EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial

Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial

IntroductionMore than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI.Methods and analysisEPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI.Ethics and disseminationEPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials.Trial registration numberNCT04165369

Antioxidant potential of extra virgin olive oils extracted from three different varieties cultivated in the Italian province of Reggio Calabria

In this study, the physicochemical properties and bioactive compounds of olive oils from cultivars “Roggianella”, “Sinopolese” and “Ottobratica”, grown in the province of Reggio Calabria (Italy) have been evaluated. Polyphenols are a large family of compounds found in fruits and vegetables, which exhibit strong antioxidant activity by scavenging different families of Reactive Oxygen Species (ROS). Dialdehydic form decarboxymethyl oleuropein aglycon, hydroxytyrosol acetate, dialdehydic form oleuropein aglycon, pinoresinol, 1-acetoxypinoresinol, tyrosol and vanillic acid were the main phenolic compounds in all samples analyzed. Pinoresinol was the most abundant compound in the lignin fraction. In all oil samples analyzed the highest antioxidant capacity was attributed to Roggianella oil (36.85% I of DPPH and 4.07% I of ABTS) compared to Ottobratica (27.37% I of DPPH and 2.52% I of ABTS) and Sinopolese (18.33% I of DPPH and 1.72% I of ABTS). The main characteristics of the Roggianella cultivar were a very high concentration of total phenols (530 mg/kg of gallic acid) and α-tocopherol (211 mg/kg)

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry : a meta-analysis

Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. Methods In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15126 cases and 95 725 controls of European ancestry. We identified common variants by fixed-effect inverse-variance meta-analysis. Significant genome-wide signals (p Findings We identified and replicated 13 new risk loci for restless legs syndrome and confirmed the previously identified six risk loci. MEIS1 was confirmed as the strongest genetic risk factor for restless legs syndrome (odds ratio 1.92, 95% CI 1 85-1.99). Gene prioritisation, enrichment, and genetic correlation analyses showed that identified pathways were related to neurodevelopment and highlighted genes linked to axon guidance (associated with SEMA6D), synapse formation (NTNG1), and neuronal specification (HOXB cluster family and MYT1). Interpretation Identification of new candidate genes and associated pathways will inform future functional research. Advances in understanding of the molecular mechanisms that underlie restless legs syndrome could lead to new treatment options. We focused on common variants; thus, additional studies are needed to dissect the roles of rare and structural variations.Peer reviewe

Modèles de coût pour la sélection de vues matérialisées dans le nuage, application aux services Amazon EC2 et S3

National audienceDans les bases et entrepôts de données, la performance des requêtes est classiquement assurée grâce à des structures comme les caches, les index et les vues matérialisées. Dans ce contexte, des modèles de coût permettent de sélectionner un ensemble efficace de ce type de structures. Toutefois, cette tâche de sélection devient plus complexe dans le nuage, car en plus des temps de réponse, il faut simultanément optimiser le coût monétaire d'utilisation du nuage. En conséquence, nous proposons dans cet article de nouveaux modèles de coût qui intègrent le paradigme de paiement à la demande en vigueur dans les nuages informatiques. Sur la base de ces modèles, nous définissons un problème d'optimisation consistant à sélectionner, parmi un ensemble de vues candidates, celles qu'il faut matérialiser pour minimiser le coût d'interrogation et de maintenance de la base de données, ainsi que le temps de réponse à une charge de requêtes donnée. Dans un premier temps, nous optimisons les deux critères précédents séparément: le temps de réponse est optimisé sous contrainte de coût et vice versa. Les expériences que nous avons menées pour valider cette proposition montrent que la matérialisation de vues dans le nuage est toujours avantageuse

Maria natare, montes transire: l’amore nei modelli epistolari latini del XII secolo

This paper focuses on the phenomenology of love in twelfth-century letter construction of a lexicon of love, and the initial development of the distinction between love letters and letters of friendship and of family ties. The love letters affect several areas: real love, physically more and more explicit, marriage, and literary (or courtly) love, akin to romance themes. On the other hand, the models convey the ecclesiastical law on sexual norms, showing the daily needs, the aspirations, and the conventions of a changing society, in all its rich complexity

The Theory and Phenomenology of Love

This second issue of Interfaces: A Journal fo Medieval European Literatures addresses the subject of "The Theory and Phenomenology of Love." It brings together readings of medieval representations and explanations of love as an affection, passion, sentiment, attraction, or tension, with work on the connections between literary discourses of love and the history both of emotions and gender roles. Approaching the subject of the nature of love, and the ways it manifests itself, the authors create links between scientific and poetic discourse and highlight the relationship between the experiences of love, described and treated in literary texts, and the specific historical, cultural, and social environments in which those texts were produced.Not only do the articles reach original results within their fields; taken as a whole, the dossier, ranging as it does from the Late Antiquity to the fifteenth century, and across a Europe situated within a wider Eurasian space, offers deep insights into social history, the history of emotions, and the study of gender and sexuality