Factores relacionados a la adherencia del sulfato ferroso en gestante del Centro de Salud Monterrey, Huaraz 2022

Anemia represents a serious public health problem for the country and the world. The purpose of this study was to determine the factors related to adherence to ferrous sulfate in pregnant women. Basic research, non-experimental design; conducted in 83 pregnant women who attended prenatal care at the Monterrey-Huaraz-Ancash-Peru Health Center, the data were collected with a questionnaire that evaluates the socioeconomic factors, therapeutic factors, obstetric factors and health services factors related to adherence to ferrous sulfate in pregnant women. The analysis was performed using the SPSSV26 program, and the Chi-square test was applied to contrast the hypothesis. The results indicated that low adherence to ferrous sulfate is related to sociodemographic factors such as age between 25 and 29 years (21.7%), high school education (27.7%), housewives (51.8%), cohabitants (47%), rural origin (36.1%). The therapeutic factors were: 31.3% of the pregnant women received supplementation from 1 to 3 months; they presented (24.1%) nausea and constipation when taking ferrous sulfate as a side effect; in relation to the obstetric factors, pregnant women with less than 6 prenatal visits (42.7%); in relation to the obstetric factors, pregnant women with less than 6 prenatal visits (42.7%); in relation to the therapeutic factors, pregnant women with less than 3 months of prenatal visits presented (24.7%) nausea and constipation when taking ferrous sulfate. 7%); in relation to the health service factors, the delivery of ferrous sulfate was timely (54.2%) with the complete dose (53.0%) and they received counseling on the importance and benefits of ferrous sulfate consumption (54.2%), however, they had low adherence to ferrous sulfate, with a confidence level of 95%.It is concluded that there are sociodemographic factors, therapeutic factors, obstetric factors and health service factors related to low adherence to ferrous sulfateLa anemia representa un grave problema de salud pública para el país y el mundo. El propósito del presente estudio fue determinar los factores relacionados a la adherencia del sulfato ferroso en gestantes. Investigación básica, de diseño no experimental; realizado en 83 gestantes que asistieron a la atención prenatal en el Centro de Salud de Monterrey-Huaraz- Ancash- Perú, los datos fueron recolectados con un cuestionario que evalúa los factores socioeconómicos, factores terapéuticos, factores obstétricos y los factores de servicios de salud relacionados a la adherencia del sulfato ferroso en gestantes. El análisis se realizó mediante el programa SPSSV26, se aplicó la prueba Chi Cuadrado para contrastar la hipótesis. Los Resultados indicaron que la baja adherencia del sulfato ferroso están relacionados con los factores sociodemográficos como la edad entre 25 a 29 años (21.7 %), grado de instrucción secundaria (27.7%), amas de casa (51.8%), convivientes (47%), procedencia zona rural (36.1%); asimismo los factores terapéuticos fueron: El (31.3 %) de las gestantes recibieron suplementación de 1 a 3 meses; presentaron (24.1%)  náuseas y estreñimiento al tomar el sulfato ferroso como efecto secundario, en relación a los  factores obstétricos gestantes  con menos  de 6 atenciones  prenatales (42.7%); en relación a los factores de servicio de salud la entrega del sulfato ferroso fue oportuna (54.2%) con  la dosis completa (53.0%) y recibieron consejería sobre la importancia y beneficios del consumo de sulfato ferroso (54.2%), sin embargo tuvieron baja adherencia al sulfato ferroso, con un nivel de confianza de 95%. Se concluye que existen factores sociodemográficos, factores terapéuticos, factores obstétricos y factores de servicios de salud relacionados a la baja adherencia del sulfato ferros

The Grizzly, May 5, 1999

Spring Fling Success • Students Compete in First-Ever Ursinus Drag Competition • Student Speakers Selected • Commencement Program Announced • Mr. Ursinus: Anthony Petrino • Graduation Events Slated: Five Honorary Degrees to be Delivered at Graduation; Baccalaureate Speaker Announced • Let\u27s Throw Some Shoes! • Final Exam Schedule • Ursinus Lacrosse, Baseball Take Centennial Conference by Storm • UC Baseball Dominated the Centennial Conference Behind Great Pitching Performances by Wiatrak and Goldwater • Softball Falls Short of Top Shot • Newmaster Wins Pitcher of the Year • Adegunwa, O\u27Hara Dominate at CC Champs • Best Wishes to Spring Sports Seniorshttps://digitalcommons.ursinus.edu/grizzlynews/1443/thumbnail.jp

Land-use dynamics influence estimates of carbon sequestration potential in tropical second-growth forest

Many countries have made major commitments to carbon sequestration through reforestation under the Paris Climate Agreement, and recent studies have illustrated the potential for large amounts of carbon sequestration in tropical second-growth forests. However, carbon gains in second-growth forests are threatened by non-permanence, i.e. release of carbon into the atmosphere from clearing or disturbance. The benefits of second-growth forests require long-term persistence on the landscape, but estimates of carbon potential rarely consider the spatio-temporal landscape dynamics of second-growth forests. In this study, we used remotely sensed imagery from a landscape in the Peruvian Amazon to examine patterns of second-growth forest regrowth and permanence over 28 years (1985–2013). By 2013, 44% of all forest cover in the study area was second growth and more than 50% of second-growth forest pixels were less than 5 years old. We modeled probabilities of forest regrowth and clearing as a function of landscape factors. The amount of neighboring forest and variables related to pixel position (i.e. distance to edge) were important for predicting both clearing and regrowth. Forest age was the strongest predictor of clearing probability and suggests a threshold response of clearing probability to age. Finally, we simulated future trajectories of carbon sequestration using the parameters from our models. We compared this with the amount of biomass that would accumulate under the assumption of second-growth permanence. Estimates differed by 900 000 tonnes, equivalent to over 80% of Peru's commitment to carbon sequestration through 'community reforestation' under the Paris Agreement. Though the study area has more than 40 000 hectares of second-growth forest, only a small proportion is likely to accumulate significant carbon. Instead, cycles between forest and non-forest are common. Our results illustrate the importance of considering landscape dynamics when assessing the carbon sequestration potential of second-growth forests

Evaluation of canine leishmaniosis vaccine CaniLeish® under field conditions in native dog populations from an endemic Mediterranean area - a randomized controlled trial.

Dog vaccination is considered an effective way of reducing Leishmania infantum infection incidence in the canine population, as well as its transmission to humans. However, the use of partially effective vaccines can have the detrimental effect of 'masking' vaccinated asymptomatic carriers, capable of harbouring the parasite and transmitting it to naïve individuals. After eight years on the European market, few studies have been released on CaniLeish® vaccine safety and efficacy. The present study, a one-year randomized CaniLeish® vaccine field trial, was performed in a canine leishmaniosis endemic area and included animals selected from a native dog population (n=168). No severe adverse reactions were observed in vaccinated dogs (n=85). Cases of active L. infantum infection were detected by serological, molecular and clinical follow-up of dogs. One-year post-vaccination, no differences in number or severity of L. infantum active infections were observed between study groups (n=4 in each group). Vaccine-induced cellular immunity, assessed through interferon-γ quantification, showed significantly higher levels of this cytokine one-month post-vaccination in the vaccine group (p<0.001), but no differences were observed after nine months between trial groups (p=0.078). These results fail to support the reported CaniLeish® efficacy in the prevention of active L. infantum infection in dogs from endemic areas and naturally exposed to the parasite

Resettlement experiences and resilience in refugee youth in Perth, Western Australia

Background: In Australia, the two major pathways of refugee entry are the United Nations High Commissioner for Refugees resettlement programme and irregular maritime arrivals (IMAs) seeking asylum. The Australian Government’s policies towards IMAs since July 2013 are controversial, uncompromising and consistently harsh, with asylum seekers held in detention centres for prolonged periods. Refugees and asylum seekers have distinct and unique stressors that make resettlement difficult. Methods: This exploratory study examines resettlement experiences for refugee youth in Western Australia using the psychosocial conceptual framework and qualitative methods. Focus group discussions and key informant interviews were undertaken with verbatim transcripts analysed using thematic analysis to identify themes. Results: Themes documented that language and its impact, and experience with education, health, and social activities, support structures provided to youth and supporting future aspirations as critical to successful resettlement. This exploratory study contributes to developing a broader understanding of the resettlement experiences of refugee youth, drawing on their current and past experiences, cultural differences and mechanisms for coping. Conclusion: Fluency in English language, especially spoken, was a facilitator of successful resettlement. Our results align with previous studies documenting that support programs are vital for successful resettlement. Although faced with immense difficulties refugee youth are resilient, want to succeed and have aspirations for the future. Strategies and recommendations suggested by refugee youth themselves could be used for developing interventions to assist successful resettlement

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV (PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors

Rare and low-frequency coding variants alter human adult height

Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to similar to 370,000 women, we identify 389 independent signals (P <5 x 10(-8)) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain similar to 7.4% of the population variance in age at menarche, corresponding to similar to 25% of the estimated heritability. We implicate similar to 250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility