HIGH RESOLUTION SPECTROSCOPY OF ACETYLENE-FURAN IN HE NANO-DROPLETS}

[2]E. Sanchez-Garcya, A. Mardyukov, A. Tekin, R. Crespo-Otero, L.A. Montero, W. Sander, G. Jansen, submittedthis work was supported by FOR 618 of the German Science FoundationAuthor Institution: Department of Physical Chemistry II; Ruhr-University Bochum, Universitatsstr. 150, D-44780Acetylene-furan is an interesting benchmark system for the evaluation of hydrogen bonds. Since acetylene is the smallest molecule containing two hydrogens and a $\pi$-system it is interesting to study the influence of a C-H \"{}lone-pair\"{ } hydrogen-bond and a CH-$\pi$ or even a $\pi$-$\pi$ interaction. The global and local minimum structures have been predicted in a recent study}. For the experiment the molecules have been embedded in superfluid helium nanodroplets. The radiation source was a singly resonant OPO with an output power of up to 2.7 W and a resolution of up to $4 \times10^{-5}$~cm$^{-1}$. Helium clusters, which have a temperature of 0.37 K are doped with acetylene (pick-up pressure $1.3 \times 10^{-5}$ mbar) and furan (pick-up pressure $0.9 \times 10^{-5}$ mbar) and are then excited with the OPO-radiation. A mass-spectrometer is used to detect the depletion of the cluster beam. With this setup measurements were carried out in the region of the asymmetric stretch vibration of the acetylene. Between 3256 cm$^{-1}$ and 3280 cm$^{-1}$ five acetylene-furan cluster peaks could be detected. Two of these could be assigned to the acetylene-furan dimer. We will present a detailed analysis of the data

SOLVATION OF HCl, AGGREGATION OF H2_2O, HCl AND THEIR DEUTERATED ISOTOPES IN SUPERFLUID He DROPLETS}

this work was supported by FOR 618 of the German Science FoundationAuthor Institution: Department of Physical Chemistry II; Ruhr-University Bochum, Universitatsstr. 150, D-44780We investigate aggregates of HCl, H$_2$O and their deuterated isotopes embedded in superfluid helium using a helium nanodroplet spectrometer combined with a cw infrared OPO set up with an output power of up to 2.7 W and a resolution of better than 0.001 cm$^{-1}$. Depletion spectra of the super cooled aggregates (0.37 K) were recorded between 2650 cm$^{-1}$ and 2720 cm$^{-1}$. We were able to assign the HCl stretch vibration of the HCl-H$_2$O complex. We also observed spectral features of (HCl)$_m$(H$_2$O)$_n$ aggregates and isotopes in the region of the H$_3$O$^+$ stretch vibration. The question of how many H$_2$O molecules are needed to solvate HCl will be addressed

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Contains fulltext : 118576.pdf (publisher's version ) (Open Access)Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Contains fulltext : 118459.pdf (publisher's version ) (Closed access)Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 x 10(-9)) and 10p12 (rs1243180, P = 1.8 x 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 x 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer