilicen
en el desarrollo de un currículum
comprensivo de la misma.
En este trabajo realizamos unas revisión
acerca de cómo se ha desarrollado, en los
inicios de la educación sexual, el aprendizaje
de contenidos vinculados a la sexualidad,
las fuentes de información más usadas en el
ámbito de la sexualidad, así como las técnicas
de trabajo que han favorecido la implantación
de la educación afectivo sexual en las
escuelas
Porosity-based models for estimating the mechanical properties of self-compacting concrete with coarse and fine recycled concrete aggregate
Predicting the mechanical properties of Self-Compacting Concrete (SCC) containing Recycled Concrete Aggregate (RCA) generally depends, in great part, on the RCA fraction in use. In this study, predictive equations for estimating SCC mechanical properties are developed through SCC porosity indices, so they are applicable to any RCA fraction and amount that may be used. A total of ten SCC mixes were prepared, nine of which containing different proportions of coarse and/or fine RCA (0%, 50% or 100% for both fractions), and the tenth mixed with 100% coarse and fine RCA, and RCA powder 0–1 mm. The following properties were evaluated: compressive strength, modulus of elasticity, splitting tensile strength, flexural strength, and effective porosity as measured with the capillary-water-absorption test. Negative effects on the above properties were recorded for increasing contents of both RCA fractions. The application of simple regression models yielded porosity-based estimations of the mechanical properties of the SCC with an accuracy margin of ±20%, regardless of the RCA fraction and amount. The results of the multiple regression models with compressive strength as a secondary predictive variable presented even greater robustness with accuracy margins of ±10% and almost no significant effect of accidental porosity variations on prediction accuracy. Furthermore, porosity predictions using the 24-h effective water also yielded accurate estimations of all the above mechanical properties. Finally, comparisons with the results of other studies validated the reliability of the models and their accuracy, especially the minimum expected values at a 95% confidence level, at all times lower than the experimental results.Spanish Ministry of Universities within the framework of the State Program for the Promotion of Talent and its Employability in R + D + i, State Mobility Subprogram, of the State Plan for Scientific and Technical Research and Innovation 2017–2020 [PRX21/00007]; the Spanish Ministry MCI, AEI, EU and ERDF [grant numbers PID2020-113837RB-I00; 10.13039/501100011033; FPU17/03374]; the Junta de Castilla y León (Regional Government) and ERDF [grant numbers UIC-231; BU119P17]; Youth Employment Initiative (JCyL) and ESF [grant number UBU05B_1274]; and finally, the University of Burgos [grant numbers SUCONS, Y135.GI] and the University of Padova
Helminth parasites in fishes from Valdivia and Tornagaleones river estuaries in the south of Chile
Compuestos neurogénicos basados en melatonina y su uso en el tratamiento de enfermedades del sistema nervioso
La presente invención, que se incluye en el campo de
la investigación e industria farmacéutica, se refiere a
nuevas entidades químicas derivadas de melatonina
con propiedades neurogénicas, moduladoras de los
receptores de melatonina y/o serotonina,
antioxidantes y/o colinérgicas. También se refiere a
los procedimientos para la preparación de estos
nuevos compuestos, a las composiciones
farmacéuticas que los contienen y a su uso para la
fabricación de un medicamento para el tratamiento de
enfermedades del sistema nervioso relacionadas con
degeneración neuronal, depresión, trastornos
psiquiátricos y cognitivos, trauma o lesión celular, u
otro trastorno neurológico relacionado, tratamiento de
fatiga diurna, trastornos del sueño, pérdida de eficacia
mental, debilidad e irritabilidad y síntomas
relacionados con la descompensación horaria (efecto
jet-lag o síndrome transoceánico).Peer reviewedConsejo Superior de Investigaciones Científicas, Universidad Autónoma de MadridB1 Patente sin examen previ
Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea,
behavioral disturbances and dementia, caused by a pathological expansion of the CAG
trinucleotide in the HTT gene. Several patients have been recognized with the typical HD
phenotype without the expected mutation. The objective of this study was to assess the
occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia
(SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis
(ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group
analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not
reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in
the group analyzed, and is attributable to the African ancestry of this population. However,
the etiology of the disease remains undetermined in the majority of the HD negative
patients with HD-like phenotype.
Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis,
Huntington’s disease-like 2
Automatic linguistic reporting of customer activity patterns in open malls
In this work, we present a complete system to produce an automatic linguistic reporting about the customer activity patterns inside open malls, a mixed distribution of classical malls joined with the shops on the street. These reports can assist to design marketing campaigns by means of identifying the best places to catch the attention of customers. Activity patterns are estimated with process mining techniques and the key information of localization. Localization is obtained with a parallelized solution based on WiFi fingerprint system to speed up the solution. In agreement with the best practices for human evaluation of natural language generation systems, the linguistic quality of the generated report was evaluated by 41 experts who filled in an online questionnaire. Results are encouraging, since the average global score of the linguistic quality dimension is 6.17 (0.76 of standard deviation) in a 7-point Likert scale. This expresses a high degree of satisfaction of the generated reports and validates the adequacy of automatic natural language textual reports as a complementary tool to process model visualization. © 2021, The Author(s)
Job Creation and Trade in Manufactures: Industry-Level Analysis Across Countries
This paper examines industry-level responses of manufacturing employment in the context of globalization using a large sample of developed, developing, and transition economies. We find that developing countries need atypically high rates of value-added growth (about 10 %) to increase manufacturing employment appreciably (about 4 %). The employment benefits of export orientation are also modest even in “comparative advantage” industries of developing countries. However, diversifying the export basket contributes significantly to employment growth, particularly in the medium- and high-technology industries. Import competition does not undermine employment growth in low-technology industries of developing countries while it displaces jobs in the same industries in Organisation for Economic Co-operation and Development (OECD) and transition economies. For developing countries, import-induced job losses are higher in the more capital-intensive medium-technology industries. Jobs in high-technology industries are less sensitive to imports with positive relationships observed in the OECD. Investment also complements job creation in low-technology industries of developing countries that have yet to industrialize
X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation
Contiene 3 ficheros adicionales con información suplementaria.-- et al.[Background] Aproximately 5–10% of cases of mental retardation in males are due to copy number variations (CNV) on the X chromosome. Novel technologies, such as array comparative genomic hybridization (aCGH), may help to uncover cryptic rearrangements in X-linked mental retardation (XLMR) patients. We have constructed an X-chromosome tiling path array using bacterial artificial chromosomes (BACs) and validated it using samples with cytogenetically defined copy number changes. We have studied 54 patients with idiopathic mental retardation and 20 controls subjects.[Results] Known genomic aberrations were reliably detected on the array and eight novel submicroscopic imbalances, likely causative for the mental retardation (MR) phenotype, were detected. Putatively pathogenic rearrangements included three deletions and five duplications (ranging between 82 kb to one Mb), all but two affecting genes previously known to be responsible for XLMR. Additionally, we describe different CNV regions with significant different frequencies in XLMR and control subjects (44% vs. 20%).[Conclusion] This tiling path array of the human X chromosome has proven successful for the detection and characterization of known rearrangements and novel CNVs in XLMR patients.The authors thank the "Genoma España" and Genome Canada joint R+D+I projects in human health, plants and aquiculture; the former "Departament d'Universitats i Societat de la Informació" (DURSI) and the "Departament de Salut", from the Catalan Autonomous Government (2005SGR00008 - Generalitat de Catalunya); the Instituto de Salud Carlos III (PI041126, CIBER-ESP), the EU's Sixth Framework Programme [FP6-2005-LIFESCIHEALTH-7; ANEUPLOIDY No. 037627] and Fundación Areces (U-2006-FARECES-O).Peer reviewe
Can ecosystem-based deep-sea fishing be sustained?
Can there ever be a truly sustainable deep-sea fishery and if
so, where and under what conditions? Ecosystembased
fisheries management requires that this question be
addressed such that habitat, bycatch species, and targeted
fish populations are considered together within an ecosystem
context.
To this end, we convened the first workshop to develop an
ecosystem approach to deep-sea fisheries and to ask whether
deep-sea species could be fished sustainably. The workshop
participants were able to integrate bycatch information into
their framework but found it more difficult to integrate other
ecosystem indicators such as habitat characteristics.
(First two paragraphs from the Executive Summary
Clinical implication of FMR1 intermediate alleles in a Spanish population
FMR1 premutation carriers (55-200 CGGs) are at risk of developing Fragile X-associated primary ovarian insufficiency as well as Fragile X-associated tremor/ataxia syndrome. FMR1 premutation alleles are also associated with a variety of disorders, including psychiatric, developmental, and neurological problems. However, there is a major concern regarding clinical implications of smaller CGG expansions known as intermediate alleles (IA) or gray zone alleles (45-54 CGG). Although several studies have hypothesized that IA may be involved in the etiology of FMR1 premutation associated phenotypes, this association still remains unclear. The aim of this study was to provide new data on the clinical implications of IA. We reviewed a total of 17 011 individuals: 1142 with primary ovarian insufficiency, 478 with movement disorders, 14 006 with neurodevelopmental disorders and 1385 controls. Similar IA frequencies were detected in all the cases and controls (cases 1.20% vs controls 1.39%, P =.427). When comparing the allelic frequencies of IA = 50CGGs, a greater, albeit not statistically significant, number of alleles were detected in all the cohorts of patients. Therefore, IA below 50 CGGs should not be considered as risk factors for FMR1 premutation-associated phenotypes, at least in our population. However, the clinical implication of IA = 50CGGs remains to be further elucidated
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