80 research outputs found
INVESTIGATION OF C1Q AND C1S IN CHRONIC INFLAMMATION AND AUTOIMMUNITY
Ph.DDOCTOR OF PHILOSOPH
Immunomics in Pediatric Rheumatic Diseases
The inherent complexity in the immune landscape of pediatric rheumatic disease necessitates a holistic system approach. Uncertainty in the mechanistic workings and etiological driving forces presents difficulty in personalized treatments. The development and progression of immunomics are well suited to deal with this complexity. Immunomics encompasses a spectrum of biological processes that entail genomics, transcriptomics, epigenomics, proteomics, and cytomics. In this review, we will discuss how various high dimensional technologies in immunomics have helped to grow a wealth of data that provide salient clues and biological insights into the pathogenesis of autoimmunity. Interfaced with critical unresolved clinical questions and unmet medical needs, these platforms have helped to identify candidate immune targets, refine patient stratification, and understand treatment response or resistance. Yet the unprecedented growth in data has presented both opportunities and challenges. Researchers are now facing huge heterogeneous data sets from different origins that need to be integrated and exploited for further data mining. We believe that the utilization and integration of these platforms will help unravel the complexities and expedite both discovery and validation of clinical targets
Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool For Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis
Objective: Juvenile dermatomyositis (DM) is a heterogeneous systemic immune-mediated vasculopathy. This study was undertaken to 1) identify inflammation/endothelial dysfunction–related biomarker profiles reflecting disease severity at diagnosis, and 2) establish whether such biomarker profiles could be used for predicting the response to treatment in patients with juvenile DM. Methods: In total, 39 biomarkers related to activation of endothelial
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19
Measurements of the branching fractions for decays at Belle II
This paper reports a study of decays using
fb of data collected during 2019--2020 by the Belle II experiment at the
SuperKEKB asymmetric-energy collider, corresponding to events. We find , ,
, and signal events in the decay modes , ,
, and , respectively. The uncertainties quoted for the
signal yield are statistical only. We report the branching fractions of these
decays: where the first
uncertainty is statistical, and the second is systematic. The results are
consistent with world-average values
Measurement of the branching fraction for the decay at Belle II
We report a measurement of the branching fraction of decays, where or
, using electron-positron collisions recorded at an energy at or near
the mass and corresponding to an integrated luminosity of
fb. The data was collected during 2019--2021 by the Belle II experiment
at the SuperKEKB asymmetric-energy collider. We reconstruct
candidates in the , , and
final states. The signal yields with statistical uncertainties are ,
, and for the decays , , and , respectively.
We measure the branching fractions of these decays for the entire range of the
dilepton mass, excluding the very low mass region to suppress the background and regions compatible with decays
of charmonium resonances, to be \begin{equation} {\cal B}(B \to
K^{\ast}(892)\mu^+\mu^-) = (1.19 \pm 0.31 ^{+0.08}_{-0.07}) \times 10^{-6},
{\cal B}(B \to K^{\ast}(892)e^+e^-) = (1.42 \pm 0.48 \pm 0.09)\times 10^{-6},
{\cal B}(B \to K^{\ast}(892)\ell^+\ell^-) = (1.25 \pm 0.30 ^{+0.08}_{-0.07})
\times 10^{-6}, \end{equation} where the first and second uncertainties are
statistical and systematic, respectively. These results, limited by sample
size, are the first measurements of branching
fractions from the Belle II experiment
The Belle II Physics Book
We present the physics program of the Belle II experiment, located on the
intensity frontier SuperKEKB collider. Belle II collected its first
collisions in 2018, and is expected to operate for the next decade. It is
anticipated to collect 50/ab of collision data over its lifetime. This book is
the outcome of a joint effort of Belle II collaborators and theorists through
the Belle II theory interface platform (B2TiP), an effort that commenced in
2014. The aim of B2TiP was to elucidate the potential impacts of the Belle II
program, which includes a wide scope of physics topics: B physics, charm, tau,
quarkonium, electroweak precision measurements and dark sector searches. It is
composed of nine working groups (WGs), which are coordinated by teams of
theorist and experimentalists conveners: Semileptonic and leptonic B decays,
Radiative and Electroweak penguins, phi_1 and phi_2 (time-dependent CP
violation) measurements, phi_3 measurements, Charmless hadronic B decay, Charm,
Quarkonium(like), tau and low-multiplicity processes, new physics and global
fit analyses. This book highlights "golden- and silver-channels", i.e. those
that would have the highest potential impact in the field. Theorists
scrutinised the role of those measurements and estimated the respective
theoretical uncertainties, achievable now as well as prospects for the future.
Experimentalists investigated the expected improvements with the large dataset
expected from Belle II, taking into account improved performance from the
upgraded detector.Comment: 689 page
- …