53 research outputs found
Caso epidermólisis ampollosa en lactante
La epidermolisis ampollosa es un grupo heterogéneo de enfermedades hereditarias de la piel, en la que aparece de forma de flictenas de forma espontánea o por traumatismos mínimos. Esto se debe a una mutación genética que provoca una alteración de las proteínas estructurales que mantienen la unión dermoepidérmica, formando una ampolla subepidérmica, que facilita la aparición de cicatrices y retracciones de la piel. Las características principales de esta enfermedad son, erupción de flictenas de contenido serohemorrágico, pudiendo afectar a mucosas, piel y uñas, presencia de sindactilias, piel seca, manosen garra con formación de muñones, enfermedades dentales. Otras complicaciones más graves son la sineniquia conjuntival, ronquera, estenosisesofágica, neumonía.La epidermolisis ampollosa afecta a ambos sexos por igual y a todas las razas, la frecuencia oscila entre 1 de cada 50.000 nacidos y la edad de aparición es en el nacimiento o la lactancia.Enfermerí
Search for coherent charged pion production in neutrino-carbon interactions
We report the result from a search for charged-current coherent pion
production induced by muon neutrinos with a mean energy of 1.3 GeV. The data
are collected with a fully active scintillator detector in the K2K
long-baseline neutrino oscillation experiment. No evidence for coherent pion
production is observed and an upper limit of is set on
the cross section ratio of coherent pion production to the total
charged-current interaction at 90% confidence level. This is the first
experimental limit for coherent charged pion production in the energy region of
a few GeV.Comment: 5 pages, 4 figure
Evidence for muon neutrino oscillation in an accelerator-based experiment
We present results for muon neutrino oscillation in the KEK to Kamioka (K2K)
long-baseline neutrino oscillation experiment. K2K uses an accelerator-produced
muon neutrino beam with a mean energy of 1.3 GeV directed at the
Super-Kamiokande detector. We observed the energy dependent disappearance of
muon neutrino, which we presume have oscillated to tau neutrino. The
probability that we would observe these results if there is no neutrino
oscillation is 0.0050% (4.0 sigma).Comment: 5 pages, 4 figure
Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study
Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases,
biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these
patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk,
disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA).
Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients
were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after
the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I
(P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (b-CTX) were analysed at all points in the study. Data on
disease progression, SREs development and survival were recorded.
Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were
predictive of survival time, with b-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the
beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also
predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship
between bone markers and disease progression.
Conclusion: In patients with PCa and bone metastases treated with ZA, b-CTX and P1NP can be considered suitable predictors for
mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of
treatment are especially importantThis study was supported by Novartis Oncology Spai
R-Allyl Nickel(II) Complexes with Chelating N-Heterocyclic Carbenes: Synthesis, Structural Characterization, and Catalytic Activity
The N-heterocyclic carbene (NHC) nickel complexes [(L)Ni(NHC)][BArF4] (ArF = 3,5-bis(trifluoromethyl)-
phenyl; L = allyl (1), methylallyl (2); NHC = 1-(2-picolyl)-3-methylimidazol-2-ylidene (a), 1-(2-picolyl)-3-isopropylimidazol-2-ylidene (b), 1-(2-picolyl)-3-n-butylimidazol-2-ylidene (c), 1-(2-picolyl)-3-phenylimidazol-2-ylidene (d), 1-(2-picolyl)-3- methylbenzoimidazol-2-ylidene (e), 1-(2-picolyl)-4,5-dichloro-3-methylimidazol-2-ylidene (f)) have been obtained in high yields and characterized by NMR spectroscopy. Furthermore, 1d was unambiguously characterized by single-crystal X-ray crystallography. Complexes 1a−f/2a−f have shown catalytic activity toward dimerization and hydrosilylation of styrenes. In particular, 1a proved to be the most efficient catalyst in the dimerization of styrene derivatives in the absence of cocatalyst. Also, complexes 1a,d showed high selectivity and moderate to good yields in hydrosilylation reactions
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