Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle

Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific binding proteins to instigate pro-inflammatory response. Some of these DNA binding proteins also participate in canonical DNA repair pathways and recognise damaged DNA to initiate DNA damage response. In this review we aim to capture the essence of the complex interplay between DNA damage response and the pro-inflammatory signalling through representative examples

Gaze-grasp coordination in obstacle avoidance: differences between binocular and monocular viewing

Most adults can skillfully avoid potential obstacles when acting in everyday cluttered scenes. We examined how gaze and hand movements are normally coordinated for obstacle avoidance and whether these are altered when binocular depth information is unavailable. Visual fixations and hand movement kinematics were simultaneously recorded, while 13 right-handed subjects reached-to-precision grasp a cylindrical household object presented alone or with a potential obstacle (wine glass) located to its left (thumb's grasp side), right or just behind it (both closer to the finger's grasp side) using binocular or monocular vision. Gaze and hand movement strategies differed significantly by view and obstacle location. With binocular vision, initial fixations were near the target's centre of mass (COM) around the time of hand movement onset, but usually shifted to end just above the thumb's grasp site at initial object contact, this mainly being made by the thumb, consistent with selecting this digit for guiding the grasp. This strategy was associated with faster binocular hand movements and improved end-point grip precision across all trials than with monocular viewing, during which subjects usually continued to fixate the target closer to its COM despite a similar prevalence of thumb-first contacts. While subjects looked directly at the obstacle at each location on a minority of trials and their overall fixations on the target were somewhat biased towards the grasp side nearest to it, these gaze behaviours were particularly marked on monocular vision-obstacle behind trials which also commonly ended in finger-first contact. Subjects avoided colliding with the wine glass under both views when on the right (finger side) of the workspace by producing slower and straighter reaches, with this and the behind obstacle location also resulting in 'safer' (i.e. narrower) peak grip apertures and longer deceleration times than when the goal object was alone or the obstacle was on its thumb side. But monocular reach paths were more variable and deceleration times were selectively prolonged on finger-side and behind obstacle trials, with this latter condition further resulting in selectively increased grip closure times and corrections. Binocular vision thus provided added advantages for collision avoidance, known to require intact dorsal cortical stream processing mechanisms, particularly when the target of the grasp and potential obstacle to it were fairly closely separated in depth. Different accounts of the altered monocular gaze behaviour converged on the conclusion that additional perceptual and/or attentional resources are likely engaged compared to when continuous binocular depth information is available. Implications for people lacking binocular stereopsis are briefly considered

Constructing a national higher education brand for the UK: positional competition and promised capitals

This article examines national branding of UK higher education, a strategic intent and action to collectively brand UK higher education with the aim to attract prospective international students, using a Bourdieusian approach to understanding promises of capitals. We trace its development between 1999 and 2014 through a sociological study, one of the first of its kind, from the 'Education UK' and subsumed under the broader 'Britain is GREAT' campaign of the Coalition Government. The findings reveal how a national higher education brand is construed by connecting particular representations of the nation with those of prospective international students and the higher education sector, which combine in the brand with promises of capitals to convert into positional advantage in a competitive environment. The conceptual framework proposed here seeks to connect national higher education branding to the concept of the competitive state, branded as a nation and committed to the knowledge economy

Belgrade vs. Serbia: Spatial re-configurations of belonging

This article explores the relationship between the nation, the city, narratives, and belonging in Serbia through an analysis of narratives of a set of 30 interviews with young Belgrade intellectuals aged 23-35. I argue that what appears to be emerging in post-Milosevic Serbia is a new articulation and a new scale of belonging. Most of my informants are mobilising their city identities, moving from a national to an urban perspective. They imaginatively defend their city identity through a discourse that, others' its newcomers, i.e. the rural residents. However, the article is critical of their articulated dichotomous rhetoric of 'Us, the City Cosmopolitans' vs. I Them, the Rural Nationalists' My overall aim is to offer an analysis of the Serbian case, where one sees that the city of Belgrade has become a microcosm and a symbolic expression for modernity, resistance, openness and democracy. However, instead of seeing urbanity as the only locus of modernity, one needs to understand that urbanity does not one-dimensionally lead to the urbanisation of the mind, implying that once you have cities, or live in a city, there is a specific urban, cosmopolitan experience

Mapping civil society in former Yugoslavia

From the break up of the New Left into single issue groups at the end of the 1960s came a variety of groups representing the peace movement, environmental movement, student movement, women’s movement, and gay liberation movement. This explosion of new social movement activism has been heralded as the age of new radical politics. Many theorists and activists understand new social movements, as replacing the working class as an agent for progressive social change. Scholars and activists now alike debate the possibilities for revolutionary change in this era of multinational capitalism and new nationalisms. This paper examines some of the above claims in the context of the contemporary Serbian civil society. It explores the relationship between the civil society, activism, and narratives in Serbia. In particular, it examines the anti-Milosevic’ movement Otpor! (Resistance), and its discourse, practice and politics in public spaces, through an analysis of narratives of a set of roughly 20 interviews with Otpor! activists, aged 18-35. In the following discussion, then, I will focus on some of the particular dilemmas of contemporary Serbian popular movements - they are dilemmas to do with the growing complexity of media life in the Serbian spaces. I ground my debate on particular uses of the notion of civil society in the narratives of Otpor! activists, while I focus on the question of how do Otpor! activists relate to Leftist/radical politics and the idea of civil society

Yugo-nostalgia: Cultural memory and media in the former Yugoslavia

Media and other cultural practices are being mobilized in former-Yugoslav communities in an attempt to re-create a shared cultural memory. Yugo-nostalgia paradoxically harkens back to a shared cultural history, even as it provides the raw material for new forms of national identities that continue to divide the former-Yugoslav republics