1,058 research outputs found
High angular resolution N-band observation of the silicate carbon star IRAS08002-3803 with the VLTI/MIDI instrument
We present the results of N-band spectro-interferometric observations of the
silicate carbon star IRAS08002-3803 with the MID-infrared Interferometric
instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) of the
European Southern Observatory (ESO). The observations were carried out using
two unit telescopes (UT2 and UT3) with projected baseline lengths ranging from
39 to 47 m. Our observations of IRAS08002-3803 have spatially resolved the
dusty environment of a silicate carbon star for the first time and revealed an
unexpected wavelength dependence of the angular size in the N band: the
uniform-disk diameter is found to be constant and ~36 mas (72 Rstar) between 8
and 10 micron, while it steeply increases longward of 10 micron to reach ~53
mas (106 Rstar) at 13 micron. Model calculations with our Monte Carlo radiative
transfer code show that neither spherical shell models nor axisymmetric disk
models consisting of silicate grains alone can simultaneously explain the
observed wavelength dependence of the visibility and the spectral energy
distribution (SED). We propose that the circumstellar environment of
IRAS08002-3803 may consist of two grain species coexisting in the disk:
silicate and a second grain species, for which we consider amorphous carbon,
large silicate grains, and metallic iron grains. Comparison of the observed
visibilities and SED with our models shows that such disk models can fairly --
though not entirely satisfactorily -- reproduce the observed SED and N-band
visibilities. Our MIDI observations and the radiative transfer calculations
lend support to the picture where oxygen-rich material around IRAS08002-3803 is
stored in a circumbinary disk surrounding the carbon-rich primary star and its
putative low-luminosity companion.Comment: 15 pages, 8 figures, accepted for publication in A&
Characterizations of how species mediate ecosystem properties require more comprehensive functional effect descriptors
The importance of individual species in mediating ecosystem process and functioning is generally accepted, but categorical descriptors that summarize species-specific contributions to ecosystems tend to reference a limited number of biological traits and underestimate the importance of how organisms interact with their environment. Here, we show how three functionally contrasting sediment-dwelling marine invertebrates affect fluid and particle transport - important processes in mediating nutrient cycling - and use high-resolution reconstructions of burrow geometry to determine the extent and nature of biogenic modification. We find that individual functional effect descriptors fall short of being able to adequately characterize how species mediate the stocks and flows of important ecosystem properties and that, in contrary to common practice and understanding, they are not substitutable with one another because they emphasize different aspects of species activity and behavior. When information derived from these metrics is combined with knowledge of how species behave and modify their environment, however, detailed mechanistic information emerges that increases the likelihood that a species functional standing will be appropriately summarized. Our study provides evidence that more comprehensive functional effect descriptors are required if they are to be of value to those tasked with projecting how altered biodiversity will influence future ecosystems
Multiple imputation for estimating hazard ratios and predictive abilities in case-cohort surveys
<p>Abstract</p> <p>Background</p> <p>The weighted estimators generally used for analyzing case-cohort studies are not fully efficient and naive estimates of the predictive ability of a model from case-cohort data depend on the subcohort size. However, case-cohort studies represent a special type of incomplete data, and methods for analyzing incomplete data should be appropriate, in particular multiple imputation (MI).</p> <p>Methods</p> <p>We performed simulations to validate the MI approach for estimating hazard ratios and the predictive ability of a model or of an additional variable in case-cohort surveys. As an illustration, we analyzed a case-cohort survey from the Three-City study to estimate the predictive ability of D-dimer plasma concentration on coronary heart disease (CHD) and on vascular dementia (VaD) risks.</p> <p>Results</p> <p>When the imputation model of the phase-2 variable was correctly specified, MI estimates of hazard ratios and predictive abilities were similar to those obtained with full data. When the imputation model was misspecified, MI could provide biased estimates of hazard ratios and predictive abilities. In the Three-City case-cohort study, elevated D-dimer levels increased the risk of VaD (hazard ratio for two consecutive tertiles = 1.69, 95%CI: 1.63-1.74). However, D-dimer levels did not improve the predictive ability of the model.</p> <p>Conclusions</p> <p>MI is a simple approach for analyzing case-cohort data and provides an easy evaluation of the predictive ability of a model or of an additional variable.</p
Hyperspectral imaging of cuttlefish camouflage indicates good color match in the eyes of fish predators
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of National Academy of Sciences for personal use, not for redistribution. The definitive version was published in Proceedings of the National Academy of Sciences of the United States of America 108 (2011):9148-9153, doi:10.1073/pnas.1019090108.Camouflage is a widespread phenomenon throughout nature and an important
anti-predator tactic in natural selection. Many visual predators have keen color
perception, thus camouflage patterns should provide some degree of color matching in
addition to other visual factors such as pattern, contrast, and texture. Quantifying
camouflage effectiveness in the eyes of the predator is a challenge from the
perspectives of both biology and optical imaging technology. Here we take advantage
of Hyperspectral Imaging (HSI), which records full-spectrum light data, to
simultaneously visualize color match and pattern match in the spectral and the spatial
domains, respectively. Cuttlefish can dynamically camouflage themselves on any
natural substrate and, despite their colorblindness, produce body patterns that appear
to have high-fidelity color matches to the substrate when viewed directly by humans
or with RGB images. Live camouflaged cuttlefish on natural backgrounds were
imaged using HSI, and subsequent spectral analysis revealed that most reflectance
spectra of individual cuttlefish and substrates were similar, rendering the color match
possible. Modeling color vision of potential di- and tri-chromatic fish predators of
cuttlefish corroborated the spectral match analysis and demonstrated that camouflaged
cuttlefish show good color match as well as pattern match in the eyes of fish predators.
These findings (i) indicate the strong potential of HSI technology to enhance studies
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of biological coloration, and (ii) provide supporting evidence that cuttlefish can
produce color-coordinated camouflage on natural substrates despite lacking color
vision.We gratefully acknowledge financial support from the
National Science Council of Taiwan NSC-98-2628-B-007-001-MY3 to CCC, from
the Network Science Center at West Point and the Army Research Office to JKW,
from the NDSEG Fellowship to JJA, and from ONR grant N000140610202 to RTH
Cerebral aneurysm exclusion by CT angiography based on subarachnoid hemorrhage pattern: a retrospective study
<p>Abstract</p> <p>Background</p> <p>To identify patients with spontaneous subarachnoid hemorrhage for whom CT angiography alone can exclude ruptured aneurysms.</p> <p>Methods</p> <p>An observational retrospective review was carried out of all consecutive patients with non-traumatic subarachnoid hemorrhage who underwent both CT angiography and catheter angiography to exclude an aneurysm. CT angiography negative cases (no aneurysm) were classified according to their CT hemorrhage pattern as "aneurismal", "perimesencephalic" or as "no-hemorrhage."</p> <p>Results</p> <p>Two hundred and forty-one patients were included. A CT angiography aneurysm detection sensitivity and specificity of 96.4% and 96.0% were observed. All 35 cases of perimesencephalic or no-hemorrhage out of 78 CT angiography negatives also had negative angiography findings.</p> <p>Conclusions</p> <p>CT angiography is self-reliant to exclude ruptured aneurysms when either a perimesencephalic hemorrhage or no-hemorrhage pattern is identified on the CT within a week of symptom onset.</p
Dynamics of Barred Galaxies
Some 30% of disc galaxies have a pronounced central bar feature in the disc
plane and many more have weaker features of a similar kind. Kinematic data
indicate that the bar constitutes a major non-axisymmetric component of the
mass distribution and that the bar pattern tumbles rapidly about the axis
normal to the disc plane. The observed motions are consistent with material
within the bar streaming along highly elongated orbits aligned with the
rotating major axis. A barred galaxy may also contain a spheroidal bulge at its
centre, spirals in the outer disc and, less commonly, other features such as a
ring or lens. Mild asymmetries in both the light and kinematics are quite
common. We review the main problems presented by these complicated dynamical
systems and summarize the effort so far made towards their solution,
emphasizing results which appear secure. (Truncated)Comment: This old review appeared in 1993. Plain tex with macro file. 82 pages
18 figures. A pdf version with figures at full resolution (3.24MB) is
available at http://www.physics.rutgers.edu/~sellwood/bar_review.pd
DNA Barcode Goes Two-Dimensions: DNA QR Code Web Server
The DNA barcoding technology uses a standard region of DNA sequence for species identification and discovery. At present, “DNA barcode” actually refers to DNA sequences, which are not amenable to information storage, recognition, and retrieval. Our aim is to identify the best symbology that can represent DNA barcode sequences in practical applications. A comprehensive set of sequences for five DNA barcode markers ITS2, rbcL, matK, psbA-trnH, and CO1 was used as the test data. Fifty-three different types of one-dimensional and ten two-dimensional barcode symbologies were compared based on different criteria, such as coding capacity, compression efficiency, and error detection ability. The quick response (QR) code was found to have the largest coding capacity and relatively high compression ratio. To facilitate the further usage of QR code-based DNA barcodes, a web server was developed and is accessible at http://qrfordna.dnsalias.org. The web server allows users to retrieve the QR code for a species of interests, convert a DNA sequence to and from a QR code, and perform species identification based on local and global sequence similarities. In summary, the first comprehensive evaluation of various barcode symbologies has been carried out. The QR code has been found to be the most appropriate symbology for DNA barcode sequences. A web server has also been constructed to allow biologists to utilize QR codes in practical DNA barcoding applications
Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate
Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures using conditional logistic regression models. While no single nucleotide polymorphism (SNP) achieved genome-wide significance when considered alone, markers in SLC2A9 and the neighboring WDR1 on chromosome 4p16.1 gave suggestive evidence of gene-environment interaction with environmental tobacco smoke (ETS) among 259 Asian trios when the models included a term for GxE interaction. Multiple SNPs in these two genes were associated with increased risk of nonsyndromic CP if the mother was exposed to ETS during the peri-conceptual period (3 months prior to conception through the first trimester). When maternal ETS was considered, fifteen of 135 SNPs mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance (10-6<P<10-4) in a test for GxETS interaction. SNPs rs3733585 and rs12508991 in SLC2A9 yielded P = 2.26×10-7 in a test for GxETS interaction. SNPs rs6820756 and rs7699512 in WDR1 also yielded P = 1.79×10-7 and P = 1.98×10-7 in a 1 df test for GxE interaction. Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest SLC2A9 and WDR1 should be considered as candidate genes for CP. © 2014 Wu et al
Properties of Graphene: A Theoretical Perspective
In this review, we provide an in-depth description of the physics of
monolayer and bilayer graphene from a theorist's perspective. We discuss the
physical properties of graphene in an external magnetic field, reflecting the
chiral nature of the quasiparticles near the Dirac point with a Landau level at
zero energy. We address the unique integer quantum Hall effects, the role of
electron correlations, and the recent observation of the fractional quantum
Hall effect in the monolayer graphene. The quantum Hall effect in bilayer
graphene is fundamentally different from that of a monolayer, reflecting the
unique band structure of this system. The theory of transport in the absence of
an external magnetic field is discussed in detail, along with the role of
disorder studied in various theoretical models. We highlight the differences
and similarities between monolayer and bilayer graphene, and focus on
thermodynamic properties such as the compressibility, the plasmon spectra, the
weak localization correction, quantum Hall effect, and optical properties.
Confinement of electrons in graphene is nontrivial due to Klein tunneling. We
review various theoretical and experimental studies of quantum confined
structures made from graphene. The band structure of graphene nanoribbons and
the role of the sublattice symmetry, edge geometry and the size of the
nanoribbon on the electronic and magnetic properties are very active areas of
research, and a detailed review of these topics is presented. Also, the effects
of substrate interactions, adsorbed atoms, lattice defects and doping on the
band structure of finite-sized graphene systems are discussed. We also include
a brief description of graphane -- gapped material obtained from graphene by
attaching hydrogen atoms to each carbon atom in the lattice.Comment: 189 pages. submitted in Advances in Physic
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