The prevalence and nature of unrequited love

Unrequited love (UL) is unreciprocated love that causes yearning for more complete love. Five types of UL are delineated and conceptualized on a continuum from lower to greater levels of interdependence: crush on someone unavailable, crush on someone nearby, pursuing a love object, longing for a past lover, and an unequal love relationship. Study 1a found all types of UL relationships to be less emotionally intense than equal love and 4 times more frequent than equal love during a 2-year period. Study 1b found little evidence for limerent qualities of UL. Study 2 found all types of UL to be less intense than equal love on passion, sacrifice, dependency, commitment, and practical love, but more intense than equal love on turmoil. These results suggest that UL is not a good simulation of true romantic love, but an inferior approximation of that ideal

Scale-free networks as preasymptotic regimes of superlinear preferential attachment

We study the following paradox associated with networks growing according to superlinear preferential attachment: superlinear preference cannot produce scale-free networks in the thermodynamic limit, but there are superlinearly growing network models that perfectly match the structure of some real scale-free networks, such as the Internet. We obtain an analytic solution, supported by extensive simulations, for the degree distribution in superlinearly growing networks with arbitrary average degree, and confirm that in the true thermodynamic limit these networks are indeed degenerate, i.e., almost all nodes have low degrees. We then show that superlinear growth has vast preasymptotic regimes whose depths depend both on the average degree in the network and on how superlinear the preference kernel is. We demonstrate that a superlinearly growing network model can reproduce, in its preasymptotic regime, the structure of a real network, if the model captures some sufficiently strong structural constraints -- rich-club connectivity, for example. These findings suggest that real scale-free networks of finite size may exist in preasymptotic regimes of network evolution processes that lead to degenerate network formations in the thermodynamic limit

Seismic Test of Solar Models, Solar Neutrinos and Implications for Metal-Rich Accretion

The Sun is believed to have been the recipient of a substantial amount of metal-rich material over the course of its evolution, particularly in the early stages of the Solar System. With a long diffusion timescale, the majority of this accreted matter should still exist in the solar convection zone, enhancing its observed surface abundance, and implying a lower-abundance core. While helioseismology rules out solar models with near-zero metallicity cores, some solar models with enhanced metallicity in the convection zone might be viable, as small perturbations to the standard model. Because of the reduced interior opacity and core temperature, the neutrino flux predicted for such models is lower than that predicted by the standard solar model. This paper examines how compatible inhomogeneous solar models of this kind are with the observed low and intermediate degree p-mode oscillation data, and with the solar neutrino data from the SNO Collaboration. We set an upper limit on how much metal-rich accretion took place during the early evolution of the Sun at about 2 Earth masses of iron (or about 40 Earth masses of meteoric material).Comment: Revision: 23 pages, 8 figures, 3 tables, to be published in ApJ, Sept 2002. Used newer neutrino cross sections, modified text accordingly, other minor revisions as wel

Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson\u27s Disease Off Episodes

Parkinson\u27s Disease (PD) is a common neurodegenerative disorder and the leading cause of disability. It causes significant morbidity and disability through a plethora of symptoms, including movement disorders, sleep disturbances, and cognitive and psychiatric symptoms. The traditional pathogenesis theory of PD involves the loss of dopaminergic neurons in the substantia nigra (SN). Classically, treatment is pursued with an assortment of medications that are directed at overcoming this deficiency with levodopa being central to most treatment plans. Patients taking levodopa tend to experience off episodes with decreasing medication levels, causing large fluctuations in their symptoms. These off episodes are disturbing and a source of morbidity for these patients. Opicapone is a novel, peripherally acting Catechol-O-methyl transferase (COMT) inhibitor that is used as adjunctive therapy to carbidopa/levodopa for treatment and prevention of off episodes. It has been approved for use as an adjunct to levodopa since 2016 in Europe and has recently (April 2020) gained FDA approval for use in the USA. By inhibiting COMT, opicapone slows levodopa metabolism and increases its availability. Several clinical studies demonstrated significant improvement in treatment efficacy and reduction in duration of off episodes. The main side effect demonstrated was dyskinesia, mostly with the 100mg dose, which is higher than the approved, effective dose of 50mg. Post-marketing surveillance and analysis are required to further elucidate its safety profile and contribute to patient selection. This paper reviews the seminal and latest evidence in the treatment of PD off episodes with the novel drug Opicapone, including efficacy, safety, and clinical indications

The Pierre Auger Observatory III: Other Astrophysical Observations

Astrophysical observations of ultra-high-energy cosmic rays with the Pierre Auger ObservatoryComment: Contributions to the 32nd International Cosmic Ray Conference, Beijing, China, August 201

Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV

We describe the measurement of the depth of maximum, Xmax, of the longitudinal development of air showers induced by cosmic rays. Almost four thousand events above 10^18 eV observed by the fluorescence detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selected for the analysis. The average shower maximum was found to evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/- 0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The interpretation of these results in terms of the cosmic ray mass composition is briefly discussed.Comment: Accepted for publication by PR

Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200

Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory

The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies $E>E_{th}=5.5\times 10^{19}$ eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at $E>E_{th}$ are heavy nuclei with charge $Z$, the proton component of the sources should lead to excesses in the same regions at energies $E/Z$. We here report the lack of anisotropies in these directions at energies above $E_{th}/Z$ (for illustrative values of $Z=6,\ 13,\ 26$). If the anisotropies above $E_{th}$ are due to nuclei with charge $Z$, and under reasonable assumptions about the acceleration process, these observations imply stringent constraints on the allowed proton fraction at the lower energies