Estrategias desde el proyecto de paisaje para la recuperación de los bienes patrimoniales de la región costera del Gran La Plata

El presente trabajo se propone investigar sobre nuevas estrategias y recursos proyectuales que incorporen la configuración paisajística en las ciudades costeras de Berisso y Ensenada a partir del estudio y puesta en valor de los bienes patrimoniales, en pos de aportar al desarrollo productivo y turístico de la región costera del Gran La Plata. La región costera del Gran La Plata nunca fue tratada como lo que es: un sistema ecológico complejo con gran biodiversidad, en el que se interrelaciona lo trópico y lo antrópico. Como consecuencia, se constituye un territorio de interface caracterizado por su fragilidad a partir de: la ocupación de las planicies de inundación; el impacto negativo producto de las actividades industriales y del área de enterramientos de residuos sólidos urbanos; de la naturaleza inter-jurisdiccional de las problemáticas y, de la vulnerabilidad social resultante. Es por ello que las distintas disciplinas y prácticas involucradas en la conformación de esta área de alta vulnerabilidad se ven compelidas a revisar y problematizar los paradigmas y tradiciones de intervención, cuestión que esta investigación aborda, operando desde el campo de la arquitectura, el paisaje y el urbanismo.The present work proposes to investigate new strategies and project resources that incorporate the landscape configuration in the coastal cities of Berisso and Ensenada, founded on the study and enrichment of heritage assets, to contribute to the productive and tourist development of the coastal region of Gran La Plata. The coastal region of Gran La Plata was never treated for what it is: a complex ecological system with great biodiversity, in which the tropic and the anthropic are interrelated. As a consequence, an interface territory is constituted characterized by its fragility from: the occupation of the floodplains; the negative impact of industrial activities and the urban solid waste burial area; of the inter-jurisdictional nature of the problems and of the resulting social vulnerability. That is why the different disciplines and practices, which are involved in this highly vulnerable area conformation, are compelled to review and problematize the intervention´s paradigms and traditions; this investigation approach all this items, operating from the architecture, landscape and urbanism.Peer Reviewe

La naturaleza y el hombre: utopías, eutopías y atopías en la literatura rumana. En busca del espacio perfecto

Tomando como base una serie de diferentes autores de la literatura rumana de los siglos XIX y XX hemos querido analizar el tratamiento y la visión que cada uno de ellos hace de la naturaleza a la hora de configurar la posible existencia de un espacio donde el hombre pueda, en mayor o menor medida, construir un lugar idílico y utópico.Taking some XIXth and XXth Romanian writers, our purpose is just to see the particular point of view that all of them have about Nature in order to create a mythical space where human being can build an utopical and marvelous place to live

A systematic review on machine learning approaches in the diagnosis and prognosis of rare genetic diseases

JALE has received funds from Instituto de Salud Carlos III (Grant# PI20-1126), CIBERER (Grant# PIT21_GCV21), Andalusian University, Research and Innovation Department (PY20-00303, EPIMEN), Andalusian Health Department (Grant# PI027-2020), Asociación Síndrome de Meniere España (ASMES) and Meniere’s Society, UK. PRNV is supported by PY20-00303 Grant (EPIMEN). AMPP is a PhD student in the Biomedicine Program at Universidad de Granada and his salary was supported by Andalusian University, Research and Innovation Department (Grant# PREDOC2021/00343).Background: The diagnosis of rare genetic diseases is often challenging due to the complexity of the genetic underpinnings of these conditions and the limited availability of diagnostic tools. Machine learning (ML) algorithms have the potential to improve the accuracy and speed of diagnosis by analyzing large amounts of genomic data and identifying complex multiallelic patterns that may be associated with specific diseases. In this systematic review, we aimed to identify the methodological trends and the ML application areas in rare genetic diseases. Methods: We performed a systematic review of the literature following the PRISMA guidelines to search studies that used ML approaches to enhance the diagnosis of rare genetic diseases. Studies that used DNA-based sequencing data and a variety of ML algorithms were included, summarized, and analyzed using bibliometric methods, visualization tools, and a feature co-occurrence analysis. Findings: Our search identified 22 studies that met the inclusion criteria. We found that exome sequencing was the most frequently used sequencing technology (59%), and rare neoplastic diseases were the most prevalent disease scenario (59%). In rare neoplasms, the most frequent applications of ML models were the differential diagnosis or stratification of patients (38.5%) and the identification of somatic mutations (30.8%). In other rare diseases, the most frequent goals were the prioritization of rare variants or genes (55.5%) and the identification of biallelic or digenic inheritance (33.3%). The most employed method was the random forest algorithm (54.5%). In addition, the features of the datasets needed for training these algorithms were distinctive depending on the goal pursued, including the mutational load in each gene for the differential diagnosis of patients, or the combination of genotype features and sequence-derived features (such as GC-content) for the identification of somatic mutations. Conclusions: ML algorithms based on sequencing data are mainly used for the diagnosis of rare neoplastic diseases, with random forest being the most common approach. We identified key features in the datasets used for training these ML models according to the objective pursued. These features can support the development of future ML models in the diagnosis of rare genetic diseases.Salud Carlos III PI20-1126CIBERER PIT21_GCV21Research and Innovation Department PY20-00303, EPIMENAndalusian Health Department PI027-2020Asociación Síndrome de Meniere España, ASMESMeniere’s Society, UKAndalusian University, Research and Innovation Department PREDOC2021/0034

Spatiotemporal evolution of light during propagation in filamentation regime

The full description of the evolution of light during its nonlinear propagation represents a valuable help to the complete understanding of important nonlinear phenomena such as light filamentation. In this paper we present a comparison between theoretical and experimental results of the spatiotemporal structure of a light filament at different propagation distances. In order to obtain the experimental spatiotemporal structure, we have used a technique based on spatially resolved spectral interferometry called STARFISH, for spatiotemporal amplitude-and-phase reconstruction by Fourier transform of interference spectra of high-complex beams. We have been able to observe important nonlinear pulse dynamics during the nonlinear propagation, including pulse splitting and the subsequent competition among the pulses that result from the splitting, obtaining a full insight into the general nonlinear behaviorWe acknowledge support from the Spanish Ministerio de Ciencia e Innovación through the Consolider Program Science and Applications of Ultrafast and Ultra-intense Lasers (SAUUL) (CSD2007-00013) and Research Project FIS2009-09522; from Junta de Castilla y León through the Program for Groups of Excellence (GR27) and Research Project SA002B08; and from the European Community’s Seventh Framework Programme (LASERLAB-EUROPE) grant agreement 228334). We also acknowledge support from the Centro de Laseres Pulsados (CLPU), Salamanca, Spain. B. Alonso and I. J. Sola acknowledge the support of the Spanish Ministerio de Ciencia e Innovación through the “Formación de Profesorado Universitario” and “Ramón y Cajal” grant programs, respectively

Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction

The following are available online at https://www.mdpi.com/article/ 10.3390/genes14040831/s1A.A.M.S. received a scholarship from the Philippine Council for Health and Research Development of the Department of Science and Technology (PCHRD-DOST) under the Research Enrichment (Sandwich) Grant of the Accelerated Science and Technology Human Resource Devel- opment Program. O.A.K. was supported by the US National Institutes of Health (NIH)—National Institute on Deafness and Other Communication Disorders (NIDCD) grant T32 DC012280 (to Sue C. Kinnamon and Herman A. Jenkins). This work was supported by the NIH through the NIDCD grants R01 DC019642 (to R.L.P.S.-C. and Ivana V. Yang) and R01 DC013912 (to S.P.G.); and the National Insti- tute of Arthritis and Musculoskeletal and Skin Diseases grant R01 AR068292 (to N.H.-M.). Funding was also provided by Junta de Andalucia, grant Retos en Investigacion PY20_00303 (to J.A.L.-E.).Vertigo due to vestibular dysfunction is rare in children. The elucidation of its etiology will improve clinical management and the quality of life of patients. Genes for vestibular dysfunction were previously identified in patients with both hearing loss and vertigo. This study aimed to identify rare, coding variants in children with peripheral vertigo but no hearing loss, and in patients with potentially overlapping phenotypes, namely, Meniere’s disease or idiopathic scoliosis. Rare variants were selected from the exome sequence data of 5 American children with vertigo, 226 Spanish patients with Meniere’s disease, and 38 European–American probands with scoliosis. In children with vertigo, 17 variants were found in 15 genes involved in migraine, musculoskeletal phenotypes, and vestibular development. Three genes, OTOP1, HMX3, and LAMA2, have knockout mouse models for vestibular dysfunction. Moreover, HMX3 and LAMA2 were expressed in human vestibular tissues. Rare variants within ECM1, OTOP1, and OTOP2 were each identified in three adult patients with Meniere’s disease. Additionally, an OTOP1 variant was identified in 11 adolescents with lateral semicircular canal asymmetry, 10 of whom have scoliosis. We hypothesize that peripheral vestibular dysfunction in children may be due to multiple rare variants within genes that are involved in the inner ear structure, migraine, and musculoskeletal disease.Philippine Council for Health and Research Development of the Department of Science and Technology (PCHRD-DOST) under the Research Enrichment (Sandwich) Grant of the Accelerated Science and Technology Human Resource Development ProgramUS National Institutes of Health (NIH)-National Institute on Deafness and Other Communication Disorders (NIDCD) T32 DC012280NIH through the NIDCD R01 DC019642, R01 DC013912United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01 AR068292Junta de Andalucia PY20_0030

Paisajes salinos, de la invisibilidad a la gestión : Una mirada necesaria en la Argentina contemporánea

Argentina, una de las áreas más extensas del vasto territorio sudamericano, constituye en si un verdadero e invaluable patrimonio. La sincronía y simultaneidad de sus diversas áreas bioclimáticas, topografías y una muy extensa red hidrográfica de aguas superficiales moldean el territorio desde la cordillera hasta el mar, conformando su paisaje de singular heterogeneidad natural y cultural, dando lugar a imágenes, mensajes, experiencias y signos de identidad nacional y una identidad territorial de sus habitantes. En este contexto, este artículo se centra en analizar el paisaje constituido por salares y salinas, una especie de cenicienta, que forma parte de los “paisajes blancos” relacionados con la nieve y el hielo, el cual gracias a su divulgación en los últimos tiempos está buscando su lugar en el firmamento. A través del análisis de las diversas localizaciones se trata de establecer inicialmente, a partir de información secundaria, la relación entre las posibilidades económicas, las diversas formas de extractivismo a las que están sometidas y la de constituirse en una nueva forma de turismo. Esta situación se enfrenta a la necesidad del encuadre jurídico/normativo, que establezca los requisitos que impidan la depredación de ese territorio y puedan constituirse en un recurso sostenible y diverso. Como lo veremos seguramente y muy bien desarrollado en otros apartados de este libro, esta problemática no es solo patrimonio de uno de los países de la región sino que se constituye en un patrimonio conjunto, que deberemos tomar como desafío urgente de abordaje de un futuro común en ciernes.Facultad de Arquitectura y Urbanism

Evaluation of Extracurricular Sports Activities as an Educational Element for Sustainable Development in Educational Institutions

Education that instills healthy habits has acquired much attention in recent years due to concerns related to obesity and the sedentary lifestyle of the scholastic population. Extracurricular sports activities can contribute to the creation of healthy habits and can promote active lifestyles. These positive habits provide social benefits and are a facilitator of sustainable development. Thisstudy had two objectives: To assess the quality and value of extracurricular sports activities offered by schools, as well as the satisfaction of the participants and their future intentions to participate; and to assess the relationship between these constructs, with the aim of identifying factors that encourage schoolchildren to be active. Information was gathered from 1080 children in secondary education in Spain (n = 1080) (65.90% boys, 13.76 1.39 years). The instruments used were the Scale of Perception of Sports Organizations (EPOD2) and a future intentions scale. The evaluation of satisfaction, quality, and value, as well as the intentions expressed by the young athletes to continue participating in extracurricular sports activities were positive, with average values close to the maximum. The best-rated quality variables were human resources. A significant association was identified between communication and loyalty, and response capacity and sports spaces. Likewise, perceived satisfaction and value were related to loyalty and price. In short, student perceptions establish a clear relationship between evaluations of activities and the intention to continue practicing sports in schools

Online audio-visual information on oral cancer for Spanish-speaking laypersons. A cross-sectional study

Lack of knowledge and awareness of oral cancer seem to be the main causes of diagnostic delay. Online resources are often used by patients to obtain health/medical information. However, there are no reports on the quality and usefulness of oral cancer audio-visual resources in Spanish. The aims of this investigation were to disclose the type of information about oral cancer available, and whether it may be useful to shorten the patients? oral cancer appraisal time-interval. Cross-sectional study undertaken at three video-sharing sites on October, 13th 2019. Keywords: ?Cáncer oral?; ?cáncer de boca?. The first 100 results in each viewing list were retrieved by three reviewers. Demographical data was recorded, and interaction indexes, viewing rates, comprehensiveness, and usefulness were calculated for each video. The presence of non-scientifically supported information was also assessed. A descriptive analysis was undertaken, and relationships between variables were explored using the Spearman correlation test. A total of 127 videos were selected. They were produced mainly by mass-media (46.5%; n=59) and their length ranged from 0.28 to 105.38 minutes (median 4.15 minutes; IQR: 2.34-9.67). The most viewed video (10,599,765 views; visualization rate 726,508.9) scored 0 both in usefulness and comprehensiveness. The most useful video gathered 44,119 views (visualization rate 2.033.13). A highly significant positive correlation (0.643; p<0.001) could be observed between usefulness and comprehensiveness of the videos, together with negative correlations between the visualization rate and usefulness (-0.186; p<0.05), and visualization rate and comprehensiveness (-0.183; p<0.05). Online audio-visual material about oral cancer in Spanish is incomplete, of limited usefulness, and often includes non-scientifically supported information. Most of these resources are produced by mass media and healthcare professionals, with minor contributions from educational and healthcare institutions. Visualization rates negatively correlated with the usefulness and comprehensiveness of the contents in these digital objects

La planificación urbano-regional desde el concepto de paisaje como adaptación al cambio climático en la región del Gran La Plata

El presente trabajo se enfoca en la región del Gran La Plata, la cual se ve afectada regularmente por sudestadas e inundaciones que evidencian, en términos de vulnerabilidad, los desequilibrios territoriales en la región como así también los efectos del cambio climático, ya sea por las sucesivas crecidas del Río de La Plata o por lluvias extraordinarias en un corto lapso de tiempo. Se trata de pensar desde el concepto de paisaje la vulnerabilidad hídrica, los riesgos frente al cambio climático y en particular frente a los eventos hidrometeorológicos extremos, para proponer estrategias de acción. Las mismas surgen en respuesta a la necesidad de tratar la gestión integral de riesgos de origen hidrometeorológico como un tema fundamental para la región mediante un sistema de espacios verdes que se incorporan como reservorios y espacios de absorción al sistema hídrico.Trabajo publicado en Acta Bioquímica Clínica Latinoamericana; no. 52, supl. 2, parte II, diciembre de 2018.Universidad Nacional de La Plat

Enhancement of filamentation postcompression by astigmatic focusing

The energy scaling up of pulse postcompression is still an open issue. In this work we analyze the use of astigmatic focusing to improve the output pulses in a filamentation based postcompression setup. Unlike spherical conditions, astigmatic focusing enhances the output energy and the spectral broadening of the filament. This is due to the increase of critical power, allowing a considerable improvement of the postcompression energy and stability in a simple way. We demonstrated compression from FWHM 100 fs, 10 nm, 3 mJ input pulses to 13 fs, 142 nm, near 1 mJ pulses.We acknowledge support from the Spanish Ministerio de Ciencia e Innovación through the Consolider Program SAUUL (CSD2007-00013), Research project FIS2009- 09522, and grant programs Formación de Profesorado Universitario (for B. Alonso and R. Borrego-Varillas) and Ramón y Cajal (for I. J. Sola), and from the Junta de Castilla y León through the Program for Groups of Excellence (GR27). We also acknowledge support from the Centro de Láseres Pulsados, Salamanca, Spain