Taller de Diseño Industrial: Cátedra A : Profesor titular: Ricardo Cortes, Adjunto: Martin Favre

La cátedra concibe al Taller como el ámbito de construcción de saberes conceptuales y materiales para el aprendizaje de la práctica proyectual de objetos de uso. Nuestra propuesta es un taller con un enfoque integral, holístico y que segmente ejercitaciones sobre objetivos programados para cada uno de los años lectivos: el desarrollo del proceso de diseño en el segundo año, la fundamentación del hacer en el tercer año, la síntesis tecnomorfológica en el cuarto año y, por último, la gestión profesional en el medio productivo y social en el quinto. El objetivo es que elaboren conclusiones junto con profesionales de diversas disciplinas y que expongan sus soluciones.Facultad de Bellas Arte

Taller de Diseño Industrial: Cátedra A : Profesor titular: Ricardo Cortes, Adjunto: Martin Favre

La cátedra concibe al Taller como el ámbito de construcción de saberes conceptuales y materiales para el aprendizaje de la práctica proyectual de objetos de uso. Nuestra propuesta es un taller con un enfoque integral, holístico y que segmente ejercitaciones sobre objetivos programados para cada uno de los años lectivos: el desarrollo del proceso de diseño en el segundo año, la fundamentación del hacer en el tercer año, la síntesis tecnomorfológica en el cuarto año y, por último, la gestión profesional en el medio productivo y social en el quinto. El objetivo es que elaboren conclusiones junto con profesionales de diversas disciplinas y que expongan sus soluciones.Facultad de Bellas Arte

Taller de Diseño Industrial: Cátedra A : Profesor titular: Ricardo Cortes, Adjunto: Martin Favre

La cátedra concibe al Taller como el ámbito de construcción de saberes conceptuales y materiales para el aprendizaje de la práctica proyectual de objetos de uso. Nuestra propuesta es un taller con un enfoque integral, holístico y que segmente ejercitaciones sobre objetivos programados para cada uno de los años lectivos: el desarrollo del proceso de diseño en el segundo año, la fundamentación del hacer en el tercer año, la síntesis tecnomorfológica en el cuarto año y, por último, la gestión profesional en el medio productivo y social en el quinto. El objetivo es que elaboren conclusiones junto con profesionales de diversas disciplinas y que expongan sus soluciones.Facultad de Bellas Arte

Taller de Diseño Industrial V: cátedra A : Profesor titular: Ricardo Cortes. Adjunto: Martin Favre

Concebimos al taller como el eje troncal de Diseño Industrial, núcleo sintetizador y articulador de los conocimientos curriculares, sobre una base proyectual. Es en un encuadre metodológico creativo, en busca de respuestas innovadoras que motive a los estudiantes a valorar soluciones a las necesidades sociales. Es un enfoque integral, holístico. Segmenta ejercitaciones sobre objetivos programados e incorpora el desarrollo del proceso de diseño, la fundamentación del hacer, la síntesis tecnomorfológica y la gestión profesional en el medio productivo y social. Para el segundo trabajo práctico la cátedra propuso desarrollar dos temáticas diferentes que el alumno podía escoger libremente entre dos temas: el INTA y las maderas.Facultad de Bellas Arte

The earliest evidence for Upper Paleolithic occupation in the Armenian Highlands at Aghitu-3 Cave

With its well-preserved archaeological and environmental records, Aghitu-3 Cave permits us to examine the settlement patterns of the Upper Paleolithic (UP) people who inhabited the Armenian Highlands. We also test whether settlement of the region between ∼39–24,000 cal BP relates to environmental variability. The earliest evidence occurs in archaeological horizon (AH) VII from ∼39–36,000 cal BP during a mild, moist climatic phase. AH VI shows periodic occupation as warm, humid conditions prevailed from ∼36–32,000 cal BP. As the climate becomes cooler and drier at ∼32– 29,000 cal BP (AH V-IV), evidence for occupation is minimal. However, as cooling continues, the deposits of AH III demonstrate that people used the site more intensively from ∼29–24,000 cal BP, leaving behind numerous stone artifacts, faunal remains, and complex combustion features. Despite the climatic fluctuations seen across this 15,000-year sequence, lithic technology remains attuned to one pattern: unidirectional reduction of small cores geared towards the production of bladelets for tool manufacture. Subsistence patterns also remain stable, focused on medium-sized prey such as ovids and caprids, as well as equids. AH III demonstrates an expansion of social networks to the northwest and southwest, as the transport distance of obsidian used to make stone artifacts increases. We also observe the addition of bone tools, including an eyed needle, and shell beads brought from the east, suggesting that these people manufactured complex clothing and wore ornaments. Remains of micromammals, birds, charcoal, pollen, and tephra relate the story of environmental variability. We hypothesize that UP behavior was linked to shifts in demographic pressures and climatic changes. Thus, by combining archaeological and environmental data, we gain a clearer picture about the first UP inhabitants of the Armenian Highlands

Preliminary evaluation of breeding perspectives of Ukrainian sweet cherry cultivars: nutraceutical properties and self-incompatibility

Some traditional sweet cherry cultivars of Ukrainian origin may represent perspective material for Hungarian cherry breeding. A total of eight cultivars analysed represent great diversity in several phenotypic traits including fruit ripening time or fruit flesh colour. Considerable differences in the anthocyanin content may result in different antioxidant capacity of fruits. In the present study, we used ferric reducing antioxidant power (FRAP) and total phenolic content (TPC) assays to characterize fruits’ nutraceutical properties. These values were compared with the respective values measured for eight commercial cultivars grown in Hungary. The average of FRAP and TPC values was higher for the Ukrainian cherries compared with commercial cultivars suggesting they might be included in functional breeding programs. Since, cherry is a self-incompatible species, the determination of S-genotype is required for both breeding and successful cultivar association in commercial orchards. Complete or partial S-genotypes were determined for 5 and 3 cultivars, respectively

Preliminary evaluation of breeding perspectives of Ukrainian sweet cherry cultivars: nutraceutical properties and self-incompatibility

Some traditional sweet cherry cultivars of Ukrainian origin may represent perspective material for Hungarian cherry breeding.A total of eight cultivars analysed represent great diversity in several phenotypic traits including fruit ripening time or fruit flesh colour.Considerable differences in the anthocyanin content may result in different antioxidant capacity of fruits. In the present study, we used ferricreducing antioxidant power (FRAP) and total phenolic content (TPC) assays to characterize fruits’ nutraceutical properties. These values werecompared with the respective values measured for eight commercial cultivars grown in Hungary. The average of FRAP and TPC values washigher for the Ukrainian cherries compared with commercial cultivars suggesting they might be included in functional breeding programs.Since, cherry is a self-incompatible species, the determination of S-genotype is required for both breeding and successful cultivar associationin commercial orchards. Complete or partial S-genotypes were determined for 5 and 3 cultivars, respectively

Cementomimetics—constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides

This is the published version. Copyright 2012 Nature Publishing GroupCementum is the outer-, mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated, may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix, we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that, in turn, supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed, we afford new insights into the evolution of protein–mineral interactions. By exploiting small peptide domains of native proteins, our understanding of structure–function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally, the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events