Conversations About Race and Perceptions of Racial Discrimination Among Emerging Adults

Conversations About Race and Perceptions of Racial Discrimination Among Emerging Adults Alanna Cason, Depts. of Psychology and Criminal Justice, Angel Whitfield, Maria Cisneros, Dept. of Psychology Graduate Student, Arlenis Santana, Dept. of Psychology Graduate Student, & Eryn DeLaney, Dept. of Psychology Graduate Student, with Dr. Chelsea D. Williams, Dr. Tricia Smith, Dr. Amy Adkins, and Dr. Danielle Dick College students of color have positive race-related experiences (e.g.., positive conversations), as well as negative race-related experiences (e.g., racial discrimination and negative experiences about race; Spencer 2006). Limited work has focused on conversations students have about race, although the U.S. has become more diverse especially in college settings (Martinez-Acosta & Favero, 2018). To address these gaps, the current study focused on bidirectional relations between students’ conversations about race and how they are related to discrimination experiences among 95 college-age students of color. We hypothesized that (1) more negative conversations about race (and less positive conversations) would increase students’ perceptions of racial discrimination, and (2) the more students experienced discrimination, they would have more negative conversations (less positive conversations) about race. Two linear regression analyses were conducted. The first analysis indicated that negative conversations about race (B = .38, phttps://scholarscompass.vcu.edu/uresposters/1303/thumbnail.jp

Vicarious Trauma Exposure and Its Effects on Mental Health among Adolescents and Adults: A Narrative Research Review

Vicarious Trauma Exposure and Its Effects on Mental Health among Adolescents and Adults: A Narrative Research Review Harris Davis, Dept. of Psychology, Angel Whitfield, Sydney Judge, Bailee Beverly, Jenna Minter, Harrison Davis, and Eryn DeLaney and Chloe Walker, Dept. of Psychology Graduate Students, with Dr. Chelsea Williams, Dept. of Psychology A narrative research review was conducted to examine studies that have tested the relation between vicarious trauma (i.e., witnessing abuse of others; Trautmann, S., Reineboth, M., Trikojat, K., Richter, J., Hagenaars, M. A., Kanske, P., & Schäfer, J. (2018). and mental health in adolescents and young adults. Using psycinfo to find research conducted to date, this review indicated that there are various types of trauma that adolescents might be exposed to (e.g., domestic abuse, emotional abuse, and physical abuse) and various forms of mental health issues (e.g., post traumatic stress disorder, depression, and anxiety) that might result from such trauma. (Erolin, K. S., Wieling, E., & Parra, R. E. A. (2014)., , Stowkowy, J., Goldstein, B. I., MacQueen, G., Wang, J., Kennedy, S. H., Bray, S., Lebel, C., & Addington, J. (2020). Findings from this review also suggest that there is a relation between varying types of traumatic exposure and several types of depressive symptoms (Monfort, E., Afzali M. H. (2015), Merza, K., Papp, G., & Szabó, I. K. (2015) and that there are more studies on adults than on adolescents. These effects will be discussed. Gaps in the literature will be referenced and potential future research directions will be acknowledged. In conclusion, this narrative research review emphasizes the importance of knowing the effects of vicarious trauma on adolescents and adults for preventative purposes.https://scholarscompass.vcu.edu/uresposters/1336/thumbnail.jp

New Oldowan locality Sare-Abururu (ca. 1.7 Ma) provides evidence of diverse hominin behaviors on the Homa Peninsula, Kenya

The Homa Peninsula, in southwestern Kenya, continues to yield insights into Oldowan hominin landscape behaviors. The Late Pliocene locality of Nyayanga (∼3–2.6 Ma) preserves some of the oldest Oldowan tools. At the Early Pleistocene locality of Kanjera South (∼2 Ma) toolmakers procured a diversity of raw materials from over 10 km away and strategically reduced them in a grassland-dominated ecosystem. Here, we report findings from Sare-Abururu, a younger (∼1.7 Ma) Oldowan locality approximately 12 km southeast of Kanjera South and 18 km east of Nyayanga. Sare-Abururu has yielded 1754 artifacts in relatively undisturbed low-energy silts and sands. Stable isotopic analysis of pedogenic carbonates suggests that hominin activities were carried out in a grassland-dominated setting with similar vegetation structure as documented at Kanjera South. The composition of a nearby paleo-conglomerate indicates that high-quality stone raw materials were locally abundant. Toolmakers at Sare-Abururu produced angular fragments from quartz pebbles, representing a considerable contrast to the strategies used to reduce high quality raw materials at Kanjera South. Although lithic reduction at Sare-Abururu was technologically simple, toolmakers proficiently produced cutting edges, made few mistakes and exhibited a mastery of platform management, demonstrating that expedient technical strategies do not necessarily indicate a lack of skill or suitable raw materials. Lithic procurement and reduction patterns on the Homa Peninsula appear to reflect variation in local resource contexts rather than large-scale evolutionary changes in mobility, energy budget, or toolmaker cognition

Biological Convergence of Cancer Signatures

Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular associations were identified with the immune response in different cancer types and conditions that complement the contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis

Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription factor c-Jun are important regulators of this cell death program in post-mitotic neurons following survival-factor withdrawal. Our study demonstrates that ceramide levels increase upon survival-factor withdrawal in primary cultured cortical neurons. Furthermore, survival-factor withdrawal or addition of exogenous c2-ceramide induces JNK pathway activation in these cells. Western blot analyses of JNK and c-Jun using phospho-specific antibodies reveal that JNK and subsequent c-Jun phosphorylation occur hours before the initiation of apoptosis, reflected morphologically by neurite retraction and fragmentation, cell-body shrinkage and chromatin fragmentation. Immunocytochemistry using the same antibodies shows that phospho-JNK are localized in the neurites of control neurons and translocate to the nucleus where phospho-c-Jun concurrently appears upon ceramide-induced apoptosis. To determine if ceramide-induced c-Jun activation is responsible for the induction of the apoptotic program, we performed transient transfections of a dominant negative form of c-Jun, truncated in its transactivation region. Our results show that DNc-Jun partially protects cortical neurons from ceramide-induced apoptosis. Treatment of dominant negative c-Jun-expressing neurons with the pharmacological inhibitor of p38 kinase, SB203580, completely blocked neuronal death. Thus our data show that p38 and JNK/c-Jun pathways cooperate to induce neuronal apoptosis