Analysis of solutions dedicated to non-conformity prevention

Research financed from the NCN research project no. UMO-2012/05 / B / HS4 / 04139.Purpose: The purpose of the work is to analyze the use of solutions aimed at preventing incompatibilities and assess the effectiveness of these solutions to minimize the risk associated with the quality of manufactured products. The analysis presented in the work is based on the Poka-Yoke error prevention concept used in the selected enterprise. The paper presents the state of the company before and after the introduction of Poka-Yoke method. Approach/Methodology/Design: The research methods used in the paper were the analysis of company data, analysis of literature states, as well as methods using the Poka-Yoke concept. The company was surveyed in 2017/2018 during the system implementation. Findings: The results on the control card for nonconforming units of type "p" were also presented, where the analysis showed that the introduction of the Poka-Yoke system to the company reduced the number of nonconformities by 6.69%. Practical Implications: Implementation of the Poka-Yoke system will allow enterprises to create conditions in which an error cannot happen, or will be immediately visible. The result of such an action may be distracting operators from repetitive operations, reducing the number of deficiencies and induce immediate action when a problem occurs. Originality/Value: Showing how the use of the Poka-Yoke system affects the prevention of inadvertent error in enterprises, by determining the differences between the state of the enterprise before and after the introduction of the Poka-Yoke system, there is an opportunity to improve the economy and contribute to the social and economic sphere.peer-reviewe

Abiotic formation of O2 and O3 in high-CO2 terrestrial atmospheres

Previous research has indicated that high amounts of ozone (O3) and oxygen (O2) may be produced abiotically in atmospheres with high concentrations of CO2. The abiotic production of these two gases, which are also characteristic of photosynthetic life processes, could pose a potential "false-positive" for remote-sensing detection of life on planets around other stars.We show here that such false positives are unlikely on any planet that possesses abundant liquid water, as rainout of oxidized species onto a reduced planetary surface should ensure that atmospheric H2 concentrations remain relatively high, and that O2 and O3 remain low. Our aim is to determine the amount of O3 and O2 formed in a high CO2 atmosphere for a habitable planet without life. We use a photochemical model that considers hydrogen (H2) escape and a detailed hydrogen balance to calculate the O2 and O3 formed on planets with 0.2 of CO2 around the Sun, and 0.02, 0.2 and 2 bars of CO2 around a young Sun-like star with higher UV radiation. The concentrations obtained by the photochemical model were used as input in a radiative transfer model that calculated the spectra of the modeled planets. The O3 and O2 concentrations in the simulated planets are extremely small, and unlikely to produce a detectable signature in the spectra of those planets. We conclude that with a balanced hydrogen budget, and for planets with an active hydrological cycle, abiotic formation of O2 and O3 is unlikely to create a possible false positive for life detection in either the visible/near-infrared or mid-infrared wavelength regimes.Comment: 27 pages, 15 figures, Astronomy & Astrophysics accepte

Normal aging and Parkinson's disease are associated with the functional decline of distinct frontal-striatal circuits.

Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well-established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit remain unclear. In this study, an fMRI-optimised variant of a classic paradigm for assessing attentional control (Hampshire and Owen 2006) was used to contrast activity in dissociable executive circuits in early-stage PD patients and controls. The results demonstrated that the neural basis of the executive performance impairments in PD is accompanied by hypoactivation within the striatum, anterior cingulate cortex (vACC), and inferior frontal sulcus (IFS) regions. By contrast, in aging it is associated with hypoactivation of the anterior insula/inferior frontal operculum (AI/FO) and the pre-supplementary motor area (preSMA). Between group behavioural differences were also observed; whereas normally aging individuals exhibited routine-problem solving deficits, PD patients demonstrated more global task learning deficits. These findings concur with recent research demonstrating model-based reinforcement learning deficits in PD and provide evidence that the AI/FO and IFS circuits are differentially impacted by PD and normal aging

Analysis of the Thermal and Magnetic Properties of Amorphous Fe 61Co10Zr2.5Hf2.5Me2W2B20 (Where Me = Mo, Nb, Ni Or Y) Ribbons

The paper presents the results of structural and magnetic properties and thermal stability for a group of functional materials based on Fe61Co10Zr2.5Hf2.5Me2W2B20 (where Me = Mo, Nb, Ni or Y). Samples were obtained in the form of ribbons using melt-spinning method. The X-ray diffraction patterns of investigated samples confirmed their amorphous structure. Based on the analysis of DSC curves characteristic temperatures: glass forming temperature (Tg), crystallization temperature (Tx) and temperature range of the supercooled liquid ΔTx were determined. Small addition of transition metals elements has strong influence on magnetic and thermal parameters of studied materials. The comprehensive studies revealed that in terms of magnetic properties the Ni-addition resulted in highest reduction in coercivity and anisotropy field

AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells

The AML1/ETO fusion protein found in acute myeloid leukemias functions as a transcriptional regulator by recruiting co-repressor complexes to its DNA binding site. In order to extend the understanding of its role in preleukemia, we expressed AML1/ETO in a murine immortalized pluripotent hematopoietic stem/progenitor cell line, EML C1, and found that genes involved in functions such as cell-to-cell adhesion and cell motility were among the most significantly regulated as determined by RNA sequencing. In functional assays, AML1/ETO-expressing cells showed a decrease in adhesion to stromal cells, an increase of cell migration rate in vitro, and displayed an impairment in homing and engraftment in vivo upon transplantation into recipient mice. Our results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression