New investigations into the stability of Mesna using LC-MS/MS and NMR

Both LC-MS/MS and NMR analyses confirmed the instability of Mesna and its conversion into Dimesna

INTEGRAL/SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

The center of our Galaxy is a known strong source of electron-positron 511-keV annihilation radiation. Thus far, however, there have been no reliable detections of annihilation radiation outside of the central radian of our Galaxy. One of the primary objectives of the INTEGRAL (INTErnational Gamma-RAy Astrophysics Laboratory) mission, launched in Oct. 2002, is the detailed study of this radiation. The Spectrometer on INTEGRAL (SPI) is a high resolution coded-aperture gamma-ray telescope with an unprecedented combination of sensitivity, angular resolution and energy resolution. We report results from the first 10 months of observation. During this period a significant fraction of the observing time was spent in or near the Galactic Plane. No positive annihilation flux was detected outside of the central region (|l| > 40 deg) of our Galaxy. In this paper we describe the observations and data analysis methods and give limits on the 511-keV flux.Comment: Accepted for publication in the Astrophysical Journal. 13 pages, 3 figure

The experience of long-term opiate maintenance treatment and reported barriers to recovery: A qualitative systematic review

Background/Aim: To inform understanding of the experience of long-term opiate maintenance and identify barriers to recovery. Methods: A qualitative systematic review. Results: 14 studies in 17 papers, mainly from the USA (65%), met inclusion criteria, involving 1,088 participants. Studies focused on methadone prescribing. Participants reported stability; however, many disliked methadone. Barriers to full recovery were primarily ‘inward focused'. Conclusion: This is the first review of qualitative literature on long-term maintenance, finding that universal service improvements could be made to address reported barriers to recovery, including involving ex-users as positive role models, and increasing access to psychological support. Treatment policies combining harm minimisation and abstinence-orientated approaches may best support individualised recovery

Sequence of two gonadotropin releasing hormones from tunicate suggest an important role of conformation in receptor activation

AbstractThe primary structure of two forms of gonadotropin releasing hormone (GnRH) from tunicate (Chelyosoma productum) have been determined based on mass spectrometric and chemical sequence analyses. The peptides, tunicate GnRH-I and -II, contain features unprecedented in vertebrate GnRH. Tunicate GnRH-I contains a putative salt bridge between Asp5 and Lys8. A GnRH analog containing a lactam bridge between Asp5 and Lys8 was found to increase release of estradiol compared with that of the native tunicate GnRH-I and -II. Tunicate GnRH-II contains a cysteine residue and was isolated as a dimeric peptide. These motifs suggest that the conformation plays an important role in receptor activation

Swift observations of the 2006 outburst of the recurrent nova RS Ophiuchi: I. Early X-ray emission from the shocked ejecta and red giant wind

RS Ophiuchi began its latest outburst on 2006 February 12. Previous outbursts have indicated that high velocity ejecta interact with a pre-existing red giant wind, setting up shock systems analogous to those seen in Supernova Remnants. However, in the previous outburst in 1985, X-ray observations did not commence until 55 days after the initial explosion. Here we report on Swift observations covering the first month of the 2006 outburst with the Burst Alert (BAT) and X-ray Telescope (XRT) instruments. RS Oph was clearly detected in the BAT 14-25 keV band from t=0 to $t\sim6$ days. XRT observationsfrom 0.3-10 keV, started at 3.17 days after outburst. The rapidly evolving XRT spectra clearly show the presence of both line and continuum emission which can be fitted by thermal emission from hot gas whose characteristic temperature, overlying absorbing column, $[N_H]_W$, and resulting unabsorbed total flux decline monotonically after the first few days. Derived shock velocities are in good agreement with those found from observations at other wavelengths. Similarly, $[N_H]_W$ is in accord with that expected from the red giant wind ahead of the forward shock. We confirm the basic models of the 1985 outburst and conclude that standard Phase I remnant evolution terminated by $t\sim10$ days and the remnant then rapidly evolved to display behaviour characteristic of Phase III. Around t=26 days however, a new, luminous and highly variable soft X-ray source began to appear whose origin will be explored in a subsequent paper.Comment: 20 pages, 4 figures (2 updated), accepted by Ap

INTEGRAL/SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

The center of our Galaxy is a known strong source of electron-positron 511 keV annihilation radiation. Thus far, however, there have been no reliable detection of annihilation radiation outside of the central radian of our Galaxy. One of the primary objectives of the INTEGRAL (International Gamma-Ray Astrophysics Laboratory mission, resolution, coded-apeture gamma-ray telescope with an unprecedented combination of sensitivity, angular resolution, and energy resolution. We resport results from the first 10 months of observation. During this period a significant fraction of the observing time was spent in or near the Galactic plan. No positive annihilation flux was detected outside of the central regin ( l \u3e 40°) of our Galaxy. In this paper we describe observation and data analysis method and give limits on the 511 keV flu

Gamma-Ray Emission Concurrent with the Nova in the Symbiotic Binary V407 Cygni

Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce X-ray emission but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable gamma-ray (0.1-10 GeV) emission from the recently-detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary, and that particles can be accelerated effectively to produce pi0 decay gamma-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.Comment: 38 pages, includes Supplementary Online Material; corresponding authors: C.C. Cheung, A.B. Hill, P. Jean, S. Razzaque, K.S. Woo

INTEGRAL/SPI ground calibration

Three calibration campaigns of the spectrometer SPI have been performed before launch in order to determine the instrument characteristics, such as the effective detection area, the spectral resolution and the angular resolution. Absolute determination of the effective area has been obtained from simulations and measurements. At 1 MeV, the effective area is 65 cm^2 for a point source on the optical axis, the spectral resolution ~2.3 keV. The angular resolution is better than 2.5 deg and the source separation capability about 1 deg. Some temperature dependant parameters will require permanent in-flight calibration.Comment: 9 pages, 12 figures, 2 tables. Accepted for publication in A&AL (INTEGRAL Special issue

Calibration of the Spectrometer aboard the INTEGRAL satellite

SPI, the Spectrometer on board the ESA INTEGRAL satellite, to be launched in October 2002, will study the gamma-ray sky in the 20 keV to 8 MeV energy band with a spectral resolution of 2 keV for photons of 1 MeV, thanks to its 19 germanium detectors spanning an active area of 500 cm2. A coded mask imaging technique provides a 2 deg angular resolution. The 16 deg field of view is defined by an active BGO veto shield, furthermore used for background rejection. In April 2001 the flight model of SPI underwent a one-month calibration campaign at CEA in Bruy\`eres le Ch\^atel using low intensity radioactive sources and the CEA accelerator for homogeneity measurements and high intensity radioactive sources for imaging performance measurements. After integration of all scientific payloads (the spectrometer SPI, the imager IBIS and the monitors JEM-X and OMC) on the INTEGRAL satellite, a cross-calibration campaign has been performed at the ESA center in Noordwijk. A set of sources has been placed in the field of view of the different instruments in order to compare their performances and determine their mutual influence. Some of those sources had already been used in Bruy\`eres during the SPI standalone test. For the lowest energy band calibration an X-ray generator has been used. We report on the scientific goals of this calibration activity, and present the measurements performed as well as some preliminary results.Comment: 12 pages, 19 figures, Published in Proceedings of SPIE conference, 24-28 August 2002, Waikoloa, Hawaii, US