Governança corporativa : análise de gestão da responsabilidade socioambiental em empresa multinacional italiana do segmento de pneus

Trabalho de Conclusão de Curso, apresentado para obtenção do grau de Bacharel no Curso de Ciências Contábeis, da Universidade do Extremo Sul Catarinense, UNESC.A Governança Corporativa é um campo das finanças relevante para academia e organizações e, ainda, com muitas áreas a serem exploradas. Com raízes na proliferação das organizações, a Governança Corporativa recebeu atenção de pesquisadores a partir do conflito de interesses entre propriedade e gestão. Daí a concepção da nominada teoria da agência com o desenvolvimento de mecanismos mitigadores de conflitos. Tais mecanismos foram questionados em decorrência de vários escândalos financeiros no âmbito mundial, como os da WorldCom e Enron no início dos anos 2000. Este trabalho, a partir da revisão teórica, tem abordagem eminentemente qualitativa, com uso de estratégia de pesquisa de estudo de caso, emprega técnicas de entrevista, levantamento de documentos e consulta em demais meios corporativos, para analisar a estrutura de governança voltada a responsabilidade socioambiental de uma empresa do segmento de pneus e verificar se ambas estão contribuindo para a criação de valor do grupo. Após os estudos realizados, observou-se uma forte tendência a efeitos positivos para geração de valor da empresa a partir de suas atitudes socioambientais. Por isso, percebe-se claramente que a Governança Corporativa se insere no ambiente empresarial não mais como uma simples alternativa aos administradores, mas sim, como um meio necessário às tendências do mercado, essencial ao alcance de metas, que impulsiona fortemente a criação de valor e contribui para a perenidade do negócio. Este estudo sugere que as pessoas envolvidas nas organizações se conscientizem sobre as vantagens oriundas das práticas de Governança e as pratiquem para cada vez mais a economia se fortalecer e gerar riquezas para a sociedade concomitante ao desenvolvimento sustentável da mesma

Statistics as a tool for decision making in agricultural and environmental experiments

This study aimed to identify and present applications of statistical methods in problems of agricultural and environmental nature. To achieve this objective, applied research of exploratory and quantitative nature was carried out. Two case studies were adopted as method and technical procedures. As a contribution to this research, the use of statistical methods in problem solving and as a tool for decision making is pointed out

Alavancagem de marca: um estudo de caso

O trabalho foi realizado em uma empresa denominada Alfa, indústria farmacêutica e de produtos naturais, localizada na Região Noroeste do Estado do Rio Grande do Sul. O objetivo geral do trabalho é a captação de recursos e investimentos financeiros dos atuais e principais distribuidores da referida empresaa fim de alavancar a marca no cenário nacional, sem onerá-la diretamente e postergar o investimento a longo prazo. Nesse caso a marca foi muito divulgada em cenário nacional, com o investimento sendo absorvido pelos distribuidores e com benefício de colocar 6.400 unidades de um produto da empresa no mercado. A metodologia do presente trabalho, quanto aos fins, é descritiva, explicativa e aplicada. Quanto aos meios, o trabalho é bibliográfico, pesquisa de campo e estudo de caso. Optou-se pela aplicação de questionários entre os principais distribuidores da empresa, sendo pesquisa quantitativa. Nesse trabalho, optou-se pela amostragem não probabilística por tipicidade. Os sujeitos da pesquisa foram os sócios proprietários das distribuidoras. O resultado do trabalho foi extremamente gratificante, pois se teve propagação da marca em cenário nacional, a colocação de produtos em diversos estados brasileiros e investimentos financeiros realizados diretamente pelos distribuidores, obtendo-se um lucro significativo sobre a venda

Biochemical and thermodynamic characteristics of a new serine protease from Mucor subtilissimus URM 4133

A protease from the fungus Mucor subtilissimus URM 4133, capable of producing bioactive peptides from goat casein, was purified. SDS-PAGE and zymography showed a molecular mass of 30 kDa. The enzyme was active and stable in a wide pH range (6.0–10.5) and (5.0–10.5), respectively. Optimum temperature was at 45–50 °C and stability was above 80 % (40 °C/2 h). Activity was not influenced by ions or organic substances (Triton, Tween, SDS and DMSO), but was completely inhibited by PMSF, suggesting that it belongs to the serine protease family. The Km and Vmax were 2.35 mg azocasein.mL-1 and 333.33 U.mg protein-1, respectively. Thermodynamic parameters of irreversible denaturation (40–60 °C) were enthalpy 123.63 – 123.46 kJ.mol-1, entropy 120.24–122.28 kJ.mol-1 and Gibbs free energy 85.97 – 82.45 kJ.mol-1. Any peptide sequences compatible with this protease were found after analysis by MALDI-TOF, which suggests that it is a new serine protease.info:eu-repo/semantics/publishedVersio

High-resolution genetic map and QTL analysis of growth-related traits of Hevea brasiliensis cultivated under suboptimal temperature and humidity conditions

Rubber tree (Hevea brasiliensis) cultivation is the main source of natural rubber worldwide and has been extended to areas with suboptimal climates and lengthy drought periods; this transition affects growth and latex production. High-density genetic maps with reliable markers support precise mapping of quantitative trait loci (QTL), which can help reveal the complex genome of the species, provide tools to enhance molecular breeding, and shorten the breeding cycle. In this study, QTL mapping of the stem diameter, tree height, and number of whorls was performed for a full-sibling population derived from a GT1 and RRIM701 cross. A total of 225 simple sequence repeats (SSRs) and 186 single-nucleotide polymorphism (SNP) markers were used to construct a base map with 18 linkage groups and to anchor 671 SNPs from genotyping by sequencing (GBS) to produce a very dense linkage map with small intervals between loci. The final map was composed of 1,079 markers, spanned 3,779.7 cM with an average marker density of 3.5 cM, and showed collinearity between markers from previous studies. Significant variation in phenotypic characteristics was found over a 59-month evaluation period with a total of 38 QTLs being identified through a composite interval mapping method. Linkage group 4 showed the greatest number of QTLs (7), with phenotypic explained values varying from 7.67 to 14.07%. Additionally, we estimated segregation patterns, dominance, and additive effects for each QTL. A total of 53 significant effects for stem diameter were observed, and these effects were mostly related to additivity in the GT1 clone. Associating accurate genome assemblies and genetic maps represents a promising strategy for identifying the genetic basis of phenotypic traits in rubber trees. Then, further research can benefit from the QTLs identified herein, providing a better understanding of the key determinant genes associated with growth of Hevea brasiliensis under limiting water conditions

The Importance of C4d in Biopsies of Kidney Transplant Recipients

Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. Despite the general acceptance of the usefulness of C4d in the identification of acute AMR, the data for C4d staining in chronic AMR is variable. The presence of C4d in the majority of the biopsies with features of chronic antibody-mediated rejection is reported, but this rejection without C4d staining is observed as well, suggesting that C4d is specific but not sensitive. Further studies on AMR with positive C4d staining in biopsy specimens are really important, as well as the study of novel routine markers that may participate in the pathogenesis of this process

Educação em saúde na sala de espera de uma policlínica infantil: relato de experiência

Aim: to report the experience of Nursing students in regards to the educational activities developed in a waiting room at the Children's Polyclinic of the municipality of Uruguaiana-RS. Method:  experience report about the practices of health education carried out in the waiting room of the Children's Polyclinic. These practices were divided into four moments, based on Freire’s circles of culture. Results: through the practices of health education, conducted with users of the service, it was possible to clarify doubts about childcare by addressing myths and truths on themes such as: breastfeeding, childhood accidents and personal hygiene. It is believed that the waiting room is a dynamic space that is ideal for the development of educational activities. Final considerations: the actions provided the Nursing students with development of health education practices and comprehension of the exchange of knowledge among users, relatives, caregivers, students and health professionals.Objetivo: presentar la experiencia de estudiantes de enfermería, ante las actividades educativas desarrolladas en una sala de espera en la Policlínica Infantil del municipio de Uruguayana (RS, Brasil). Método: relato de experiencia sobre la práctica de la educación sanitaria efectuada en la sala de espera del Policlínico Infantil. Estas prácticas se dividen en cuatro momentos, fundamentados en los círculos de cultura de Paulo Freire. Resultados: mediante las prácticas de educación en salud, realizadas con los usuarios del servicio, fue posible aclarar dudas sobre el cuidado de los niños, abordando mitos y verdades en los temas: lactancia materna, accidentes en la infancia e higiene corporal. Se cree que la sala de espera es un espacio dinámico, ideal para el desarrollo de actividades educativas. Consideraciones finales: las acciones emprendidas proporcionaron a los estudiantes de enfermería el desarrollo de prácticas en educación sanitaria y entender el intercambio de conocimientos entre usuarios, familiares, cuidadores, estudiantes y profesionales de la salud.Objetivo: relatar a experiência de acadêmicas do curso de enfermagem frente às ações educativas desenvolvidas em uma sala de espera na Policlínica Infantil do município de Uruguaiana-RS. Método: relato de experiência acerca das práticas de educação em saúde realizadas na sala de espera da Policlínica Infantil. Essas práticas dividiram-se em quatro momentos fundamentados pelos círculos de cultura de Freire. Resultados: por meio das práticas de educação em saúde, realizadas com os usuários do serviço, foi possível esclarecer as dúvidas acerca dos cuidados à criança, abordando mitos e verdades nas temáticas: amamentação, acidentes na infância e higiene corporal. Acredita-se que a sala de espera é um espaço dinâmico, ideal para o desenvolvimento de atividades educacionais. Considerações Finais: as ações desenvolvidas proporcionaram às discentes de enfermagem desenvolver práticas de educação em saúde e compreender a troca de saberes entre usuários, familiares, acompanhantes, discentes e profissionais da saúde

Linkage disequilibrium and population structure in wild and cultivated populations of rubber tree (Hevea brasiliensis).

Abstract: Among rubber tree species, which belong to the Hevea genus of the Euphorbiaceae family, Hevea brasiliensis (Willd. ex Adr.de Juss.) Muell. Arg. is the main commercial source of natural rubber production worldwide. Knowledge of the population structure and linkage disequilibrium (LD) of this species is essential for the efficient organization and exploitation of genetic resources. Here, we obtained single-nucleotide polymorphisms (SNPs) using a genotyping-by-sequencing (GBS) approach and then employed the SNPs for the following objectives: (i) to identify the positions of SNPs on a genetic map of a segregating mapping population, (ii) to evaluate the population structure of a germplasm collection, and (iii) to detect patterns of LD decay among chromosomes for future genetic association studies in rubber tree. A total of 626 genotypes, including both germplasm accessions (368) and individuals from a genetic mapping population (254), were genotyped. A total of 77,660 and 21,283 SNPs were detected by GBS in the germplasm and mapping populations, respectively. The mapping population, which was previously mapped, was constructed with 1,062 markers, among which only 576 SNPs came from GBS, reducing the average interval between two adjacent markers to 4.4 cM. SNPs from GBS genotyping were used for the analysis of genetic structure and LD estimation in the germplasm accessions. Two groups, which largely corresponded to the cultivated and wild populations, were detected using STRUCTURE and via principal coordinate analysis. LD analysis, also using the mapped SNPs, revealed that non-random associations varied along chromosomes, with regions of high LD interspersed with regions of low LD. Considering the length of the genetic map (4,693 cM) and the mean LD (0.49 for cultivated and 0.02 for wild populations), a large number of evenly spaced SNPs would be needed to perform genome-wide association studies in rubber tree, and the wilder the genotypes used, the more difficult the mapping saturation

Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure

Objective. To evaluate the expression of inflammatory markers in experimental renal failure after fetal programming. Methods. The offspring aged two and fivemonths were divided into four groups: CC (control dams, control offspring)DC (diabetic dams, control offspring)CFA (control dams, folic acid offspring, 250 mg/Kg)and DFA (diabetic dams, folic acid offspring). Gene expression of inflammatory markersMCP-1, IL-1, NOS3, TGF-beta, TNF-alpha, and VEGF was evaluated by RT-PCR. Results. MCP-1 was increased in the CFA and DFA groups at two and fivemonths of age, as well as in DC5 when compared to CC5. There was a higher expression of IL-1 in the CFA2, DFA2, and DC2 groups. There was a decrease in NOS3 and an increase in TNF-alpha in DFA5 in relation to CFA5. The gene expression of TGF-beta increased in cases that had received folic acid at two and five months, and VEGF decreased in the CFA5 and DFA5 groups. DC5 showed increased VEGF expression in comparison with CC5. Conclusions. Gestational diabetes mellitus and folic acid both change the expression of inflammatory markers, thus demonstrating that the exposure to harmful agents in adulthood has a more severe impact in cases which underwent fetal reprogramming.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundacao de Ensino e Pesquisa de Uberaba (FUNEPU)Discipline of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilDepartment of Health Sciences, Lavras Federal University, Lavras, MG, BrazilDiscipline of Physiology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilDepartment of Immunology, Institute of Biomedical Sciences IV, University of São Paulo (USP), São Paulo, SP, BrazilDepartment of General Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilWeb of Scienc