Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents

Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Robles Botero, Viviana. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Casañas-Pimentel, Rocío. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Rojas, Florencia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Angiolella, Letizia. Università degli Studi di Roma "La Sapienza"; ItaliaFil: San Martín Martínez, Eduardo. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentin

Planeamiento estratégico para el sector de energía eólica del Perú

El presente Plan Estratégico para el sector de generación de energía eólica ha sido escrito proyectándolo a un plazo de desarrollo de diez años hasta el 2028. Este estudio busca la interrelación entre todos los actores del sector con la finalidad de lograr el crecimiento de la industria en el Perú y la internacionalización de la misma. Para alcanzar los objetivos a largo plazo trazados se definieron estrategias que se implementarán a corto y mediano plazo. Desde el 2008, con apoyo del Estado, se iniciaron procesos para la implementación de proyectos basados en energía eólica y otros tipos de energías renovables. En el año 2016, la energía eólica representó el 2.2% del total de la energía generada en el país y cuenta con proyección de crecimiento, dado que el Perú posee un gran potencial de este recurso renovable. La creciente demanda nacional y el desabastecimiento de energía eléctrica en algunas zonas del territorio peruano, especialmente en las zonas rurales, sumado al gran potencial eólico del Perú, en lugares como Ica, Cajamarca, Lambayeque, Piura, La Libertad, etc., representan un escenario ideal para atraer inversionistas nacionales y extranjeros que propicien el desarrollo del sector de la generación de energía eólica en el país. Como consecuencia del desarrollo e implementación del presente plan estratégico y el análisis realizado del sector de generación de energía eólica, se plantea la implementación de estrategias específicas, a través de las cuales se alcanzarán los objetivos de largo plazo orientados a incrementar las ventas, maximizar la rentabilidad y generar mayor empleabilidad dentro del sector de generación de energía eólica en el PerúThis Strategic Plan for the Wind Power Generation Sector and the sustainability was written thinking of ten years period until 2028. This study seeks an interrelation among all the stakeholders in order to achieve the growth of this sector in Peru and its internationalization. To achieve the long-term objectives outlined strategies were defined in order to be implemented in short-term and medium-term. Since 2008, many processes for the implementation of projects based on renewable energy were started with the government support. In 2016, wind energy is just 2.2% of the total energy generated in the country but it has an outstanding projection, since it has the necessary potential. The growing national demand and the shortage of electricity in some areas of the Peruvian territory, especially in rural areas, added to the great wind potential of Peru, in places like Ica, Cajamarca, Lambayeque, Piura, La Libertad, etc., where the usable winds for the generation of wind power energy represents an ideal scenario to attract national and foreign investors that propitiate the development of the wind power generation sector in the country. Because of the development of the Strategic Plan and the analysis carried out of the wind power generation sector, the implementation of specific strategies is proposed, through long-term objectives aimed at protecting the environment, improving sales, improving investment, generate greater employability within the wind power generation sector in PeruTesi

Elaboración de paisajes sonoros para la monitorización y seguimiento de la contaminación acústica submarina

Comunicación presentada en el 54º Congreso Español de Acústica – TECNIACÚSTICA 2023, Cuenca, 18-20 de octubre de 2023.El ruido submarino antropogénico es una amenaza creciente para la vida marina debido al incremento de la actividad humana en el medio marino. En Europa se publicó la Directiva 2008/56/CE del Parlamento Europeo y del Consejo con el objetivo de establecer un marco de actuación comunitaria en el ámbito de la política medioambiental marina. La directiva introduce la energía acústica submarina, tal y como se detalla en el Descriptor 11, como fuente contaminante, por lo que se hace necesario realizar la monitorización y seguimiento de los niveles acústicos en el entorno marítimo. Se establecen dos metodologías para determinar el nivel de contaminación acústica submarina; la monitorización mediante el despliegue de hidrófonos y la elaboración de paisajes o mapas sonoros. El primer método requiere un despliegue de larga duración lo que implica un alto coste por lo que la elaboración de mapas sonoros es una alternativa real para establecer los niveles acústicos en una demarcación marítima determinada. En el presente trabajo se presentan las necesidades y procesos necesarios para la elaboración de paisajes sonoros en el contexto del proyecto: Filling the gap: Thresholds assessment and impact beyond acoustic pressure level linked to emerging blue-growth activities (SONORA) referencia PCI2022-135081-2.Anthropogenic noise is a growing threat to marine life due to the increment of human activity in the marine environment. In Europe, the Directive 2008/56/EC of the European Parliament and of the Council was published with the aim of establishing a framework for community action in the field of marine environmental policy. The directive introduces underwater acoustic energy, as detailed in Descriptor 11, as a polluting source, which makes it necessary to monitor and follow the acoustic levels in the maritime environment. Two methodologies are established to determine the level of underwater pollution; monitoring through the deployment of hydrophones and the elaboration of landscapes or sound maps. The first method requires a long-term deployment, which implies a high cost, so the elaboration of sound maps is a real alternative to establish the noise levels in a given maritime area. This paper presents the requirements and processes needed for the elaboration of soundscapes in the context of the Project: Filling the gap: Thresholds assessment and impact beyond acoustic pressure level linked to emerging blue-growth activities (SONORA) reference PCI2022-135081-2.El presente trabajo ha sido realizado por SAES y la Universidad de Alicante en el contexto del proyecto: Filling the gap: Thresholds assessment and impact beyond acoustic pressure level linked to emerging blue-growth activities (SONORA) referencia PCI2022-135081-2

The effects of interset rest on adaptation to 7 weeks of explosive training in young soccer players

The aim of the study was to compare the effects of plyometric training using 30, 60, or 120 s of rest between sets on explosive adaptations in young soccer players. Four groups of athletes (age 10.4 ± 2.3 y; soccer experience 3.3 ± 1.5 y) were randomly formed: control (CG; n = 15), plyometric training with 30 s (G30; n = 13), 60 s (G60; n = 14), and 120 s (G120; n = 12) of rest between training sets. Before and after intervention players were measured in jump ability, 20-m sprint time, change of direction speed (CODS), and kicking performance. The training program was applied during 7 weeks, 2 sessions per week, for a total of 840 jumps. After intervention the G30, G60 and G120 groups showed a significant (p = 0.0001 – 0.04) and small to moderate effect size (ES) improvement in the countermovement jump (ES = 0.49; 0.58; 0.55), 20 cm drop jump reactive strength index (ES = 0.81; 0.89; 0.86), CODS (ES = -1.03; -0.87; -1.04), and kicking performance (ES = 0.39; 0.49; 0.43), with no differences between treatments. The study shows that 30, 60, and 120 s of rest between sets ensure similar significant and small to moderate ES improvement in jump, CODS, and kicking performance during high-intensity short-term explosive training in young male soccer players

Expectativas de supervivencia tras la reanimación cardiopulmonar. Predicciones y deseos de los cardiópatas.

La supervivencia al alta tras una parada cardiorrespiratoria (PCR) intrahospitalaria es menor del 25%, presentando cerca del 30% de los supervivientes, secuelas neurológicas significativas1. Las preferencias de los pacientes respecto a la reanimación cardiopulmonar (RCP) están relacionadas con la percepción que tienen de su probabilidad de éxito2,3. Un excesivo optimismo de nuestros pacientes respecto a maniobras como la RCP podría afectar a sus expectativas, condicionando de esta forma el desarrollo de las órdenes de no reanimar o de los documentos de voluntades anticipadas en el ámbito de la enfermedad cardiovascular. Nuestro objetivo principal es conocer el pronóstico que otorgan a la PCR intrahospitalaria los pacientes cardiológicos y valorar su posible influencia en sus deseos de reanimación.pre-print214 K

Propuesta de innovación docente para Filología: programa de inclusión del alumnado en la investigación universitaria y la adquisición de experiencias científicas y formativas

El proyecto busca satisfacer la creciente voluntad de participación del alumnado en los procesos y ámbitos académicos profesionales, dinamizando su interacción con el cuerpo docente, así como la apertura de horizontes laborales a nivel universitario.Depto. de Estudios Ingleses: Lingüística y LiteraturaFac. de FilologíaFALSEsubmitte

Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes)

Persistent Pulmonary Hypertension in Corrected Valvular Heart Disease: Hemodynamic Insights and Long-Term Survival.

Background The determinants and consequences of pulmonary hypertension after successfully corrected valvular heart disease remain poorly understood. We aim to clarify the hemodynamic bases and risk factors for mortality in patients with this condition. Methods and Results We analyzed long-term follow-up data of 222 patients with pulmonary hypertension and valvular heart disease successfully corrected at least 1 year before enrollment who had undergone comprehensive hemodynamic and imaging characterization as per the SIOVAC (Sildenafil for Improving Outcomes After Valvular Correction) clinical trial. Median (interquartile range) mean pulmonary pressure was 37 mm Hg (32-44 mm Hg) and pulmonary artery wedge pressure was 23 mm Hg (18-26 mm Hg). Most patients were classified either as having combined precapillary and postcapillary or isolated postcapillary pulmonary hypertension. After a median follow-up of 4.5 years, 91 deaths accounted for 4.21 higher-than-expected mortality in the age-matched population. Risk factors for mortality were male sex, older age, diabetes mellitus, World Health Organization functional class III and higher pulmonary vascular resistance-either measured by catheterization or approximated from ultrasound data. Higher pulmonary vascular resistance was related to diabetes mellitus and smaller residual aortic and mitral valve areas. In turn, the latter correlated with prosthetic nominal size. Six-month changes in the composite clinical score and in the 6-minute walk test distance were related to survival. Conclusions Persistent valvular heart disease-pulmonary hypertension is an ominous disease that is almost universally associated with elevated pulmonary artery wedge pressure. Pulmonary vascular resistance is a major determinant of mortality in this condition and is related to diabetes mellitus and the residual effective area of the corrected valve. These findings have important implications for individualizing valve correction procedures. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT00862043.This study was funded by the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain, the European Union–European Regional Development Fund (EC07/90772 and PI19/00649), and the Consorcio de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV).S

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study

Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk, disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA). Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I (P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (b-CTX) were analysed at all points in the study. Data on disease progression, SREs development and survival were recorded. Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were predictive of survival time, with b-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship between bone markers and disease progression. Conclusion: In patients with PCa and bone metastases treated with ZA, b-CTX and P1NP can be considered suitable predictors for mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of treatment are especially importantThis study was supported by Novartis Oncology Spai

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice