Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex

One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and differentiation of gastric epithelial cells. In Helicobacter pylori infected patients, gastrin secretion can be upregulated by the pathogen, resulting in hypergastrinaemia. H pylori induced hypergastrinaemia is described as being a major risk factor for the development of gastric adenocarcinoma

Offline time is quality time: comparing within-group self-disclosure in mobile messaging applications and face-to-face interactions

In contrast to the prominent individualistic view on self-disclosure, this study focuses on self-disclosure in groups of prior acquaintances that both meet offline and communicate online. It compares within-group self-disclosure between offline face-to-face (FtF) interactions and online communication via mobile messaging applications (MMAs). An online-survey (N = 357) was conducted to test for differences between within-group self-disclosure online and offline across four dimensions (amount, depth, breadth, valence). The results show that there is more amount, more breadth and more depth for offline within-group self-disclosure, but it is less positively valenced than online within-group self-disclosure. Interestingly, the mere frequency of communication is higher in an MMA environment. In spite of the permanent availability of the online communication sphere, group members do not permanently disclose personal information to each other online. Thus, for within-group self-disclosure, offline time seems quality time

Supporting data for "Helicobacter pylori induces short term trained immunity in monocytes via accumulation of NF-кB proteins"

<p>This data repository contains several datasets supplementing the paper "Helicobacter pylori induces short term trained immunity in monocytes via accumulation of NF-кB proteins" by Frauenlob et al. (2023)</p&gt

Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections

Despite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity. A promising strategy to treat such infections is to target these toxins and not the bacteria. Although the exoenzymes produced by B. cereus are thoroughly investigated, little is known about the role of B. cereus collagenases in wound infections. In this report, the collagenolytic activity of secreted collagenases (Col) is characterized in the B. cereus culture supernatant (csn) and its isolated recombinantly produced ColQ1 is characterized. The data reveals that ColQ1 causes damage on dermal collagen (COL). This results in gaps in the tissue, which might facilitate the spread of bacteria. The importance of B. cereus collagenases is also demonstrated in disease promotion using two inhibitors. Compound 2 shows high efficacy in peptidolytic, gelatinolytic, and COL degradation assays. It also preserves the fibrillar COLs in skin tissue challenged with ColQ1, as well as the viability of skin cells treated with B. cereus csn. A Galleria mellonella model highlights the significance of collagenase inhibition in vivo