148 research outputs found
The allure of otherness: transnational cult film fandom and the exoticist assumption
- Author
- Alemán Gabriela
- Aslan Mehmet
- Atadeniz Yilmaz
- Bordwell David
- Bordwell David
- Chan Edward K.
- Chin Bertha
- Djalil H. Tjut
- Djalil H. Tjut
- Evans Elizabeth
- Hoberman J.
- Hunt Leon
- Hunt Leon
- Hutchings Peter
- Jancovich Mark
- Jenkins Henry
- Jires Jaromil
- Jodorowsky Alejandro
- Jodorowsky Alejandro
- Kovács András Bálint
- Mendik Xavier
- Neale Steve
- Peterson James
- Petho Ágnes
- Roy Elodie A.
- Shapiro Ron
- Starke Andrew
- Taylor Greg
- Telotte J. P.
- Tohill Cathal
- Tombs Pete
- Willis Andrew
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2017
- Field of study
Academic scholarship addressing transnational cult fandom, particularly Western cult fans forming attachments to films outside their cultures, has frequently addressed the issue of exoticism. Much attention has been paid to how Western fans are problematically drawn to artefacts outside of their own cultures because of exotic qualities, resulting in a shallow and often condescending appreciation of such films. In this article, I critique a number of such articles for merely assuming such processes without proffering sufficient supporting evidence. In fact, I argue that a number of such exotic-oriented critiques of transnational cultism are actually guilty of practising what they preach against: an insufficient contextualization of fandom and a tendency to downplay the messiness of empirical data in favour of generalized abstractions. Further, I argue that the constant critique of fans as avoiding contextualization has not only been overstated but stringently used as a yardstick to denigrate fan engagements with texts as improper. As such, fans are often ‘othered’ within such articles, a process mirroring the ways they are accused of othering distant cultural artefacts
Oral health behaviour in migrant and non-migrant adults in Germany: the utilization of regular dental check-ups
- Author
- A Chattopadhyay
- A Hjern
- A Keller
- A Riesberg
- AR Bissar
- B Busse
- B Cvikl
- BG Tabachnick
- C Bedos
- C Stecksén-Blicks
- Dorothee Waury
- E Diaz
- E Scheppers
- Fabian Erdsiek
- Federal Office for Migration and Refugees
- G Aarabi
- H Knopf
- J Kühnisch
- J Spallek
- K Bozorgmehr
- K Pitkin Derose
- L Schenk
- LA Lebrun
- LB Christensen
- M Norredam
- M Norredam
- M Steenkiste van
- M Steenkiste van
- P Brzoska
- P Brzoska
- P Brzoska
- P Carrasco-Garrido
- Patrick Brzoska
- Robert Koch-Institut
- S Listl
- StataCorp
- Statistisches Bundesamt
- T Brand
- T Lampert
- TK Sakki
- WV Giannobile
- XL Gao
- Y Yilmaz-Aslan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
High diagnostic rate of trio exome sequencing in consanguineous families with neurogenetic diseases.
- Author
- Arslan N
- Aslan M
- Beltran S
- Broad Center for Mendelian Genomics
- Chinnery PF
- Edem PP
- Ekinci B
- Gao F
- Güngör S
- Hathazi D
- Hiz Kurul S
- Horvath R
- Houlden H
- Kalafatcilar İP
- Laurie S
- Lochmüller A
- Lochmüller H
- Lovgren AK
- Maroofian R
- Matalonga L
- Müller JS
- Nair A
- O'Heir E
- Oktay Y
- Paramonov I
- Polavarapu K
- Rieger A
- Roos A
- Schon K
- Sonmezler E
- Szabó NZ
- Töpf A
- Yaramis A
- Yilmaz E
- Yis U
- Özgör B
- Publication venue
- Oxford University Press
- Publication date
- 17/11/2021
- Field of study
Consanguineous marriages have a prevalence rate of 24% in Turkey. These carry an increased risk of autosomal recessive genetic conditions, leading to severe disability or premature death, with a significant health and economic burden. A definitive molecular diagnosis could not be achieved in these children previously, as infrastructures and access to sophisticated diagnostic options were limited. We studied the cause of neurogenetic disease in 246 children from 190 consanguineous families recruited in three Turkish hospitals between 2016 and 2020. All patients underwent deep phenotyping and trio whole exome sequencing, and data were integrated in advanced international bioinformatics platforms. We detected causative variants in 119 known disease genes in 72% of families. Due to overlapping phenotypes 52% of the confirmed genetic diagnoses would have been missed on targeted diagnostic gene panels. Likely pathogenic variants in 27 novel genes in 14% of the families increased the diagnostic yield to 86%. Eighty-two per cent of causative variants (141/172) were homozygous, 11 of which were detected in genes previously only associated with autosomal dominant inheritance. Eight families carried two pathogenic variants in different disease genes. De novo (9.3%), X-linked recessive (5.2%) and compound heterozygous (3.5%) variants were less frequent compared to non-consanguineous populations. This cohort provided a unique opportunity to better understand the genetic characteristics of neurogenetic diseases in a consanguineous population. Contrary to what may be expected, causative variants were often not on the longest run of homozygosity and the diagnostic yield was lower in families with the highest degree of consanguinity, due to the high number of homozygous variants in these patients. Pathway analysis highlighted that protein synthesis/degradation defects and metabolic diseases are the most common pathways underlying paediatric neurogenetic disease. In our cohort 164 families (86%) received a diagnosis, enabling prevention of transmission and targeted treatments in 24 patients (10%). We generated an important body of genomic data with lasting impacts on the health and wellbeing of consanguineous families and economic benefit for the healthcare system in Turkey and elsewhere. We demonstrate that an untargeted next generation sequencing approach is far superior to a more targeted gene panel approach, and can be performed without specialized bioinformatics knowledge by clinicians using established pipelines in populations with high rates of consanguinity
Sociodemographic and health-(care-)related characteristics of online health information seekers: a cross-sectional German study
- Author
- A Deursen van
- A Mielck
- AG Crocco
- Alexander Krämer
- AT McCray
- B Lausen
- C Marton
- C Rossmann
- CD Norman
- Claudia Hornberg
- D Delic
- D Deufert
- E Renahy
- G Eysenbach
- HK Andreassen
- I Renahy
- J Powell
- J Winkler
- JA Diaz
- JB Weaver
- JB Weaver
- JD Johnson
- JM Pelikan
- K Horch
- K Siegrist
- KE Flynn
- KM AlGhamdi
- L Baker
- Landeszentrum Gesundheit Nordrhein-Westfalen
- Landeszentrum Gesundheit Nordrhein-Westfalen
- Laura Nölke
- M Franz
- M Lemire
- M Marr
- M McMullan
- MK Bundorf
- MK Lam
- ML Ybarra
- Monika Mensing
- MP Wang
- MP Wang
- N Xiao
- N Zilien
- NL Atkinson
- NR Hardiker
- O Razum
- Organisation for Economic Cooperation and Development
- P Bansil
- R Cullen
- R Gauld
- R Siliquini
- RC Dumitru
- RE Rice
- RS Sadasivam
- S Dickerson
- S Fox
- S Koch-Weser
- S Schmidt-Kaehler
- S Wangberg
- SC Wangberg
- SD Lambert
- SJ Chang
- Skopos Institut für Markt- und Kommunikationsforschung
- SL Ayers
- SR Cotten
- T Berger
- T Faltermaier
- T Lampert
- U Sarkar
- U Walter
- V Hüfken
- World Health Organization
- Y Yilmaz-Aslan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Serum Myeloperoxidase Activity, Total Antioxidant Capacity and Nitric Oxide Levels in Patients with Chronic Otitis Media
- Author
- A Kantar
- Ahmet Kozan
- B Aktan
- Bakır Tuna
- C Ozcan
- E Baysal
- E Olszewska
- EA Podrez
- EL Thomas
- FJ García Callejo
- GJ Westerveld
- GK Shukla
- H Moshage
- Hakan Cankaya
- HF Cay
- JA Ursick
- JA Vita
- K Uchida
- L Gaté
- L Kruidenier
- M Faith
- MA Melikoglu
- Mehmet Aslan
- Mehmet Fatih Garça
- MS Joshi
- MT Semaan
- O Erel
- P Zalewski
- RF Hamilton Jr
- RR Parks
- S Kalender
- S Koc
- S Vertuoni
- SG Young
- T Karlidag
- T Yilmaz
- T Yilmaz
- TG Takoudes
- YG Min
- ZA Placer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
- Author
- A Boing
- A Gaspari
- A Kübler
- A Marudi
- A Matheson
- A Tridente
- A. A. Amelia
- A. Abbas
- A. Adams
- A. Agnoli
- A. Al Khulaifi
- A. Al Khulaifi
- A. Aldawood
- A. AlHussain
- A. Ali
- A. Almenyar
- A. Alrashid
- A. Alsheikhly
- A. Alves
- A. Ankuli
- A. Arbouti
- A. Armaganidis
- A. Artigas
- A. Asimakos
- A. B. Belli
- A. B. Cayci Sivri
- A. Bandyopadhyay
- A. Basu
- A. Bedova
- A. Belli
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Bond
- A. Borgman
- A. Borowska
- A. Boutin
- A. Boutin
- A. Boyce
- A. Braschi
- A. Budnyuk
- A. C. Rodrigues
- A. Cariou
- A. Casazza
- A. Chakraborty
- A. Cirodde
- A. Crizaldo Toledo
- A. Cudia
- A. Cuoghi
- A. D. Dubrawski
- A. Dardashti
- A. Dean
- A. Dean
- A. Delfosse
- A. Dhaliwal
- A. Dhaliwal
- A. Dobru
- A. Docherty
- A. Doronzio
- A. Douvdevani
- A. Dukoff-Gordon
- A. Durward
- A. E Van den Berg
- A. Eden
- A. Eissa
- A. Enguix-Armada
- A. Escalante
- A. Escalante
- A. Ezzamouri
- A. F. Francke
- A. F. Turgeon
- A. F. Turgeon
- A. F. Van Rootselaar
- A. F. Van Rootselaar
- A. Fayed
- A. Fernandez
- A. Fischer
- A. Fogagnolo
- A. Fuller
- A. Fuller
- A. G. Murchison
- A. G. Proudfoot
- A. Garcia
- A. Garcia-Alcantara
- A. Garcia-De la Torre
- A. Garland
- A. Garland
- A. Gaspari
- A. Ghuysen
- A. Giannini
- A. Gobatto
- A. Goloubev
- A. Grubb
- A. Gruber
- A. Gultekin
- A. H. Zwinderman
- A. Hagiwara
- A. Hana
- A. Hana
- A. Harts
- A. Hejazi
- A. Hernández-Lozano
- A. Hernández-Lozano
- A. Hovingh
- A. Huber
- A. Itani
- A. J. Groeneveld
- A. J. Hoogendijk
- A. K. Kink
- A. K. Kuzovlev
- A. K. Tashima
- A. Kapuagasi
- A. Kar
- A. Kaskovagheorgescu
- A. Kaushal
- A. Khaghani
- A. Kindawi
- A. Kleinsasser
- A. Kodaira
- A. Kutz
- A. Kuzovlev
- A. Körner
- A. L Luciani
- A. L. Lange
- A. Lepape
- A. Lesmes
- A. Lima
- A. Lima
- A. Linder
- A. Loza
- A. López Lago
- A. M. Magnuson
- A. M. Tuip-de Boer
- A. Maaoui
- A. Machado
- A. Mahrous
- A. Malamas
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Martins
- A. Marudi
- A. Marudi
- A. Matroud
- A. Mebazaa
- A. Mignon
- A. Min
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Morelli
- A. Morris
- A. Motos
- A. N. Ahmad
- A. Nadeem
- A. Nau
- A. Neill
- A. Nyman
- A. Núñez
- A. Oglinda
- A. Omar
- A. Omar
- A. Omar
- A. Omar
- A. Orlando
- A. Osipov
- A. Ozcan
- A. O’Loughlin
- A. O’Sullivan
- A. O’Sullivan
- A. O’Sullivan
- A. P. Pagano
- A. P. Torelly
- A. Pagano
- A. Patarchi
- A. Pautova
- A. Pavli
- A. Pesenti
- A. Prekates
- A. Psirides
- A. Puerto-Morlan
- A. Puxty
- A. Pérez-Calatayud
- A. R. Robles Caballero
- A. Radford
- A. Raithatha
- A. Raithatha
- A. Raithatha
- A. Reiter
- A. Rhodes
- A. Rhodes
- A. Rhodes
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riviere
- A. Riviere
- A. Riviere
- A. Robles
- A. Rogers
- A. Rousseau
- A. Roze des Ordons
- A. Ruijter
- A. Rutten
- A. S. Alsaawi
- A. S. Stieglitz
- A. Salgueiro
- A. Salgueiro
- A. Salgueiro
- A. Sarmento
- A. Sarmento
- A. Savitsky
- A. Scheirer
- A. Schiavi
- A. Seldon
- A. Sell
- A. Sen
- A. Sergeev
- A. Shabanov
- A. Shafie
- A. Shafquat
- A. Shiraishi
- A. Silva-Pinto
- A. Silva-Pinto
- A. Spassov
- A. Stella
- A. Steuber
- A. Stieglitz
- A. Stilwell
- A. Sánchez-López
- A. Sánchez-López
- A. Taha
- A. Taha
- A. Taskin
- A. Temple
- A. Tinmouth
- A. Tinmouth
- A. Torres
- A. Torres
- A. Torres
- A. Touborg Lassen
- A. Tridente
- A. Tridente
- A. Tridente
- A. Tridente
- A. Trifi
- A. Trifi
- A. Tsimogianni
- A. Turgeon
- A. Turgeon
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Van Assche
- A. Van Assche
- A. Varma
- A. Vassi
- A. Vercueil
- A. Vieillard-Baron
- A. Violaki
- A. Violaki
- A. Vuylsteke
- A. W. Waldmann
- A. Wald
- A. Waldmann
- A. Waldmann
- A. Webber
- A. Wheeler
- A. Yalcin
- A. Zepeda-Mendoza
- A. Zerman
- AF Donneau
- AK Güler
- AT Tesnieres
- B Adamik
- B Avard
- B. Al Raiy
- B. AlGhamdi
- B. Alhamadi
- B. Alotaibi
- B. Avard
- B. Avard
- B. Balicco
- B. Basarýk Aydogan
- B. Besen
- B. Bilgili
- B. Bilgili
- B. Borgatta
- B. Bouhemad
- B. C. Civantos
- B. Carr
- B. Civantos
- B. De Cagny
- B. De Cagny
- B. De Cagny
- B. De Cagny
- B. De Laat
- B. Delwarde
- B. Eilers
- B. François
- B. François
- B. Fyntanidou
- B. Fyntanidou
- B. Fyntanidou
- B. Goncalves
- B. Guidet
- B. J. Hunt
- B. Jeribi
- B. Jones
- B. K. Lopansri
- B. Khwannimit
- B. Khwannimit
- B. Köves
- B. Laribi
- B. Laribi
- B. Lord
- B. Loureiro
- B. López Matamala
- B. Miles
- B. Mueller
- B. Mueller
- B. Mueller
- B. Nyamaizi
- B. O. Alotabi
- B. Oliveira
- B. Oliveira
- B. Oliveira
- B. P. Scicluna
- B. Pasquet
- B. Peroni
- B. Saugel
- B. Sauneuf
- B. Shenkman
- B. Sloan
- B. Stessel
- B. Stessel
- B. Söderquist
- B. Tudor
- B. Vidal
- B. Waldum-Grevbo
- B. Wanta
- B. Xavier
- C. A. Volta
- C. Aldecoa
- C. Aldecoa
- C. Arrowsmith
- C. Ashton
- C. Battle
- C. Battle
- C. Battle
- C. Bell
- C. Bor
- C. Bor
- C. Brunborg
- C. Carvalho
- C. Chaddock
- C. Chiurazzi
- C. Choong
- C. Cobilinschi
- C. Cobilinschi
- C. Cobilinschi
- C. Cobilinschi
- C. Cohen
- C. Dalrymple
- C. De Deyne
- C. De Haro
- C. Dinter
- C. Doig
- C. Doree
- C. Downey
- C. Dridi
- C. E. Luyt
- C. Ertmer
- C. Ertmer
- C. F. Fuchs
- C. Feldmann
- C. Fenlon
- C. Fitton
- C. Fleischmann
- C. Fleischmann
- C. G. Ellis
- C. Gemelli
- C. Genbrugge
- C. Gerrard
- C. Glynos
- C. Gogos
- C. Goldfuss
- C. Goossens
- C. Gu
- C. H. Toh
- C. Haas
- C. Haas
- C. Hamilton-Davies
- C. Hawthorne
- C. Heidegger
- C. Hoermann
- C. Hoffmann
- C. Hymers
- C. Ince
- C. Ince
- C. Ince
- C. J. Hodiamont
- C. J. Kirwan
- C. J. Kirwan
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. K. Karagiannidis
- C. Karagiannidis
- C. Karagiannidis
- C. Karnjanarachata
- C. Katsenos
- C. Kaymak
- C. Kirwan
- C. Kongkamol
- C. Koutsogiannidis
- C. Krenn
- C. Kruger
- C. L. Sprung
- C. Lee
- C. Lemaire
- C. Leon
- C. Leães
- C. Lister
- C. Lum
- C. Lum
- C. Lynch
- C. Magalhaes
- C. Magalhaes
- C. Marenghi
- C. Martín Parra
- C. Martínez Díaz
- C. Maury
- C. Mazo Torre
- C. McBride
- C. Mcgrath
- C. Mitaka
- C. Oglinda
- C. Ostrowska
- C. P. Lee
- C. Palazzi
- C. Park
- C. Patet
- C. Pelletier
- C. Pereira
- C. Peters
- C. Pichard
- C. Pierrakos
- C. Plourde
- C. Poi
- C. Pretty
- C. Pretty
- C. Pritchett
- C. Reutelingsperger
- C. Rodrigues
- C. Rodríguez Gallego
- C. Routsi
- C. Ryan
- C. S. Bouman
- C. S. Scheer
- C. S. Serra
- C. Sampson
- C. Scarrot
- C. Senver
- C. Sittipunt
- C. Skourtis
- C. Stone
- C. Suthisisang
- C. Svensen
- C. Tordoff
- C. Travierso
- C. Turrini
- C. Ugur Yilmaz
- C. Ulusoy
- C. Valdez
- C. Valencia
- C. Van Walraven
- C. Van Walraven
- C. Volta
- C. Volta
- C. Vrettou
- C. W. Park
- C. W. Park
- C. W. Park
- C. Walsh
- C. Willars
- C. Wissmann
- D Bryden
- D Jakubczyk
- D. A. Fergusson
- D. Adukauskiene
- D. Amin
- D. Ballesteros
- D. Bastoni
- D. Benoit
- D. Berger
- D. Bergmans
- D. Brown
- D. Bryden
- D. Bryden
- D. C. Angus
- D. Castanares-Zapatero
- D. Chroni
- D. Ciprandi
- D. Dawson
- D. De Bels
- D. Diedrich
- D. Dreyfuss
- D. Dreyfuss
- D. Du Cheyron
- D. Enoch
- D. Eschbach
- D. Eversole
- D. Evoy
- D. Fergusson
- D. Fergusson
- D. Fineberg
- D. Forte
- D. Forte
- D. Forte
- D. Freitag
- D. Gavrychenko
- D. Gavrychenko
- D. Gineityte
- D. Gokmen
- D. Griesdale
- D. Griesdale
- D. Griesdale
- D. Griesdale
- D. Heyland
- D. Heyland
- D. Heyland
- D. Huskens
- D. Inverarity
- D. Jacobsen
- D. Jarczak
- D. Kindgen-Milles
- D. Koutete
- D. L. Lucchesi
- D. M. Dalcomune
- D. M. Dalcomune
- D. M. Dalcomune
- D. Macias
- D. Mackle
- D. Mackle
- D. Markopoulou
- D. Memis
- D. Miller
- D. Moisidou
- D. Moisidou
- D. Moisidou
- D. Monkhouse
- D. Mota
- D. O. Thomas-Rüddel
- D. Pandit
- D. Pavlovic
- D. Pilsgaard Henriksen
- D. R. Cranendonk
- D. Reuter
- D. Ricci
- D. Ringaitiene
- D. S. Stavi
- D. Sangaran
- D. Sbiti-Rohr
- D. Silva
- D. Stott
- D. Thevenin
- D. Thomas-Rueddel
- D. Titeca
- D. Titeca
- D. Titeca
- D. Titeca
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Valanciene
- D. Wyncoll
- D. Ysebaert
- E Bertellini
- E George
- E Prandi
- E. A Volakli
- E. A. Osawa
- E. A. Volakli
- E. Aguilera
- E. Akin Korhan
- E. Akýn Korhan
- E. Almeida
- E. Antoniadou
- E. Antypa
- E. Arch-Tirado
- E. Arita
- E. B. Dias
- E. Bellazzi
- E. Bertellini
- E. Bertellini
- E. Boezeman
- E. Borg-Seng-Shu
- E. C. Carella
- E. Carlson
- E. Cerrato
- E. Chernevskaya
- E. Chinou
- E. Chochliourou
- E. Chochliourou
- E. Colombaroli
- E. Colombaroli
- E. Colombaroli
- E. D. Arul
- E. Dalampini
- E. Dalampini
- E. Der Kinderen
- E. Derom
- E. Doumaki
- E. Dubief
- E. Fan
- E. Frenoy
- E. G. Gayat
- E. George
- E. George
- E. Ghosh
- E. Giamarellos-Bourboulis
- E. Grins
- E. Gómez-Pesquera
- E. Gómez-Pesquera
- E. Gómez-Sánchez
- E. Gómez-Sánchez
- E. Helme
- E. Helme
- E. Herrera-Ramos
- E. Hoste
- E. Ischaki
- E. Jeong
- E. Joelsson-Alm
- E. K. Kishinevsky
- E. Kaya
- E. Kompanje
- E. Koonthalloor
- E. Kotzapanagiotou
- E. L. V. Costa
- E. Lafuente
- E. Lafuente
- E. Lafuente
- E. Llopart
- E. M. Siqueira
- E. Mancini
- E. Marrinan
- E. McCarron
- E. McCarron
- E. Michael
- E. Moltchanova
- E. Moreira
- E. Mukeria
- E. Mukeria
- E. Nakstad
- E. Nieuwkoop
- E. Nsutebu
- E. Nyberg
- E. Oloktsidou
- E. Oloktsidou
- E. Orenbuch-Harroch
- E. Papapostolou
- E. Peronnet
- E. Peters
- E. Pokorna
- E. R. Ruggiero
- E. Rodríguez Ruíz
- E. Samkinidou
- E. Samkinidou
- E. Scarlatescu
- E. Schurgers
- E. Senturk
- E. Senturk
- E. Tamayo
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- Publication venue
- Springer Nature
- Publication date
- 01/01/2016
- Field of study
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial
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- Tzimas P.
- Téllez L.F.
- Ugur S.
- Universitat Autònoma de Barcelona
- Urrestizala A.U.
- Vadalà M.C.
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- Özaslan N.
- Özbilgin S.
- Özdemir L.
- Ünlügenç H.
- Publication venue
- Publication date
- 01/01/2021
- Field of study
More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369
Health literacy among different age groups in Germany: results of a cross-sectional survey.
- Author
- A Shaghaghi
- Advisory Council on the Assessment of Developments in the Healthcare System
- BD Weiss
- D Tiller
- DA DeWalt
- Dominique Vogt
- Doris Schaeffer
- E Berens
- Eva-Maria Berens
- G Rowlands
- HLS-EU Consortium
- I Rootman
- K Hurrelmann
- K Sørensen
- K Sørensen
- K Sørensen
- KA Kaphingst
- Klaus Hurrelmann
- L Nolke
- LC Kobayashi
- LC Kobayashi
- M Kutner
- Melanie Messer
- ND Berkman
- ND Berkman
- RM Parker
- S Bostock
- S Schneider
- T Faltermaier
- TL Scott
- World Health Organization (WHO)
- Y Yilmaz-Aslan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Berens E-M, Vogt D, Messer M, Hurrelmann K, Schaeffer D. Health literacy among different age groups in Germany: results of a cross-sectional survey. In: BMC Public Health. Vol 16. Biomed Central; 2016.Background
Health literacy is of increasing importance in public health research. It is a necessary pre-condition for the involvement in decisions about health and health care and related to health outcomes. Knowledge about limited health literacy in different age groups is crucial to better target public health interventions for subgroups of the population. However, little is known about health literacy in Germany. The study therefore assesses the prevalence of limited health literacy and associated factors among different age groups.
Methods
The Health Literacy Survey Germany is a cross-sectional study with 2,000 participants aged 15 years or older in private households. Perceived health literacy was assessed via computer-assisted personal interviews using the HLS-EU-Q-47 questionnaire. Descriptive analyses, chi-square tests and odds ratios were performed stratified for different age groups.
Results
The population affected by limited perceived health literacy increases by age. Of the respondents aged 15–29 years, 47.3 % had limited perceived health literacy and 47.2 % of those aged 30–45 years, whereas 55.2 % of the respondents aged 46–64 years and 66.4 % aged 65 years and older showed limited perceived health literacy. In all age groups, limited perceived health literacy was associated with limited functional health literacy, low social status, and a high frequency of doctor visits.
Conclusions
The results suggest a need to further investigate perceived health literacy in all phases of the life-course. Particular attention should be devoted to persons with lower social status, limited functional health literacy and/or a high number of doctor visits in all age groups
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
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- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
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- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
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- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
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- Baker Jessica H.
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- Bass Nicholas
- Bass Nicholas
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- Young Hannah
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- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
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- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
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- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
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- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
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- Barbaro Antonio
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- Barka Sharf
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- Barsoum Fady
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- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
- Baziotis-Kalfas Kristian
- Beatson Nicholas
- Bei Michael
- Bektas Sebnem
- Bell David
- Benamor Oumayma
- Benek Duygu Ece
- Benham Emily
- Benismai Israa
- Bensalem Marya
- Bensalem Serien Hossain
- Benyani Simran Vinod
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- Bezweek Adel
- Bhikha Jainey
- Bindra Randipsingh
- Binnawara Muhannud
- Bird Katie
- Bisgin Tayfun
- Bitsianis Stefanos
- Blake Jessica
- Bland Laura
- Blassey Aneel
- Blundell Jian
- Bobba Sriya
- Bockxmeer John Van
- Bolam Scott Matthew
- Bolton Damien
- Bosi Simone
- Bouaoud Souad
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- Salem Mohammed
- Saliaris Konstantinos
- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
- Samalavicius Narimantas
- Sami Wesam
- Sammour Tarik
- Sampatha-Waduge Tharushi
- Sanad Aly
- Sandhu Jaspreet Kaur
- Sanguesa Maria Jose
- Sani Samuel Ali
- Sanli Ahmet Necati
- Sanz-Romera Jorge
- Sara Rachel
- Saraçoğlu Ayten
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- Sarangadasa Pavatharane
- Sarhan Osama
- Sarı Ahmet Can
- Sarih Monira
- Sarwar Albash
- Sathasivam Vinogi
- Sathiyaseelan Avinash
- Sawaftah Khaled
- Sayed Ahmed M
- Sayed Mohamed Al
- Sayed Yasmeen
- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
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- Segaran Sharrada
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- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
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- Shabaneh Amin
- Shafaat Amna
- Shagroun Esra
- Shah Jainil
- Shah Jainil
- Shahat Mohammed A
- Shaheen Nourhan
- Shahin Mahmoud
- Shalaby Mostafa
- Shalalfeh Sa'ed
- Shaltout Asmaa S
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- Wu Hongyi
- Wycliff Daniel
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- Xie Maria
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- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
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- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
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- Yeung Justin
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- Yi Kevin
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- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
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