204 research outputs found

    Puritanism and Graham Greene

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    In lieu of an abstract, below is the essay\u27s first paragraph. The introduction to the recent Time edition of The Power and the Glory by Graham Greene makes a familiar charge against the author. The editor, however, does not lend the repeated generalization its usual venomous twist; indeed, he praises Greene for the wrong reason. The charge is that Greene is a hater of the material, that he despises man\u27s body and loves the spiritual in man, that he has a neo-Augustine loathing of sexual union. This observation may be true of Greene\u27s other works. It certainly is not true of The Power and the Glory. In matters of sexuality, it is the abuse of this gift that Greene regrets. (And Greene would be the first to say that there are far worse sins than these: pride and greed, for example.

    Chesterton: The Youthful Joy

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    In lieu of an abstract, below is the essay\u27s first paragraph. In a wry moment Wordsworth remarked that the child is father to the man. The insight which he meant to convey was that by some undesired mental growth we have the nasty habit of losing our youthful joy, acceptance and wonder. The process of maturation jades our vision; the awful sense of loneliness, of isolation from our environment, enters and warps all hope, banishes all our better dreams. In this era, of new inventions, for killing bodies and for saving souls, all propagated with best intentions, we find it hard to view with delight any spontaneous action, to deal kindly with the joyous man who is probably blind; and are forever conscious of the pall of gloom that hangs over happiness

    Chaos In Egypt

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    In lieu of an abstract, below is the essay\u27s first paragraph. Many authors have toyed with the notion of the elusiveness of truth. Even those who would hold for an ultimate, stable truth, admit the difficulty of human comprehension of it. Human subjectivity reduces almost all statements to mere opinion. At any rate, the author\u27s epistemological bias is certain to affect his attitude towards his characters\u27 motivation, freedom, dignity, and convictions

    God, Man and the Devil in The Talent Scout

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    In lieu of an abstract, below is the essay\u27s first paragraph. In 1961 a very fine little novel by Romain Gary slipped into publication in the United States almost unnoticed by the reviewers. I feel that the few critics, however, that did discuss the book missed its message. Atlantic Monthly\u27s reviewer, for instance, found the theme of the book to be centered in a denial of the existence of God and the devil: any power attributed by man to the supernatural was merely man\u27s Faith in the words God and \u27\u27devil.\u27\u27 Following a semantic approach, the Atlantic reviewer went on to discuss the varied meanings that these words may have for each individual man. The central lesson Romain Gary was teaching, concluded the article, was that man --and not any supernatural force--was the real master of his fate. This interpretation of the book would place the author in the same Gnostic tradition as Archibald MacLeish,(J. B.) and Paddy Chayefsky, (Gideon)

    Growing Up with the Rochester Red Wings in the Forties and Fifties

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    I grew up an avid fan of baseball, football, and basketball in Rochester, NY, in the postwar years. The Rochester Royals were the only major league team but for me basketball was a stopgap until baseball began. The Royals and their players were fine, and I filled scrapbooks with the doings of Bobbie Davies and others. However, the Red Wings were the real deal for me. True, they were a minor league team but they were my minor league team. The games were easy to get to, and I could easily take a bus or even walk to them. The Knothole Gang card let kids into 9 or 10 free games, and my Dad often came with me on weekends for double-headers. He, too, was a baseball nut and socialized me into becoming a Yankee fan. The Italian ballplayers were our heroes, and the Red Wings had a few for us to follow and support. The fact that their parent club was in St. Louis at the time was fine since it was a National League team and good players would not go to Yankee rivals. By the time Baltimore became the parent club I was losing interest in the Wings and had moved on to other cities. However, the Wings kept a hold on me, as tenuous as it was. This paper examines that significant tie between a boy and his home team in a minor league city and its impact on his maturing young years

    « Oh! Vous voilà ! » L'anthropologue hétérosexuel et le sexe

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    * Oh ! Vous voilĂ  ! »L'anthropologue hĂ©tĂ©rosexuel et le sexeJ'ai rĂ©alisĂ© sept enquĂȘtes sur le terrain au Nigeria, une au Kenya, cinq en Angleterre, d'autres aux États-Unis, avec des musiciens de jazz, des Asiatiques ougandais et des Italo-AmĂ©ricains, ainsi qu'au Canada, parmi les immigrants asiatiques ougandais. À chaque voyage je me trouvais Ă  une Ă©tape diffĂ©rente de ma vie et de ma carriĂšre. De plus, chaque voyage fut diffĂ©rent quant Ă  sa «signification sexuelle». Par exemple, j'ai cherchĂ© des prostituĂ©es lors d'un voyage, une autre fois j'Ă©tais accompagnĂ© par une Ă©tudiante adulte, puis par ma fiancĂ©e de quelques semaines, enfin ma femme et mes enfants Ă©taient avec moi lors de mon dernier sĂ©jour au Nigeria. Je mets Ă  profit mes propres expĂ©riences pour discuter plusieurs variables qui affectent les pratiques hĂ©tĂ©rosexuelles sur le terrain et influencent l'enquĂȘte en cours : notamment l'Ăąge, le statut professionnel, le lieu de l'enquĂȘte, les personnes qui accompagnent le chercheur, etc. À cette Ă©tape de notre connaissance de l'enquĂȘte sur le terrain en lien avec la sexualitĂ©, une bonne analyse passe d'abord par une bonne description.« Oh ! There You Are ! »Sex and the Heterosexual AnthropologistI have conducted fieldwork in Nigeria on seven separate occasions, in Kenya once, in England on five separate occasions, in the United States for many years with jazz musicians, resettled Ugandan Asians, and Italian-Americans, and in Canada on resettled Ugandan Asians. For each of these trips, I have been at a diffĂ©rent stage of professional and life-span development In addition, each trip has been diffĂ©rent in ils « sexual meaning ». For example, on one trip I sought out prostitutes, on another I had an adult student with me, my bride of a few weeks on yet another, and my wife and children on my last trip to Nigeria. I am using my expĂ©eiences to discuss a number of variables that affect heterosexual practices in the field and influence the fieldwork that is conducted; specifically, age, professional status, place of fieldwork, persons accompanying the field worker, and so on. At this stage of our knowledge of fieldwork and sexuality, good description is essential to good analysis

    Cet homme me sortit de ma déprime

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    Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression

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    Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such as serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated. Epidemiological data suggest that caffeine consumption can have an impact on aspects of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for A1/A2A receptors, and has been demonstrated to modulate behavior in classical animal models of depression. Moreover, selective adenosine receptor antagonists are being assessed for their antidepressant effects in animal studies. This review focuses on how caffeine and selective adenosine antagonists can improve different aspects of depression in humans, as well as in animal models. The effects on motivational symptoms of depression such as anergia, fatigue, and psychomotor slowing receive particular attention. Thus, the ability of adenosine receptor antagonists to reverse the anergia induced by dopamine antagonism or depletion is of special interest. In conclusion, although further studies are needed, it appears that caffeine and selective adenosine receptor antagonists could be therapeutic agents for the treatment of motivational dysfunction in depression

    The M3 muscarinic receptor Is required for optimal adaptive immunity to Helminth and bacterial infection

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    Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus brasiliensis and Salmonella enterica serovar Typhimurium, as M3R-/- mice were impaired in their ability to resolve infection with either pathogen. CD4 T cell activation and cytokine production were reduced in M3R-/- mice. Immunity to secondary infection with N. brasiliensis was severely impaired, with reduced cytokine responses in M3R-/- mice accompanied by lower numbers of mucus-producing goblet cells and alternatively activated macrophages in the lungs. Ex vivo lymphocyte stimulation of cells from intact BALB/c mice infected with N. brasiliensis and S. typhimurium with muscarinic agonists resulted in enhanced production of IL-13 and IFN-Îł respectively, which was blocked by an M3R-selective antagonist. Our data therefore indicate that cholinergic signalling via the M3R is essential for optimal Th1 and Th2 adaptive immunity to infection
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