Tratamiento del Síndrome del Túnel Carpiano con la Técnica del Retinaculotomo de PAINE

Los autores han realizado un estudio con 36 casos intervenidos quirúrgicamente en el Servicio de Neurocirugía del Hospital General de Especialidades "Virgen de las Nieves" de Granada, tanto a corto como a largo plazo, empleando la técnica quirúrgica de PAINE, basada en el instrumento por él diseñado, el retinaculotomo. Realizan un estudio de los resultados obtenidos, siendo totalmente satisfactorios en el 74% de los casos. Finalmente exponen las ventajas de esta técnica quirúrgica, así como, la práctica ausencia de complicaciones.36 Patients with Carpal Tunnel Syndrome are colected. All of them -were operated on by PAINE's Technique and Procedur e (Retinaculotome). The authors made a study of the results obtained, 74% of good results. Finally, they explain the advantage s of this surgical procedure, as well as, absence of complications

Identification of Homogeneous Groups of Actors in a Local AHP-Multiactor Context with a High Number of Decision-Makers: A Bayesian Stochastic Search

The identification of homogeneous groups of actors in a local AHP-multiactor context based on their preferences is an open problem, particularly when the number of decision-makers is high. To solve this problem in the case of using stochastic AHP, this paper proposes a new Bayesian stochastic search methodology for large-scale problems (number of decision-makers greater than 20). The new methodology, based on Bayesian tools for model comparison and selection, takes advantage of the individual preference structures distributions obtained from stochastic AHP to allow the identification of homogeneous groups of actors with a maximum common incompatibility threshold. The methodology offers a heuristic approach with several near-optimal partitions, calculated by the Occam’s window, that capture the uncertainty that is inherent when considering intangible aspects (AHP). This uncertainty is also reflected in the graphs that show the similarities of the decision-maker’s opinions and that can be used to achieve representative collective positions by constructing agreement paths in negotiation processes. If a small number of actors is considered, the proposed algorithm (AHP Bayesian clustering) significantly reduces the computational time of group identification with respect to an exhaustive search method. The methodology is illustrated by a real case of citizen participation based on e-Cognocracy. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Metasurface imaging with entangled photons

Plasmonics and metamaterials have recently been shown to allow the control and interaction with non-classical states of light, a rather counterintuitive finding given the high losses typically encountered in these systems. Here, we demonstrate a range of functionalities that are allowed with correlated and entangled photons that are used to illuminate multiple, overlaid patterns on plasmonic metasurfaces. Correlated photons allow to nonlocally determine the pattern that is imaged or, alternatively to un-scramble an image that is otherwise blurred. Entangled photons allow a more important functionality whereby the images imprinted on the metasurface are individually visible only when illuminated with one of the entangled photons. Correlated single photon imaging of functional metasurfaces could therefore promise advances towards the use of nanostructured subwavelength thin devices in quantum information protocols.Comment: 8 page

Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

[EN]Background/Aims: Animal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. The aims of this study were to develop an experimental TB infection model in sheep with a Mycobacterium caprae field strain isolated from a tuberculous diseased ewe, and to use this to evaluate the safety and efficacy of two vaccines against TB in sheep, the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. Methods: Eighteen 2 month-old lambs were experimentally challenged with M. caprae by the endotracheal route (1.5 × 103 CFU). They were separated per treatment group into parenterally vaccinated with a live BCG Danish strain vaccine (n = 6), orally vaccinated with a suspension of HIMB (n = 6) and unvaccinated controls (n = 6). Clinical, immunological, pathological and bacteriological parameters of infection were measured. Results: All lambs were successfully infected and developed gross TB lesions in the respiratory system. The BCG vaccine conferred considerable protection against experimental TB in lambs, as measured by a reduction of the gross lesion volumes and bacterial load. However, HIMB vaccinated animals did not show protection. Conclusions: This study proposes a reliable new experimental model for a better understanding of tuberculosis in sheep. BCG vaccination offers an effective prospect for controlling the disease. Moreover alternative doses and/or routes of administration should be considered to evaluate the efficacy of the HIMB vaccine candidate.SIWe are grateful to Albert Canturri (UAB), Maite Martín, Zoraida Cervera and the staff of the BSL-3 Unit of IRTA-CReSA for their technical support. We also thank Kevin P. Dalton for critically reviewing the manuscript. IRTA is supported by CERCA Programme / Generalitat de Catalunya

Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

Animal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. The aims of this study were to develop an experimental TB infection model in sheep with a Mycobacterium caprae field strain isolated from a tuberculous diseased ewe, and to use this to evaluate the safety and efficacy of two vaccines against TB in sheep, the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. Methods: Eighteen 2 month-old lambs were experimentally challenged with M. caprae by the endotracheal route (1.5 × 10 CFU). They were separated per treatment group into parenterally vaccinated with a live BCG Danish strain vaccine (n = 6), orally vaccinated with a suspension of HIMB (n = 6) and unvaccinated controls (n = 6). Clinical, immunological, pathological and bacteriological parameters of infection were measured. Results: All lambs were successfully infected and developed gross TB lesions in the respiratory system. The BCG vaccine conferred considerable protection against experimental TB in lambs, as measured by a reduction of the gross lesion volumes and bacterial load. However, HIMB vaccinated animals did not show protection. Conclusions: This study proposes a reliable new experimental model for a better understanding of tuberculosis in sheep. BCG vaccination offers an effective prospect for controlling the disease. Moreover alternative doses and/or routes of administration should be considered to evaluate the efficacy of the HIMB vaccine candidate

Clinical spectrum of STX1B-related epileptic disorders

OBJECTIVE: The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B, encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants. METHODS: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. To estimate the pathogenicity of the variants, we used established and newly developed in silico prediction tools. RESULTS: We describe 17 new variants in STX1B, which are distributed across the whole gene. We discerned 4 different phenotypic groups across the newly identified and previously published patients (49 patients in 23 families): (1) 6 sporadic patients or families (31 affected individuals) with febrile and afebrile seizures with a benign course, generally good drug response, normal development, and without permanent neurologic deficits; (2) 2 patients with genetic generalized epilepsy without febrile seizures and cognitive deficits; (3) 13 patients or families with intractable seizures, developmental regression after seizure onset and additional neuropsychiatric symptoms; (4) 2 patients with focal epilepsy. More often, we found loss-of-function mutations in benign syndromes, whereas missense variants in the SNARE motif of syntaxin-1B were associated with more severe phenotypes. CONCLUSION: These data expand the genetic and phenotypic spectrum of STX1B-related epilepsies to a diverse range of epilepsies that span the International League Against Epilepsy classification. Variants in STX1B are protean and contribute to many different epilepsy phenotypes, similar to SCN1A, the most important gene associated with fever-associated epilepsies

Clinical spectrum of STX1B-related epileptic disorders

Objective The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B, encoding the presynaptic protein syntaxin- 1B, and establish genotype-phenotype correlations by identifying further disease related variants. Methods We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. To estimate the pathogenicity of the variants, we used established and newly developed in silico prediction tools. Results We describe 17 new variants in STX1B, which are distributed across the whole gene. We discerned 4 different phenotypic groups across the newly identified and previously published patients (49 patients in 23 families): (1) 6 sporadic patients or families (31 affected individuals) with febrile and afebrile seizures with a benign course, generally good drug response, normal development, and without permanent neurologic deficits; (2) 2 patients with genetic generalized epilepsy without febrile seizures and cognitive deficits; (3) 13 patients or families with intractable seizures, developmental regression after seizure onset and additional neuropsychiatric symptoms; (4) 2 patients with focal epilepsy. More often, we found loss-of-function mutations in benign syndromes, whereas missense variants in the SNARE motif of syntaxin-1B were associated with more severe phenotypes. Conclusion These data expand the genetic and phenotypic spectrum of STX1B-related epilepsies to a diverse range of epilepsies that span the International League Against Epilepsy classification. Variants in STX1B are protean and contribute to many different epilepsy phenotypes, similar to SCN1A, the most important gene associated with fever-associated epilepsies