On Secular Resonances of Small Bodies in the Planetary Systems

We investigate the secular resonances for massless small bodies and Earth-like planets in several planetary systems. We further compare the results with those of Solar System. For example, in the GJ 876 planetary system, we show that the secular resonances $\nu_1$ and $\nu_2$ (respectively, resulting from the inner and outer giant planets) can excite the eccentricities of the Earth-like planets with orbits 0.21 AU $\leq a <$ 0.50 AU and eject them out of the system in a short timescale. However, in a dynamical sense, the potential zones for the existence of Earth-like planets are in the area 0.50 AU $\leq a \leq$ 1.00 AU, and there exist all stable orbits last up to $10^5$ yr with low eccentricities. For other systems, e.g., 47 UMa, we also show that the Habitable Zones for Earth-like planets are related to both secular resonances and mean motion resonances in the systems.Comment: 8 pages, 3 figures, accepted to IAU236. Proceeding of IAU 236: Near Earth Objects, Our Celestial Neighbors: Opportunity and Risk, in pres

Metabolic turnover and dynamics of modified ribonucleosides by ¹³C labeling

Tandem mass spectrometry (MS/MS) is an accurate tool to assess modified ribonucleosides and their dynamics in mammalian cells. However, MS/MS quantification of lowly abundant modifications in non-ribosomal RNAs is unreliable, and the dynamic features of various modifications poorly understood. Here, we developed a 13C labeling approach, called 13C-dynamods, to quantify the turnover of base modifications in newly transcribed RNA. This turnover-based approach helped to resolve mRNA from ncRNA modifications in purified RNA or free ribonucleoside samples, and showed the distinct kinetics of the N6-methyladenosine (m6A) versus 7-methylguanosine (m7G) modification in polyA+-purified RNA. We uncovered that N6,N6-dimethyladenosine (m62A) exhibits distinct turnover in small RNAs and free ribonucleosides when compared to known m62A-modified large rRNAs. Finally, combined measurements of turnover and abundance of these modifications informed on the transcriptional versus posttranscriptional sensitivity of modified ncRNAs and mRNAs, respectively, to stress conditions. Thus, 13C-dynamods enables studies of the origin of modified RNAs at steady-state and subsequent dynamics under non-stationary conditions. These results open new directions to probe the presence and biological regulation of modifications in particular RNAs

Habitable Zones for Earth-mass Planets in Multiple Planetary Systems

We perform numerical simulations to study the Habitable zones (HZs) and dynamical structure for Earth-mass planets in multiple planetary systems. For example, in the HD 69830 system, we extensively explore the planetary configuration of three Neptune-mass companions with one massive terrestrial planet residing in 0.07 AU $\leq a \leq$ 1.20 AU, to examine the asteroid structure in this system. We underline that there are stable zones of at least $10^5$ yr for low-mass terrestrial planets locating between 0.3 and 0.5 AU, and 0.8 and 1.2 AU with final eccentricities of $e < 0.20$. Moreover, we also find that the accumulation or depletion of the asteroid belt are also shaped by orbital resonances of the outer planets, for example, the asteroidal gaps at 2:1 and 3:2 mean motion resonances (MMRs) with Planet C, and 5:2 and 1:2 MMRs with Planet D. In a dynamical sense, the proper candidate regions for the existence of the potential terrestrial planets or HZs are 0.35 AU $< a <$ 0.50 AU, and 0.80 AU $< a <$ 1.00 AU for relatively low eccentricities, which makes sense to have the possible asteroidal structure in this system.Comment: 4 pages, 1 figures, accepted to IAU 249. Proceeding of IAU S249: Exoplanets: Detection, Formation and Dynamics, in pres

Vaccine strategies: Optimising outcomes

AbstractSuccessful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine. Reliable immunisation service funding is another important factor and low income countries often need external supplementary sources of finance. Many regions also obtain support in generating an evidence base for vaccination via initiatives created by organisations including World Health Organization (WHO), the Pan American Health Organization (PAHO), the Agence de Médecine Préventive and the Sabin Vaccine Institute. Strong monitoring and surveillance mechanisms are also required. An example is the efficient and low-cost approaches for measuring the impact of the hepatitis B control initiative and evaluating achievement of goals that have been established in the WHO Western Pacific region. A review of implementation strategies reveals differing degrees of success. For example, in the Americas, PAHO advanced a measles-mumps-rubella vaccine strategy, targeting different population groups in mass, catch-up and follow-up vaccination campaigns. This has had much success but coverage data from some parts of the region suggest that children are still not receiving all appropriate vaccines, highlighting problems with local service infrastructures. Stark differences in coverage levels are also observed among high income countries, as is the case with HPV vaccine implementation in the USA versus the UK and Australia, reflecting differences in delivery settings. Experience and research have shown which vaccine strategies work well and the factors that encourage success, which often include strong support from government and healthcare organisations, as well as tailored, culturally-appropriate local approaches to optimise outcomes

On the Fundamental Mass-Period Functions of Extrasolar Planets

Employing a catalog of 175 extrasolar planets (exoplanets) detected by the Doppler-shift method, we constructed the independent and coupled mass-period functions. It is the first time in this field that the selection effect is considered in the coupled mass-period functions. Our results are consistent with those in Tabachnik and Tremaine (2002) with the major differences that we obtain a flatter mass function but a steeper period function. Moreover, our coupled mass-period functions show that about 2.5 percent of stars would have a planet with mass between Earth Mass and Neptune Mass, and about 3 percent of stars would have a planet with mass between Neptune Mass and Jupiter Mass.Comment: Accepted by ApJ Supplement Series in Nov. 2009, Acknowledgment added in Dec. 2009, a Reference-Based Catalog of Exoplanets can be obtained electronically from Appendix A of the latex file or from the authors for further studies

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long-term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia-induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.Peer reviewe

Chandra and XMM-Newton observations of the merging cluster of galaxies PLCK G036.7+14.9

We present Chandra and XMM-Newton observations of PLCK G036.7+14.9 from the Chandra-Planck Legacy Program. The high resolution X-ray observations reveal two close subclusters, G036N and G036S, which were not resolved by previous ROSAT, optical, or recent Planck observations. We perform detailed imaging and spectral analyses and use a simplified model to study the kinematics of this system. The basic picture is that PLCK G036.7+14.9 is undergoing a major merger (mass ratio close to unity) between the two massive subclusters, with the merger largely along the line-of-sight and probably at an early stage. G036N hosts a small, moderate cool-core, while G036S has at most a very weak cool-core in the central 40 kpc region. The difference in core cooling times is unlikely to be caused by the ongoing merger disrupting a pre-existing cool-core in G036S. G036N also hosts an unresolved radio source in the center, which may be heating the gas if the radio source is extended. The Planck derived mass is higher than the X-ray measured mass of either subcluster, but is lower than the X-ray measured mass of the whole cluster, due to the fact that Planck does not resolve PLCK G036.7+14.9 into subclusters and interprets it as a single cluster. This mass discrepancy could induce significant bias to the mass function if such previously unresolved systems are common in the Planck cluster sample. High resolution X-ray observations are necessary to identify the fraction of such systems and correct such a bias for the purpose of precision cosmological studies.Comment: 23 pages, 8 figures (low resolution) with additional 12 figures in the Appendix, accepted for publication in Ap

Square-lattice s=1/2 XY model and the Jordan-Wigner fermions: The ground-state and thermodynamic properties

Using the 2D Jordan-Wigner transformation we reformulate the square-lattice s=1/2 XY (XZ) model in terms of noninteracting spinless fermions and examine the ground-state and thermodynamic properties of this spin system. We consider the model with two types of anisotropy: the spatial anisotropy interpolating between 2D and 1D lattices and the anisotropy of the exchange interaction interpolating between isotropic XY and Ising interactions. We compare the obtained (approximate) results with exact ones (1D limit, square-lattice Ising model) and other approximate ones (linear spin-wave theory and exact diagonalization data for finite lattices of up to N=36 sites supplemented by finite-size scaling). We discuss the ground-state and thermodynamic properties in dependence on the spatial and exchange interaction anisotropies. We pay special attention to the quantum phase transition driven by the exchange interaction anisotropy as well as to the appearance/disappearance of the zero-temperature magnetization in the quasi-1D limit.Comment: 28 pages, 7 figures include

Phase transitions in MgSiO3 post-perovskite in super-Earth mantles

The highest pressure form of the major Earth-forming mantle silicate is MgSiO3 post-perovskite (PPv). Understanding the fate of PPv at TPa pressures is the first step for understanding the mineralogy of super-Earths-type exoplanets, arguably the most interesting for their similarities with Earth. Modeling their internal structure requires knowledge of stable mineral phases, their properties under compression, and major element abundances. Several studies of PPv under extreme pressures support the notion that a sequence of pressure induced dissociation transitions produce the elementary oxides SiO2 and MgO as the ultimate aggregation form at ~3 TPa. However, none of these studies have addressed the problem of mantle composition, particularly major element abundances usually expressed in terms of three main variables, the Mg/Si and Fe/Si ratios and the Mg#, as in the Earth. Here we show that the critical compositional parameter, the Mg/Si ratio, whose value in the Earth's mantle is still debated, is a vital ingredient for modeling phase transitions and internal structure of super-Earth mantles. Specifically, we have identified new sequences of phase transformations, including new recombination reactions that depend decisively on this ratio. This is a new level of complexity that has not been previously addressed, but proves essential for modeling the nature and number of internal layers in these rocky mantles.Comment: Submitted to Earth Planet. Sci. Lett., 28 pages, 6 figure