Chemical composition, in vitro cytotoxic and antioxidant activities of the essential oil of Peruvian Minthostachys mollis Griseb

The composition of the essential oil obtained by hydrodistillation from Minthostachys mollis Griseb (Lamiaceae) aerial parts was determined by GC and GC/MS. Menthone (13.2%), pulegone (12.4%), cis-dihydrocarvone (9.8%) and carvacrol acetate (8.8%) were the main essential oil components. The cytotoxic activity of the essential oil was in vitro measured using the MTT colorimetric assay. IC50values were calculated on healthy non-tumor cells (HEK-293) and three human cancer cell lines (T24, DU-145 and MCF-7). In such latter cells, the estimated values were around 0.2 mg/mL. In addition, the antioxidant activity was determined by interaction with the stable freeradical 2,2”-diphenyl-1-picrylhydrazyl. The essential oil was almost devoid of antioxidant activity indicating that its anti-proliferative action relies on other unknown mechanism

EVALUACIÓN MICROBIOLÓGICA DEL PROGRAMA DE LIMPIEZA Y DESINFECCIÓN DE UNA PLANTA PROCESADORA DE PRODUCTOS ALIMENTICIOS AVÍCOLAS DE CARTAGENA-BOLÍVAR, COLOMBIA.

Evaluar microbiológicamente el programa de limpieza y desinfección de una planta procesadora de productos alimenticios avícolas de Cartagena-Bolívar, Colombia. Se realizó una investigación con enfoque cuantitativo, con un diseño de estudio Observacional, Descriptivo y Transversal. Las muestras recolectadas corresponden en ambientes a 80, superficies a 56 y manipuladores a 29. La evaluación se realizó mediante la determinación de la carga microbiológica en ambientes, superficies de contacto y utensilios empleando los indicadores microbiológicos Aerobios mesófilos, Mohos y levaduras y Salmonella spp., además se realizó una caracterización microbiológica de las colonias aisladas; El procedimiento de lavados manos en el manipulador se evaluó con los indicadores aerobios mesófilos, Escherichia coli y Staphylococcus aureus; Para evaluar los desinfectantes de superficies y manos se realizó la prueba de efectividad antimicrobiana. Las superficies evaluadas presentaron recuentos elevados de aerobios mesófilos antes de los procedimientos de limpieza y desinfección, que no fueron reducidos eficazmente después de su realización. La superficie de la banda transportadora presentó la mayor carga microbiana después de la sanitización debido a su diseño. No se aisló Salmonella spp. En las superficies evaluadas. El lavado de manos fue inadecuado, evidenciado por recuentos de mesoaerobios inaceptables, presencia de S. aureus y E. coli. Los desinfectantes evaluados inhibieron el crecimiento de Pseudomonas spp., Micrococcus luteus, aislados en superficies, y S. aureus y E. coli aisladas en las manos de los manipuladores

EVALUACIÓN MICROBIOLÓGICA DEL PROGRAMA DE LIMPIEZA Y DESINFECCIÓN DE UNA PLANTA PROCESADORA DE PRODUCTOS ALIMENTICIOS AVÍCOLAS DE CARTAGENA-BOLÍVAR, COLOMBIA.

Evaluar microbiológicamente el programa de limpieza y desinfección de una planta procesadora de productos alimenticios avícolas de Cartagena-Bolívar, Colombia. Se realizó una investigación con enfoque cuantitativo, con un diseño de estudio Observacional, Descriptivo y Transversal. Las muestras recolectadas corresponden en ambientes a 80, superficies a 56 y manipuladores a 29. La evaluación se realizó mediante la determinación de la carga microbiológica en ambientes, superficies de contacto y utensilios empleando los indicadores microbiológicos Aerobios mesófilos, Mohos y levaduras y Salmonella spp., además se realizó una caracterización microbiológica de las colonias aisladas; El procedimiento de lavados manos en el manipulador se evaluó con los indicadores aerobios mesófilos, Escherichia coli y Staphylococcus aureus; Para evaluar los desinfectantes de superficies y manos se realizó la prueba de efectividad antimicrobiana. Las superficies evaluadas presentaron recuentos elevados de aerobios mesófilos antes de los procedimientos de limpieza y desinfección, que no fueron reducidos eficazmente después de su realización. La superficie de la banda transportadora presentó la mayor carga microbiana después de la sanitización debido a su diseño. No se aisló Salmonella spp. En las superficies evaluadas. El lavado de manos fue inadecuado, evidenciado por recuentos de mesoaerobios inaceptables, presencia de S. aureus y E. coli. Los desinfectantes evaluados inhibieron el crecimiento de Pseudomonas spp., Micrococcus luteus, aislados en superficies, y S. aureus y E. coli aisladas en las manos de los manipuladores

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Search for dijet resonances using events with three jets in proton-proton collisions at root s=13 TeV

A search for a narrow resonance with a mass between 350 and 700 GeV, and decaying into a pair of jets, is performed using proton-proton collision events containing at least three jets. The data sample corresponds to an integrated luminosity of 18.3 fb(-1) recorded at root s = 13 TeV with the CMS detector. Data are collected with a technique known as "data scouting", in which the events are reconstructed, selected, and recorded at a high rate in a compact form by the high-level trigger. The three-jet final state provides sensitivity to lower resonance masses than in previous searches using the data scouting technique. The spectrum of the dijet invariant mass, calculated from the two jets with the largest transverse momenta in the event, is used to search for a resonance. No significant excess over a smoothly falling background is found. Limits at 95% confidence level are set on the production cross section of a narrow dijet resonance and compared with the cross section of a vector dark matter mediator coupling to dark matter particles and quarks. Translating to a model where the narrow resonance interacts only with quarks, upper limits on this coupling range between 0.10 and 0.15, depending on the resonance mass. These results represent the most stringent upper limits in the mass range between 350 and 450 GeV obtained with a flavor-inclusive dijet resonance search. (C) 2020 The Author(s). Published by Elsevier B.V.Peer reviewe

Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sNN\sqrt{^{s}NN} =5.02 TeV

The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of $\sqrt{^{s}NN}$=5.02 TeV per nucleon pair, using the decay chain X(3872)→J/ψπ$^{+}$ π$^{–}$→μ$^{+}$μ$^{–}$π$^{+}$ π$^{–}$. The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb$^{-1}$. The measurement is performed in the rapidity and transverse momentum ranges |y|<1.6 and 15<pT<50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to ψ2S yield ratio is found to be ρ$^{Pb-Pb}$=1.08±0.49(stat)±0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state

Measurement of the Y(1S) pair production cross section and search for resonances decaying to Y(1S)μ⁺μ⁻ in proton-proton collisions at √s = 13 TeV

The fiducial cross section for Y(1S) pair production in proton-proton collisions at a center-of-mass energy of 13 TeV in the region where both Y(1S) mesons have an absolute rapidity below 2.0 is measured to be 79±11(stat)±6(syst)±3(B) pb assuming the mesons are produced unpolarized. The last uncertainty corresponds to the uncertainty in the Y(1S) meson dimuon branching fraction. The measurement is performed in the final state with four muons using proton-proton collision data collected in 2016 by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9fb⁻¹. This process serves as a standard model reference in a search for narrow resonances decaying to Y(1S)μ⁺μ⁻ in the same final state. Such a resonance could indicate the existence of a tetraquark that is a bound state of two b quarks and two b antiquarks. The tetraquark search is performed for masses in the vicinity of four times the bottom quark mass, between 17.5 and 19.5 GeV, while a generic search for other resonances is performed for masses between 16.5 and 27 GeV. No significant excess of events compatible with a narrow resonance is observed in the data. Limits on the production cross section times branching fraction to four muons via an intermediate Y(1S) resonance are set as a function of the resonance mass