Design criteria of a transcutaneous power delivery system for implantable devices.

Implantable cardiac assist devices such as artificial hearts and blood pumps are a rapidly growing therapy used for treating moderate to severe congestive heart failure. While current treatments offer improved heart failure survival and increased patient functionality with enhanced quality of life, powering these devices are still constraining. In practice, percutaneous cables passing through skin are used for power and control data transmission requiring patients to maintain a sterile dressing on the skin cable-exit site. This contact site limits patient movement as it is vulnerable to wound infection due to trauma and poor healing. As a result, a sterile dressing has to be maintained and nursed regularly for treating the wound. Complications from the exit site infections are a leading cause of death in long-term support with these devices. Wireless power and control transmission systems have been studied and developed over years in order to avoid percutaneous cables while supplying power efficiently to the implanted device. These power systems, commonly named Transcutaneous Energy Transfer (TET) systems, enable power transmission across the skin without direct electrical connectivity to the power source. TET systems use time-varying electromagnetic induction produced by a primary coil that is usually placed near skin outside the body. The induced voltage in an implanted secondary coil is then rectified and regulated to transfer energy to an implanted rechargeable battery in order to power the biomedical load device. Efficient and optimum energy transfer using such transcutaneous methods is more complex for mobile patients due to coupling discrepancies caused by variations in the alignment of the coil. The research studies equivalent maximum power transfer topologies for evaluating voltage gain and coupling link efficiency of TET system. Also, this research adds to previous efforts by generalizing different scenarios of misalignments of different coil size that affects the coupling link. As a whole, this study of geometric coil misalignments reconsiders potential anatomic location for coil placement to optimize TET systems performance in anticipated environment for efficient and safe operation.--Abstract

Applications of Wireless Power Transfer in Medicine : State-of-the-Art Reviews

Magnetic resonance within the field of wireless power transfer has seen an increase in popularity over the past decades. This rise can be attributed to the technological advances of electronics and the increased efficiency of popular battery technologies. The same principles of electromagnetic theory can be applied to the medical field. Several medical devices intended for use inside the body use batteries and electrical circuits that could be powered wirelessly. Other medical devices limit the mobility or make patients uncomfortable while in use. The fundamental theory of electromagnetics can improve the field by solving some of these problems. This survey paper summarizes the recent uses and discoveries of wireless power in the medical field. A comprehensive search for papers was conducted using engineering search engines and included papers from related conferences. During the initial search, 247 papers were found then non-relevant papers were eliminated to leave only suitable material. Seventeen relevant journal papers and/or conference papers were found, then separated into defined categories: Implants, Pumps, Ultrasound Imaging, and Gastrointestinal (GI) Endoscopy. The approach and methods for each paper were analyzed and compared yielding a comprehensive review of these state of the art technologies

Swallowable Wireless Capsule Endoscopy: Progress and Technical Challenges

Wireless capsule endoscopy (WCE) offers a feasible noninvasive way to detect the whole gastrointestinal (GI) tract and revolutionizes the diagnosis technology. However, compared with wired endoscopies, the limited working time, the low frame rate, and the low image resolution limit the wider application. The progress of this new technology is reviewed in this paper, and the evolution tendencies are analyzed to be high image resolution, high frame rate, and long working time. Unfortunately, the power supply of capsule endoscope (CE) is the bottleneck. Wireless power transmission (WPT) is the promising solution to this problem, but is also the technical challenge. Active CE is another tendency and will be the next geneion of the WCE. Nevertheless, it will not come true shortly, unless the practical locomotion mechanism of the active CE in GI tract is achieved. The locomotion mechanism is the other technical challenge, besides the challenge of WPT. The progress about the WPT and the active capsule technology is reviewed

Remote power delivery and signal amplification for MEMS applications

Device such as remotely located sensors and bio-implanted devices such as gastric pacer require power for operation. The most commonly used energy source for such devices is a battery cell included in the receiver capsule. Wires can also be used with an external power source but in some applications have serious limitations. This work examines a wireless power transmitter and receiver system to provide power to a remotely located microsystem. Inductive power coupling is the method of choice. For gastric pacer application, external transmitter coil can be worn around the waist as a belt and the receiver coil can be a part of a remotely located bio-implanted system. The coupling between transmitter and receiver coils when the diameters are markedly different is analyzed. A conventional rectifier circuit converts ac voltage to required dc voltage. This dc voltage supplies power to the charging chip, which is used to recharge lithium batteries in the implanted system. For an input supply voltage of 0.35 Vrms, the induced voltage in the receiver coil across the load resistor was 0.37 Vrms, when the receiver coil was placed at the center of the transmitter coil. When the receiver coil was placed close to the rim of the transmitter, the induced voltage across the load resistor for the same input supply voltage was 0.67 Vrms. Corresponding transmitted power to the load resistor of the receiver coil were 4 and 13.2 mW, respectively. Means are suggested to improve the power transfer to the receiver coil. The second objective of this thesis is to design an op-amp for on-chip amplification of sensor signals. On-chip detection and amplification are crucial for obtaining high sensitivity and improved signal to noise ratio. Designed op-amp is simulated using PSPICE with Level-3 MOS model parameters. The simulation results show a gain of 40.7 dB and a 3-dB bandwidth of 580 kHz. Experimental measurements made on the fabricated chip observed a gain of 3 and a 3-dB bandwidth of 1 MHz, which was attributed to differences in the values of simulated model parameters and the values appropriate for the fabrication process used by the foundry

Enhancing wireless power transfer efficiency for potential use in cardiovascular applications

Left Ventricular Assist Devices (LVAD) are being used to assist blood circulation in heart failure patients. The requirement to have a continuous energy supply is deteriorating the patients’ life quality since they need either to carry along two heavy battery packs or to attach a power cable. For this reason, a wireless power transmission (WPT) system is developed to power the LVAD. Within its effective charging region, the WPT system will offer an autonomous charging process which may lead to a smaller battery pack and cableless experience to the user. Previous WPT systems for cardiovascular applications are either compromised by poor transfer efficiency, short transmission distance or safety issues. To address these problems, an impedance matching WPT system is being designed. For increasing the overall transfer efficiency, both sides impedance matching technique and low loss matching networks are being worked on. In addition, efficiency specific design approach is being developed to reduce design complexity. As a result, the transfer efficiency and transmission distance of the impedance matched WPT have been increased by a factor of 7 and 6 times respectively. The conceptual idea for implementing such a system is also discussed in this thesis. Furthermore, safety measurements have been performed to ensure the system is safe to be used

Leveraging Aberrant Iron Metabolism as a Method for Selective Drug Delivery and Imaging In Vivo

Iron is a nutrient essential for cell growth and proliferation, however too high of a concentration can cause the formation of toxic reactive oxygen species. As a result, normal cells tightly regulate iron metabolism. Many cancers have been noted to possess aberrant expression of various proteins in the iron metabolism pathway, with a strong correlation between a higher avidity for iron and worse patient prognosis. Recently the Renslo lab has sought to leverage this elevated level of iron utilizing an Fe(II)-activated prodrug platform based on the reactivity of 1,2,4-trioxolanes (TRX). Previous studies have demonstrated selective delivery of amine-bearing cytotoxins to cancers with elevated Fe(II) pools. Here we report expanding this work in three ways: 1. Design of a therapeutic diagnostic PET probe to identify potential suitable cancers for this TRX-based approach. 2. Delivery of targeted anticancer therapeutics in order to gain an additional level of selectivity. 3. Expanding the TRX scaffold to accommodate hydroxamate-containing chemotherapeutics

Structure of a bacterial cell surface decaheme electron conduit

Some bacterial species are able to utilize extracellular mineral forms of iron and manganese as respiratory electron acceptors. In Shewanella oneidensis this involves decaheme cytochromes that are located on the bacterial cell surface at the termini of trans-outer-membrane electron transfer conduits. The cell surface cytochromes can potentially play multiple roles in mediating electron transfer directly to insoluble electron sinks, catalyzing electron exchange with flavin electron shuttles or participating in extracellular intercytochrome electron exchange along “nanowire” appendages. We present a 3.2-Å crystal structure of one of these decaheme cytochromes, MtrF, that allows the spatial organization of the 10 hemes to be visualized for the first time. The hemes are organized across four domains in a unique crossed conformation, in which a staggered 65-Å octaheme chain transects the length of the protein and is bisected by a planar 45-Å tetraheme chain that connects two extended Greek key split ß-barrel domains. The structure provides molecular insight into how reduction of insoluble substrate (e.g., minerals), soluble substrates (e.g., flavins), and cytochrome redox partners might be possible in tandem at different termini of a trifurcated electron transport chain on the cell surface

Analysis of a 115MW, 3 shaft, helium Brayton cycle

This research theme is originated from a development project that is going on in South Africa, for the design and construction of a closed cycle gas turbine plant using gas-cooled reactor as the heat source to generate 115 MW of electricity. South African Power utility company, Eskom, promotes this developmental work through its subsidiary called PBMR (Pebble Bed Modular Reactor). Some of the attractive features of this plant are the inherent and passive safety features, modular geometry, small evacuation area, small infrastructure requirements for the installation and running of the plant, small construction time, quick starting and stopping and also low operational cost. This exercise is looking at the operational aspects of a closed cycle gas turbine, the finding of which will have a direct input towards the successful development and commissioning of the plant. A thorough understanding of the fluid dynamics in this three-shaft system and its transient performance analysis were the two main objectives of this research work. A computer programme called GTSI, developed by a previous Cranfield University research student, has been used in this as a base programme for the performance analysis. Some modifications were done on this programme to improve its control abilities. The areas covered in the performance analysis are Start-up, Shutdown and Load ramping. A detailed literature survey has been conducted to learn from the helium Turbo machinery experiences, though it is very limited. A critical analysis on the design philosophy of the PBMR is also carried out as part of this research work. The performance analysis has shown the advantage, disadvantage and impact of various power modulation methods suggested for the PBMR. It has tracked the effect of the operations of the various valves included in the PBMR design. The start-up using a hot gas injection has been analysed in detail and a successful start region has been mapped. A start-up procedure is also written based on this. The analysis on the normal and emergency load rejection using various power modulation devices has been done and it stress the importance of more control facilities during full load rejection due to generator faults. A computational fluid dynamics (CFD) analysis, using commercial software, has been carried out on some geometry of the PBMR design to find out whether its flow characteristic will have any serious impact on the performance on the cycle during the load control of the plant. The analysis has demonstrated that there will not be much impact on the performance, during load control using pressure level changes, from this geometry. However, some locations in the geometry have been identified as areas where the flow is experiencing comparatively high pressure losses. Recommendations, which include modification in the physical design, were made to improve this. The CFD analysis has extended to a cascade to compare the flow behaviour of Air and Helium with an objective of using air, being inexpensive, to test the helium flow characteristic in a test rig to simulate the behavioural pattern of helium in the PBMR pressure vessel. The specification of a hypothetical test rig and the necessary scaling parameters has been derived from this exercise. This will be useful for designing test rigs during the developmental and operational stage of the PBMR project

Comet Science Working Group report on the Halley Intercept Mission

The Halley Intercept Mission is described and the scientific benefits expected from the program are defined. One characteristic of the mission is the optical navigation and resulting accurate delivery of the spacecraft to a desired point near the nucleus. This accuracy of delivery has two important implications: (1) high probability that the mass spectrometers and other in situ measurement devices will reach the cometary ionosphere and the zone of parent molecules next to the nucleus; (2) high probability that sunlit, high resolution images of Halley's nucleus will be obtained under proper lighting conditions. In addition an observatory phase is included during which high quality images of the tail and coma structure will be obtained at progressively higher spatial resolutions as the spacecraft approaches the comet. Complete measurements of the comet/solar wind interaction can be made around the time of encounter. Specific recommendations are made concerning project implementation and spacecraft requirements