EDMON - Electronic Disease Surveillance and Monitoring Network: A Personalized Health Model-based Digital Infectious Disease Detection Mechanism using Self-Recorded Data from People with Type 1 Diabetes

Through time, we as a society have been tested with infectious disease outbreaks of different magnitude, which often pose major public health challenges. To mitigate the challenges, research endeavors have been focused on early detection mechanisms through identifying potential data sources, mode of data collection and transmission, case and outbreak detection methods. Driven by the ubiquitous nature of smartphones and wearables, the current endeavor is targeted towards individualizing the surveillance effort through a personalized health model, where the case detection is realized by exploiting self-collected physiological data from wearables and smartphones. This dissertation aims to demonstrate the concept of a personalized health model as a case detector for outbreak detection by utilizing self-recorded data from people with type 1 diabetes. The results have shown that infection onset triggers substantial deviations, i.e. prolonged hyperglycemia regardless of higher insulin injections and fewer carbohydrate consumptions. Per the findings, key parameters such as blood glucose level, insulin, carbohydrate, and insulin-to-carbohydrate ratio are found to carry high discriminative power. A personalized health model devised based on a one-class classifier and unsupervised method using selected parameters achieved promising detection performance. Experimental results show the superior performance of the one-class classifier and, models such as one-class support vector machine, k-nearest neighbor and, k-means achieved better performance. Further, the result also revealed the effect of input parameters, data granularity, and sample sizes on model performances. The presented results have practical significance for understanding the effect of infection episodes amongst people with type 1 diabetes, and the potential of a personalized health model in outbreak detection settings. The added benefit of the personalized health model concept introduced in this dissertation lies in its usefulness beyond the surveillance purpose, i.e. to devise decision support tools and learning platforms for the patient to manage infection-induced crises

Modeling landscape dynamics and environmental association for spruce mortality

2016 Summer.Includes bibliographical references.This study addresses important issues related to mortality of spruce species (Picea sp.) associate with outbreaks of spruce beetle (Dendroctonus rufipennis Kirby) by 1) modeling large scale landscape dynamics of spruce mortality associated with long-term climate in Colorado and Alaska; 2) modeling environmental association between spruce mortality and small scale environmental covariates including climatic factors. In the first chapter, we review the ecology and etiology of spruce mortality in Colorado. In the second chapter, we evaluate landscape dynamics of spruce mortality at the regional scale of Colorado and Alaska. We used climate transition matrices (CTMs) as a method to assess the influence of climate on spruce forest extent and mortality. We quantify the probabilities of observing spruce forest, spruce mortality, and the mismatches between probabilities for the presence of host and mortality as indicated by differential effects. All values were calculated to populate elements of CTMs. The polynomial functions of ordinary regressive model and spatial autoregressive model were implemented to represent the association between climate zones and the responses. The results show us that there are influences of long-term precipitation and temperature on both probabilities. Presence of spruce forest in Colorado is associated with high precipitation at moderately low temperatures while probability of spruce mortality has a similar association. High probability of observing spruce forest in Alaska is associated with low to moderate precipitation while the probabilities of observing spruce mortality are positively associated with high precipitation at warmer temperatures. From the differential effects, there are mismatches of responses between host and mortality implying the advantageous of host associate with moderate temperatures and high precipitation in Colorado while healthy forest is found in the moderately low temperature and moderate precipitation in Alaska. In the third chapter, we describe associations between stand scale environmental conditions and spruce mortality. We modeled the association using zero-and-one inflated beta regression model based on hierarchical Bayesian framework. Two-stage Bernoulli logistic models were applied to indicate the occurrence of the extreme values represent presence and absence of mortality; continuous proportional responses were then addressed by beta regressive model. Multivariate Gaussian latent process was included in the function to express the exponential spatial errors term. The results indicate that spatial distribution of the occurrence and intensity of spruce mortality were both associated with the local stand covariates of temperature zone, precipitation zone, class of stand structure level, relative dominance class, and size class. The colder temperature zones have highly negative effects on both the probability of mortality occurrence and the probability of full mortality occurrence, while the warmer temperature zone is positively associated with the presence of full mortality. The results also indicate that stand characteristics are important factors associated with mortality. Mortality occurrence is positively associated with single-story stands with medium to large size classes. The higher-complexity stand structures have highly positive associations with the probability of entire stand mortality, while medium to high dominance classes have negative effects on full mortality. The largest size class and the highest dominance class have negative associations with the proportion of partial mortality

EXPLORING VOLUNTEERED GEOGRAPHIC INFORMATION WITH DATA QUALITY CONTROL FOR INTEGRATED PEST MANAGEMENT

Ph.DDOCTOR OF PHILOSOPH

Advances in crop insect modelling methods—Towards a whole system approach

A wide range of insects affect crop production and cause considerable yield losses. Difficulties reside on the development and adaptation of adequate strategies to predict insect pests for their timely management to ensure enhanced agricultural production. Several conceptual modelling frameworks have been proposed, and the choice of an approach depends largely on the objective of the model and the availability of data. This paper presents a summary of decades of advances in insect population dynamics, phenology models, distribution and risk mapping. Existing challenges on the modelling of insects are listed; followed by innovations in the field. New approaches include artificial neural networks, cellular automata (CA) coupled with fuzzy logic (FL), fractal, multi-fractal, percolation, synchronization and individual/agent based approaches. A concept for assessing climate change impacts and providing adaptation options for agricultural pest management independently of the United Nations Intergovernmental Panel on Climate Change (IPCC) emission scenarios is suggested. A framework for estimating losses and optimizing yields within crop production system is proposed and a summary on modelling the economic impact of pests control is presented. The assessment shows that the majority of known insect modelling approaches are not holistic; they only concentrate on a single component of the system, i.e. the pest, rather than the whole crop production system. We suggest system thinking as a possible approach for linking crop, pest, and environmental conditions to provide a more comprehensive assessment of agricultural crop production.Peer reviewe

FRONTIERS IN INVASIVE SPECIES DISTRIBUTION MODELING (iSDM): ASSESSING EFFECTS OF ABSENCE DATA, DISPERSAL CONSTRAINTS, STAGE OF INVASION AND SPATIAL DEPENDENCE

Successful management of biological invasions depends heavily on our ability to predict their geographic ranges and potential habitats. Species distribution modeling (SDM) provides a methodological framework to predict spatial distributions of organisms but the unique aspects of modeling invasive species have been largely ignored in previous applications. Here, three unresolved challenges facing invasive species distribution modeling (iSDM) were examined in an effort to increase prediction accuracy and improve ecological understanding of actual and potential distributions of biological invasions. The effects of absence data and dispersal constraints, stage of invasion, and spatial dependence were assessed, using an extensive collection of field-based data on the invasive forest pathogen Phytophthora ramorum. Spatial analyses were based on a range of statistical techniques (generalized linear models, classification trees, maximum entropy, ecological niche factor analysis, multicriteria evaluation) and four groups of environmental parameters that varied in space and time: atmospheric moisture and temperature, topographic variability, abundance and susceptibility of host vegetation, and dispersal pressure. Results show that incorporating data on species absence and dispersal limitations is crucial not only to avoid overpredictions of the actual invaded range in a specific period of time but also for ecologically meaningful evaluation of iSDMs. When dispersal and colonization cannot be estimated explicitly, e.g. via dispersal kernels of propagule pressure, spatial dependence measured as spatial autocorrelation at multiple scales can serve as an important surrogate for dynamic processes that explain ecological mechanisms of invasion. If the goal is to identify habitats at potential risk of future spread, the stage of invasion should be considered because it represents the degree to which an organism is at equilibrium with its environment and limits the extent to which occurrence observations provide a sample of the species ecological niche. This research provides insight into several key principles of the SDM discipline, with implications for practical management of biological invasions

The application of biomedical engineering techniques to the diagnosis and management of tropical diseases: A review

This paper reviews a number of biomedical engineering approaches to help aid in the detection and treatment of tropical diseases such as dengue, malaria, cholera, schistosomiasis, lymphatic filariasis, ebola, leprosy, leishmaniasis, and American trypanosomiasis (Chagas). Many different forms of non-invasive approaches such as ultrasound, echocardiography and electrocardiography, bioelectrical impedance, optical detection, simplified and rapid serological tests such as lab-on-chip and micro-/nano-fluidic platforms and medical support systems such as artificial intelligence clinical support systems are discussed. The paper also reviewed the novel clinical diagnosis and management systems using artificial intelligence and bioelectrical impedance techniques for dengue clinical applications

Evolution and challenges in the design of computational systems for triage assistance

AbstractCompared with expert systems for specific disease diagnosis, knowledge-based systems to assist decision making in triage usually try to cover a much wider domain but can use a smaller set of variables due to time restrictions, many of them subjective so that accurate models are difficult to build. In this paper, we first study criteria that most affect the performance of systems for triage assistance. Such criteria include whether principled approaches from machine learning can be used to increase accuracy and robustness and to represent uncertainty, whether data and model integration can be performed or whether temporal evolution can be modeled to implement retriage or represent medication responses. Following the most important criteria, we explore current systems and identify some missing features that, if added, may yield to more accurate triage systems

Large-Scale Modelling of the Environmentally-Driven Population Dynamics of Temperate Aedes albopictus (Skuse)

The Asian tiger mosquito, Aedes albopictus, is a highly invasive vector species. It is a proven vector of dengue and chikungunya viruses, with the potential to host a further 24 arboviruses. It has recently expanded its geographical range, threatening many countries in the Middle East, Mediterranean, Europe and North America. Here, we investigate the theoretical limitations of its range expansion by developing an environmentally-driven mathematical model of its population dynamics. We focus on the temperate strain of Ae. albopictus and compile a comprehensive literature-based database of physiological parameters. As a novel approach, we link its population dynamics to globally-available environmental datasets by performing inference on all parameters. We adopt a Bayesian approach using experimental data as prior knowledge and the surveillance dataset of Emilia-Romagna, Italy, as evidence. The model accounts for temperature, precipitation, human population density and photoperiod as the main environmental drivers, and, in addition, incorporates the mechanism of diapause and a simple breeding site model. The model demonstrates high predictive skill over the reference region and beyond, confirming most of the current reports of vector presence in Europe. One of the main hypotheses derived from the model is the survival of Ae. albopictus populations through harsh winter conditions. The model, constrained by the environmental datasets, requires that either diapausing eggs or adult vectors have increased cold resistance. The model also suggests that temperature and photoperiod control diapause initiation and termination differentially. We demonstrate that it is possible to account for unobserved properties and constraints, such as differences between laboratory and field conditions, to derive reliable inferences on the environmental dependence of Ae. albopictus populations

Climate-Triggered Drought as Causes for Different Degradation Types of Natural Forests: A Multitemporal Remote Sensing Analysis in NE Iran

Climate-triggered forest disturbances are increasing either by drought or by other climate extremes. Droughts can change the structure and function of forests in long-term or cause large-scale disturbances such as tree mortality, forest fires and insect outbreaks in short-term. Traditional approaches such as dendroclimatological surveys could retrieve the long-term responses of forest trees to drought conditions; however, they are restricted to individual trees or local forest stands. Therefore, multitemporal satellite-based approaches are progressing for holistic assessment of climate-induced forest responses from regional to global scales. However, little information exists on the efficiency of satellite data for analyzing the effects of droughts in different forest biomes and further studies on the analysis of approaches and large-scale disturbances of droughts are required. This research was accomplished for assessing satellite-derived physiological responses of the Caspian Hyrcanian broadleaves forests to climate-triggered droughts from regional to large scales in northeast Iran. The 16-day physiological anomalies of rangelands and forests were analysed using MODIS-derived indices concerning water content deficit and greenness loss, and their variations were spatially assessed with monthly and inter-seasonal precipitation anomalies from 2000 to 2016. Specifically, dimensions of forest droughts were evaluated in relations with the dimensions of meteorological and hydrological droughts. Large-scale effects of droughts were explored in terms of tree mortality, insect outbreaks, and forest fires using field observations, multitemporal Landsat and TerraClimate data. Various approaches were evaluated to explore forest responses to climate hazards such as traditional regression models, spatial autocorrelations, spatial regression models, and panel data models. Key findings revealed that rangelands’ anomalies did show positive responses to monthly and inter-seasonal precipitation anomalies. However, forests’ droughts were highly associated with increases in temperatures and evapotranspiration and were slightly associated with the decreases in precipitation and surface water level. The hazard intensity of droughts has affected the water content of forests higher than their greenness properties. The stages of moderate to extreme dieback of trees were significantly associated with the hazard intensity of the deficit of forests’ water content. However, the stage of severe defoliation was only associated with the hazard intensity of forests’ greenness loss. Climate hazards significantly triggered insect outbreaks and forest fires. Although maximum temperatures, precipitation deficit, availability of soil moisture and forest fires of the previous year could significantly trigger insect outbreaks, the maximum temperatures were the only significant triggers of forest fires from 2010‒2017. In addition to climate factors, environmental and anthropogenic factors could control fire severity during a dry season. The overall evaluation indicated the evidence of spatial associations between satellite-derived forest disturbances and climate hazards. Future studies are required to apply the approaches that could handle big-data, use the satellite data that have finer wavelengths for large-scale mapping of forest disturbances, and discriminate climate-induced forest disturbances from those that induced by other biotic and abiotic agents.Klimagbedingte Waldstörungen nehmen entweder durch Dürre oder durch andere Klimaextreme zu. Dürren können langfristig die Struktur und Funktion der Wälder verändern oder kurzfristig große Störungen wie Baumsterben, Waldbrände und Insektenausbrüche verursachen. Traditionelle Ansätze wie dendroklimatologische Untersuchungen könnten die langfristigen Reaktionen von Waldbäumen auf Dürrebedingungen aufzeigen, sie sind aber auf einzelne Bäume oder lokale Waldbestände beschränkt. Daher werden multitemporale satellitengestützte Ansätze zur ganzheitlichen Bewertung von klimabedingten Waldreaktionen auf regionaler bis globaler Ebene weiterentwickelt. Es gibt jedoch nur wenige Informationen über die Effizienz von Satellitendaten zur Analyse der Auswirkungen von Dürren in verschiedenen Waldbiotopen. Daher sind weitere Studien zur Analyse von Ansätzen und großräumigen Störungen von Dürren erforderlich. Diese Forschung wurde durchgeführt, um die aus Satellitendaten gewonnenen physiologischen Reaktionen der im Nordosten Irans gelegenen kaspischen hyrkanischen Laubwälder auf klimabedingte Dürren auf lokaler und regionaler Ebene zu bewerten. Auf der Grundlage der aus MODIS-Daten abgeleiteten Indizes wurden die 16-tägigen physiologischen Anomalien von Weideland und Wäldern in Bezug auf Wassergehaltsdefizit und Grünverlust analysiert und ihre Variationen räumlich mit monatlichen und intersaisonalen Niederschlagsanomalien von 2000 bis 2016 bewertet. Insbesondere wurden die Dimensionen der Walddürre in Verbindung mit den Dimensionen der meteorologischen und hydrologischen Dürre bewertet. Großräumige Auswirkungen von Dürren wurden in Bezug auf Baumsterblichkeit, Insektenausbrüche und Waldbrände mit Hilfe von Feldbeobachtungen, multitemporalen Landsat- und TerraClimate Daten untersucht. Verschiedene Ansätze wurden ausgewertet, um Waldreaktionen auf Klimagefahren wie traditionelle Regressionsmodelle, räumliche Autokorrelationen, räumliche Regressionsmodelle und Paneldatenmodelle zu untersuchen. Die wichtigsten Ergebnisse zeigten, dass die Anomalien von Weideland positive Reaktionen auf monatliche und intersaisonale Niederschlagsanomalien aufweisen. Die Dürren in den Wäldern waren jedoch in hohem Maße mit Temperaturerhöhungen und Evapotranspiration verbunden und standen in geringem Zusammenhang mit dem Rückgang von Niederschlägen und des Oberflächenwasserspiegels. Die Gefährdungsintensität von Dürren hat den Wassergehalt von Wäldern stärker beeinflusst als die Eigenschaften ihres Blattgrüns. Die Stufen mittlerer bis extremer Baumsterblichkeit waren signifikant mit der Gefährdungsintensität des Defizits des Wassergehalts der Wälder verbunden. Das Ausmaß der starken Entlaubung hing jedoch nur mit der Gefährdungsintensität des Grünverlustes der Wälder zusammen. Die Klimagefahren haben zu deutlichen Insektenausbrüchen und Waldbränden geführt. Obwohl Maximaltemperaturen, Niederschlagsdefizite, fehlende Bodenfeuchte und Waldbrände des Vorjahres deutlich Insektenausbrüche auslösen konnten, waren die Maximaltemperaturen die einzigen signifikanten Auslöser von Waldbränden von 2010 bis 2017. Neben den Klimafaktoren können auch umweltbedingte und anthropogene Faktoren den Schweregrad eines Brandes während einer Trockenzeit beeinflussen. Die Gesamtbewertung zeigt Hinweise auf räumliche Zusammenhänge zwischen aus Satellitendaten abgeleiteten Waldstörungen und Klimagefahren. Weitere Untersuchungen sind erforderlich, um Ansätze anzuwenden, die mit großen Datenmengen umgehen können, die Satellitendaten in einer hohen spektralen Auflösung für die großmaßstäbige Kartierung von Waldstörungen verwenden und die klimabedingte Waldstörungen von denen zu unterscheiden, die durch andere biotische und abiotische Faktoren verursacht werden

Women in Artificial intelligence (AI)

This Special Issue, entitled "Women in Artificial Intelligence" includes 17 papers from leading women scientists. The papers cover a broad scope of research areas within Artificial Intelligence, including machine learning, perception, reasoning or planning, among others. The papers have applications to relevant fields, such as human health, finance, or education. It is worth noting that the Issue includes three papers that deal with different aspects of gender bias in Artificial Intelligence. All the papers have a woman as the first author. We can proudly say that these women are from countries worldwide, such as France, Czech Republic, United Kingdom, Australia, Bangladesh, Yemen, Romania, India, Cuba, Bangladesh and Spain. In conclusion, apart from its intrinsic scientific value as a Special Issue, combining interesting research works, this Special Issue intends to increase the invisibility of women in AI, showing where they are, what they do, and how they contribute to developments in Artificial Intelligence from their different places, positions, research branches and application fields. We planned to issue this book on the on Ada Lovelace Day (11/10/2022), a date internationally dedicated to the first computer programmer, a woman who had to fight the gender difficulties of her times, in the XIX century. We also thank the publisher for making this possible, thus allowing for this book to become a part of the international activities dedicated to celebrating the value of women in ICT all over the world. With this book, we want to pay homage to all the women that contributed over the years to the field of AI