Estrés y técnica de arbitraje en baloncesto en función del género

El propósito de estudio ha sido conocer las diferencias en función del género en la intervención técnica del árbitro y las situaciones de estrés que se presentan durante un partido de baloncesto. La muestra consta de seis árbitros de categoría nacional (4 hombres y 2 mujeres), durante la celebración de un torneo internacional U-16. Para conocer las diferencias en la intervención técnica se ha empleado el instrumento IOVAB y para observar las diferencias en las situaciones de estrés el cuestionario LISEA. Los resultados muestran que no existen diferencias significativas en la intervención técnica, exceptuando los movimientos de árbitro de cabeza, donde las mujeres obtienen valores más elevados. Por contra, si se reflejan diferencias entre grupos en las situaciones de estrés. Las mujeres poseen valores más altos cuando se hace referencia al nombre de los entrenadores y jugadores, al puesto que ocupa cada equipo en la competición, al compañero de arbitraje, a la localidad y pabellón en el que arbitran y a la existencia o no de delegado de campo. Los resultados muestran la necesidad de realizar un programa de intervención para regular esta ansiedad antes y después de los partidos.The aim of this research was to determine the differences that may exist in the gender of the referee about the technical intervention and stressful situations during basketball matches. The subjects are six national referees (4 men and 2 women) officiating an international tournament U-16. IOVAB instrument has been used to calculate the differences in the technical intervention and LISEA questionnaire in order to observe differences in stress situations. The results show no significant differences in technical intervention, except the head referee movements, where the women performance is better. However, there are differences between groups in stressful situations. Women have higher values in reference to the name of the coaches and players, the position occupied by each team in the competition, the workmate referee, the place and stadium and the existence of field official. Results show the need to implement an intervention program to regulate the anxiety of the referees before and after the games

Stress and technique of basketball refereeing according to gender

El propósito de estudio ha sido conocer las diferencias en función del género en la intervención técnica del árbitro y las situaciones de estrés que se presentan durante un partido de baloncesto. La muestra consta de seis árbitros de categoría nacional (4 hombres y 2 mujeres), durante la celebración de un torneo internacional U-16. Para conocer las diferencias en la intervención técnica se ha empleado el instrumento IOVAB y para observar las diferencias en las situaciones de estrés el cuestionario LISEA. Los resultados muestran que no existen diferencias significativas en la intervención técnica, exceptuando los movimientos de árbitro de cabeza, donde las mujeres obtienen valores más elevados. Por contra, si se reflejan diferencias entre grupos en las situaciones de estrés. Las mujeres poseen valores más altos cuando se hace referencia al nombre de los entrenadores y jugadores, al puesto que ocupa cada equipo en la competición, al compañero de arbitraje, a la localidad y pabellón en el que arbitran y a la existencia o no de delegado de campo. Los resultados muestran la necesidad de realizar un programa de intervención para regular esta ansiedad antes y después de los partidos.The aim of this research was to determine the differences that may exist in the gender of the referee about the technical intervention and stressful situations during basketball matches. The subjects are six national referees (4 men and 2 women) officiating an international tournament U-16. IOVAB instrument has been used to calculate the differences in the technical intervention and LISEA questionnaire in order to observe differences in stress situations. The results show no significant differences in technical intervention, except the head referee movements, where the women performance is better. However, there are differences between groups in stressful situations. Women have higher values in reference to the name of the coaches and players, the position occupied by each team in the competition, the workmate referee, the place and stadium and the existence of field official. Results show the need to implement an intervention program to regulate the anxiety of the referees before and after the games.• Junta de Extremadura y Fondo Europeo de Desarrollo Regional. Ayuda GR15122peerReviewe

Stress and technique of basketball refereeing according to gender

El propósito de estudio ha sido conocer las diferencias en función del género en la intervención técnica del árbitro y las situaciones de estrés que se presentan durante un partido de baloncesto. La muestra consta de seis árbitros de categoría nacional (4 hombres y 2 mujeres), durante la celebración de un torneo internacional U-16. Para conocer las diferencias en la intervención técnica se ha empleado el instrumento IOVAB y para observar las diferencias en las situaciones de estrés el cuestionario LISEA. Los resultados muestran que no existen diferencias significativas en la intervención técnica, exceptuando los movimientos de árbitro de cabeza, donde las mujeres obtienen valores más elevados. Por contra, si se reflejan diferencias entre grupos en las situaciones de estrés. Las mujeres poseen valores más altos cuando se hace referencia al nombre de los entrenadores y jugadores, al puesto que ocupa cada equipo en la competición, al compañero de arbitraje, a la localidad y pabellón en el que arbitran y a la existencia o no de delegado de campo. Los resultados muestran la necesidad de realizar un programa de intervención para regular esta ansiedad antes y después de los partidos.The aim of this research was to determine the differences that may exist in the gender of the referee about the technical intervention and stressful situations during basketball matches. The subjects are six national referees (4 men and 2 women) officiating an international tournament U-16. IOVAB instrument has been used to calculate the differences in the technical intervention and LISEA questionnaire in order to observe differences in stress situations. The results show no significant differences in technical intervention, except the head referee movements, where the women performance is better. However, there are differences between groups in stressful situations. Women have higher values in reference to the name of the coaches and players, the position occupied by each team in the competition, the workmate referee, the place and stadium and the existence of field official. Results show the need to implement an intervention program to regulate the anxiety of the referees before and after the games.• Junta de Extremadura y Fondo Europeo de Desarrollo Regional. Ayuda GR15122peerReviewe

Stress and technique of basketball refereeing according to gender

El propósito de estudio ha sido conocer las diferencias en función del género en la intervención técnica del árbitro y las situaciones de estrés que se presentan durante un partido de baloncesto. La muestra consta de seis árbitros de categoría nacional (4 hombres y 2 mujeres), durante la celebración de un torneo internacional U-16. Para conocer las diferencias en la intervención técnica se ha empleado el instrumento IOVAB y para observar las diferencias en las situaciones de estrés el cuestionario LISEA. Los resultados muestran que no existen diferencias significativas en la intervención técnica, exceptuando los movimientos de árbitro de cabeza, donde las mujeres obtienen valores más elevados. Por contra, si se reflejan diferencias entre grupos en las situaciones de estrés. Las mujeres poseen valores más altos cuando se hace referencia al nombre de los entrenadores y jugadores, al puesto que ocupa cada equipo en la competición, al compañero de arbitraje, a la localidad y pabellón en el que arbitran y a la existencia o no de delegado de campo. Los resultados muestran la necesidad de realizar un programa de intervención para regular esta ansiedad antes y después de los partidos.The aim of this research was to determine the differences that may exist in the gender of the referee about the technical intervention and stressful situations during basketball matches. The subjects are six national referees (4 men and 2 women) officiating an international tournament U-16. IOVAB instrument has been used to calculate the differences in the technical intervention and LISEA questionnaire in order to observe differences in stress situations. The results show no significant differences in technical intervention, except the head referee movements, where the women performance is better. However, there are differences between groups in stressful situations. Women have higher values in reference to the name of the coaches and players, the position occupied by each team in the competition, the workmate referee, the place and stadium and the existence of field official. Results show the need to implement an intervention program to regulate the anxiety of the referees before and after the games.• Junta de Extremadura y Fondo Europeo de Desarrollo Regional. Ayuda GR15122peerReviewe

The arms race: adversarial search defeats entropy used to detect malware

Malware creators have been getting their way for too long now. String-based similarity measures can leverage ground truth in a scalable way and can operate at a level of abstraction that is difficult to combat from the code level. At the string level, information theory and, specifically, entropy play an important role related to detecting patterns altered by concealment strategies, such as polymorphism or encryption. Controlling the entropy levels in different parts of a disk resident executable allows an analyst to detect malware or a black hat to evade the detection. This paper shows these two perspectives into two scalable entropy-based tools: EnTS and EEE. EnTS, the detection tool, shows the effectiveness of detecting entropy patterns, achieving 100% precision with 82% accuracy. It outperforms VirusTotal for accuracy on combined Kaggle and VirusShare malware. EEE, the evasion tool, shows the effectiveness of entropy as a concealment strategy, attacking binary-based state of the art detectors. It learns their detection patterns in up to 8 generations of its search process, and increments their false negative rate from range 0–9%, up to the range 90–98.7%

Safety and efficacy of ApTOLL in patients with ischemic stroke undergoing endovascular treatment: a phase 1/2 randomized clinical trial

Clinical trial[Abstract] Importance: ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. Objective: To assess the safety and efficacy of ApTOLL in combination with endovascular treatment (EVT) for patients with ischemic stroke. Design, setting, and participants: This phase 1b/2a, double-blind, randomized, placebo-controlled study was conducted at 15 sites in Spain and France from 2020 to 2022. Participants included patients aged 18 to 90 years who had ischemic stroke due to large vessel occlusion and were seen within 6 hours after stroke onset; other criteria were an Alberta Stroke Program Early CT Score of 6 to 10, estimated infarct core volume on baseline computed tomography perfusion of 5 to 70 mL, and the intention to undergo EVT. During the study period, 4174 patients underwent EVT. Interventions: In phase 1b, 0.025, 0.05, 0.1, or 0.2 mg/kg of ApTOLL or placebo; in phase 2a, 0.05 or 0.2 mg/kg of ApTOLL or placebo; and in both phases, treatment with EVT and intravenous thrombolysis if indicated. Main outcomes and measures: The primary end point was the safety of ApTOLL based on death, symptomatic intracranial hemorrhage (sICH), malignant stroke, and recurrent stroke. Secondary efficacy end points included final infarct volume (via MRI at 72 hours), NIHSS score at 72 hours, and disability at 90 days (modified Rankin Scale [mRS] score). Results: In phase Ib, 32 patients were allocated evenly to the 4 dose groups. After phase 1b was completed with no safety concerns, 2 doses were selected for phase 2a; these 119 patients were randomized to receive ApTOLL, 0.05 mg/kg (n = 36); ApTOLL, 0.2 mg/kg (n = 36), or placebo (n = 47) in a 1:1:√2 ratio. The pooled population of 139 patients had a mean (SD) age of 70 (12) years, 81 patients (58%) were male, and 58 (42%) were female. The primary end point occurred in 16 of 55 patients (29%) receiving placebo (10 deaths [18.2%], 4 sICH [7.3%], 4 malignant strokes [7.3%], and 2 recurrent strokes [3.6%]); in 15 of 42 patients (36%) receiving ApTOLL, 0.05 mg/kg (11 deaths [26.2%], 3 sICH [7.2%], 2 malignant strokes [4.8%], and 2 recurrent strokes [4.8%]); and in 6 of 42 patients (14%) receiving ApTOLL, 0.2 mg/kg (2 deaths [4.8%], 2 sICH [4.8%], and 3 recurrent strokes [7.1%]). ApTOLL, 0.2 mg/kg, was associated with lower NIHSS score at 72 hours (mean difference log-transformed vs placebo, -45%; 95% CI, -67% to -10%), smaller final infarct volume (mean difference log-transformed vs placebo, -42%; 95% CI, -66% to 1%), and lower degrees of disability at 90 days (common odds ratio for a better outcome vs placebo, 2.44; 95% CI, 1.76 to 5.00). Conclusions and relevance: In acute ischemic stroke, 0.2 mg/kg of ApTOLL administered within 6 hours of onset in combination with EVT was safe and associated with a potential meaningful clinical effect, reducing mortality and disability at 90 days compared with placebo. These preliminary findings await confirmation from larger pivotal trials.This study was sponsored by aptaTargets, Madrid, Spain, and cofunded by grants from the Spanish Ministry of Science, Innovation and Universities (RTC-2017-6651-1 and RTC-2019-006795-1).España. Ministerio de Ciencia, Innovación e Universidades; RTC-2017-6651-1España. Ministeriod e Ciencia, Innovación e Universidades; RTC-2019-006795-

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting an efficient anti-microbial defense while preserving vascular health. Here, we identify a neutrophil-intrinsic program that enabled both. The gene Bmal1 regulated expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in the transcriptional and migratory properties of circulating neutrophils. These diurnal alterations, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted anti-microbial activity in tissues. Mice engineered for constitutive neutrophil aging became resistant to infection, but the persistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death. Thus, diurnal compartmentalization of neutrophils, driven by an internal timer, coordinates immune defense and vascular protection. Neutrophils display circadian oscillations in numbers and phenotype in the circulation. Adrover and colleagues now identify the molecular regulators of neutrophil aging and show that genetic disruption of this process has major consequences in immune cell trafficking, anti-microbial defense, and vascular health.This study was supported by Intramural grants from A∗STAR to L.G.N., BES-2013-065550 to J.M.A., BES-2010-032828 to M.C.-A, and JCI-2012-14147 to L.A.W (all from Ministerio de Economía, Industria y Competitividad; MEIC). Additional MEIC grants were SAF2014-61993-EXP to C.L.-R.; SAF2015-68632-R to M.A.M. and SAF-2013-42920R and SAF2016-79040Rto D.S. D.S. also received 635122-PROCROP H2020 from the European Commission and ERC CoG 725091 from the European Research Council (ERC). ERC AdG 692511 PROVASC from the ERC and SFB1123-A1 from the Deutsche Forschungsgemeinschaft were given to C.W.; MHA VD1.2/81Z1600212 from the German Center for Cardiovascular Research (DZHK) was given to C.W. and O.S.; SFB1123-A6 was given to O.S.; SFB914-B08 was given to O.S. and C.W.; and INST 211/604-2, ZA 428/12-1, and ZA 428/13-1 were given to A.Z. This study was also supported by PI12/00494 from Fondo de Investigaciones Sanitarias (FIS) to C.M.; PI13/01979, Cardiovascular Network grant RD 12/0042/0054, and CIBERCV to B.I.; SAF2015-65607-R, SAF2013-49662-EXP, and PCIN-2014-103 from MEIC; and co-funding by Fondo Europeo de Desarrollo Regional (FEDER) to A.H. The CNIC is supported by the MEIC and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505)

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting an efficient anti-microbial defense while preserving vascular health. Here, we identify a neutrophil-intrinsic program that enabled both. The gene Bmal1 regulated expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in the transcriptional and migratory properties of circulating neutrophils. These diurnal alterations, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted anti-microbial activity in tissues. Mice engineered for constitutive neutrophil aging became resistant to infection, but the persistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death. Thus, diurnal compartmentalization of neutrophils, driven by an internal timer, coordinates immune defense and vascular protection.We thank all members of the Hidalgo Lab for discussion and insightful comments; J.M. Ligos, R. Nieto, and M. Viton for help with sorting and cytometric analyses; I. Ortega and E. Santos for animal husbandry; D. Rico, M.J. Gomez, C. Torroja, and F. Sanchez-Cabo for insightful comments and help with transcriptomic analyses; V. Labrador, E. Arza, A.M. Santos, and the Microscopy Unit of the CNIC for help with microscopy; S. Aznar-Benitah, U. Albrecht, Q.-J. Meng, B. Staels, and H. Duez for the generous gift of mice; J.A. Enriquez and J. Avila for scientific insights; and J.M. Garcia and A. Diez de la Cortina for art. This study was supported by Intramural grants from A* STAR to L.G.N., BES-2013-065550 to J.M.A., BES-2010-032828 to M.C.-A, and JCI-2012-14147 to L.A.W (all from Ministerio de Economia, Industria y Competitividad; MEIC). Additional MEIC grants were SAF2014-61993-EXP to C.L.-R.; SAF2015-68632-R to M.A.M. and SAF-2013-42920R and SAF2016-79040Rto D.S. D.S. also received 635122-PROCROP H2020 from the European Commission and ERC CoG 725091 from the European Research Council (ERC). ERC AdG 692511 PROVASC from the ERC and SFB1123-A1 from the Deutsche Forschungsgemeinschaft were given to C.W.; MHA VD1.2/81Z1600212 from the German Center for Cardiovascular Research (DZHK) was given to C.W. and O.S.; SFB1123-A6 was given to O.S.; SFB914-B08 was given to O.S. and C.W.; and INST 211/604-2, ZA 428/12-1, and ZA 428/13-1 were given to A.Z. This study was also supported by PI12/00494 from Fondo de Investigaciones Sanitarias (FIS) to C.M.; PI13/01979, Cardiovascular Network grant RD 12/0042/0054, and CIBERCV to B.I.; SAF2015-65607-R, SAF2013-49662-EXP, and PCIN-2014-103 from MEIC; and co-funding by Fondo Europeo de Desarrollo Regional (FEDER) to A.H. The CNIC is supported by the MEIC and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505).S

Competencia digital, alfabetización mediática y formación del profesorado: vinculación de la teoría y la práctica a través de la colaboración inter-nivelar

Depto. de Estudios EducativosFac. de EducaciónFALSEsubmitte

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio