4,561 research outputs found
Postsettlement growth of two estuarine crab species, Chasmagnathus granulata and Cyrtograpsus angulatus (Crustacea, Decapoda, Grapsidae): laboratory and field observations
The estuarine grapsid crabs Chasmagnathus granulata and Cyrtograpsus angulatus belong to the most typical and dominant inhabitants of brackish coastal lagoons in southeastern South America. In a combined laboratory and field investigation of juvenile growth, we measured the increase in body size in these species under controlled conditions as well as in field experiments (in Mar Chiquita lagoon, Argentina), seasonal changes in size frequency distribution of a natural population, and growth related changes in selected morphometric traits of male and female juveniles (relations between carapace width, carapace length, propodus height and length of the cheliped, and pleon width). At 24°C, Cy. angulatus grew faster than Ch. granulata; it reached the crab-9 instar (C9; 13 mm carapace width) after 92 days, while Ch. granulata required 107 days to reach the C8 instar (7.4 mm). At 12°C, growth ceased in both species. The pleon begins to show sexual differences in the C5 (Cy. angulatus) and C8 instar (Ch. granulata), respectively, while the chelae differentiate earlier in Ch. granulata than in Cy. angulatus (in C4 vs C6). In the field, growth was maximal in summer, and was generally faster than in laboratory cultures. However, there is great individual variability in size (about 25% even in the first crab instar) and in size increments at ecdysis, increasing throughout juvenile growth. Our data indicate that, in the field, small-scale and short-term variations in feeding conditions, temperature, and salinity account for an extremely high degree of variability in the absolute and relative rates of growth as well as in the time to sexual differentiation
Phosphorylation and dephosphorylation of tau protein during synthetic torpor
Tau protein is of primary importance for many physiological processes in neurons, where it affects the dynamics of the microtubule system. When hyperphosphorylated (PP-Tau), Tau monomers detach from microtubules and tend to aggregate firstly in oligomers, and then in neurofibrillary tangles, as it occurs in a group of neurodegenerative disorders named thauopathies. A hypothermia-related accumulation of PP-Tau, which is quickly reversed after the return to normothermia, has been shown to occur in the brain of hibernators during torpor. Since, recently, in our lab, a hypothermic torpor-like condition (synthetic torpor, ST) was pharmacologically induced in the rat, a non-hibernator, the aim of the present work was to assess whether ST can lead to a reversible PP-Tau accumulation in the rat brain. PP-Tau was immunohistochemically assessed by staining for AT8 (phosphorylated Tau) and Tau-1 (non-phosphorylated Tau) in 19 brain structures, which were chosen mostly due to their involvement in the regulation of autonomic and cognitive functions in relation to behavioral states. During ST, AT8 staining was strongly expressed throughout the brain, while Tau-1 staining was reduced compared to control conditions. During the following recovery period, AT8 staining progressively reduced close to zero after 6 h from ST. However, Tau-1 staining remained low even after 38 h from ST. Thus, overall, these results show that ST induced an accumulation of PP-Tau that was, apparently, only partially reversed to normal during the recovery period. While the accumulation of PP-Tau may only depend on the physicochemical characteristics of the enzymes regulating Tau phosphorylation, the reverse process of dephosphorylation should be actively regulated, also in non-hibernators. In conclusion, in this work a reversible and widespread PP-Tau accumulation has been induced through a procedure that leads a non-hibernator to a degree of reversible hypothermia, which is comparable to that observed in hibernators. Therefore, the physiological mechanism involved in this process can sustain an adaptive neuronal response to extreme conditions, which may however lead to neurodegeneration when particular intensities and durations are exceeded
Neural control of fasting-induced torpor in mice
Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the activation of all thermogenic organs that could potentially defend body temperature must be prevented. Most of these organs, such as the brown adipose tissue, are controlled by the key thermoregulatory region of the Raphe Pallidus (RPa). Currently, it is not known which brain areas mediate the entrance into torpor. To identify these areas, the expression of the early gene c-Fos at torpor onset was assessed in different brain regions in mice injected with a retrograde tracer (Cholera Toxin subunit b, CTb) into the RPa region. The results show a network of hypothalamic neurons that are specifically activated at torpor onset and a direct torpor-specific projection from the Dorsomedial Hypothalamus to the RPa that could putatively mediate the suppression of thermogenesis during torpor
E835 at FNAL: Charmonium Spectroscopy in Annihilations
I present preliminary results on the search for in its
and decay modes. We observe an excess of \eta_c\gamma{\cal P} \sim 0.001M=3525.8 \pm 0.2 \pm 0.2
\Gamma\leq10.6\pm 3.7\pm3.4(br) <
\Gamma_{\bar{p}p}B_{\eta_c\gamma} < 12.8\pm 4.8\pm4.5(br) J/\psi\pi^0$ mode.Comment: Presented at the 6th International Conference on Hyperons, Charm and
Beauty Hadrons (BEACH 2004), Chicago(Il), June 27-July 3,200
Interference Study of the chi_c0 (1^3P_0) in the Reaction Proton-Antiproton -> pi^0 pi^0
Fermilab experiment E835 has observed proton-antiproton annihilation
production of the charmonium state chi_c0 and its subsequent decay into pi^0
pi^0. Although the resonant amplitude is an order of magnitude smaller than
that of the non-resonant continuum production of pi^0 pi^0, an enhanced
interference signal is evident. A partial wave expansion is used to extract
physics parameters. The amplitudes J=0 and 2, of comparable strength, dominate
the expansion. Both are accessed by L=1 in the entrance proton-antiproton
channel. The product of the input and output branching fractions is determined
to be B(pbar p -> chi_c0) x B(chi_c0 -> pi^0 pi^0)= (5.09 +- 0.81 +- 0.25) x
10^-7.Comment: 4 pages, 4 figures, Accepted by PRL (July 2003
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract
: Rising environmental awareness drives green consumers to purchase sustainable cosmetics based on natural bioactive compounds. The aim of this study was to deliver Rosa canina L. extract as a botanical ingredient in an anti-aging gel using an eco-friendly approach. Rosehip extract was first characterized in terms of its antioxidant activity through a DPPH assay and ROS reduction test and then encapsulated in ethosomal vesicles with different percentages of ethanol. All formulations were characterized in terms of size, polydispersity, zeta potential, and entrapment efficiency. Release and skin penetration/permeation data were obtained through in vitro studies, and cell viability was assessed using an MTT assay on WS1 fibroblasts. Finally, ethosomes were incorporated in hyaluronic gels (1% or 2% w/v) to facilitate skin application, and rheological properties were studied. Rosehip extract (1 mg/mL) revealed a high antioxidant activity and was successfully encapsulated in ethosomes containing 30% ethanol, having small sizes (225.4 ± 7.0 nm), low polydispersity (0.26 ± 0.02), and good entrapment efficiency (93.41 ± 5.30%). This formulation incorporated in a hyaluronic gel 1% w/v showed an optimal pH for skin application (5.6 ± 0.2), good spreadability, and stability over 60 days at 4 °C. Considering sustainable ingredients and eco-friendly manufacturing technology, the ethosomal gel of rosehip extract could be an innovative and green anti-aging skincare product
Проблема правової культури в історії філософсько-педагогічної думки
(uk) Стаття присвячена проблемі правової культури в історії філософсько-педагогічної думки
Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients
Monocyte Distribution Width (MDW), a new cytometric parameter correlating with cytomorphologic changes occurring upon massive monocyte activation, has recently emerged as promising early biomarker of sepsis. Similar to sepsis, monocyte/macrophage subsets are considered key mediators of the life-threatening hyper-inflammatory disorder characterizing severe COVID-19. In this study, we longitudinally analyzed MDW values in a cohort of 87 COVID-19 patients consecutively admitted to our hospital, showing significant correlations between MDW and common inflammatory markers, namely CRP (p < 0.001), fibrinogen (p < 0.001) and ferritin (p < 0.01). Moreover, high MDW values resulted to be prognostically associated with fatal outcome in COVID-19 patients (AUC = 0.76, 95% CI: 0.66\u20130.87, sensitivity 0.75, specificity 0.70, MDW threshold 26.4; RR = 4.91, 95% CI: 1.73\u201313.96; OR = 7.14, 95% CI: 2.06\u201324.71). This pilot study shows that MDW can be useful in the monitoring of COVID-19 patients, as this innovative hematologic biomarker is: (1) easy to obtain, (2) directly related to the activation state of a fundamental inflammatory cell subset (i.e. monocytes, pivotal in both cytokine storm and sepsis immunopathogenesis), (3) well correlated with clinical severity of COVID-19-associated inflammatory disorder, and, in turn, (4) endowed with relevant prognostic significance. Additional studies are needed to define further the clinical impact of MDW testing in the management of COVID-19 patients
Precision measurements of the total and partial widths of the psi(2S) charmonium meson with a new complementary-scan technique in antiproton-proton annihilations
We present new precision measurements of the psi(2S) total and partial widths
from excitation curves obtained in antiproton-proton annihilations by Fermilab
experiment E835 at the Antiproton Accumulator in the year 2000. A new technique
of complementary scans was developed to study narrow resonances with
stochastically cooled antiproton beams. The technique relies on precise
revolution-frequency and orbit-length measurements, while making the analysis
of the excitation curve almost independent of machine lattice parameters. We
study the psi(2S) meson through the processes pbar p -> e+ e- and pbar p ->
J/psi + X -> e+ e- + X. We measure the width to be Gamma = 290 +- 25(sta) +-
4(sys) keV and the combination of partial widths Gamma_e+e- * Gamma_pbarp /
Gamma = 579 +- 38(sta) +- 36(sys) meV, which represent the most precise
measurements to date.Comment: 17 pages, 3 figures, 3 tables. Final manuscript accepted for
publication in Phys. Lett. B. Parts of the text slightly expanded or
rearranged; results are unchange
First Observation of CP Violation in B0->D(*)CP h0 Decays by a Combined Time-Dependent Analysis of BaBar and Belle Data
We report a measurement of the time-dependent CP asymmetry of B0->D(*)CP h0
decays, where the light neutral hadron h0 is a pi0, eta or omega meson, and the
neutral D meson is reconstructed in the CP eigenstates K+ K-, K0S pi0 or K0S
omega. The measurement is performed combining the final data samples collected
at the Y(4S) resonance by the BaBar and Belle experiments at the
asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The
data samples contain ( 471 +/- 3 ) x 10^6 BB pairs recorded by the BaBar
detector and ( 772 +/- 11 ) x 10^6, BB pairs recorded by the Belle detector. We
measure the CP asymmetry parameters -eta_f S = +0.66 +/- 0.10 (stat.) +/- 0.06
(syst.) and C = -0.02 +/- 0.07 (stat.) +/- 0.03 (syst.). These results
correspond to the first observation of CP violation in B0->D(*)CP h0 decays.
The hypothesis of no mixing-induced CP violation is excluded in these decays at
the level of 5.4 standard deviations.Comment: 9 pages, 2 figures, submitted to Physical Review Letter
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