Virtual testing of advanced composites, cellular materials and biomaterials: A review

This paper documents the emergence of virtual testing frameworks for prediction of the constitutive responses of engineering materials. A detailed study is presented, of the philosophy underpinning virtual testing schemes: highlighting the structure, challenges and opportunities posed by a virtual testing strategy compared with traditional laboratory experiments. The virtual testing process has been discussed from atomistic to macrostructural length scales of analyses. Several implementations of virtual testing frameworks for diverse categories of materials are also presented, with particular emphasis on composites, cellular materials and biomaterials (collectively described as heterogeneous systems, in this context). The robustness of virtual frameworks for prediction of the constitutive behaviour of these materials is discussed. The paper also considers the current thinking on developing virtual laboratories in relation to availability of computational resources as well as the development of multi-scale material model algorithms. In conclusion, the paper highlights the challenges facing developments of future virtual testing frameworks. This review represents a comprehensive documentation of the state of knowledge on virtual testing from microscale to macroscale length scales for heterogeneous materials across constitutive responses from elastic to damage regimes

Efficient evaluation of the material response of tissues reinforced by statistically oriented fibres

For several classes of soft biological tissues, modelling complexity is in part due to the arrangement of the collagen fibres. In general, the arrangement of the fibres can be described by defining, at each point in the tissue, the structure tensor (i.e. the tensor product of the unit vector of the local fibre arrangement by itself) and a probability distribution of orientation. In this approach, assuming that the fibres do not interact with each other, the overall contribution of the collagen fibres to a given mechanical property of the tissue can be estimated by means of an averaging integral of the constitutive function describing the mechanical property at study over the set of all possible directions in space. Except for the particular case of fibre constitutive functions that are polynomial in the transversely isotropic invariants of the deformation, the averaging integral cannot be evaluated directly, in a single calculation because, in general, the integrand depends both on deformation and on fibre orientation in a non-separable way. The problem is thus, in a sense, analogous to that of solving the integral of a function of two variables, which cannot be split up into the product of two functions, each depending only on one of the variables. Although numerical schemes can be used to evaluate the integral at each deformation increment, this is computationally expensive. With the purpose of containing computational costs, this work proposes approximation methods that are based on the direct integrability of polynomial functions and that do not require the step-by-step evaluation of the averaging integrals. Three different methods are proposed: (a) a Taylor expansion of the fibre constitutive function in the transversely isotropic invariants of the deformation; (b) a Taylor expansion of the fibre constitutive function in the structure tensor; (c) for the case of a fibre constitutive function having a polynomial argument, an approximation in which the directional average of the constitutive function is replaced by the constitutive function evaluated at the directional average of the argument. Each of the proposed methods approximates the averaged constitutive function in such a way that it is multiplicatively decomposed into the product of a function of the deformation only and a function of the structure tensors only. In order to assess the accuracy of these methods, we evaluate the constitutive functions of the elastic potential and the Cauchy stress, for a biaxial test, under different conditions, i.e. different fibre distributions and different ratios of the nominal strains in the two directions. The results are then compared against those obtained for an averaging method available in the literature, as well as against the integration made at each increment of deformation

Shear-promoted drug encapsulation into red blood cells: a CFD model and μ-PIV analysis

The present work focuses on the main parameters that influence shear-promoted encapsulation of drugs into erythrocytes. A CFD model was built to investigate the fluid dynamics of a suspension of particles flowing in a commercial micro channel. Micro Particle Image Velocimetry (μ-PIV) allowed to take into account for the real properties of the red blood cell (RBC), thus having a deeper understanding of the process. Coupling these results with an analytical diffusion model, suitable working conditions were defined for different values of haematocrit

Mechanics of Materials

All up-to-date engineering applications of advanced multi-phase materials necessitate a concurrent design of materials (including composition, processing routes, microstructures and properties) with structural components. Simulation-based material design requires an intensive interaction of solid state physics, material physics and chemistry, mathematics and information technology. Since mechanics of materials fuses many of the above fields, there is a pressing need for well founded quantitative analytical and numerical approaches to predict microstructure-process-property relationships taking into account hierarchical stationary or evolving microstructures. Owing to this hierarchy of length and time scales, novel approaches for describing/ modelling non-equilibrium material evolution with various degrees of resolution are crucial to linking solid mechanics with realistic material behavior. For example, approaches such as atomistic to continuum transitions (scale coupling), multiresolution numerics, and handshaking algorithms that pass information to models with different degrees of freedom are highly relevant in this context. Many of the topics addressed were dealt with in depth in this workshop

Supramolecular assembly and mechanical properties of dermis

The present work is a part of a wider research project which aims at the in vitro tissues and biohybrid generation. The process of generating biological tissues requires benchmarks in order to define the optimal set of design and performance parameters for the tissue of interest. As a consequence of that, my efforts have been devoted to the study of natural tissue. In particular I have focused my attention to their composition, microstructure and macroscopic properties. The first part of the thesis reviews recent studies concerning the assembly and spatial arrangement of some biological macromolecules of interest, which compose the extracellular matrix. The extracellular matrix is indeed largely responsible for the macroscopic physical properties of connective tissues. Skin has been chosen as model of connective tissue to study. This choice is motivated by the fact that skin is a more general model rather then tendons, which are mainly subjected to uniaxal tension, and the osmosis-supported cartilage. An experimental campaign has been designed in order to gather information on dermal composition and structure, and how these characteristics can affect the macroscopic behaviour of the tissue. The results of this experimental campaign are shown in the second part of the work. At last two constitutive equations are presented. Both of them are developed within the framework of continuum mechanics. The first one is a full three dimensional model able to capture the elastic behaviour of dermis at large deformations. The second model is able to predict the viscoelastic behaviour. Both model accounts for the anisotropy of the native tissue and are structural model, since they contain parameters on the underlying histology. The development of these models provide noteworthy information on the performance of tissue-engineered constructs whose properties have been designed ab initio. In particular, since the mechanical properties of biohybrids can be on-line monitored during culturing in bioreactors. Thus constitutive models can provide cues on the evolution of the mechanical properties, giving the chance to investigate on the complex relationship between mechanical stimulus and tissue remodelling

Numerical modelling of additive manufacturing process for stainless steel tension testing samples

Nowadays additive manufacturing (AM) technologies including 3D printing grow rapidly and they are expected to replace conventional subtractive manufacturing technologies to some extents. During a selective laser melting (SLM) process as one of popular AM technologies for metals, large amount of heats is required to melt metal powders, and this leads to distortions and/or shrinkages of additively manufactured parts. It is useful to predict the 3D printed parts to control unwanted distortions and shrinkages before their 3D printing. This study develops a two-phase numerical modelling and simulation process of AM process for 17-4PH stainless steel and it considers the importance of post-processing and the need for calibration to achieve a high-quality printing at the end. By using this proposed AM modelling and simulation process, optimal process parameters, material properties, and topology can be obtained to ensure a part 3D printed successfully